ABSTRACT Innovation districts are purposefully designed places that unite businesses, research institutions, local communities, and cultural assets in one bounded location. While providing numerous benefits, the ultimate outcome of a successful innovation district is the creation of a robust, collaborative, and sustainable innovation ecosystem. Despite their importance, academic comprehension of innovation districts as dynamic places, particularly the relationship between person and place, remains limited. Accordingly, this research addresses this gap by exploring innovation districts through the theoretical lens of sense of place. In doing so, this paper seeks to reframe the understanding of the person-place relationship by drawing on concepts including place attachment, place identity, place dependence, and social bonding. An original propositional framework is introduced, which positions sense of place of an innovation district as an outcome of established (place dependence, place identity, place attachment) and emerging (functional, cognitive, and affective social bonding) place dimensions. Furthermore, the framework delineates critical developmental stages and anticipates innovative and social outcomes associated with these districts. Conceiving sense of place within innovation districts as a holistic consequence of their design, management, and utilisation not only enhances these districts’ economic and social vitality but also ensures their sustainability and resilience in the face of changing economic and social conditions.