The purpose of this study is to analyze whether the construction of road infrastructure, sea and air transportation infrastructure, economic infrastructure, agricultural infrastructure, education infrastructure, and health infrastructure has a varied picture of improving community welfare and economic growth in Merauke and Boven Digoel Districts. This study used a qualitative approach with descriptive analysis methods. The data analyzed were secondary time-series data for 2005-2014. Secondary data sources were infrastructure development data with indicators each in BPS in two districts and Papua Province. The results showed that road infrastructure, sea and air transportation infrastructure, agricultural infrastructure with irrigation channel indicators, economic infrastructure with traditional market indicators, and education infrastructure had a positive effect on people’s welfare, but did not have a positive effect on economic growth. Health infrastructure has a positive effect on people’s welfare. Economic growth does not have a positive picture of the level of community welfare.