ABSTRACT Nigeria's construction industry, which mirrors a global trend, actively seeks methods to ensure a sustainable future. Sustainable construction practices have become a focal point for research and development, and biomimicry presents significant potential in achieving this goal. However, despite its advantages, challenges impede its widespread adoption. This study employed a multi-pronged approach, combining an in-depth literature review with descriptive and exploratory factor analysis (EFA) of data collected through well-structured questionnaires administered to construction professionals. The study of 243 responses, alongside existing literature, suggests that a lack of awareness regarding biomimicry principles presents the primary barrier to its adoption. Furthermore, the identified challenges were categorised into three distinct groups: regulatory, institutional, and attitudinal. To address the challenges of biomimicry adoption in the construction industry, the paper proposes a three-pronged solution: implementing regulatory measures, improving professional practices, and prioritising stakeholder education.