Learning Objective A multi-disciplinary and multi-ecological comprehensive health program to facilitate role transition for hematopoietic stem cell transplant caregivers. Topic Significance & Study Purpose/Background/Rationale Patients undergoing hematopoietic stem cell transplantation (HSCT) have an illness trajectory that is long and uncertain with varying demands of care (Gemmill, 2011). The responsibility for safely caring for these patients after discharge is placed on identified informal caregivers. However, the potential burden on these caregivers is considerable. Literature states that they experience a lack of preparation and confidence needed to be successful in their role (Kurtz et al., 2005; Beatie and Lebel, 2011; Gemmill et al., 2011; Bevans and Sternberg, 2012; Metoyer, 2013). Additionally, poorer physical and mental quality of life was found within this sub-group (Fred Hutchinson Cancer Research Center, 2017). Sampling of informal caregivers on a 16-bed Hematopoetic Stem Cell Transplant unit within an 862-bed academic medical center in New York, New York mirror these themes of under-preparedness and unmet support. Such implications pose a risk of delayed discharge, re-admission, and poor quality of life. The essential role that caregivers play in survivorship must be acknowledged. Methods, Intervention, & Analysis The Care Coordination, Social Work, and Nursing departments developed a task force to address this important issue. A comprehensive health program was constructed through the Intervention Mapping (IM) process and included the review of scientific literature, health behavioral theory, interviews with key informants, and dissemination of a mixed-methods Caregiver Readiness Survey over a 2-month period using a convenience sample of 28 (n=28) informal allogenic and autologous caregivers. Collected data was used to create an educational curriculum. Findings & Interpretation Studies underscore the need for clear, consistent, and tailored education for caregivers before the caregiving skills are needed (McDonald et.al, 1996; Foxall and Gaston- Johansson, 1996; Simoneu et al., 2017). Caregiver Readiness Surveys showed greatest uncertainty regarding central line catheter care (92%) and handling instances of nausea and vomiting (85%). Discussion & Implications A monthly 2-hour intervention was constructed with 1-hour devoted to skills-based education and a 1-hour support group, following. This class will be led by multi-disciplinary staff members and cover topics across the physical, psychosocial, and spiritual domains of care for comprehensive support. Projected evaluative measures include attendance monitoring, evaluation sheets, and pre- and post- testing to gauge information retention.