Concentrations In Children Research Articles

Prediction of Glucose Concentration in Children with Type 1 Diabetes Using Neural Networks: An Edge Computing Application.

Background: Type 1 Diabetes Mellitus (T1D) is an autoimmune disease that can cause serious complications that can be avoided by preventing the glycemic levels from exceeding the physiological range. Straightforwardly, many data-driven models were developed to forecast future glycemic levels and to allow patients to avoid adverse events. Most models are tuned on data of adult patients, whereas the prediction of glycemic levels of pediatric patients has been rarely investigated, as they represent the most challenging T1D population. Methods: A Convolutional Neural Network (CNN) and a Long Short-Term Memory (LSTM) Recurrent Neural Network were optimized on glucose, insulin, and meal data of 10 virtual pediatric patients. The trained models were then implemented on two edge-computing boards to evaluate the feasibility of an edge system for glucose forecasting in terms of prediction accuracy and inference time. Results: The LSTM model achieved the best numeric and clinical accuracy when tested in the .tflite format, whereas the CNN achieved the best clinical accuracy in uint8. The inference time for each prediction was far under the limit represented by the sampling period. Conclusion: Both models effectively predict glucose in pediatric patients in terms of numerical and clinical accuracy. The edge implementation did not show a significant performance decrease, and the inference time was largely adequate for a real-time application.

Serum Asprosin Concentrations in Children with Prader-Willi Syndrome: Correlations with Metabolic Parameters.

Children with Prader–Willi syndrome (PWS) are characterized by severe obesity. Asprosin is a newly discovered protein hormone produced by the white adipose tissue and is correlated with insulin resistance. The aim of our study was to describe the concentrations of serum asprosin in children with PWS compared to those with overweight/obesity and normal weight, and to explore the postprandial change in asprosin concentrations in participants with PWS and BMI-z matched controls. We enrolled 52 children, 23 with PWS, 8 with overweight/obesity, and 21 with normal weight. Fasting levels of asprosin, glucose, and insulin were collected in all children, and postprandial asprosin and fasting levels of acyl ghrelin (AG) and leptin were also determined in a subsample of participants. There were no significant differences among groups in fasting levels of asprosin, glucose, insulin, and HOMA-IR. Fasting serum asprosin and 1-h post-meal serum asprosin did not differ in children with PWS nor in BMI-z matched controls. Fasting asprosin showed an adjusted positive correlation with glucose in children with obesity (r = 0.93, p = 0.007) but not in children with PWS nor children with normal weight. Circulating asprosin might be a predictor of early alterations in glucose metabolism in children with obesity. More research is needed to further explain the association between asprosin, food intake, metabolism, and obesity in PWS.

Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis.

Alzheimer’s disease (AD) has emerged as a growing threat to human health. It is a multifactorial disorder, in which abnormal amyloid beta metabolism and neuroinflammation have been demonstrated to play a key role. Intrathecal inflammation can be triggered by infections and precede brain damage for years. We analyzed the influence of infections of the central nervous system on biomarkers that are crucially involved in AD pathology. Analyses of the cerebrospinal fluid (CSF) levels of Aβ1–42, Aβ1–40, Tau, and pTau proteins were performed in 53 children with neuroinfections of viral (n = 26) and bacterial origin (n = 19), and in controls (n = 8). We found no changes in CSF amyloid Aβ1–42 concentrations, regardless of etiology. We showed an increase in tau and phosphorylated tau concentrations in purulent CNS infections of the brain, compared to other etiologies. Moreover, the total concentrations of tau in the CSF correlated with the CSF absolute number of neutrophils. These findings and the Aβ 42/40 concentration quotient discrepancies in CFS between meningitis and encephalitis suggest that infections may affect the metabolism of AD biomarkers.

Concentration of Children's Learning in Motor-Sensory Play Management Development Framework

In growing a child's concentration level, an appropriate method is needed to stimulate more stable focus and concentration. This study aims to examine efforts to increase children's learning concentration by managing sensory-motor play in early childhood, which is carried out at an institution under the auspices of the Nusus Salam Foundation, namely RA Nurus Salam. The research method uses a qualitative case study approach. To get an idea of the Efforts to Increase Children's Learning Concentration Through Sensory Motor Play Management, the researcher went directly to the institution and observed the RA Nurus Salam institution by interviewing the principal and three teachers. The results showed that; The RA Nurus Salam institution uses the management of sensory-motor play to stimulate the increase in children's learning concentration and the involvement of teachers' strategies in the direction of sensory-motor play using; first, lesson planning. Second, implementation of learning design, and third, evaluation. The implication is that children's concentration and focus are more stable when carrying out activities with sensory-motor management.

The Implications of Naturalist Illustration Image Media on Early Childhood Learning Concentration and Motivation

Early childhood between the ages of 0 and 6 years experiences rapid growth and development. Children at this age have considerable potential that must be nurtured by providing essential knowledge, attitudes, and skills. Teachers are responsible for helping students reach their full potential through learning activities. One of them is creating exciting learning media that increases students' concentration and motivation. This study aims to adapt the use of naturalist illustration media to children's concentration and learning motivation. This research is a qualitative descriptive study using documentation, observation, and interviews. The results show that using realistic images can arouse children's curiosity, increase their focus, and encourage learning through activities and consequences. Based on the findings of this study, it can be concluded that the use of naturalist images is very suitable for early childhood education, as evidenced by the increase in children's attention and learning motivation

Physical Exercise and Brain-Derived Neurotrophic Factor Concentration in Children and Adolescents: A Systematic Review With Meta-Analysis.

To systematically review the literature on the relationship between physical activity and the effect of physical training on brain-derived neurotrophic factor (BDNF) concentrations in children and adolescents. The searches were conducted in the databases: PubMed, ScienceDirect, Web of Science, Scopus, SPORTDiscus, Latin American and Caribbean Center for Science Information of Health, and SciELO. All original studies that analyzed the relationship between the practice of physical activity and the effect of physical training on plasma and serum BDNF concentrations in children and adolescents were included. The standardized mean difference (SMD), correlation coefficient (r), and 95% confidence interval were calculated. Eleven studies were selected, totaling 1424 children and adolescents. Cross-sectional studies indicated a significant inverse relationship between physical activity and BDNF concentrations in boys (r = -.117 [-.222, -.009]; P = .033), but not in girls (P = .230). Adolescent athletes tend to have lower serum, but higher plasma BDNF concentrations than sedentary ones (SMD = -0.677 [0.188]; P < .001). An increase in serum BDNF was observed after physical training (SMD = 0.437 [0.183]; P = .017), with no effect in the control group (SMD = 0.235 [0.193]; P = .225). Adolescent athletes tend to show lower serum, but higher plasma BDNF concentrations compared with sedentary individuals. Furthermore, physical training seems to increase serum BDNF concentrations in sedentary adolescents to a small extent.

Monitoring Glucose Concentrations in Children with Epilepsy on a Ketogenic Diet.

Ketogenic diet (KD) and pulsatile dexamethasone therapy (PDT) are commonly used in the treatment of children with drug resistant epilepsy. Potential side effects of the KD are hypoglycemia, whereas PDT might lead to hyperglycemia. One practical option to measure glucose concentrations regularly is the flash glucose monitoring system (FGM). In this single-center study in Germany, two pediatric patients with epilepsy (age: 6.0 and 6.8 years) received FGM from the beginning of the KD over six months, in the year 2020, and one patient (9.8 years) was observed for one month on PDT and switched to the KD thereafter. Glucose concentrations were measured by using an FGM system and capillary blood measurement. Seizure frequency, changes in cognition, motor performance, social behavior, and sleep quality were evaluated. The mean hypoglycemia rate per day (65 mg/dL and lower) declined significantly in patient 1 and 2 after three months. Patient 3 showed in total seven hyperglycemic events during PDT. Patient 1 became seizure free. Improvement of attention and memory performance were reported. FGM during the KD as a treatment for drug resistant epilepsies in childhood is a practical option to explore and to avoid hypoglycemia during the KD and hyperglycemia during PDT.

Melatih Konsentrasi Melalui Permainan Sensorimotor pada Anak Kelompok A dalam Pembelajaran Masa Kenormalan Baru di RA Muslimat NU 10 Banin Banat Gresik

The background of this research is that there are students who have difficulty concentrating when learning the new normal period in class A1 RA Muslimat NU 10 Banin-Banat Gresik. The purpose of this study was to describe the application of sensorimotor play used to train concentration and to find out the supporting and inhibiting factors for the application of sensorimotor play used to train concentration. This research uses qualitative research with a case study approach. The results showed that the teacher of class A1 applied auditory sensorimotor play using pop up story books at the beginning of the lesson and at the end of the lesson. In addition, the teacher also applies a proprioceptive sensorimotor play using lego and bombic which are usually done during the safety corner, when the child has completed all his tasks. Factors that support the application of sensorimotor play to train children's concentration are the availability of media, increase children's insight, increase children's vocabulary, develop aspects of children's social emotional development, while the inhibiting factors are difficulties in conditioning students, the amount or quantity of media that is lacking.

Strategi Pembelajaran Anak Usia Dini Pada Masa Pandemi Covid-19 Di Kepahiang

Parents play an important role in helping the growth and development of children. During the pandemic, children are learning from home or distance learning. In this study, what strategies were used by parents during the Covid-19 pandemic at RT 06 Pasar Ujung Kepahiang Village, what were the results obtained and what were the obstacles faced by parents while their children were studying at home. The purpose of this study is to find out what strategies parents use and what obstacles and what are the results of studying at home during the pandemic. This research is descriptive qualitative. the main data sources are parents, children and teachers. Data collection techniques conducted interviews, observations and documentation. From the research it was concluded that as follows: First, the learning strategies of parents during the pandemic are, 1) Time management, 2) Place management, 3) Rewards, 4) Punishment, 5) Technology utilization. Second, parents' obstacles are, 1) Children's concentration is difficult to focus on, 2) Running out of fun ways to learn, 3) Internet access, and 4) Uncertain study time. Third, the results of the children's achievement are, 1) the achievement of religious and moral values, 2) the physical-motor achievement, 3) the cognitive achievement, 4) the socio-emotional achievement, 5) the language achievement, and 6) the artistic achievement

Mengasah Keterampilan Motorik Halus Dalam Kegiatan Menggunting Dan Menempel Pada Tk Al Maftuh Di Masa Pandemi Covid-19

This research was conducted aimed at improving children's fine motor skills and increasing children's concentration power by cutting and sticking activities. The research was conducted at the Al-Maftuh Kindergarten unit, Sukamulya Village, Sukabumi. Where the researchers conducted research on 25 children of group B Al-Maftuh Kindergarten in Sukamulya Village. The research was conducted due to the lack of children's motor results in the previous year, so with this they would like to further improve their fine motor skills to be more thorough and neat in terms of writing, coloring, drawing with cutting and sticking activities where their fingers are trained as well as eye and eye coordination. careful hand.

WITHDRAWN: Educational philosophies and theoretical perspective for self-cultivation in early childhood education

Education philosophies of self-cultivation have the basis and societal ideology of learning a powerful and traditionally efficient heritage that stretches back to ancient times in the traditional methods. There are many challenges in incorporating the philosophies in the theoretical perspective in early childhood education. Therefore in this paper, the educational philosophies and theoretical perspective (EP-TP) model has been proposed for self-cultivation in Early Childhood Education (ECE). Preparation for primary school is only one aspect of early childhood education (ECCE). One of its goals is to provide a firm and comprehensive basis for lifetime learning and well-being by addressing each child's social, emotional, cognitive, and physical requirements. In ECCE, we have the opportunity to cultivate caring, competent, and responsible citizens of the future. The training procedure includes a commitment to study, improve individual and be directed by one's instructor through religious observance and moral living. The freedom and the interconnectivity of the self are highlighted all across the learning experience. The section presented important impacts for self-directed education from an analysis of self-cultivation. The simulation analysis shows that the proposed EP-IP model enhances children's performance and concentration level compared to other popular methods. • ECE and young children's psychological activities utilizing multimedia • It encourages the degree of implementation of technological advances. • Lack of early childhood literacy provides considerable significance.

Abstract 11934: Lipoprotein(a) Serum Concentrations in Children Are Not Affected by Age, Sex, or Body Mass Index

Background: Lipoprotein(a) (Lp(a)) has emerged as an inherited marker of premature atherosclerotic cardiovascular disease (ASCVD). Current ESC guidelines recommend Lp(a) measurement once in the lifetime to identify individuals with high ASCVD risk. Limited data are available on Lp(a) serum concentrations in children. Methods: We analyzed 1189 blood samples of 605 healthy children aged 5 to 17 enrolled in the population-based LIFE CHILD (German civilization diseases cohort study). Lp(a) was quantitated using the Cobas/Roche assay. Results: The mean Lp(a) of the 605 children was 20.8 ± 1.0 mg/dl (SEM). 74 children (12.2%) showed Lp(a) concentrations between 30 and 50 mg/dl. 78 children (12.8%) exhibited Lp(a) &gt; 50 mg/dl. The mean Lp(a) serum concentrations were distributed evenly between age 5 to 17 years without effects of age on Lp(a) concentrations. Repeated measurements were available in 207 children (2- 6 measurements at least 1 year apart). The measurements were highly reproducible over time (mean percentual difference between repeated measurements of Lp(a) concentration 38.5%, SEM 5%) with a clinically relevant dynamic of Lp(a) values in only 3% of cases. There was no significant correlation between sex and Lp(a) (r=0.09) or body mass index and Lp(a) (r=0.06) whereas higher LDL-cholesterol levels occurred more often in children with elevated Lp(a) (r=0.44, p&lt;0.0001). 6 children with both Lp(a) &gt;50 mg/dl and LDL-cholesterol &gt;150 mg/dl were identified (1% of the 605 children). Conclusions: In conclusion, lipoprotein(a) serum concentrations in children between 5 and 17 years are not significantly affected by age, sex, or body weight. These data indicate that Lp(a) may be useful as a marker to identify children at increased lifetime risk for ASCD and suggest that Lp(a) could be used for reverse family screenings. Therefore, Lp(a) may be a valuable addition to screening examinations in children.

Reduction in Blood Lead Concentration in Children across the Republic of Georgia following Interventions to Address Widespread Exceedance of Reference Value in 2019.

In recent years, reports of lead contamination have dramatically increased in Georgia. Given concerns about the exposure of children to lead (Pb), the National Multiple Indicator Cluster Survey (MICS-2018) included a blood sampling component. The results showed that 41% of the children that participated had blood Pb levels (BLL) ≥ 5 µg/dL and that BLL in children living in Western Georgia were higher than those in Eastern regions. In response to these findings, NCDC implemented written and verbal advice to the families of children who participated in the MICS-2018 on how to reduce Pb exposure. From August 2019 onwards, the state program of clinical follow-up was implemented. The design of this study was a longitudinal study. The intervention of interest was the public health advice and medical follow-up, and the outcome was defined as the difference in BLL between the MICS-2018 survey and the state program follow-up. We observed a significant overall reduction in median BLL between MICS-2018 and state program follow-up in both August 2019 and the latest results (until December 2019). However, we did not observe any significant further reduction between August and the most recent BLL results. In the Georgian setting, written and verbal communication targeting individual households, alongside home visits to the most exposed, effectively reduced BLL in children.

Low Etanercept Concentrations in Children With Obesity and Juvenile Idiopathic Arthritis.

To evaluate the impact of obesity on etanercept (ETN) drug exposure in children with juvenile idiopathic arthritis (JIA). We conducted a pilot, cross-sectional, observational study in a real-world cohort of children with JIA receiving ETN as standard of care from a single center. We analyzed the relationship between body size and ETN plasma concentrations, adjusting for dosage. Body size was analyzed as a continuous measure using weight and body mass index (BMI) percentiles and categorically using BMI percentile classifications according to the CDC guidelines. We enrolled a total of 29 children. Each child provided one plasma sample for ETN concentration measurement, and all participants were receiving subcutaneous ETN dosed weekly. We observed that the ETN concentration normalized for dose decreased significantly as a function of weight (p = 0.004) and BMI percentile (p = 0.04). Similarly, we observed a progressive decline in mean and median dose-normalized concentrations across higher body size categories. Because of reaching maximum ETN dosage (50 mg), 7 of 8 children (87.5%) with obesity received a weight-based dosage < 0.8 mg/kg/dose. We found that higher body weight and BMI percentile are significantly and negatively associated with ETN drug serum concentration, accounting for differences in dosing. Our data suggest that children who are obese may be routinely under-dosed using current dosing strategies. Inadequate dosing may increase the risk for therapeutic failure and long-term morbidity in a developing child. As a result, characterizing adequate drug exposure in children of all sizes is an important step toward precision dosing.

The first wave of the COVID-19 pandemic in primary schools in the Czech Republic: Parental perspectives.

The article presents results of a survey among parents of primary‐school pupils, in which they commented on education during school closures due to the COVID‐19 disease pandemic in the spring of 2020. The questionnaire mapped family arrangements, parents' competencies, parenting practices concerning learning, and communication with the school. It was administered to more than 2,500 respondents at the end of the period of school closures (May–June 2020). The analysis focused on the question of whether the parents of pupils in primary schools assessed the home‐based distance learning as well handled and whether they felt concerned about their child's future school results. We understand parents' satisfaction as a result of the interaction between family arrangements on one hand, and requirements formulated by the schools on the other. The analysis showed that most parents rated home education positively. However, the socio‐economic status (SES) and cultural status of parents was a significant factor. Among the low‐SES parents, 47% reported concerns, while among the high‐SES parents, only 30% did. The strongest moderators of the link between SES and concerns about the school results of children were: school‐family communication during closures, adequacy of curriculum, parental practices supporting child's concentration and motivation, perceived school success of a child and parents' educational aspirations for the child.

The Effect of Storytelling Method Using Big Book in Improving Children's Learning Concentration in Kindergarten

This article is motivated by the research results revealing the low children's learning concentration in Insan Bangsa Kindergarten. It was caused by the unattractiveness of the learning media provided by the teacher. For this reason, this study aims to see the effect of the storytelling method using Big Book in improving children's learning concentration in Insan Bangsa Kindergarten. The Big Book was chosen to increase children's learning concentration since it has the advantage of highlighting the colors and pictures in the book to make students interested in books and concentrate when studying. This study used quantitative research methods, namely quasi-experimental. The samples in this study were group B2 with ten children as the experimental class and group B1 with ten children as the control class. The sampling technique used in this research was purposive sampling, and data collection employed observation. The research data were then analyzed utilizing the SPSS type 17 application. The results of this study revealed that t-count t-table, namely 2.386 2.101, so it can be said that the hypothesis Ha was accepted or H0 was rejected. This study concludes that the storytelling method using the Big Book significantly improved children's learning concentration in Insan Bangsa Kindergarten. It was obtained from the children's learning concentration level, which was higher than before using Big Book.

Effect of Casein Phospho Peptide-Amorphous Calcium Phosphate on Some Salivary Ions Concentration in Children with Early Childhood Caries

Abstract: Objective: directed to evaluate to Effect of Casein Phospho PeptideAmorphous Calcium Phosphate on Some Salivary Ions Concentration in Children with Early Childhood Caries in comparison with the use CPP-ACPF and sodium fluoride 5% varnish. Patients and methods: A total of 36 children with early child-caries (ECC), aged between 2.5-5 years were selected for this clinical trial study. Registered children were split into three groups at random according to the tested materials, group A; treated with non-fluoridated CPP-ACP-paste, group B; treated with CPP-ACPF-paste, and group C; treated with 5% sodium fluoride (NaF) paste. At first, 1 ml of unstimulated saliva was collected from whole enrolled children. In the next step, each tested material was applied on the tooth surfaces and then the saliva sampling was performed after 48 hours. The amount of phosphate ions was measured by spectrophotometer, while, calcium, and fluoride ions were measured by chromatographic device. Data were analyzed utilized paired t-test also used One-way ANOVA test at a p Results: This study revealed that; significant increase in phosphate and calcium ions condensation of the saliva before and after applying the CPP-ACP and CPP-ACPF pastes. However, the applying of CPP-ACPF paste, and 5% sodium fluoride paste significantly raise the fluoride scores of the saliva. Conclusion: In this study, the utilize of CPP-ACP also the use of CPP-ACPF pastes can easily the remineralization of tooth surfaces and is beneficial for protecting the primary teeth.

KHẢ NĂNG SỬ DỤNG KỊCH VẢI TRONG PHÁT TRIỂN GIAO TIẾP CHO TRẺ RỐI LOẠN PHÁT TRIỂN Ở BẬC HỌC MẦM NON: TIẾP CẬN TRÊN GÓC ĐỘ LÍ LUẬN

Panel Theatre is a new type of expression method using the context of a theater with simple material made of P paper and felt board at school. Panel theatre helps increase children's concentration, emotion, interest, motivation to speak and ability to respond, and develops their communication skills. Panel Theatre can be used to develop communication skills for children with developmental disorders. Teachers can flexibly change the speed of performance, adjust and sub-divide the content of the drama, adjust the acting in gestures, faces expression, especially adjust words and way of interacting with children, the way of using rhythm to encourage participation and responsiveness, engage children in activities to develop emotions, pleasure and develop basic communication skills. Teachers need to use panel theatre for specific case studies to test the impact of each characteristic element of panel theatre on the development of specific communication skills of children with developmental disorder in the future.

Investigating the Structure of the Children's Concentration and Empathy Scale Using Exploratory Graph Analysis

Abstract. The current paper investigates the structural validity of the Children's Concentration and Empathy Scale (CCES), which was designed based on Montessori's developmental theory to assess, using teacher ratings, the coherence of attention-related characteristics (concentration, empathy, and normalization) in children from 1.5 to 12 years old. The dimensionality analysis was carried out using exploratory graph analysis (EGA), and the stability of the items and factors were checked using a bootstrap version of EGA, and the results contrasted to exploratory factor analysis. The results point to a four-factor structure (emotion regulation, fantasy, task engagement, and empathy) after eliminating items with low replicability across bootstrapped samples. Beyond pointing to ways to improve the CCES, our paper presents a number of data analytical strategies that can be useful for studies investigating the structural validity of measurement instruments and demonstrates how EGA can effectively be used in the scale construction and validation process. Our manuscript and results are fully reproducible and are available on the Open Science Framework.

A multimedia Environmental Model to Predict the Lead Concentration in Children’s Blood Near Al-Dorah Refinery in Baghdad

Lead-contaminated water, soil, and air have been perceived as potential sources of lead exposure for a considerable length of time, which continues to threaten human health; particularly that of young children. An Integrated Exposure, Uptake, and Biokinetic (IEUBK) as a human health risk model were applied to predict the Blood lead levels (BLLs) in children. A variety of data for air, soil, and water were obtained from the industrial region in Al-Dorah city in Baghdad for the period 2012- 2014. The result found that the predicted BLLs value of 11.17 μg/dL obtained from the IEUBK model was exceeding the agency’s threshold of concern of 10 μg/jdL which was considered as the lowest level of concern for BLL in children, this result of the IEUBK model was in agreement with the actual value of BLLs which were taken from previous literature for 24 blood samples of school children matched for age curried out in the same Al-Dorah region. This technique propels logical comprehension of the connection between BLLs in children and environmental media in both air and soil for the pollute condition. It can control national health-based benchmarks for lead and related community public health decisions.