Homogeneous Conductivity Research Articles

The functional role of oscillatory dynamics in neocortical circuits: A computational perspective

The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings. When trained on standard pattern recognition tasks, these harmonic oscillator recurrent networks (HORNs) outperformed nonoscillatory architectures with respect to learning speed, noise tolerance, and parameter efficiency. HORNs also reproduced a many characteristic features of neuronal systems, such as the cerebral cortex and the hippocampus. In trained HORNs, stimulus-induced interference patterns holistically represent the result of comparing sensory evidence with priors stored in recurrent connection weights, and learning-induced weight changes are compatible with Hebbian principles. Implementing additional features characteristic of natural networks, such as heterogeneous oscillation frequencies, inhomogeneous conduction delays, and network modularity, further enhanced HORN performance without requiring additional parameters. Taken together, our model allows us to give plausible a posteriori explanations for features of natural networks whose computational role has remained elusive. We conclude that neuronal systems are likely to exploit the unique dynamics of recurrent oscillator networks whose computational superiority critically depends on the oscillatory patterning of their nodal dynamics. Implementing the proposed computational principles in analog hardware is expected to enable the design of highly energy-efficient and self-adapting devices that could ideally complement existing digital technologies.

Inhomogeneous Nanoscale Conductivity and Friction on Graphite Terraces Explored via Atomic Force Microscopy

The interplay of conductivity and friction in layered materials such as graphite is an open area of investigation. Here, we measure local conductivity and friction on terraces of freshly cleaved highly oriented pyrolytic graphite via atomic force microscopy under ambient conditions. The graphite surface is found to exhibit a rich electrical landscape, with different terraces exhibiting different levels of conductivity. A peculiar dependency of conductivity on scan direction is observed on some terraces. The terraces that exhibit this dependency are also found to show enhanced friction values. A hypothesis based on tip asymmetry and the puckering effect is proposed to explain the findings. Our results highlight the non-triviality of the electrical and tribological properties of graphite on the nanoscale, as well as their interplay.

Inelastic scattering effects on the inhomogeneous transverse conductivity of liquid metals and plasmas

Abstract On the basis of the quantum Wigner density operator formalism for multicomponent charged particle systems, the wavenumber (k)- and frequency (ω)- dependent transverse conductivity σ^T (k,ω) of simple liquid metals is presented for homogeneous (k = 0) and inhomogeneous (k≠0) electric fields separately. The theory takes into account correlated density fluctuations of electrons and ions, with their mutual inelastic scattering being described by the ionic dynamic structure factors. Since homogeneous and inhomogeneous fields perturb the diagonal and off-diagonal elements of the density matrix, respectively, the corresponding transport equations exhibit a dissimilarity in their collision terms. In both cases, approximate solutions to the transport equations yield a conductivity of generalized Drude form characterized by the k- and ω-dependent complex relaxation time. It is shown that the k→0 limit of the inhomogeneous conductivity, σ^T (k→0,ω), coincides with the homogeneous one in classical ion regime such that βℏω_i≪1, where β is the inverse temperature and ω_i is a characteristic frequency of ionic density fluctuation; this condition may be satisfied for metals well above melting. At lower temperatures, it is suggested that the (homogeneous) DC conductivity σ(0) can exceed the (inhomogeneous) optical conductivity extrapolated to zero frequency, σ^T (k→0,0). This trend is qualitatively consistent with earlier observations for liquid polyvalent metals.

Acoustoelectric Effect due to an In-Depth Inhomogeneous Conductivity Change in ZnO/Fused Silica Substrates

The acoustoelectric (AE) effect induced by the absorption of ultraviolet (UV) light at 365 nm in piezoelectric ZnO films was theoretically and experimentally studied. c-ZnO films 4.0 µm thick were grown by the RF reactive magnetron sputtering technique onto fused silica substrates at 200 °C. A surface acoustic wave (SAW) delay line was fabricated with two split-finger Al interdigital transducers (IDTs) photolithographically implemented onto the ZnO-free surface to excite and reveal the propagation of the fundamental Rayleigh wave and its third harmonic at about 39 and 104 MHz. A small area of a few square millimeters on the surface of the ZnO layer, in between the two IDTs, was illuminated by UV light at different light power values (from about 10 mW up to 1.2 W) through the back surface of the SiO2 substrate, which is optically transparent. The UV absorption caused a change of the ZnO electrical conductivity, which in turn affected the velocity and insertion loss (IL) of the two waves. It was experimentally observed that the phase velocity of the fundamental and third harmonic waves decreased with an increase in the UV power, while the IL vs. UV power behavior differed at large UV power values: the Rayleigh wave underwent a single peak in attenuation, while its third harmonic underwent a further peak. A two-dimensional finite element study was performed to simulate the waves IL and phase velocity vs. the ZnO electrical conductivity, under the assumption that the ZnO layer conductivity undergoes an in-depth inhomogeneous change according to an exponential decay law, with a penetration depth of 325 nm. The theoretical results predicted single- and double-peak IL behavior for the fundamental and harmonic wave due to volume conductivity changes, as opposed to the AE effect induced by surface conductivity changes for which a single-peak IL behavior is expected. The phenomena predicted by the theoretical models were confirmed by the experimental results.

Investigation on the electro-magneto-thermoviscoelastic response of multilayer rotating hollow cylinder based on two-temperature theory and fractional-order viscoelastic systems

Hollow cylinder structures play a crucial role in scientific experiment and industrial production, and are widely used in various fields, including pipeline transportation of gases and liquids, high-speed engines, porous combustors, and other engineering equipments. As a result, they have garnered considerable academic interest over the years. However, as science and technology progress, studying hollow cylinders under a single physical field is no longer sufficient for real-world applications. Additionally, the classical viscoelastic model has become inadequate in accurately describing complex materials with properties that fall between elasticity and viscosity. Therefore, this article investigates the electro-magneto-thermoviscoelastic coupling behavior of an infinitely long rotating multilayer homogeneous hollow cylindrical conductor. In this study, based on the fractional-order three-phase lag thermoelasticity theory, the fractional-order viscoelastic system and the two-temperature theory are introduced to further increase the accuracy of the model. To solve the corresponding equations, the Laplace transform technique is employed, resulting in solutions with dimensionless physical quantities. Graphs and tables are used to make relevant comparisons and assess the effects of time, material layering properties, different thermoelastic theoretical models, fractional-order parameters and angular velocity on the considered physical quantities. Finally, the numerical results are discussed to reveal the dynamic response of a homogeneous multilayered hollow cylinder under the complex coupling of multiple physical fields.

AFM-sMIM Characterization of the Recombination-Enhancing Buffer Layer for Bipolar Degradation Free SiC MOSFETs

Due to the expansion of defects like single Shockley-type Stacking Faults inside the SiC epitaxial drift layer, during high current stress, classical SiC MOSFETs can be victims of the degradation of their electrical characteristics. The introduction of an epitaxial SiC buffer layer between the substrate and the n- drift epilayer, called recombination-enhancing buffer layer, was shown to avoid this degradation. In this paper, TCAD simulations of the electrical behavior of such a commercial SiC MOSFET device with varying buffer layer thickness are studied, indicating only small modifications of the electrical characteristics. These simulations are combined with the characterization of the local electrical properties using an AFM-sMIM technique, allowing to determine the real thickness of the different layers of the device. These measurements highlight an inhomogeneous conductivity in the SiC substrate, being probably compensated by the introduction of the SiC buffer layer.

“Stick–slip” fluctuations in local electrical conductivity maps on graphite surfaces: A revisit

Electrical conductivity images of graphite surfaces are routinely obtained using scanning probe microscopy. Although the acquired conductivity maps often display a trigonal pattern with smooth variations, a “stick–slip” type of fluctuation has also been reported, where the local conductivity inversely correlates with the friction force during probe scanning. In this work, we revisit the lattice-resolved variations in local conductivity on graphite surfaces and reveal a new series of behaviors. Unlike previous observations, we demonstrate that local conductivity can exhibit in-phase, out-of-phase, or mixed-mode correlations with “stick–slip” lateral force signals. These behaviors are attributed to the cross-talk effect between interface contact conductivity and lateral force, induced by the inhomogeneous conductivity of the tip apex. This mechanism is experimentally validated, showing that local conductivity variations can switch within a single scan due to spontaneous changes in the conductivity of the tip. Our findings enhance the understanding of lattice-resolved electrical conductivity data on graphite surfaces and suggest a novel approach to amplify small lateral forces using inhomogeneous probe tips.

Robust and Adhesive Laminar Solid Electrolyte with Homogenous and Fast Li-Ion Conduction for High-Performance All-Solid-State Lithium Metal Battery.

Constructing composite solid electrolytes (CSEs) integrating the merits of inorganic and organic components is a promising approach to developing high-performance all-solid-state lithium metal batteries (ASSLMBs). CSEs are now capable of achieving homogeneous and fast Li-ion flux, but how to escape the trade-off between mechanical modulus and adhesion is still a challenge. Herein, a strategy to address this issue is proposed, that is, intercalating highly conductive, homogeneous, and viscous-fluid ionic conductors into robust coordination laminar framework to construct laminar solid electrolyte with homogeneous and fast Li-ion conduction (LSE-HFC). A 9µm-thick LSH-HFC, in which poly(ethylene oxide)/succinonitrile is adsorbed by coordination laminar framework with metal-organic framework nanosheets as building blocks, is used here as an example to determine the validity. The Li-ion transfer mechanism is verified and works across the entire LSE-HFC, which facilitates homogeneous Li-ion flux and low migration energy barriers, endowing LSE-HFC with high ionic conductivity of 5.62×10-4Scm-1 and Li-ion transference number of 0.78 at 25°C. Combining the outstanding mechanical strength against punctures and the enhanced adhesion force with electrodes, LSE-HFC harvests uniform Li plating/stripping behavior. These enable the realization of high-energy-density ASSLMBs with excellent cycling stability when being assembled as LiFePO4/Li and LiNi0.6Mn0.2Co0.2O2/Li cells.

Transforming an Ionic Conductor into an Electronic Conductor via Crystallization: In Situ Evolution of Transference Numbers and Structure in (La,Sr)(Ga,Fe)O3‐x Perovskite Thin Films

AbstractMixed‐conducting perovskites are workhorse electrochemically active materials, but typical high‐temperature processing compromises their catalytic activity and chemo‐mechanical integrity. Low‐temperature pulsed laser deposition of amorphous films plus mild thermal annealing is an emerging route to form homogeneous mixed conductors with exceptional catalytic activity, but little is known about the evolution of the oxide‐ion transport and transference numbers during crystallization. Here the coupled evolution of ionic and electronic transport behavior and structure in room‐temperature‐grown amorphous (La,Sr)(Ga,Fe)O3‐x films as they crystallize is explored. In situ ac‐impedance spectroscopy with and without blocking electrodes, simultaneous capturingsynchrotron‐grazing‐incidence X‐ray diffraction, dc polarization, transmission electron microscopy, and molecular dynamics simulations are combined to evaluate isothermal and non‐isothermal crystallization effects and the role of grain boundaries on transference numbers. Ionic conductivity increases by ≈2 orders of magnitude during crystallization, with even larger increases in electronic conductivity. Consequently, as crystallinity increases, LSGF transitions from a predominantly ionic conductor to a predominantly electronic conductor. The roles of evolving lattice structural order, microstructure, and defect chemistry are examined. Grain boundaries appear relatively nonblocking electronically but significantly blocking ionically. The results demonstrate that ionic transference numbers can be tailored over a wide range by tuning crystallinity and microstructure without having to change the cation composition.

FDM-based alternating iterative algorithms for inverse BVPs in 2D steady-state anisotropic heat conduction with heat sources

In the framework of steady-state inhomogeneous anisotropic heat conduction with heat sources, we study the convergent and stable numerical reconstruction of the missing boundary conditions (temperatures and normal heat fluxes) on an inaccessible boundary and the thermal field in a 2D solid from the knowledge of over-prescribed data on an accessible portion of the boundary and temperature data on the remaining boundary. This inverse boundary value problem is approached by employing the alternating iterative algorithms of Kozlov et al. (1991), in conjunction with the standard finite-difference method and a novel modified one, for both exact and perturbed data. For noisy data available on the over-prescribed boundary, the numerical solution is retrieved by using three regularising/stabilising stopping criteria. Numerical results are presented for 2D simply and doubly connected domains bounded by a (piecewise) smooth curve, as well as exact and noisy boundary data, whilst appropriate errors in the fractional Sobolev spaces corresponding to the boundary temperatures and normal heat fluxes, respectively, are computed efficiently.

Non-contact microwave sensor for FDM 3D printing quality control

ABSTRACT In recent years, 3D printing has undergone a transformational journey – from prototyping technology, limited to laboratories, to a production method used in industry – becoming a powerful tool for creating functional objects. Despite this progress, 3D printing faces ongoing challenges related to defect detection and print quality control. We present an innovative, non-contact, fast and cheap microwave sensor for detecting defects in printed components, related to both mechanical errors and conductivity inhomogeneities. We discuss in detail the methodology of the microwave surface mapping technique and the results obtained for several samples printed with popular filaments. Tests show the ability to detect faults with millimetre precision. The simple design of the entire quality control module allows for easy integration with various types of 3D printers, from popular ones used by hobbyists to professional, highly specialised ones.

The Relevance of Surface Resistances on the Conductive Thermal Resistance of Lightweight Steel-Framed Walls: A Numerical Simulation Study

The accurate evaluation of the thermal performance of building envelope components (e.g., facade walls) is crucial for the reliable evaluation of their energy efficiency. There are several methods available to quantify their thermal resistance, such as analytical formulations (e.g., ISO 6946 simplified calculation method), numerical simulations (e.g., using finite element method), experimental measurements under lab-controlled conditions or in situ. Regarding measurements, when using the heat flow meter (HFM) method, very often, the measured value is based on surface conditions (e.g., temperature and heat flux), achieving in this way the so-called surface-to-surface or conductive thermal resistance (Rcond). When the building components are made of homogeneous layers, their Rcond values are constant, regardless of their internal and external surface boundary conditions. However, whenever this element is composed of inhomogeneous layers, such as in lightweight steel-framed (LSF) walls, their Rcond values are no longer constant, depending on their thermal surface resistance. In the literature, such systematic research into how these Rcond values vary is not available. In this study, the values of four LSF walls were computed, with different levels of thermal conductivity inhomogeneity, making use of four finite elements’ numerical simulation tools. Six external thermal surface resistances (Rse) were modelled, ranging from 0.00 up to 0.20 m2·K/W. The average temperature of the partition LSF walls is 15 °C, while for the facade LSF walls it is 10 °C. It was found that the accuracy values of all evaluated numerical software are very high and similar, the Rcond values being nearly constant for walls with homogeneous layers, as expected. However, the variation in the Rcond value depends on the level of inhomogeneity in the LSF wall layers, increasing up to 8%, i.e., +0.123 m2·K/W, for the evaluated Rse values.

Sensitivity analysis for the eddy current testing of carbon fiber reinforced plastic materials

In this work, a parametric study is carried out on carbon fiber-reinforced plastic (CFRP) materials to investigate how the spatially varying fiber distribution influences the measured signal in an eddy current testing (ECT) configuration. The measurement setup was modeled using finite element method, while the fiber distribution is taken into account by an inhomogeneous anisotropic conductivity tensor. The study revealed a trade-off relation between the size of the ECT coil and the maximal dynamic range of the ECT signal, which contributes to the understanding of the connection between the fiber arrangement and the ECT signal and provides an opportunity for optimal ECT coil design.

Heat transfer analysis of magnetohydrodynamics peristaltic fluid with inhomogeneous solid particles and variable thermal conductivity through curved passageway

PurposeThe particle distribution in a fluid is mostly not homogeneous. The inhomogeneous dispersion of solid particles affects the velocity profile as well as the heat transfer of fluid. This study aims to highlight the effects of varying density of particles in a fluid. The fluid flows through a wavy curved passage under an applied magnetic field. Heat transfer is discussed with variable thermal conductivity.Design/methodology/approachThe mathematical model of the problem consists of coupled differential equations, simplified using stream functions. The results of the time flow rate for fluid and solid granules have been derived numerically.FindingsThe fluid and dust particle velocity profiles are being presented graphically to analyze the effects of density of solid particles, magnetohydrodynamics, curvature and slip parameters. Heat transfer analysis is also performed for magnetic parameter, density of dust particles, variable thermal conductivity, slip parameter and curvature. As the number of particles in the fluid increases, heat conduction becomes slow through the fluid. Increase in temperature distribution is noticed as variable thermal conductivity parameter grows. The discussion of variable thermal conductivity is of great concern as many biological treatments and optimization of thermal energy storage system’s performance require precise measurement of a heat transfer fluid’s thermal conductivity.Originality/valueThis study of heat transfer with inhomogeneous distribution of the particles in a fluid has not yet been reported.

IMPROVEMENT OF THE METHODOLOGY FOR OPTIMIZING THE PARAMETERS OF COMPLEX SYSTEMS UNDER THE INFLUENCE OF THERMAL LOAD SOURCES

The article investigates some aspects of solving the problem of constructing mathematical models for optimizing the parameters of local laser action on multilayer microbiological systems. The constraints on the desired laser parameters and on the temperature field in the material subject to laser fission are set. Verification of compliance with the restrictions on not exceeding the maximum value of the temperature field requires multiple calculations of the corresponding temperature field in the microbiological material. Control over the temperature field limits ensures the viability of its parts during the biotechnological process of laser fission. To construct adequate optimization mathematical models, the author substantiates the adequacy of the computational mathematical models describing the state of a microbiological system under the action of laser radiation sources. A multi-point boundary value problem with a system of inhomogeneous differential heat conduction equations for a multilayer microbiological medium is investigated and the correctness of this problem is substantiated for minor perturbations of the right-hand side of the differential equation. The results obtained in the article guarantee the adequacy of applied optimization mathematical models for finding rational values of technical parameters of laser emitters. In order to improve the accuracy of optimization of the technical parameters of laser emitters, the article presents a mathematical modeling of the preparatory stage of embryo defrosting. The presented mathematical models and methods of their implementation are necessary to improve the quality of embryo defrosting. Improvement of the methodology for solving applied biotechnological problems will certainly lead to the complication of mathematical models, but it will increase the accuracy of calculation and optimization of technical parameters of the biotechnological process of laser embryo division.

Identification of Atrial Transmural Conduction Inhomogeneity Using Unipolar Electrogram Morphology.

(1) Background: Structural remodeling plays an important role in the pathophysiology of atrial fibrillation (AF). It is likely that structural remodeling occurs transmurally, giving rise to electrical endo-epicardial asynchrony (EEA). Recent studies have suggested that areas of EEA may be suitable targets for ablation therapy of AF. We hypothesized that the degree of EEA is more pronounced in areas of transmural conduction block (T-CB) than single-sided CB (SS-CB). This study examined the degree to which SS-CB and T-CB enhance EEA and which specific unipolar potential morphology parameters are predictive for SS-CB or T-CB. (2) Methods: Simultaneous endo-epicardial mapping in the human right atrium was performed in 86 patients. Potential morphology parameters included unipolar potential voltages, low-voltage areas, potential complexity (long double and fractionated potentials: LDPs and FPs), and the duration of fractionation. (3) Results: EEA was mostly affected by the presence of T-CB areas. Lower potential voltages and more LDPs and FPs were observed in T-CB areas compared to SS-CB areas. (4) Conclusion: Areas of T-CB could be most accurately predicted by combining epicardial unipolar potential morphology parameters, including voltages, fractionation, and fractionation duration (AUC = 0.91). If transmural areas of CB indeed play a pivotal role in the pathophysiology of AF, they could theoretically be used as target sites for ablation.

A 3D TLM code for the study of the ELF electromagnetic wave propagation in the Earth's atmosphere

The interest in the study of electromagnetic propagation through planetary atmospheres is briefly discussed. Special attention is devoted to extremely-low-frequency fields in the Earth's atmosphere for its global nature and possible applications to climate monitoring studies among others. In the Earth's case, the system can be considered as a spherical electromagnetic shell resonator in which two concentric and large conducting spheres with a radius around 6300 km are separated by a very small distance of around 100 km, the atmosphere height. A numerical solution using the Transmission Line Method is proposed. The classical spherical-coordinate description is easy to use, however, the important difference in the dimensions along the three coordinate directions causes high numerical dispersion in the results. A Cartesian scheme with equal node size for all directions is used to reduce this undesired dispersion. A pre-processing stage is the key point introduced to lessen the resulting high demand of memory and time calculation and make the solution feasible. A parallelized Fortran code together with pre- and post-processing Python programs to ease the user interface are provided with this work. Details on the Fortran code and the Python modules are included both in the paper and the source codes to allow the use and modifications by other researchers interested in electromagnetic propagation through planetary atmospheres. The program allows calculation of the time evolution of the electromagnetic field at any point in the atmosphere. It includes the possibility of considering multiple time-dependent sources and different homogeneous and inhomogeneous conductivity profiles to model different situations. Profiles to study day-night asymmetries or locally perturbed profiles which have been attributed to earthquakes in the literature are implemented, for instance.

Broadband magnetic and dielectric properties of U-type hexaferrite Sr4CoZnFe36O60

Sr4CoZnFe36O60 ceramics with U-type hexaferrite crystal structure were for the first time prepared and their structural, dielectric, magnetic and magnetoelectric properties were characterized. Broadband dielectric spectra (1 Hz −1 GHz) showed giant permittivity due to two Maxwell-Wagner dielectric relaxations whose frequencies follow the Arrhenius law. These relaxations are caused by inhomogeneous conductivity in the ceramic grains and their boundaries. Temperature and magnetic field dependences of magnetization revealed ferrimagnetic phase transition at Tc1 = 635 K and other two magnetic phase transitions at Tc2 = 305 K and Tc3 = 145 K. Magnetoelectric measurement at 10 K revealed only small polarization 35 nC/m2 which has probably extrinsic origin, so the sample is probably not multiferroic. The observed magnetocapacitance effect (-0.8 %) was attributed to the magnetoresistance (-4 %) caused by non-homogeneous conductivity of the ceramics. High-frequency magnetic permeability measured up to 1.8 GHz evidences the Curie-Weiss behavior above Tc2 and Tc3 and two magnetic field-dependent excitations which exhibit anomalies at magnetic phase transitions. We attributed these excitations to the magnetic domain wall dynamics.

Abstract 13928: Targeted Atrial Inhibition of Galphaq Signaling With Inhibitory Peptides Attenuates Fibrosis and Inducibility of Atrial Fibrillation in a Canine Heart Failure Model

Introduction: Endothelial dysfunction, a hallmark of heart failure (HF), is closely associated with atrial fibrillation (AF). However, the precise role of endothelial dysfunction in creating an atrial arrhythmogenic substrate is unknown. Endothelin-1 (ET-1) and its downstream Gα q signaling are significantly upregulated in the atria of patients with HF. We therefore hypothesized that ET-1-Gα q signaling contributes to adverse structural remodeling in the atria in the setting of HF. Hypothesis: Inhibition of atrial ET-1-Gα q signaling with Gα q inhibitory peptides (Gα q -ct) will attenuate the development of atrial fibrosis and AF inducibility in a HF model. Methods: Plasmids expressing Gα q -ct were injected and electroporated in the left atria of 4 dogs. LacZ or scrambled plasmids were used in 8 control dogs. HF was induced by ventricular tachypacing (VTP) at 240 bpm for 3 weeks. At terminal EP study, left atrial conduction vectors were recorded with high-density mapping and AF inducibility assessed. Left atrial fibrosis was quantified by Masson Trichrome. Results: All animals developed clinical HF (prolonged capillary refill time, ascites, reduced activity level) and LV systolic dysfunction by echocardiogram (LVEF 17.5±8.3% in Gα q -ct, 13.7±3.1% in controls, p=0.55). Conduction inhomogeneity was reduced in Gα q -ct animals (example of posterior left atrium recordings in Fig. A). AF was less inducible in Gα q -ct than control animals (4.8% of pacing attempts Vs 17.8%, p<0.001, Fig. B) and AF episodes were shorter (5.6±0.9 sec Vs 63.8±11.9 sec). Left atrial fibrosis was significantly attenuated in Gα q -ct animals Vs controls (Fig. C). Conclusions: Gα q signaling contributes to atrial fibrosis and subsequent AF susceptibility in VTP-induced HF, thereby highlighting an important role for ET-1 signaling in HF-related atrial remodeling. Future optimization of gene therapy targeting ET-1 signaling may lead to novel, mechanism-guided treatments for AF in the context of HF.

Characterization of unipolar electrogram morphology: a novel tool for quantifying conduction inhomogeneity.

Areas of conduction inhomogeneity (CI) during sinus rhythm may facilitate the initiation and perpetuation of atrial fibrillation (AF). Currently, no tool is available to quantify the severity of CI. Our aim is to develop and validate a novel tool using unipolar electrograms (EGMs) only to quantify the severity of CI in the atria. Epicardial mapping of the right atrium (RA) and left atrium, including Bachmann's bundle, was performed in 235 patients undergoing coronary artery bypass grafting surgery. Conduction inhomogeneity was defined as the amount of conduction block. Electrograms were classified as single, short, long double (LDP), and fractionated potentials (FPs), and the fractionation duration of non-single potentials was measured. The proportion of low-voltage areas (LVAs, <1 mV) was calculated. Increased CI was associated with decreased potential voltages and increased LVAs, LDPs, and FPs. The Electrical Fingerprint Score consisting of RA EGM features, including LVAs and LDPs, was most accurate in predicting CI severity. The RA Electrical Fingerprint Score demonstrated the highest correlation with the amount of CI in both atria (r = 0.70, P < 0.001). The Electrical Fingerprint Score is a novel tool to quantify the severity of CI using only unipolar EGM characteristics recorded. This tool can be used to stage the degree of conduction abnormalities without constructing spatial activation patterns, potentially enabling early identification of patients at high risk of post-operative AF or selection of the appropriate ablation approach in addition to pulmonary vein isolation at the electrophysiology laboratory.