Concept Of Process Research Articles

Autophagy in the nervous system: general principles and specific functions

Autophagy is an intracellular mechanism for the isolation, transport and degradation of macromolecules and organelles. The physiological significance of autophagy lies, firstly, in maintaining the constancy of the intracellular environment through the timely disposal of proteins with a disrupted structure and damaged organelles. Secondly, due to the selective degradation of macromolecules, autophagy supplies the cell with monomers, which are then used by it to synthesize new compounds, which serves to ensure the rearrangement of cellular metabolism in the processes of cell differentiation, ontogenesis and adaptation to environmental challenges. Autophagy is an extremely important mechanism for maintaining normal functioning of postmitotic and differentiated cells, including neurons. Impaired neuronal autophagy leads to the formation of aggregated protein plaques, the accumulation of damaged cellular organelles, defects in the structure of processes and neuronal degeneration, which often accompanies to the progression of some forms of neurodegenerative diseases. In addition, the role of autophagy in synaptic plasticity and memory mechanisms has been established. Since autophagy has a significant impact on cellular metabolism, the study of the regulation and main pathways of this mechanism may be crucial in the elaboration of means and approaches to the treatment and prevention of many pathologies that progress with age. This review describes the basic concepts of the autophagy process, summarizes the key functions of autophagy in cells, and also presents current data on its role in ensuring the normal metabolism and implementation of specific functions of neurons.

Personal Identity Matters

Abstract This article considers whether process philosophy can provide a more promising basis for understanding the closely related problems of persons and personal identity than more traditional or mainstream philosophical approaches. In particular, the article focuses on whether process conceptions of persons and personal identity provide an approach that offers greater potential for resolving the duplication and fission examples within the literature in this area than the approaches taken by Bernard Williams and Derek Parfit.

ANALYSIS OF PSEUDO THINKING PROCESS SKILLS IN ELEMENTARY SCHOOL STUDENTS THROUGH ETHNOMATHEMATICS BASED PROBLEM SOLVING

This research aims to analyze process skills in pseudo-thinking through ethnomathematics-based problem solving in elementary school students. The subjects used in this research were 4 students from class IVB of SD Negeri 76 Muaro Jambi involving 4 subjects, namely 2 male and female subjects who thought pseudo-true and 2 male and female subjects who thought pseudo-false. Data collection techniques in this research used tests, interviews and documentation. Data analysis used in this research includes data reduction, data presentation, and drawing conclusions. The research procedures carried out in this research include the pre-field stage, field work stage, and data analysis stage. The results of the study stated that the four subjects showed various characteristics in using pseudo thinking patterns when answering mathematics questions. Each subject has abilities in several aspects of process skills in pseudo-true thinking, such as observing information, however, they still have shortcomings and difficulties in explaining the calculation process, communicating results, and understanding mathematical concepts as a whole. Consequently, further development is required to improve their processing skills in pseudo-thinking.

Mechanical Foundations of the Generalized Second Law and the Irreversibility Principle

We follow the Boltzmann-Clausius-Maxwell (BCM) proposal to establish the generalized second law (GSL) that is applicable to a system of any size, including a single particle system as our example establishes, and that supercedes the celebrated second law (SL) of increase of entropy of an isolated system. It is merely a consequence of the mechanical equilibrium (stable or unstable) principle (Mec-EQ-P) of analytical mechanics and the first law. We justify an irreversibility priciple that covers all processes, spontaneous or not, and having both positive and negative nonequilibrium temperatures temperatures T defined by (dQ/dS)E. Our novel approach to establish GSL/SL is the inverse of the one used in classical thermodynamics and clarifies the concept of spontaneous processes so that dS≥0 for T>0 and dS<0 for T<0. Nonspontaneous processes such as creation of internal constraints are not covered by GSL/SL. Our demonstration establishes that Mec-EQ-P controls spontaneous processes, and that temperature (positive and negative) must be considered an integral part of dissipation.

Principles of the administrative process: theoretical basics and law enforcement

The article is devoted to issues of the content of the principles of the administrative process in modern administrative law. Attention is drawn to the fact that the study of the principles of the administrative process is extremely relevant for ensuring effective public administration. It is noted that the principles of the administrative process are the foundation on which the activities of executive authorities, local governments, and other state bodies are based. They define the framework and standards that public authorities must adhere to when making decisions and performing administrative functions and obligations. It is concluded that the study of these principles allows identifying problematic aspects and suggesting ways of their improvement, which contributes to increasing the efficiency of public administration. It is suggested that the principles of the administrative process should be understood as the main guiding ideas and provisions that determine the order and rules of administrative proceedings, regulate relationships between subjects of the administrative process, ensure fairness, efficiency and legality of administrative actions and decisions. It is proved that the principles serve as the basis for the formation, functioning and development of administrative law, help to avoid abuse of power and ensure the protection of the rights and freedoms of citizens. Attention is drawn to the fact that the conceptual significance of the principles of the administrative process lies in the fact that they determine the basic principles and guidelines for the construction and functioning of the administrative-procedural activity of public authorities. This means that the principles of the administrative process not only regulate specific procedures and actions, but also form a general concept of justice and management practice in the administrative sphere. It is substantiated that these principles together create a holistic concept of the administrative process and act in interaction with each other, ensuring a balance between the interests of the state and the rights of citizens, which contributes to effective management and increases trust in state institutions.

Investigation of Different Throat Concepts for Precipitation Processes in Saturated Pore-Network Models

AbstractThe development of reliable mathematical models and numerical discretization methods is important for the understanding of salt precipitation in porous media, which is relevant for environmental problems like soil salinization. Models on the pore scale are necessary to represent local heterogeneities in precipitation and to include the influence of solution-air-solid interfaces. A pore-network model for saturated flow, which includes the precipitation reaction of salt, is presented. It is implemented in the open-source simulator DuMu$$^{\textrm{X}}$$ X . In this paper, we restrict ourselves to one-phase flow as a first step. Since the throat transmissibilities determine the flow behaviour in the pore network, different concepts for the decreasing throat transmissibility due to precipitation are investigated. We consider four concepts for the amount of precipitation in the throats. Three concepts use information from the adjacent pore bodies, and one employs a pore-throat model obtained by averaging the resolved pore-scale model in a thin-tube. They lead to different permeability developments, which are caused by the different distribution of the precipitate between the pore bodies and throats. We additionally apply two different concepts for the calculation of the transmissibility. One obtains the precipitate distribution from analytical assumptions, the other from a geometric minimization principle using a phase-field evolution equation. The two concepts do not show substantial differences for the permeability development as long as simple pore-throat geometries are used. Finally, advantages and disadvantages of the concepts are discussed in the context of the considered physical problem and a reasonable effort for the implementation and computational costs.

Overcoming challenges to access ecological function: a marine soft-bottom perspective

Ecosystem functioning studies have gained prominence due to concerns about the decline of species. In marine sediments, benthic invertebrates perform important ecological functions. However, the challenges within the field of functional ecology are sparsely discussed. Our aim was to systematize the problems and suggest pathways forward. To achieve this, we review recent articles on functional ecology on marine sediments and identified two main issues. First, the absence of a clear definition of terms. Second, in terms of applicability, we observed a mismatch between the scales of functioning and traits, incomplete information on trait databases, inappropriate selection of traits, subjective measures of traits, overlooked trait variability and data analyses without the link between the taxonomy and the traits associated with functions. We propose some pathways to overcome the challenges, such as (i) reasoning of the concept of function, process and trait, (ii) increasing experiments to measure functions, (iii) clarification of the relationship between traits and functions, (iv) clear procedure for assigning trait scores, (v) experiments for understanding trait variability and function performance, and (vi) analyses that consider the sets of traits of each taxon. Overcoming these challenges will allow us to advance research and fill gaps in knowledge of ecosystem functioning.

Design of Tools for Visualizing Thermodynamic Concepts in Steam Power Plant Trainer Processes with Web-Based Exploratory Data Analysis (EDA)

Thermodynamics is considered one of the most complex and challenging subjects for many students. This is primarily due to comprehending abstract concepts such as entropy, enthalpy, and energy flow, which involve complex mathematical equations and are rarely accompanied by tangible visualizations. This research aims to design, develop, and test a data-based visualization tool for thermodynamics testing results. This study collected and processed data from thermodynamics testing and simulations, such as the mini-steam power plant trainer used as a teaching aid in thermodynamics education, as the foundation for designing a data-based visualization tool for thermodynamics concepts. The visualization tool was created using the Python programming language integrated with the web-based Streamlit framework. The designed visualization tool encompasses various features, including automated data reporting, visualization of variable correlations using correlation heatmaps, Sankey diagrams for visualizing energy flow, and the capability to predict electrical output using machine learning integrated with three different machine learning algorithms. The visualization tool was evaluated by thermodynamics experts using a Likert scale. Based on the results obtained, the experts gave an average score of 4 in the information accuracy aspect in the good category. This shows that the information displayed in this visualization tool is by thermodynamics learning at Padang State University. In the visualization aspect, experts gave an average score of 4.25, which is in the Good and Very Good range. In alignment with the education aspect, experts gave an average score of 3.75, which is close to the good category. This shows that this aspect is considered suitable for studying thermodynamics, although shortcomings still need to be corrected. Experts gave a relatively high assessment of the Ease-of-Use aspect, with an average score of 4.5, with a range of Good and Very Good. This enables students to better understand complex patterns, cause-and-effect relationships, and parameter changes within thermodynamics concepts.

On Extended Class of Totally Ordered Interval-Valued Convex Stochastic Processes and Applications

The intent of the current study is to explore convex stochastic processes within a broader context. We introduce the concept of unified stochastic processes to analyze both convex and non-convex stochastic processes simultaneously. We employ weighted quasi-mean, non-negative mapping γ, and center-radius ordering relations to establish a class of extended cr-interval-valued convex stochastic processes. This class yields a combination of innovative convex and non-convex stochastic processes. We characterize our class by illustrating its relationships with other classes as well as certain key attributes and sufficient conditions for this class of processes. Additionally, leveraging Riemann–Liouville stochastic fractional operators and our proposed class, we prove parametric fractional variants of Jensen’s inequality, Hermite–Hadamard’s inequality, Fejer’s inequality, and product Hermite–Hadamard’s like inequality. We establish an interesting relation between means by means of Hermite–Hadamard’s inequality. We utilize the numerical and graphical approaches to showcase the significance and effectiveness of primary findings. Also, the proposed results are powerful tools to evaluate the bounds for stochastic Riemann–Liouville fractional operators in different scenarios for a larger space of processes.

Reducing CO[formula omitted] emissions, energy consumption, and decarbonization costs in manganese production by integrating fuel-assisted solid oxide electrolysis cells in two-stage oxide reduction

Manganese is one of the most consumed metals due to its use in iron and steel making, which generates between 7%–9% of all CO2 emissions produced globally per annum. For the first time, this work explores the potential of a novel process concept to reduce CO2 emissions, energy consumption, and decarbonization costs in manganese production, which involves integrating fuel-assisted solid oxide electrolysis cells (FASOECs) in a two-stage scheme for the reduction of raw manganese ores. In this scheme, higher oxides that are present in raw manganese ores (MnO2, Mn2O3, Mn3O4) are pre-reduced using CO, yielding manganese monoxide (MnO) that is further reduced to Mn in a submerged arc furnace (SAF) using coke and electricity. In the proposed FASOEC integration concept, off-gas from the manganese ores after pre-reduction (a mixture of H2, CO, and CO2) is supplied to the FASOECs’ anode as fuel, in order to produce high-purity H2 in the cathode that is directed to the first stage of manganese reduction. H2 has enhanced reaction kinetics for reducing higher manganese oxides in comparison to CO; therefore, integrating FASOECs can improve manganese oxide conversion rates during pre-reduction, resulting in lower consumption rates of coke and energy in the SAF. The off-gas supplied to the FASOECs’ anode also lowers the amount of energy required for H2 production in the cathode (can also generate electricity, simultaneously) and produces anode exhaust gas containing only CO2 and steam. Since steam can be easily condensed from this stream, the integration of FASOECs also enables efficient decarbonization of the manganese production process, thus eliminating the need for a designated CO2 capture system. The techno-economic analysis performed herein demonstrates that directing the full supply of off-gas produced by the SAF to the FASOECs’ anode at 800 °C reduces the overall energy consumption of manganese production by up to 18% in comparison to conventional processes. This results in decarbonization cost reductions by as much as 3%–15% and a corresponding decarbonization price range of $4-32 per ton of manganese product for plant capacities of 50 and 200 kt, respectively.

Innovative processes: economic and legal problems of realization, management and regulation

Problem setting. The scientific work is devoted to researching issues of regulation of innovation processes to achieve and increase the efficiency of innovation activity. In Ukraine, the strategy for the development of the sphere of innovative activity for the period until 2030 is aimed at increasing the use of innovations. A process approach was chosen to achieve the goals of the Strategy. However, it is necessary to generalize the problems using a systemic approach. Analysis of recent researches and publications. Since the middle of the 20th century. scientists have done a lot of work on defining the essence, structure and classifications of innovative processes, features of their management and regulation. A large number of works are devoted to the description, construction and improvement of innovative process models. In connection with the fact that the innovation process as an object of research is heterogeneous, in recent publications the critical rethinking of the theory and practice of management of innovation processes, increasing their efficiency, continues. Purpose of the research is the development of theoretical provisions and practical recommendations for structuring the economic and legal problems of management, implementation and regulation of innovation processes using a systemic approach to improve the state innovation policy and legal regulation of innovation activity. Article’s main body. The definition of the concept of the innovation process in the scientific literature and the international standard the Oslo Manual is considered. The Oslo Manual equates the innovation process with innovation activity. It has been specified that the management of innovative activities is an innovative process. To identify and strategically solve existing economic and legal problems of innovation processes, it is proposed to build a “black box” model according to the IDEF0 functional modeling standard. Models of innovation processes in the economy, at the enterprise, in clusters and ecosystems according to the IDEF0 standard have been developed. The economic and legal problems of innovation processes are structured by groups of problems of resources, executors, regulatory tools, international interaction, economic security of the state, collaboration, interaction of enterprises with the external environment, interaction of subjects in clusters and ecosystems, exercise of powers by authorities, protection of intellectual property rights, safety of innovations, performance and efficiency of innovative activities, informing about innovation processes, reporting of enterprises, reports of state regulators. An analysis of the completeness of the list of problems specified in the Strategy for the Development of the Sphere of Innovative Activity for the period up to 2030 was carried out. The directions for improving the state innovation policy and legal regulation of innovation activities in Ukraine are substantiated. Conclusions and prospects for development. The analysis of the Strategy for the Development of the Sphere of Innovative Activity on the basis of structured groups of problems allowed us to draw a conclusion about the state’s nonsystemic innovation policy, which poses a threat to the sovereignty of Ukraine. To get out of the critical situation, the government should revise the existing Strategy, taking into account the priority of protecting national interests and the safety of innovative products and innovative technologies for consumers and society. Regardless of measures to improve the Strategy, changes should be made to the national legislation regarding the harmonization of conflicting norms, bringing basic concepts and classifications into compliance with international standards, eliminating duplication of powers of authorities and defining a single regulator. Further research will be aimed at the scientific search for effective legal regulation solutions aimed at achieving performance and efficiency implementation of innovative processes in the national economy.

Широкое понимание понятия «антимонопольный процесс»

This article attempts to put forward the concept of a broad understanding of the concept of “antimonopoly process”, examines how a number of related categories are understood in administrative law, it is proposed to include in the concept of antimonopoly process not only jurisdictional, but also administrative procedures and measures aimed at preventing violations of antimonopoly legislation, it is proposed to form the antimonopoly process as a large sub-branch of competition law.

What it Takes to be a Good International Chinese Teacher

After the recovery of international Chinese education in 2023, the demand for international Chinese teachers overseas has returned, which also means that the demand for truly excellent international Chinese teachers has also begun to rise. As a student who is about to become an international Chinese teacher, how to become an excellent international Chinese teacher and complete the teaching mission of an international Chinese teacher is the main issue worthy of deep consideration. Thinking about this issue can be carried out throughout the student's learning life and into future teaching activities. "The unity of knowledge and action" is the most common point in Chinese philosophical wisdom, and it is also the most difficult point to achieve in practical activities. As an excellent international Chinese teacher, we must achieve the "unity of knowledge and action", clarify the teaching mission in the teaching process, take positive and correct concepts as the guide, and truly achieve the responsibility and mission of "language teaching and cultural dissemination" that a Chinese language teacher should do, so as to promote the development of Chinese to the world and expand more possibilities for exchanges between China and the world.

The concepts of ‘educational process’ and ‘educated person’ from the philosophical perspective of Richard Stanley Peters: Critical review

This article aimed to examine the two concepts of the educational process and educated person from the philosophical perspective of Richard S. Peters, a prominent philosopher of education. In light of this, one of his influential works, “What is an Educational Process?”, was carefully reviewed. Some comments on the overall relevance of Peters’ positions on the two concepts are also included. The review provides valuable insights into these concepts, which are profoundly important for the education field. Finally, concluding remarks and implications of the author's perspectives on contemporary educational systems are highlighted.

Flat Recovery Process in Mental Health: A Qualitative Analysis of Autoethnography

This study aims to provide a new perspective on the concept of recovery by qualitatively analyzing the experiences of mentally ill people from the Japanese perspective through autoethnography. Traditionally, the recovery process has been viewed as a series of “ups and downs” that may not apply to individuals with chronic mental health issues. A qualitative autoethnography analysis used personal diary entries from 20XX through 20XX + 4. Using text mining with KH Coder and cluster analysis, I first classified and visualized the data from the diary content and then, after confirming the content chronologically, examined the validity of the concept of the recovery process based on the theoretical framework of the Japanese cultural perspective. External validity was ensured through triangulation with the author’s work. Coding revealed four to six groups of mental health recovery keywords for each year. Confirmation of the results according to the life history also revealed problems with the conventional recovery process concept and advantages of the flat recovery process based on the Japanese cultural perspective.

Innovative sustainable bioreactor-in-a-granule formulation of Trichoderma asperelloides

The advancement of fungal biocontrol agents depends on replacing cereal grains with low-cost agro-industrial byproducts for their economical mass production and development of stable formulations. We propose an innovative approach to develop a rice flour-based formulation of the beneficial biocontrol agent Trichoderma asperelloides CMAA1584 designed to simulate a micro-bioreactor within the concept of full biorefinery process, affording in situ conidiation, extended shelf-life, and effective control of Sclerotinia sclerotiorum, a devastating pathogen of several dicot agricultural crops worldwide. Rice flour is an inexpensive and underexplored byproduct derived from broken rice after milling, capable of sustaining high yields of conidial production through our optimized fermentation-formulation route. Conidial yield was mainly influenced by nitrogen content (0.1% w/w) added to the rice meal coupled with the fermentor type. Hydrolyzed yeast was the best nitrogen source yielding 2.6 × 109 colony-forming units (CFU)/g within 14 days. Subsequently, GControl, GLecithin, GBreak-Thru, GBentonite, and GOrganic compost+Break-Thru formulations were obtained by extrusion followed by air-drying and further assessed for their potential to induce secondary sporulation in situ, storage stability, and efficacy against Sclerotinia. GControl, GBreak-Thru, GBentonite, and GOrganic compost+Break-Thru stood out with the highest number of CFU after sporulation upon re-hydration on water-agar medium. Shelf-life of formulations GControl and GBentonite remained consistent for > 3 months at ambient temperature, while in GBentonite and GOrganic compost+Break-Thru formulations remained viable for 24 months during refrigerated storage. Formulations exhibited similar efficacy in suppressing the myceliogenic germination of Sclerotinia irrespective of their concentration tested (5 × 104 to 5 × 106 CFU/g of soil), resulting in 79.2 to 93.7% relative inhibition. Noteworthily, all 24-month-old formulations kept under cold storage successfully suppressed sclerotia. This work provides an environmentally friendly bioprocess method using rice flour as the main feedstock to develop waste-free granular formulations of Trichoderma conidia that are effective in suppressing Sclerotinia while also improving biopesticide shelf-life.Key points• Innovative “bioreactor-in-a-granule” system for T. asperelloides is devised.• Dry granules of aerial conidia remain highly viable for 24 months at 4 °C.• Effective control of white-mold sclerotia via soil application of Trichoderma-based granules.

Particle formation: Promise and challenges

Particle formation establishes fundamental particle attributes at the initiation of an overall particle production process. These attributes include particle size distribution, particle morphology, crystal form, and defect level. These fundamental properties, in turn, affect downstream particle processing and product performance properties, including rate of drying, filterability, flowability, caking tendency, rate of dissolution, and for biologically active products bioavailability. Almost always, the goal is that the properties established at formation will provide excellent performance all the way through downstream processing, product formulation, and ultimate use of the product. However, meeting this goal is often not possible for a variety of reasons. First, it may be difficult, prohibitively expensive, or even impossible to achieve the desired properties during formation. Second, there are often conflicting requirements at different stages of production and use. For example, large equant particles may be desired for good filterability and flowability through downstream process steps, but very small particles may be required in the ultimate product application. Examples from the chemical and pharmaceutical industries are presented: both cases successfully producing particles with properties meeting the needs throughout the chain of downstream processing and final application, as well as cases where it was impossible to meet those requirements. For the latter, the additional processing or adaptations required for the product to succeed are outlined. The focus here is on additive particle formation, e.g. crystallization and precipitation from solution, and not subtractive particle formation, e.g. milling. Legacy of Reg DaviesI was fortunate enough, as a budding industrial crystallization engineer, to be invited by Reg to join the newly formed PARticle Science And Technology PARSAT group at DuPont. Reg recognized and documented the importance of particle technology to a large, diverse chemical and materials company like DuPont and PARSAT was to become a leading industrial particle technology group. Reg's vision was to combine the fundamental particle unit operations into a unified, comprehensive technology organization that would address the formation and processing of particles from process concept through end use.This paper describes the first step in many particle processes: particle formation. Reg's legacy vis a vis particle formation is the recognition that particle formation is a critical, foundational process in an overall process train that ultimately produces useful particulate products and intermediates, but that particle formation is nonetheless but one part of the overall process. It may be able to produce particles exactly as needed for end use performance, or additional processes may be needed to tailor particles for their ultimate use. In addition, intermediate processes may be required to preserve useful properties developed during formation but subject to degradation in subsequent operations.Finally, Reg served as inspiration and mentor for everyone in his orbit, and we are far better scientists and engineers for it.

Historical trend analysis of the methodological teaching work management in the medical career

Introduction: The Cuban educational model of professional training in the health sciences involves the merger of the pedagogical model that has been developed with the particular historical conditions of our country, which undoubtedly distinguishes the conception and development of formative process that is very specific to the Cuban medical university. Methods: In order to support the historical trend analysis of the methodological teaching work management in the medical career, the following methods were used Historical-Logical, systematization and documentary analysis. Results: For the historical trend analysis of the methodological teaching work management in the medical career, 5 stages were established; First Stage (1962 to 1980: Consolidation of the University Reform and First Regulation of Methodological Work); Second Stage (1981 to 1987: Implementation of the Methodological Teaching and Methodological Work of the specialties of higher medical education); Third Stage (1988 to 2006: Ministerial Resolutions that recognized the existence of two fundamental directions for the development of methodological work). Fourth Stage (2007 to 2017: Implementation of Resolution 210 /2007); Fifth Stage (2018 - Present: Activity of Resolutions associated to the E curricula). Conclusions: The use of theoretical methods, such as the historical-logical method, systematization and documentary analysis, made possible to reference the historical trend analysis of the methodological teaching work management in the medical career

A Kronecker product accelerated efficient sparse Gaussian Process (E-SGP) for flow emulation

In this paper, we introduce an efficient sparse Gaussian process (E-SGP) for the surrogate modelling of fluid mechanics. This novel Bayesian machine learning algorithm enables efficient model training using databases of different structures. It extends the approximated sparse GP algorithm by combining the concept of efficient GP (E-GP) and variational energy free sparse Gaussian processes (VEF-SGP). The developed E-SGP approach leverages the arbitrariness of inducing points and the monotonically increasing nature of the objective function with respect to the number of inducing points in VEF-SGP. By specifying the inducing points on the orthogonal grid/input subspace and using the Kronecker product, E-SGP significantly enhances computational efficiency without imposing constraints on the covariance matrix or increasing the number of parameters that need to be optimised during training.The E-SGP algorithm outperforms E-GP not only in terms of scalability but also in model quality, as evidenced by mean standardised logarithmic loss (MSLL). The computational complexity of E-GP grows cubically with an increasing structured training database, while E-SGP maintains computational efficiency as the model resolution (i.e., the number of inducing points) remains the same. The examples show that E-SGP produces more accurate predictions compared to E-GP when model resolutions are similar. In the application to a partially structured database, E-GP benefits from more training data but comes with higher computational demands, while E-SGP achieves a comparable level of accuracy but is more computationally efficient, making E-SGP a potentially preferable choice for fluid mechanics. Furthermore, E-SGP can produce more reasonable estimates of model uncertainty, whilst E-GP is more likely to produce over-confident predictions. In the application to partially structured databases, the performance of E-SGP is also compared to the structured Gaussian processes latent variable model (SGPLVM). In this case, E-SGP and SGPLVM both exhibit robust performance. However, E-SGP demonstrates a slight advantage over SGPLVM, particularly in terms of MSLL, indicating that E-SGP is better at producing trustworthy and accurate estimates of the uncertainty in the predictions. . While SGPLVM also improves computational efficiency by exploiting the Kronecker product and a small number of inducing points, E-SGP's orthogonal grid specification of inducing points further enhances its scalability and robustness, making it a superior choice for complex fluid mechanics problems with partially structured data.

IT Failures in Hospitals - Structures and Processes in Hospitals for Coping Cyber Attacks

Clinics are, by definition, part of a country's critical infrastructure. In recent years, hospitals have increasingly become the target of cyber attacks, resulting in disruptions to their functionality lasting weeks to even months. According to the "National Strategy for the Protection of Critical Infrastructures (CRITIS Strategy)", clinics are legally obligated to take preventive measures against such incidents. This involves evaluating, defining, and developing failure concepts for IT-dependent processes within a clinic to be prepared for a cyber attack. Specifically tailored emergency plans for computer system failures should be created and maintained in all IT-dependent areas of a clinic.Additionally, paper-based alternative solutions, such as request forms for diagnostic or consultation services, department-specific emergency documents, and patient documentation charts, should be kept in a readily accessible location known to staff in the respective areas. The complete restoration of a clinic's network after a cyber attack often requires extensive recovery of numerous IT systems, which may take weeks to months in some cases.If the hospital has robust plans for cyber emergency preparedness, including regular scans and real-time backups, stabilization and a quicker resumption of operations may be possible.