Construction Of Lines Research Articles

Is the Tupul (Makhuam) Landslide of 29-30 June 2022 in Manipur, India Recognized as one of the Rainfall Induced Massive Landslide?

The present study deals with Tupul landslide in Manipur which triggered on the intervening night of 29th -30th June 2022 in Noney district of Manipur. The death toll was 61 persons in total from Territorial Army, NF Railway’s employees, Villagers and labours from various contractors in the construction of railway line from Jiribam to Imphal. We have conducted a drone survey on the landslide site for preparation of large-scale terrain map and compared 2009 CARTOSAT image to pick up the slip surfaces. The detailed fieldwork of the study area deciphers highly jointed, fractured, faulted rock formations and display neo-tectonic movements. The slope failure analysis was conducted using the Phase-2 software and the failure was compared with the Drone made DEM, which is used to estimate the volume of debris falling on the railway formations. The excessive precipitation (375.6mm) during the May 2022 was recorded near the landslide site which was 60% more than the normal precipitation. In order to maintain the safety of the man and materials for the future, a number of suggestions were proposed for future monitoring of slope along coming up railway lines of Northeast Frontier Railways.

Influence of Interior Column on the Behaviour of Quasi-Rectangular Tunnel

The growing population in major cities around the world requires significant development of transportation infrastructure, especially underground system. It requires the construction of more subway lines, and larger tunnel cross-sections. In underground construction, a cross-sectional shape which is a combination of circular and rectangular tunnels is an advanced trend. This shape incorporates the advantages of both forms. There are two terminologies used to classify these shapes, including sub-rectangular and quasi-rectangular tunnels. While the sub-rectangular tunnel lacks an interior column, the quasi-rectangular tunnel includes an interior column located at the center of tunnel. Recent studies focus on separately investigating the behavior of sub-rectangular and quasi-rectangular tunnels using various methods such as numerical methods, analytical methods, and experimental methods. The present study conducted a numerical comparison of these two types of tunnels. The results indicated that the presence of an interior column help to increase the stability of the lining structure. The internal forces within the quasi-rectangular tunnel with an interior column are smaller than those of the sub-rectangular tunnel and quasi-rectangular tunnel without an interior column.

Fresh, Compressive and Direct-Tensile characterization of Engineered Cementitious Composite

A new category of high-performance fiber-reinforced composite broadly known as Engineered Cementitious Composite (ECC) has gained rapid attention in the construction industry in recent years. The exceptional behaviour of ECC, therefore high ductility, toughness, and durability, make it a promising material for various structural applications such as tunnel inner lining, dam and bridge deck slab construction. This investigation aims to study the fresh and mechanical characteristics of ECC, including workability, compressive, and direct tensile strength. A total of 15 ECC mixes are prepared with varying superplasticiser-binder ratio (0.200, 0.225, 0.250, 0.275 and 0.300 %), sand-binder ratio (0.35, 0.40 and 0.45) and a constant water-binder ratio (0.27). The mini-slump cone test was performed to examine the workability of the fresh ECC mixtures. The results showed that using a higher content of the superplasticiser resulted in an upsurge in both the workability of the fresh ECC mixtures and the mechanical strength of ECC, particularly the tensile strength. Apart from this, both the mechanical tests are performed at the 7 and 28 days. As per the results, both the compressive strength and direct tensile strength of ECC are found to be comparatively higher than that of the conventional mix. In conclusion, ECC is an efficient construction material for various structural applications, especially for the latest 3D printing construction techniques. The uniform dispersion of fibers significantly improves the tensile strength and ductility of ECC, making it a suitable material for seismic-resistant structures.

Analysis of Bridge Dynamics and Response Characteristics Under The Influence of Axle Coupling Vibration

To ensure the safety and stability of high-speed rail lines and reduce external interference, it is essential to build a large number of elevated bridges. These elevated bridges account for a considerable proportion of the total length of high-speed rail lines. However, when high-speed rail lines pass through earthquake prone areas, the likelihood of earthquakes occurring when trains pass through bridges increases significantly. Therefore, it is necessary to study the dynamic response of bridge structures under earthquake action to ensure the safety of bridges during train operation and operation. The optimization scheme proposed in this article has undergone moderate impact tests, and the results show that the maximum lateral displacement of the bridge can reach 124 mm, while the maximum vertical acceleration is 5.16 m/s2, Exceeded the safety limit of 0.35 g. Through the analysis of train derailment coefficient, wheel load reduction rate, lateral sway force, lateral and vertical acceleration, and Spelling comfort index, we have come to the conclusion that bridges can ensure the safety of train operation in the absence of earthquakes and small earthquakes, and can also maintain certain stability under medium and large earthquakes. These research results have important guiding significance for the design and construction of high-speed rail lines. By optimizing the bridge structure and adopting relevant technical measures, the seismic disaster resistance of high-speed rail lines can be further improved, ensuring the safety and comfort of passengers during travel. At the same time, these research results also provide useful reference and inspiration for the construction and improvement of future high-speed rail lines.

Abstract 2819: Novel drug resistant CDX models for anti-cancer drugs discovery

Abstract Oncogene BRAF is located on chromosome 7q34, consisting of 766 amino acids and 22 exons, encoding a serine/threonine protein kinase belonging to the RAF family and plays a critical role in the MAPK signaling pathway. The mutation of BRAF was documented in nearly 8% of all human cancers including melanoma (60%), thyroid (60%), and lung adenocarcinoma (10%). The most common mutation of BRAF is V600E (Class I), which was found in more than 70% in these cancers. Despite the clinical success of approved small molecule inhibitors of BRAF V600E (vemurafenib, dabrafenib and encorafenib), this remains an area of unmet medical need because of primary or acquired drug resistance. The construction of BRAF drug-resistant cell lines plays a pivotal role in cancer research. It serves as a crucial tool for discovery of the mechanisms of drug resistance. In this study, we have developed a systematic approach for constructing drug-resistant cell lines, inducing resistance through the gradual escalation of drug concentrations. The validation of drug resistance involves morphological recordings of parent and drug-resistant cell lines, drug resistance index in vitro through IC50 measurements and in vivo through the inhibition of tumor growth (TGI) which compare to those in the parental cell line. We successfully established Vemurafenib and Dabrafenib resistant A375 cell lines (A375 Vemurafenib R, A375 Dabrafenib R) with 21 and 31.5 folds of resistance index, respectively. The in vivo drug resistance efficacy was also tested by implanting Vemurafenib resistant cells subcutaneously into NOD-SCID mice and showed that A375 Vemurafenib R exhibited robust tolerance to 50 mg/kg Vemurafenib treatment (P.O.21 days, 50mpk, TGI=17.4%), whereas the parental cells were nearly completely inhibited (P.O.21 days, 50mpk, TGI=92.3%). In addition, single-cell sequencing of A375 Vemurafenib R revealed significant gene expression differences in the MAPK and EGFR signaling pathways, aiding in the identification of new targets, and signaling pathways associated with drug resistance, thereby providing potential targets for new drug development. Citation Format: Hai-Ting Dai, Tie-Jun Bing, Zhi-Da An, Jie Yang, Tian-Yu Pang, Jia-Wei Gao, Yun-Yi Bo, Wen-Jen Yu. Novel drug resistant CDX models for anti-cancer drugs discovery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2819.

Comprehensive Evaluation of NIMBY Phenomenon with Fuzzy Analytic Hierarchy Process and Radar Chart

The risk level of the NIMBY (Not In My Back Yard) phenomenon is crucial for the safety and economy of transmission and transformation projects which is rarely studied, especially for site selection and the construction of transmission lines and substations. In order to effectively evaluate the risk level to solve the dilemma caused by the NIMBY phenomenon, an evaluation method for quantifying the level of the NIMBY phenomenon is proposed. In this paper, thirty-one evaluation criteria and a risk model are put forward according to relevant laws and regulations that should be followed in the transmission and transformation project in China, then the scores corresponding to these criteria are obtained by a questionnaire survey. The radar chart method and minimum area method are applied to determine the weights of the element and unit layers. Furthermore, the overall risk level is evaluated by the fuzzy comprehensive evaluation method. In addition, a transmission and transformation project in Xi’an City, China, is used as an example to verify the correction of the risk model and its evaluation method. The results show that the weaknesses in the transmission and transformation project are analyzed, and suggestions for decreasing the risk level are put forward to minimize losses due to the NIMBY phenomenon.

Research on the management and control information system and function design of overhead transmission line construction based on B/S architecture

Research on the management and control information system and function design of overhead transmission line construction based on B/S architecture

Derivation of Creep Parameters for Surrounding Rock through Creep Tests and Deformation Monitoring Data: Assessing Tunnel Lining Safety

Tunnel instability and lining integrity are intimately tied to the creep properties of the surrounding rock. The acquisition of rock mass creep parameters is critical in ascertaining the appropriate timing for lining construction. Nevertheless, creep tests on rock specimens conducted in a controlled setting cannot be straightforwardly extrapolated to rock mass creep analysis. This study performs laboratory-based creep tests on mudstone samples and establishes the corresponding creep constitutive model. The integration of a Mohr–Coulomb element with the Burgers model in series serves to characterize the yield creep behavior of the rock mass. Additionally, the research outlines a series of 100 orthogonal experiments utilizing randomized creep parameters and formulates a GA-BP neural network inversion model. Employing long-term deformation measurements from the crown and sidewalls of the project site, this study deduces the creep parameters of the mudstone in the investigated tunnel section and examines the prolonged deformation traits of the surrounding rock. Drawing on the deformation traits of the surrounding rock and the forces impacting the primary support and lining structures, this paper evaluates the earliest and latest viable lining casting periods and pinpoints an optimal timing interval for lining implementation. The methodologies employed herein can serve as a benchmark for analogous endeavors internationally.

Mathematical Simulation for Right of Way Corridor for Overhead Transmission Line

Transmission lines play a vital role in the operation of a reliable electrical power system and that is why the transmission line system is considered as a lifeline system for power supply. The transmission line traverses across the length and breadth of the country, and it crosses all the natural reserves like forests, rivers, vegetation, mountains, etc., to make the system effective, Right of Way (ROW) plays a decisive role in the transmission line. But in today’s growing population and economy, land acquisition for the construction of transmission lines is a major bottleneck. This leads to huge compensations for the utilities and a threat to the natural resources. This paper attempts to arrive at a mathematical simulation for effective ROW by studying different codal provisions and utility practices. The approach is made to make efficient use of the land available without compromising any relevant parameters for ROW.

Feasibility analysis of dynamic improvement of current carrying capacity of overhead lines

The demand for electricity in China has been increasing year by year. However, the construction of transmission lines is costly and has significant composite short-term peak characteristics. This article aims to study the feasibility of improving the conductor’s current capacity, analyze data characteristics of typical conductor states and micrometeorological data, figure out the real-time conductor’s current capacity based on the calculation model, analyze the margin for improving the CCC, and lift the power supply potential.

Construction and identification of a stable CT26 cell line expressing CD19-FLUC-GFP

Solid tumors lack well-defined targets for chimeric antigen receptor T-cell (CAR-T) therapy. Therefore, introducing a known target molecule, CD19, into solid tumor cell lines via lentiviral transduction to investigate the cytotoxicity of CD19 CAR-T cells can potentially support CAR-T cell therapy against solid tumors. In this study, a stable colon cancer CT26 cell line, CT26-CD19-FLUC-GFP, expressing CD19, firefly luciferase (FLUC), and green fluorescent protein (GFP), was constructed using a triple-plasmid lentiviral system. The growth characteristics of this cell line were consistent with those of the CT26 cell line. Subsequent flow cytometry analysis confirmed stable expression of CD19 and GFP in CT26-CD19-FLUC-GFP cells after serial passaging up to the 5th, 10th, and 22nd generations. Further validation revealed significantly higher levels of CD19 mRNA and FLUC expression in CT26-CD19-FLUC-GFP cells continuously passaged up to the 22nd generation compared to the control CT26 cells. In comparison to T cells, CD19 CAR-T cells demonstrated substantial cytotoxicity against CT26-CD19-FLUC-GFP cells and MC38-CD19 cells. One week after intraperitoneal implantation of CT26-CD19-FLUC-GFP cells into mice, FLUC expression in the peritoneal region could be detected. These results indicate the successful establishment of a stable CT26 cell line expressing CD19-FLUC-GFP, which can be specifically targeted by CD19 CAR-T cells.

UBE2L3 Promotes Oxidative Stress-regulated Necroptosis to Accelerate Osteosarcoma Progression.

Osteosarcoma is a highly invasive bone marrow stromal tumor with limited treatment options. Oxidative stress plays a crucial role in the development and progression of tumors, but the underlying regulatory mechanisms are not fully understood. Recent studies have revealed the significant involvement of UBE2L3 in oxidative stress, but its specific role in osteosarcoma remains poorly investigated. This study aimed to explore the molecular mechanisms by which UBE2L3 promotes oxidative stress-regulated necroptosis to accelerate the progression of osteosarcoma using in vitro cell experiments. Human osteoblast hFOB1.19 cells and various human osteosarcoma cell lines (MG-63, U2OS, SJSA-1, HOS, and 143B) were cultured in vitro. Plasmids silencing UBE2L3 and negative control plasmids were transfected into U2OS and HOS cells. The cells were divided into the following groups: U2OS cell group, HOS cell group, si-NC-U2OS cell group, si-UBE2L3-U2OS cell group, si-NC-HOS cell group, and si-UBE2L3-HOS cell group. Cell viability and proliferation capacity were measured using the Tunnel method and clonogenic assay. Cell migration and invasion abilities were assessed by Transwell and scratch assays. Cell apoptosis was analyzed by flow cytometry, and ROS levels were detected using immunofluorescence. The oxidative stress levels in various cell groups and the expression changes of necroptosis-related proteins were assessed by PCR and WB. Through these experiments, we aim to evaluate the impact of oxidative stress on necroptosis and uncover the specific mechanisms by which targeted regulation of oxidative stress promotes tumor cell necroptosis as a potential therapeutic strategy for osteosarcoma. The mRNA expression levels of UBE2L3 in human osteosarcoma cell lines were significantly higher than those in human osteoblast hFOB1.19 cells (p <0.01). UBE2L3 expression was significantly decreased in U2OS and HOS cells transfected with si-UBE2L3, indicating the successful construction of stable cell lines with depleted UBE2L3. Tunnel assay results showed a significant increase in the number of red fluorescent-labeled cells in si-UBE2L3 groups compared to si-NC groups in both cell lines, suggesting a pronounced inhibition of cell viability. Transwell assay demonstrated a significant reduction in invasion and migration capabilities of si-UBE2L3 groups in osteosarcoma cells. The clonogenic assay revealed significant suppression of proliferation and clonogenic ability in both U2OS and HOS cells upon UBE2L3 knockdown. Flow cytometry confirmed that UBE2L3 knockdown significantly enhanced apoptosis in U2OS and HOS cells. Immunofluorescence results showed that UBE2L3 silencing promoted oxidative stress levels in osteosarcoma cells and facilitated tumor cell death. WB analysis indicated a significant increase in phosphorylation levels of necroptosis-related proteins, RIP1, RIP3, and MLKL, in both osteosarcoma cell lines after UBE2L3 knockdown. In addition, the expression of necrosis-associated proteins was inhibited by the addition of the antioxidant N-acetylcysteine (NAC). UBE2L3 is upregulated in osteosarcoma cells, and silencing of UBE2L3 promotes oxidative stress in these cells, leading to enhanced necroptosis and delayed progression of osteosarcoma.

PEMBANGUNAN TRANSPORTASI KERETA API JALUR GOENDIH (GROBOGAN) – SOERABAJA TAHUN 1903-1922

This study examines the Goendih-Soerabaja railway line for the period 1903-1922. The purpose of this study is to explain the reasons for the construction of the railroad, the process of building the railroad, and its impact on the surrounding community. The results of this study indicate that the construction of the Goendih-Soerabaja railway line had a positive impact on the economy of the Dutch East Indies Government. Inaugurated on February 1, 1903, rail transportation encouraged economic growth in areas that became the path of the Goendih-Soerabaja railroad. The forced cultivation system has had a major impact on plantations, problems that have occurred due to the damage of export commodities before arriving at the port can now be resolved by the presence of rail transportation. Another factor is that the start of oil drilling operations in the Tjepu area has created the need for large-capacity oil transport in shipping to ports. Another impact of the existence of rail transportation is that the mobility of people who travel now saves more travel time.&#x0D; Keywords: Infrastructure; Railroad Extension; Goendih – Soerabaja Line; Capitalist Economy.

A Study on the Results of Risk Analyses Applying the Concept of Rock Mass Stand-Up Time for Underground Mining Sites

Throughout all the countries in the world, including Vietnam, nations with well-established mining industries have undertaken extensive research on the stability of rock masses when constructing underground tunnels in varied geological conditions. The present study aims to provide a comprehensive overview of the risk assessment related to rock masses during the construction of pit lines in mining operations. Consequently, the standing time of unsupported tunnels is assessed based on different values of the strength index and deformation characteristics of the rock mass. The objective was to perform both experimental and theoretical investigations to analyse how the stand-up time of rock masses surrounding a tunnel affects the unsupported span. The analyses were based on considering the rock parameters, including strain modulus; geological strength index; and allowable displacement values, and consideration of hereditary creep properties. By examining tunnels excavated in rock strata, it was concluded that varying geological strength index values resulted in distinct creep behaviour in the surrounding rock masses. Thus, it was reasonable to compute the unsupported span and stand-up time of tunnels. The research revealed that permissible displacements are significantly influenced by the types of rock materials surrounding the tunnel structure. Recognising the significance of time, the authors introduce a more practical interpretation and evaluation of the stability of rock masses, thus enhancing the precision of commonly available models.

Wind Farms and Power Lines Reduced the Territory Status and Probability of Fledgling Production in the Eurasian Goshawk Accipiter gentilis

Wind power is commonly used to reduce greenhouse gas emissions but often has negative effects on biodiversity. In this study, I investigated the effects of wind farm and power line construction on the territory status of the Eurasian goshawk Accipiter gentilis, whether fledglings were produced or not, and the number of fledglings. Included were 55 goshawk territories investigated before and after the construction period. I found that the territory status declined significantly in the influence area within 3 km from the disturbance compared to the control area more than 7 km away. Interestingly, the decline in territory status was similar in the distance categories 0–1 km, 1–2 km, and 2–3 km, while there was nearly no change in territory status in the control area, thus indicating that the influence area from this kind of disturbance was minimum 3 km from the nest. The number of breeding pairs declined significantly during the construction period only in the influence area. Possible reasons might be higher mortality caused by collisions with power lines, desertion, avoidance of the areas with noise and disturbance from the constructions, and possible indirect effects caused by reductions in prey species. I found no effects of the construction on the number of fledglings.

Analysing firm-level impacts of high-speed railways on reducing business costs: evidence from China

ABSTRACT Numerous studies have revealed that high-speed railways (HSRs) can efficiently reduce transportation costs for firms and therefore bring more business capacities to firms in regions with HSR services. This paper aims to adopt the difference-in-difference (DID) and PSM (propensity score matching) DID methods to examine the HSR’s causal effects on business costs. The author finds that business costs are significantly reduced due to the operation of HSR lines. Besides, private firms and firms in the secondary and tertiary sectors would experience more reductions of business costs encouraged by the HSR than state-owned and agricultural firms. The placebo test and parallel trend test have proved the feasibility of this study. Finally, this paper provides policy suggestions that the construction of HSR lines needs to be encouraged in order to promote the higher efficiency of business operations for firms and more-balanced spatial business developments in China.

Compact microstrip patch antenna loaded with Artificial Transmission Line for wireless applications

ABSTRACT This article presents an efficient yet simple spiral antenna design methodology for 2.44 GHz Wireless Local Area Network (WLAN) applications. In the suggested design, the antenna’s radiating section is redesigned with a particular Artificial Transmission Line (ATL) construction that allows for good downsizing. Circuit analysis and electromagnetic solver are used to verify the design, which demonstrate good agreement with the measured results. The electromagnetic simulation and passive component analysis reveal that the new design matches the traditional designs in terms of frequency tuning and size reduction. The overall footprint of the proposed ATL design is (33 × 25 × 1.6) mm3 which equals to 0.2684λ×0.2033λ×0.013λ, where λ is the distance travelled by the wave per cycle at the operating frequency of 2.44 GHz. The antenna has a gain of 3.8dBi and a 50Ω impedance. Modifying the interdigital capacitance and inductance used in the ATL structure to achieve a longer electrical length of the line can also improve the wave guide mode of excitation. As a result, the phase constant is regulated, allowing for good antenna size minimisation. The effect of interdigital inductance and capacitance on the operating bands is also analysed.

Long-Term Prevalence Trends in Children in Relation to Environmental Issues in the Astrakhan Region

Introduction: One of the tasks of preventive medicine and hygiene is to study the relationship between environmental factors and human health. The purpose of the study was to compare pediatric prevalence rates in the Astrakhan Region and in the city of Astrakhan in 2007–2020 with those for the Russian Federation in relation to per capita emissions of environmental pollutants. Materials and methods: We used official statistics on the size of population, prevalence rates in children, and emissions of air pollutants in the Astrakhan Region for the years under study. Methods of mathematical and statistical analysis, construction of trend lines and calculation of linear regression equations using built-in Microsoft Excel software were applied. An online Spearman’s Rho Calculator was used to compute correlation coefficients. Results: The prevalence in children showed a statistical downward trend both in Astrakhan and in the Astrakhan Region as a whole with its rates being, on average, 7.8 % and 15.6 % lower than the national ones, respectively. The Spearman’s Rho (rs) showed the presence of a high and direct statistically significant correlation between per capita emissions of air pollutants and disease prevalence in the child population in the Astrakhan Region (rs = 0.73; p = 0.003) with a moderate direct, yet insignificant, correlation for the Russian Federation as a whole (rs = 0.32; p = 0.41) and null correlation for the data computed for the of Astrakhan (rs = 0.26; p = 0.32). Conclusion: Along with the predicted decreasing trend in prevalence in the pediatric population, we established a statistical relationship between local environmental problems and children’s health, which should be taken into account in the development of disease prevention programs.

The Capacity-to-load ratio optimization method considering collaborative planning of multi-voltage level power grids

The capacity-to-load ratio is an important indicator to guide power grid planning and has a decisive influence on the selection of substation capacities and the construction of power lines. A capacity-to-load ratio optimization method concerning collaborative planning of multi-voltage level power grids is proposed in this paper. This method aims to minimize the construction cost and takes into account the collaborative planning of substations and power lines of multiple voltage levels. By combining the Bayesian optimization algorithm (BOA) and genetic algorithms (GA), a BOA-GA solving algorithm for the planning model is proposed. This algorithm automatically generates planning schemes for multi-voltage level power grids, and obtains the optimal capacity-to-load ratio, as well as the optimal investment of the power grid construction. Case studies demonstrate that the proposed model can optimize the capacity-to-load ratio and automatically plan the network structure of multi-voltage level power grids. The construction cost is significantly reduced while various technical indicators are satisfied. Additionally, the study reveals that the relationship between the capacity-to-load ratio and the overall investment of multi-voltage level power grid construction is a quadratic function over a long-time scale. And the curve is a parabola going upwards.

Preparation and characteristics of nano-MgO/polypropylene composite insulating material for ultra-high voltage DC transmission line construction

Preparation and characteristics of nano-MgO/polypropylene composite insulating material for ultra-high voltage DC transmission line construction