Effects Of Excessive Alcohol Consumption Research Articles

Metabolic dysfunction-associated fatty liver disease and heavy alcohol consumption increase mortality:A nationwide study.

The effects of excessive alcohol consumption on the prognosis of metabolic dysfunction-associated fatty liver disease (MAFLD) remain unclear. We investigated all-cause and cause-specific mortality according to the amount of alcohol consumed by Asian individuals with MAFLD. This nationwide retrospective study included 996,508 adults aged 40-79years who underwent health check-ups between 2009 and 2012. Participants were categorized by the alcohol consumption-non-alcohol, moderate alcohol, and heavy alcohol group (≥ 30g/day for men, ≥ 20g/day for women) and by the combination of the presence or absence of MAFLD. Hepatic steatosis was defined as the fatty liver index ≥ 30. Cox analyses were used to analyze the association between alcohol consumption and MAFLD and all-cause and cause-specific mortality. MAFLD significantly increased all-cause, liver-, and cancer-related mortality. Individuals with both MAFLD and heavy alcohol consumption expressed the highest mortality risk in liver-related mortality compared to non-MAFLD and non-alcohol group (adjusted hazard ratio (HR), 9.8; 95% confidence interval (CI), 8.20-12.29). Regardless of MAFLD, heavy alcohol consumption increased the risk of liver- and cancer-related mortality. MAFLD and heavy alcohol consumption increased all-cause, liver-, and cancer-related mortality. Heavy alcohol consumption and MAFLD synergistically increase liver-related mortality.

Binge drinking and the risks to adolescent health

Adolescence is a phase characterized by physical, emotional and social changes that make adolescents more susceptible to risky practices and behaviors. One of these common practices is excessive alcohol consumption, known as “binge drinking”, which causes numerous acute and chronic health problems. This article presents some characteristics observed in adolescent development and the consequences of excessive alcohol consumption for physical and emotional health, and its repercussions on community life.
 Keywords: Adolescence, Alcohol, Binge Drinking, Adolescent Health

Influences Encouraging Alcohol Use among Bachelor of Medicine and Surgery Students at Kampala International University, Western Campus, Ishaka Bushenyi, Western Uganda

Alcohol consumption poses a significant public health concern, especially among university students who often experience newfound independence from direct parental oversight. This study aimed to identify the factors driving alcohol consumption among Kampala International University's Bachelor of Medicine and Surgery students. Employing a descriptive cross-sectional approach and self-administered questionnaires, data collection focused on alcohol-consuming students via snowball sampling. Statistical Package for Social Sciences (SPSS) software facilitated data analysis. Of the 384 participating students who consumed alcohol, nearly half (47.7%) fell within the 20-24 age range, evenly representing both genders. Notably, no substantial correlations emerged between alcohol use and age, gender, religion, or academic year. A majority of students initiated alcohol consumption at 16 years or older (41.4%). Significant associations were found between alcohol consumption and upbringing, as well as university residence. Urban upbringing and off-campus residency correlated with higher alcohol consumption. Psychologically, family structure played a role, with 59.4% of participants living with both parents reporting alcohol consumption. Peer influence was prevalent, with a substantial number introduced to alcohol by friends, either at university (32%) or at home (35.2%). While 97.7% recognized alcohol as a mood-altering stimulant, only 29.1% acknowledged the link between young adult binge drinking and future alcoholism development. Merely 12.5% believed that early alcohol exposure increased the risk of dependence, yet 93.5% recognized its association with academic underperformance or dropout. Alcohol abuse among university students appears normative, shaped by family norms and peer pressure. Supervision by family and university staff, coupled with educational interventions highlighting the health risks and consequences of excessive alcohol consumption, stand as effective measures to address this societal issue. Keywords: risk factors, alcohol, students

A subchronic history of binge-drinking elicits mild, age- and sex-selective, affective, and cognitive anomalies in C57BL/6J mice.

Alcohol abuse is a risk factor for affective and cognitive disorders, with evidence indicating that adolescent-onset excessive drinking can result in long-term deficiencies in emotional regulation and cognition, with females more susceptible to the negative emotional and cognitive consequences of excessive alcohol consumption. However, our prior examination of the interactions between sex and the age of drinking-onset indicated minimal signs of anxiety-like behavior during alcohol withdrawal, which may have related to the concurrent anxiety testing of male and female subjects. The present study addressed this potential confound by assaying for alcohol withdrawal-induced negative affect separately in males and females and expanded our investigation to include measures of spatial and working memory. Following 14 days of drinking under modified Drinking-in-the-Dark procedures (10, 20, and 40% alcohol v/v; 2 h/day), adolescent and adult binge-drinking mice of both sexes exhibited, respectively, fewer and more signs of negative affect in the light-dark shuttle-box and forced swim tests than their water-drinking counterparts. Adolescent-onset binge-drinking mice also exhibited signs of impaired working memory early during radial arm maze training during early alcohol withdrawal. When tested in late (30 days) withdrawal, only adult female binge-drinking mice buried more marbles than their water-drinking counterparts. However, adolescent-onset binge-drinking mice exhibited poorer spatial memory recall in a Morris water maze. These findings indicate that a subchronic (14-day) binge-drinking history induces mild, age- and sex-selective, changes in negative affect and cognition of potential relevance to understanding individual variability in the etiology and treatment of alcohol abuse and alcohol use disorder.

Systemic effects of excessive alcohol consumption.

Nursing2023 will no longer facilitate mail-in nursing continuing professional development tests. All NCPD tests must be taken online at www.nursingcenter.com/CE. Please address any questions to customer service at 1-800-787-8985. For more than 179 additional nursing continuing professional development activities related to medical-surgical topics, go to NursingCenter.com/ce.

Systemic effects of excessive alcohol consumption.

This article presents priority nursing assessments and interventions that address the multicellular assault of excessive alcohol consumption on bodily organs and the impact on the patient's quality of life.

Aqueous extract of Laurus nobilis leaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats.

Excessive alcohol consumption has harmful health effects, including alcohol hangovers and alcohol-related liver disease. Therefore, methods to accelerate the alcohol metabolism are needed. Laurus nobilis is a spice, flavoring agent, and traditional herbal medicine against various diseases. This study examined whether the standardized aqueous extract of L. nobilis leaves (LN) accelerates the alcohol metabolism and protects against liver damage in single-ethanol binge Sprague-Dawley (SD) rats. LN was administered orally to SD rats 1 h before ethanol administration (3 g/kg body weight [BW]) at 100 and 300 mg/kg BW. Blood samples were collected 0.5, 1, 2, and 4 h after ethanol administration. The livers were excised 1 h after ethanol administration to determine the hepatic enzyme activity. The alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in the liver tissue were measured. LN decreased the serum ethanol and acetaldehyde levels in ethanol-administered rats. LN increased the hepatic ADH and ALDH activities but decreased the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities in the ethanol-administered rats. In addition, LN inhibited lipid peroxidation and increased the activities of SOD and GPx. LN modulates the mediators of various etiological effects of excessive alcohol consumption and enhances the alcohol metabolism and antioxidant activity, making it a potential candidate for hangover treatments.

The Significance of Culture and Regulations on Alcohol Abuse Among Youths in Rombo District Council

This study aimed at documenting the influence of culture and regulations on youths’ alcohol abuse in Rombo District. Questionnaires, Focus Group Discussions (FGDs) and Key-informant interviews were used for data collection. Quantitative and qualitative data were analysed by Statistical Product for Social Solutions (SPSS) version 20 and thematic analysis respectively. The study revealed that culture influence alcohol abuse among youths, and most of youths learn to consume alcohol from their parents. Study further found that there are a lot of unregistered drinking places making it difficulties for enforcement of bylaws. The study findings depict that in most cases there was less bylaws enforcement with police mainly focus on fines. The study concludes that alcohol abuse among youths in Rombo District is attributed by cultural perceptions on alcohol as a status and prestige, less by law enforcement and easily availability of alcohol in the study area. The study recommends that family heads should discourage alcohol consumption; through being role models, the government should make sure that all alcohol selling points are registered, enforcement of by laws on alcohol consumption and community is provided with education on the negative effects of excessive alcohol consumption.

Social capital and alcohol risks among older adults (50 years and over): analysis from the Drink Wise Age Well Survey

AbstractAlthough there has been significant research on the relationship between alcohol consumption and demographic and psychological influences, this does not consider the effect of social influence among older drinkers and if these effects differ between men and women. One aspect of social influence is social capital. The aim of this paper is to examine whether relational and cognitive social capital are associated with higher or lower risk of alcohol use among adults aged 50 years or older and to assess the extent to which this relationship differs between men and women. To investigate this, data were collected from a cross-sectional questionnaire survey of adults over the age of 50 in the United Kingdom who were recruited from general practitioners. The sample consisted of 9,984 individuals whose mean age was 63.87 years. From these data, we developed proxy measures of social capital and associate these with the respondent's level of alcohol consumption as measured on the Alcohol Use Disorders Identification Test (AUDIT-10) scale. In the sample, just over 20 per cent reported an increasing risk or dependency on alcohol. Using two expressions of social capital – relational (social relationships) and cognitive (knowledge acquisition and understanding) – we found that greater levels of both are associated with a reduced risk of higher drinking risk. Being female had no significant effect when combined with relational capital but did have a significant effect when combined with cognitive capital. It is argued that interventions to enhance social relations among older people and education to help understand alcohol risks would be helpful to protect older people from the damaging effects of excessive alcohol consumption.

Negative Health Effects of Excessive Alcohol Consumption: A Systematic Review

Drinking alcohol is one of the risk that faces the society, and the public health authorizes as well as the economics of countries. Several studies were conducted to understand the status of alcohol consumption. However, few studies reviewed the literature to identify the status quo of alcohol. This study aims to review the literature related to alcohol consumption. Keywords that are related to the topic were used to search for articles in reliable databases. The articles were filtered based on time, scope, language, and index. A timeframe of four years was used to have an update view of the consumption of alcohol. Only English articles related to alcohol consumption were used. The results of this systematic literature review indicate that most of the previous studies are quantitative. In addition, the result also showed that there is limited studies in developing countries. Social, economic and family related issues are consequence of excessive consumption of alcohol. There is a need for more studies in non-western context to understand the status and possible remedy for alcohol consumption.

Australia could miss the WHO hepatitis C virus elimination targets due to declining treatment uptake and ongoing burden of advanced liver disease complications.

Australia was one of the first countries to introduce government-funded unrestricted access to direct-acting antiviral (DAA) therapy, with 88,790 treated since March 2016. However, treatment uptake is declining which could potentially undermine Australia’s progress towards the WHO HCV elimination targets. Using mathematical modelling, we updated estimates for those living with chronic HCV in Australia, new cases of decompensated cirrhosis (DC), hepatocellular carcinoma (HCC), and liver-related mortality among the HCV-cured and viraemic populations from 2015 to 2030. We considered various DAA treatment scenarios incorporating annual treatment numbers to 2020, and subsequent uptake per year of 6,790 (pessimistic), 8,100 (intermediate), and 11,310 (optimistic). We incorporated the effects of excess alcohol consumption and reduction in progression to DC and HCC among cirrhosis-cured versus viraemic individuals. At the end of 2020, we estimated 117,810 Australians were living with chronic HCV. New cases per year of DC, HCC, and liver-related mortality among the HCV viraemic population decreased rapidly from 2015 (almost eliminated by 2030). In contrast, the growing population size of those cured with advanced liver disease meant DC, HCC, and liver-related mortality declined slowly. The estimated reduction in liver-related mortality from 2015 to 2030 in the combined HCV viraemic and cured population is 25% in the intermediate scenario. With declining HCV treatment uptake and ongoing individual-level risk of advanced liver disease complications, including among cirrhosis-cured individuals, Australia is unlikely to achieve all WHO HCV elimination targets by 2030.

Health warning labels and alcohol selection: a randomised controlled experiment in a naturalistic shopping laboratory.

Health warning labels (HWLs) on tobacco products reduce smoking. There is an absence of evidence concerning the impact of alcohol HWLs on selection or purchasing in naturalistic settings. Using a commercial-standard naturalistic shopping laboratory, this study aimed to estimate the impact on selection of alcoholic drinks of HWLs describing adverse health consequences of excessive alcohol consumption. A between-subjects randomised experiment with three groups was conducted: group 1: image-and-text HWL; group 2: text-only HWL; group 3: no HWL. A commercial-standard naturalistic shopping laboratory in the United Kingdom. Adults (n=399, 55% female) over the age of 18years, who purchased beer or wine weekly to drink at home. Participants were randomised to one of three groups varying in the HWL displayed on the packaging of the alcoholic drinks: (i) image-and-text HWL (n=135); (ii) text-only HWL (n=129); (iii) no HWL (n=135). Participants completed a shopping task, selecting items from a range of alcoholic and non-alcoholic drinks, and snacks. The primary outcome was the proportion of alcoholic drinks selected. Secondary outcomes included HWL ratings on negative emotional arousal and label acceptability. There was no clear evidence of a difference in the HWL groups for the percentage of drinks selected that were alcoholic compared to no HWL (44%): image-and-text HWL: 46% (odds ratio [OR]=1.08, 95% confidence interval [CI]=0.82, 1.42); text-only HWL: 41% (OR=0.87, 95% CI=0.67, 1.14). Concordant with there being no difference between groups, there was extreme evidence in favour of the null hypothesis (Bayes factor [BF]<0.01). Negative emotional arousal was higher (P<0.001) and acceptability lower (P<0.001) in the image-and-text HWL group, compared to the text-only HWL group. In a naturalistic shopping laboratory, there was no evidence that health warning labels describing the adverse health consequences of excessive alcohol consumption changed selection behaviour.

Cardiovascular Consequences of Excessive Alcohol Drinking via Electrocardiogram: A Systematic Review.

There is a link between excessive alcohol drinking and an increased risk to develop cardiovascular disease, including alcoholic cardiomyopathy. This association warrants further research on the potential utility for the electrocardiogram (ECG) in the participatory management of the chronic consequences of alcohol use disorder (AUD). Our goal is to enhance understanding about the pernicious role alcohol plays on cardiac health using the ECG, an accessible, cost-effective, validated tool to inform novel targeted treatments for AUD. In this systematic review of human studies, we examine the relationship between abnormal clinically significant changes to ECG variables and excessive alcohol drinking with the goal of identifying key patterns specific to quantity of alcohol consumed. Three independent reviewers and one consensus reviewer, adhering to the PRISMA guidelines, conducted an initial review on studies published from database inception to April 19, 2019, using PubMed, Embase, CINAHL and COCHRANE databases. The initial search generated 2,225 articles. The final selected number included 153 original articles. This systematic review provides evidence of patterns of clinically significant changes to ECG variables as a consequence of excessive alcohol consumption. Future directions include investigating whether a real-time assessment, such as the ECG, in conjunction with other key behavioral and cardiac measures, can help clinicians and patients realize the progressive and insidious cardiac damage because of excessive alcohol consumption. This theory-guided nurse science review supports the development of personalized symptom monitoring to deliver tailored feedback that illuminate risk factors as a potentially transformative approach in the management of AUD.

Association of Genetic Variation With Cirrhosis: A Multi-Trait Genome-Wide Association and Gene–Environment Interaction Study

In contrast to most other common diseases, few genetic variants have been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that predispose to cirrhosis, to test whether such variants, aggregated into a polygenic score, enable genomic risk stratification, and to test whether alcohol intake or body mass index interacts with polygenic predisposition. We conducted a multi-trait genome-wide association study combining cirrhosis and alanine aminotransferase levels performed in 5 discovery studies (UK Biobank, Vanderbilt BioVU, Atherosclerosis Risk in Communities study, and 2 case-control studies including 4829 individuals with cirrhosis and 72,705 controls and 362,539 individuals with alanine aminotransferase levels). Identified variants were replicated in 3 studies (Partners HealthCare Biobank, FinnGen, and Biobank Japan including 3554 individuals with cirrhosis and 343,826 controls). A polygenic score was tested in Partners HealthCare Biobank. Five previously reported and 7 newly identified genetic variants were associated with cirrhosis in both the discovery studies multi-trait genome-wide association study (P < 5× 10-8) and the replication studies (P < .05), including a missense variant in the APOE gene and a noncoding variant near EFN1A. These 12 variants were used to generate a polygenic score. Among Partners HealthCare Biobank individuals, high polygenic score-defined as the top quintile of the distribution-was associated with significantly increased risk of cirrhosis (odds ratio, 2.26; P < .001) and related comorbidities compared with the lowest quintile. Risk was even more pronounced among those with extreme polygenic risk (top 1% of the distribution, odds ratio, 3.16; P < .001). The impact of extreme polygenic risk was substantially more pronounced in those with elevated alcohol consumption or body mass index. Modeled as risk by age 75 years, probability of cirrhosis with extreme polygenic risk was 13.7%, 20.1%, and 48.2% among individuals with no or modest, moderate, and increased alcohol consumption, respectively (Pinteraction < .001). Similarly, probability among those with extreme polygenic risk was 6.5%, 10.3%, and 19.5% among individuals with normal weight, overweight, and obesity, respectively (Pinteraction < .001). Twelve independent genetic variants, 7 of which are newly identified in this study, conferred risk for cirrhosis. Aggregated into a polygenic score, these variants identified a subset of the population at substantially increased risk who are most susceptible to the hepatotoxic effects of excess alcohol consumption or obesity.

Alkohola edatearen eragina garun nerabean

Jakina da gure gizartean alkoholaren kontsumoa oso hedatuta eta onartuta dagoela; eta horren gehiegizko kontsumoak eragin ekonomikoak, sozialak eta osasunekoak ditu. Gehienetan alkoholaren lehendabiziko kontsumoa nerabezaroan gertatzen da. Jakinda garun nerabea heltzen ari den organoa dela, argi dago alkoholaren kontsumoak eraginak dituela haren garapenean. Haren ezaugarri biologikoak direla eta, garun nerabeak ez du gaitasun nahikoa ekintzen ondorioak aurreikusteko, eta horrek handitu egiten du alkoholaz gain beste droga batzuk gehiegi kontsumitzeko arriskua. Beraz, beharrezkoa egiten da nerabeei ezagutaraztea zeintzuk diren alkohola edatearen eragin kaltegarriak, beren kontsumo patroia alda dezaten. Horretarako, lan honetan alkoholaren gehiegizko kontsumoak garun helduan dituen eraginak azaltzen hasten gara, eta garun nerabean dituen eraginak azalduz amaituko dugu, tartean garun nerabeak dituen hainbat ezaugarri aipatuz.

Self-reported alcohol consumption in doctors.

The UK government has prioritized reducing the harmful effects of excessive alcohol consumption on mental and physical well-being. To assess self-reported alcohol consumption amongst doctors at an acute London Trust. An opportunistic, anonymous, survey was conducted by Postgraduate Education Fellows over 2 weeks in December 2018. This included all grades of doctors from Foundation Year One to Consultant. The survey consisted of nine questions, modified from the alcohol use disorders identification test (AUDIT) and CAGE questionnaire. Of 446 doctors within our institution, 109 completed the survey (24%). Fourteen per cent of those surveyed abstained from alcohol, 21% drank monthly or less, 31% drank between two to four times per month, 25% drank two to three times per week and 9% drank greater than four times per week. In the preceding 2 years, 9% reported being unable to do what was expected of them on at least one occasion due to alcohol. Five per cent were concerned about alcohol affecting their performance. Two per cent were annoyed by criticism of their drinking, 9% felt guilty about drinking and 4% needed an eye-opener. Eighteen per cent wanted to reduce their alcohol consumption; however, 43% of the 109 doctors surveyed were uncertain where to seek help. Twenty per cent of surveyed doctors reported consuming potentially hazardous levels of alcohol and 18% of respondents wanted to cut down. Forty-three per cent were unaware of sources of support. Our findings suggest a role for collaboration between Occupational Health departments and Postgraduate Education teams to support doctors misusing alcohol.

Alcohol Consumption, Brain Amyloid-β Deposition, and Brain Structural Integrity Among Older Adults Free of Dementia.

Light to moderate alcohol consumption has been variably associated with lower or higher risk of dementia, but effects on Alzheimer's disease pathology are less clear. We determined whether late-life alcohol consumption was associated with Alzheimer's disease pathology among older adults. We assessed the associations of alcohol consumption self-reported in 2000-2002 with brain amyloid-β deposition on PET scans, and white matter lesion and hippocampal volume on MRIs measured 7-9 years later in 189 participants of the Ginkgo Evaluation of Memory Study (age 75-87 years at baseline) who were free of clinical dementia, using multivariable-adjusted and inverse probability-weighted robust linear regression models. Alcohol consumption was not statistically significantly associated with amyloid-β deposition (standardized uptake value ratio difference per drink: -0.013 [95% CI: -0.027, 0.002]). Both non-drinkers and participants consuming ≥1 drink(s)/week had higher white matter lesion volume (% intracranial volume) than did the reference group of those consuming <1 drink/week (differences: 0.25 % [95% CI: 0.01, 0.50]; 0.26 % [95% CI: 0.02, 0.50]). The association of alcohol consumption and hippocampal volume was modified by age (p = 0.02). Among participants younger than 77 years, participants consuming 1-7 drinks/week had larger hippocampal volume compared with participants consuming <1 drink/week. Alcohol consumption was not statistically significantly associated with amyloid-β deposition 7-9 years later. Non-drinking and greater alcohol consumption were associated with higher white matter lesion volume compared with drinking <1 drink/week. Moderate drinking was associated with higher hippocampal volume in younger individuals. Given the selective nature of this population and adverse health effects of excessive alcohol consumption, these findings warrant further investigation, but cannot be translated into clinical recommendations.

Emotional processing and social cognition in alcohol use disorder.

To review deficits in emotional processing and social cognition potentially contributing to the dysfunctional emotion regulation and difficulties with interpersonal relationships observed in individuals with alcohol use disorder (AUD) and to provide directions for future research. First is presented a review of emotional and social-cognitive impairments in recently detoxified AUD individuals that include alexithymia, difficulties in decoding others' emotions, and reduced theory of mind and empathy skills. Social cognition disorders in AUD pose different issues discussed, such as whether (1) these deficits are consequences of excessive alcohol consumption or premorbid risk factors for addiction, (2) emotional and social impairments impede positive treatment outcome, (3) recovery of social abilities is possible with sustained abstinence, and (4) AUD patients are unaware of their emotional and social dysfunctions. Finally, current knowledge on structural and functional brain correlates of these deficits in AUD are reviewed. Emotional and social-cognitive functions affected in AUD can potentially compromise efforts to initiate and maintain abstinence by hampering efficacy of clinical treatment. Such dysfunction can obstruct efforts to enable or reinstate higher-order abilities such as emotional self-regulation, motivation to change, success in interpersonal/social interactions, and emotional insight and awareness of social dysfunctions (i.e., accurate metacognition). The present review highlights the need to account for emotional processing and social cognition in the evaluation and rehabilitation of alcohol-related neurocognitive disorders and to consider psychotherapeutic treatment involving remediation of emotional and social skills as implemented in psychiatric and neurological disorders. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

062 Alcohol associated toxic myelopathy with normal hepatic function

IntroductionAlcohol related neurological dysfunction affects the central and peripheral nervous system. We present a rare consequence of excessive alcohol consumption. A 42-year-old female consuming 2 bottles of wine daily for the preceding 5 years presented with 12 months of progressive gait disturbance. Examination revealed a spastic paraparesis with prominent dorsal column signs. Extensive work up found no alternate cause for her presentation. The final diagnosis was direct alcohol mediated toxic myelopathy. We reviewed the current literature on this rare condition.MethodsWe searched PubMED/OVID databases with the terms ‘alcohol AND myelopathy’.ResultsThere is a paucity of research on this clinical entity. Sage et al.1 described 5 well-nourished alcoholics presenting with a progressive myelopathy. As with our patient, routine laboratory tests, including nutritional screen, were normal. CT Myelogram revealed no structural cause. CSF was normal. In contrast, a myelopathic syndrome can occur in alcoholic hepatic failure, attributed to portosystemic shunting of blood, with resultant hyper-ammonaemia and demyelination of corticospinal tracts.2–4ConclusionAlcohol associated toxic myelopathy is a rare entity, distinct from hepatic myelopathy. It is thought to result from direct toxic effects of ethanol on corticospinal and large myelinated sensory tracts. The sensory involvement is unique for this entity, which distinguishes it from hepatic myelopathy, where corticospinal involvement predominates. It is prudent to look for other potentially treatable secondary causes of myelopathy. Abstinence from alcohol results in modest improvement in symptoms. Minimal literature exists on this clinical entity and further research is required.ReferencesSage JI, et al. Alcoholic myelopathy without substantial liver disease. A syndrome of progressive dorsal and lateral column dysfunction. Arch Neurol. 1984 Sep;41(9):999–1001.Premkumar M, et al. Hepatic Myelopathy in a Patient with Decompensated Alcoholic Cirrhosis and Portal Colopathy. Volume 2012, Article ID 735906, 4 pages.Koo JE, et al. Hepatic myelopathy as a presenting neurological complication in patients with cirrhosis and spontaneous splenorenal shunt. Korean J Hepatol. 2008 Mar;14(1):89–96.Kori P, et al. Hepatic myelopathy: an unusual neurological complication of chronic liver disease presenting as quadriparesis. BMJ Case Rep. 2013; 2013: bcr2013009078.

Korelasi Rasio Aspartate Aminotransferase - Alanine Aminotransferase dengan Profil Hematologi pada Peminum Alkohol

Toksisitas karena alkohol merupakan penyebab ketiga yang paling sering dari penyakit hati dan menjadi peringkat kelima dari sumber beban pembiayaan kesehatan di seluruh dunia. Pada negara maju, alkohol sebagai penyebab utama kejadian sirosis. Seseorang yang mengkonsumsi alkohol secara berlebihan beresiko mengalami komplikasi yang mempengaruhi darah dan sumsum tulang, tempat sel darah diproduksi. Efek buruk alkohol pada produksi sel darah/hematopoiesis terjadi baik langsung maupun tidak langsung. Efek langsung dari konsumsi alkohol berlebihan yaitu efek toksik pada sumsum tulang, prekusor sel darah, sel matur eritrosit, leukosit serta trombosit. Efek tidak langsung konsumsi alkohol yaitu defisiensi nutrisi yang dapat mengganggu produksi dan fungsi berbagai sel darah. Pada penelitian ini dilakukan pemeriksaan kadar aspartate aminotransferase (AST), alanine aminotransferase (ALT), hemoglobin, jumlah eritrosit, jumlah lekosit, jumlah trombosit, hematokrit serta Protrombine Time (PT) dan activated Partial Thromboplastin Time (aPTT) pada 30 laki-laki peminum alkohol yang berusia 20-50 tahun. Dari 30 data responden didapatkan data hemoglobin, jumlah eritrosit, jumlah lekosit, jumlah trombosit, hematokrit, PT, APTT, AST, ALT dan dihitung rasionya. Hasil uji Spearman didapatkan data rasio AST/ALT dengan kadar hemoglobin (p=0,741), rasio AST dengan jumlah eritrosit (p=0,778) rasio AST/ ALT dengan jumlah lekosit (p= 0,472), rasio AST/ALT dengan jumlah trombosit (p= 0,95), rasio AST/ALT dengan hematokrit (p= 0,88), rasio AST/ALT dengan PT (p=0,757), rasio AST/ALT dengan APTT (0,352). Tidak ada korelasi yang signifikan antara rasio AST/ALT dengan profil hematologi pada peminum alkohol (p&gt; 0,05). Pentingnya memperhatikan diet sebagai bagian dari usaha pencegahan penyakit.