To predict the aerothermal behavior of a transpiration cooled plate, a multiscale approach based on the homogenization method of periodic material structures is presented here. This method allows calculation of effective equivalent thermophysical properties either for each layer or for the multilayer of superalloy, bondcoat, and thermal barrier coating (TBC). From the 3-D conjugate flow and heat transfer analysis, the stationary state is extracted and transferred to the microscale unit cell discretized by finite elements. The analysis proves for different cooling configurations a significant decrease in the amount of cooling fluid to obtain a desired superalloy temperature. Beyond, the hole outlet shaping leads to a reduction of the thermal gradients on the multilayer. The effect of the different cooling designs on the effective conductivities are discussed then. Finally, the influence of the selection of the unit cell position on these effective thermal properties is investigated.