Avoidance Of Complications Research Articles

The Effectiveness of the Photoangiolytic Potassium Titanyl Phosphate (KTP) Laser in Managing Vocal Folds Reinke’s Edema A Systematic Review

Abstract Background Recently, photoangiolytic potassium titanyl phosphate (KTP) laser treatment has been proposed as an alternative treatment for managing Reinke’s edema. Unlike traditional methods that involve the physical removal of the lesion, the KTP laser causes lesion regression by disrupting the blood supply through targeting the oxyhemoglobin. Moreover, KTP could be used as an office-based procedure, indicating its advantage over other operating room surgical procedures, with lower cost and avoidance of the potential complications of microlaryngoscopy. Aim The aim of this work is to conduct a systematic review on the effectiveness of the photoangiolytic KTP Laser as a surgical method for treatment of patients with Reinke’s edema. Study Design: This was a systematic review. Methods Two electronic databases of (PubMed and Cochrane Library) were searched for articles. Relevant studies were further evaluated and studies that met inclusion criteria were reviewed and included. Results The literature search yielded 167 studies. 25 articles were further evaluated to be included. Three studies met all the inclusion criteria and were chosen for the review. The studies investigated the effectiveness of using Photoangiolytic KTP Laser in the management of Rienke’s edema. Conclusion The current systematic review suggested that photoangiolytic KTP Laser has not yet proven as an effective approach for treatment of Reinke’s edema and furthermore studies are needed to assess its effectiveness.

Small Bowel Dysmotility, Pseudoobstruction, and Functional Correlation with Histopathology: Lessons Learned.

Small bowel dysmotility is a broad heterogeneous term that encompasses a wide range of gastrointestinal disorders resulting from abnormal gut motility. Chronic intestinal pseudo-obstruction (CIPO) is a severe, rare, and complex small bowel motility disorder at the extreme end of this spectrum. It is characterized by failure of the intestinal tract to propel contents, which results in signs and symptoms of bowel obstruction albeit in the absence of any obstructive lesion(s). In this article, we discuss up-to-date diagnostic techniques, management options, and histopathological findings in CIPO. We will emphasize the latest diagnostic methodologies and therapeutic options as well as enteric histopathologic abnormalities in patients with CIPO. CIPO continues to be a clinical challenge. Several novel pharmacological agents hold promise including gastrointestinal hormone agonists and prokinetics. Furthermore, histopathologic findings may help guide therapy and provide further prognostic significance. At present, nutritional support, symptom management, and avoidance of long-term complications are the mainstay of treatment in CIPO.

Laparoscopically Assisted Ventriculoperitoneal Shunt Placement Is not Cost-Effective nor Preventive for Distal Shunt Malfunction

Laparoscopy for ventriculoperitoneal shunt creation might offer smaller incisions and more reliable placement. We assessed the reliability and cost-effectiveness of this technique compared with mini-laparotomy shunt placement. All patients undergoing ventriculoperitoneal shunt creation between November 2013 and September 2017 at a single academic institution were evaluated. Individual cases were assessed for the use of laparoscopy for peritoneal shunt placement (laparoscopy) versus mini-laparotomy for peritoneal shunt placement (open). The direct hospital costs for the laparoscopy and open groups were compared for elective shunt placement from the Vizient database. These direct costs were the proportion of the admission cost attributed to surgery. The primary endpoints included costs and revision of the peritoneal catheter within 12 months of the index procedure. A total of 68 patients met the inclusion criteria. Most cases (n= 40; 58.8%) had been performed with laparoscopy, with 28 performed using an open peritoneal approach. Three patients had required ≥1 distal shunt revision: 2 laparoscopy patients (5.0%; 1 had required a second revision) and 1 open patient (3.6%). No statistically significant differences were found for the patients requiring distal shunt revision between the 2 groups (P= 1.000; Fisher's exact test). The direct cost ($9461) of ventriculoperitoneal shunt creation with laparoscopy was greater than that with an open approach ($8247; P= 0.033). Both laparoscopy and open peritoneal shunt creation are safe procedures, with a 12-month distal revision rate in the present series of ~4%. Laparoscopy provided no relative improvement in safety or complication avoidance but had resulted in a mean increase in costs of >$1200 per patient.

Odontogenic Infections with Cutaneous Involvement in Children: a Case Series

Cutaneous involvement of dental sepsis is a rare occurrence in children. It often presents as a diagnostic dilemma, especially in the absence of oral symptoms, with initial presentation to non-dental professionals. This article discusses three cases of children presenting with cutaneous involvement of odontogenic origin to two paediatric dentistry departments in the UK. All cases had delayed presentations and were initially submitted to ineffective treatment, with significant impact on the children’s well-being. Final management included antibiotic therapy, drainage and extraction of the septic tooth. These three cases highlight the importance of considering a dental aetiology for localized inflammatory and purulent skin lesions of the mandible. Prompt diagnosis and early treatment are determinant for early resolution and avoidance of systemic or psychological complications. CPD/Clinical Relevance: This article discusses diagnosis and management of three different presentations of odontogenic sepsis with cutaneous involvement in children.

Complication profile and revision concepts for megaprosthetic reconstruction following tumour resection at the hip

Tumourous destruction of the periacetabular region and the proximal femur is atypical consequence of either primary malignant bone tumour manifestation or skeletal metastatic diseases. Pathological fractures of the proximal femur and periacetabular regions due to primary manifestation or metastatic disorders are frequent. Presentation of the most common complications of tumour endoprostheses at the hip and a description of management strategies, including therapeutic recommendations and concepts for complication avoidance. The current knowledge and our own experience of complication management with the use of megaprostheses around the hip are presented. Compared to elective/primary total hip arthroplasty, megaprosthetic reconstructions following tumour resections have an increased rate of postoperative deep infections, dislocations, incidence of pathological and periprosthetic fractures and of deep vein thrombosis. The postoperative mortality and local tumour recurrence along with deep infections represent the most serious complications. In comparison to primary arthroplasty, the risk of failure and complications following tumour-endoprosthetic replacement is increased. Precise surgical planning and careful selection and preoperative preparation of suitable patients should be performed in close interdisciplinary cooperation with final decision-making on an interdisciplinary tumour board. Wide resection and advanced reconstruction, as well as complicated palliative stabilization due to malignant bone tumour growth around the hip joint should be performed in musculoskeletal tumour centres with profound expertise in osteosynthetic and endoprosthetic reconstruction and consecutive complication management of the pelvis and the proximal femur.

Impacts on outcomes and management of preoperative magnetic resonance cholangiopancreatography in patients scheduled for laparoscopic cholecystectomy: for whom it should be considered?

PurposeWe evaluated the impact of preoperative magnetic resonance cholangiopancreatography (MRCP) on patient outcomes, and found which patients should be considered for MRCP before cholecystectomy.MethodsWe performed retrospective analysis of 2,072 patients that underwent cholecystectomy for benign gallbladder disease from January 2014 to June 2017. Patients were grouped as CT only group (n = 737) and MRCP group (n = 1,335), including both CT and MRCP (n = 1,292) or MRCP only (n = 43). The main outcome measure was associated with complications after cholecystectomy, and the secondary outcomes were hospital stay, readmission, and events that could impact patient management due to addition of MRCP.ResultsThere were no statistical differences in occurrence of intraoperative or postoperative complications or readmission rate between the 2 groups. Hospital stay was about 0.6 days longer in the MRCP group. However, MRCP group was more susceptible to complications due to underlying patient demographics (older age, higher frequency of diabetes, and higher level of the inflammatory markers). MRCP diagnosed common bile duct (CBD) stones in 6.5% of patients (84/1,292) without CBD stones in CT, and bile duct anomalies were identified in 41 patients (3.2%). Elevated γ-GT was the only independent factor for additional detection of CBD stones (adjusted odds ratio [OR], 2.89; P = 0.029) and subsequent biliary procedures (adjusted OR, 3.34; P = 0.018) when additional MRCP was performed.ConclusionMRCP is valuable for identification of bile duct variation and CBD stones. Preoperative MRCP can be considered, particularly in patients with elevated γ-GT, for proper preoperative management and avoidance of complications.

Feto–maternal outcome in pregnancy with Heart Disease: A tertiary care centre experience

Aim and Objectives: To know the prevalence and etiological types of heart disease in pregnant female and to describe the foetal and maternal outcome. Methodology: A retrospective hospital based study of all women with congenital or acquired heart disease admitted in Safdarjung hospital in 2016 was performed. The etiological type of heart disease and maternal and neonatal outcome were evaluated. Results: Median age of all the patients enrolled was 25yrs (19yrs–31yrs) which included mostly multigravida with POG from 28 to 41 weeks of gestation. Among all the patients 62% were unbooked. Rheumatic heart disease was most prevalent followed by congenital heart disease (13.6%) and Cardiomyopathy (13.7%). It was also found in the study that Instrumental Vaginal delivery was the preferred method. The fetal outcome was also evaluated and it was found that Pre term delivery, Low Birth weight and IUGR were main complications found in the mothers with heart disease which resulted in 27% NICU admissions and 5.1% neonatal mortality. Conclusion: Cardiac lesions and pregnancy both may affect each other adversely. Joint care of obstetrician, cardiologist and anesthetist, avoidance of complications that add to the burden on the heart and compliance of the patient and her family to regular follow up will go a long way in ensuing a safe outcome for mother and fetus.

Peripheral Nerve Stimulation for Facial Pain Using Conventional Devices: Technique and Complication Avoidance.

The introduction of peripheral neuromodulation to treat headache and facial pain two decades ago opened up the field to non-neurosurgical practitioners, given the relatively low risk and technical ease of the procedure. These procedures, primarily occipital nerve stimulation (ONS) and trigeminal branch stimulation such as supra- and infraorbital nerve stimulation, are now established to be effective in a number of facial pain and headache syndromes, despite their lack of approval by regulatory agencies such as the US Food and Drug Administration (FDA). For that reason and others, dedicated hardware for these procedures has not yet been developed, thus relying on hardware designed for placement in the epidural space for spinal cord stimulation (SCS). This has led to a series of technical issues and device-related complications not traditionally seen with SCS. I will review the surgical technique of ONS and peripheral nerve stimulation of the head and face utilizing this equipment, and discuss methods learned by experienced practitioners over the years to minimize device-related complications.

MIS lateral ACR for spinal deformity correction: technique and complication avoidance.

Deformity correction using minimally invasive surgical (MIS) techniques can be challenging. Here the authors present a case in which an anterior column resection was performed using an MIS lateral approach to restore lumbar lordosis and improve sagittal balance. The authors demonstrate the technique and discuss potential complications and how they may be avoided.The video can be found here: https://youtu.be/XjOdDeKrKEE.

The Subaxial Cervical Pedicle Screw for Cervical Spine Diseases: The Review of Technical Developments and Complication Avoidance.

This study aimed to review information on the subaxial cervical pedicle screw (CPS) including recent anatomical considerations, entry points, placement techniques, accuracy, learning curve, and complications. Relevant literatures were reviewed, and the authors’ experiences were summarized. The CPS is used for reconstruction of unstable cervical spine and achieves superior biomechanical stability compared to other fixation techniques. Various insertion and guidance techniques are established, among which, lateral fluoroscopy-assisted placement is the most common and cost-effective technique. Generally, placement under imaging guidance is more accurate than other techniques, and a three-dimensional template allows optimal trajectory for each pedicle regardless of intraoperative changes in spinal alignment. The free-hand technique using a curved pedicle probe without a funnel-like hole increases screw stability and reduces operation time, radiation exposure, and soft tissue injury. Compared to conventional lateral fluoroscopy-assisted placement, free-hand CPS placement by trained surgeons achieves superior accuracy comparable to that of image-guided navigation; in general, 30 training cases are sufficient for learning a safe and accurate technique for CPS placement. The complications of subaxial CPS are classified into three categories: complications due to screw misplacement, complications without screw misplacement, and others. Inexperienced surgeons may benefit from advanced techniques; however, the accuracy of CPS ultimately depends on the surgeon’s experience. Inexperienced surgeons should master the placement of the thoracolumbar pedicle screw in real practice and practice CPS insertion using cadavers. During the initial phase of the learning curve, careful preparation of surgery, reiterated identification, patterned safety steps, and supervision of the expert are necessary.

Complication Avoidance in Endonasal Endoscopic Pituitary Surgery.

Endoscopic endonasal surgery for pituitary tumors can be performed safely with a good outcome. Complications are uncommon and relate most often to nearby structures at risk. The authors detail the nuances, tips and tricks useful in avoiding complications and their early detection and management.

Aortobronchial fistula.

Aortobronchial fistulas (ABFs) are rare but fatal if left untreated. Hemoptysis is the most common symptom of the patients. ABFs may occur after any thoracic aortic lesions or maneuveurs for these lesions. The treatment of ABF can be surgical or thoracic endovascular aortic repair. Thoracic endovascular aortic repair can be a safe and less invasive procedure for the treatment of ABFs. However, ABFs might occur in much shorter time after thoracic endovascular aortic repair than any other etiologies. The prognoses of patients with ABFs are poor with a high morbidity and mortality. The selection of a suitable endovascular graft and avoidance of postinterventional complications might effectively prevent the occurrence of ABFs.

Arthroscopic, Implant-Free Bone-Grafting for Shoulder Instability with Glenoid Bone Loss

The major steps of the procedure, which are demonstrated in the present video article, include (1) detachment of the labrocapsular ligamentous complex and preparation of the anterior aspect of the glenoid, (2) establishment of a deep anterior-inferior portal and splitting of the subscapularis tendon, (3) introduction of the "waterslide," (4) osteotomy at the scapular neck 30° relative to the glenoid surface and trial impaction, (5 and 6) harvesting and preparation of a J-shaped bicortical iliac-crest bone graft, (7) press-fit impaction of the bone graft in the prepared osteotomy over the "waterslide", and (8) capsuloligamentous repair over the graft. Coracoid transfer (Latarjet-Bristow), iliac-crest bone-grafting, and distal tibial allograft. Although widely in use, nonanatomic coracoid transfer procedures or bone-block techniques relying on hardware fixation are associated with specific complications, including nonunion, osteolysis, coracoid fractures, hardware complications, and difficult revision1. Many of these disadvantages can be avoided by the use of anatomic implant-free glenoid reconstruction with a J-shaped iliac-crest bone graft. After press-fit fixation, the graft undergoes a physiological remodeling process that follows the law of bone adaptation to mechanical stresses described by Wolff, which ultimately results in the restoration of a nearly native anterior scapular neck morphology4. The open version of this technique has been successfully used for over 3 decades. The arthroscopic, minimally invasive variation of the J-bone-graft technique presented in this video article represents a further advancement of the anatomic nature of the procedure. The arthroscopic implant-free J-bone-graft technique is an alternative to other procedures widely used for the treatment of anterior glenoid bone defects. The main advantage of this technique is the avoidance of severe complications that arise from the nonanatomic reconstruction and fixation methods found with other procedures1. Early to midterm follow-up of the arthroscopic J-bone-graft technique has revealed excellent clinical results, and the traditional open technique has been in use successfully for over 3 decades2-5. Previous patients have been able to return to a variety of occupational and athletic activities including overhead, throwing, and contact sports. Return to daily living and to moderate athletic activities is usually possible within 3 months. Return to competition is allowed after 6 months2-5. •Avoid intraoperative graft fractures by applying strictly axial force during impaction.•Reduce the risk of glenoid fractures by performing an oblique osteotomy at an angle of 20° to 30° and 5 mm medial to the glenoid surface.•The postoperative physiological remodeling process determines ultimate graft fixation and glenohumeral stability. Keep this in mind when allowing return to activities.

Analysis of the logistical, economic and minimally invasive cardiac surgical training difficulties in India.

Significant advances have been made in minimally invasive cardiac surgery (MICS) over the past 3 decades. However, the acceptance and practice of MICS continue to remain low in the developing world owing to several challenges. This study aimed to analyse the logistical, economic and training difficulties in MICS with a special focus on the Indian scenario. A systematic review of the current literature on MICS with an emphasis on these challenges was performed. MICS has been shown to have clear cost-benefit advantage that stems from shorter ICU and hospital stay, lesser transfusion requirements and avoidance of sternal wound complications. However, only limited reports are currently available detailing the economic and training challenges for the application of MICS in the developing world, particularly India. Though several challenges exist in widening MICS practice in India, these can be overcome through a target-oriented approach.

A Review of Head and Neck Clinical Anatomy for the General Dental Practitioner

Knowledge of structures of the head and neck is an important aspect of safe and effective daily clinical practice. This article will review the relevant anatomy for the assessment of the temporomandibular joints (TMJs) and associated structures, delivery of local anaesthesia, understanding routes of spread of odontogenic infections and avoidance of anatomical complications in dento-alveolar surgery. CPD/Clinical Relevance: To recap key clinically relevant basics of head and neck anatomy.

Safety and efficacy of post-anastomotic intraoperative endoscopy to avoid early anastomotic complications during gastrectomy for gastric cancer.

Anastomotic complications such as leaks, bleeding, and stricture remain the most serious complications of surgery for gastric cancer. No perfect method exists for an accurate and reliable prevention of these complications. This study investigated the safety and efficacy of post-anastomotic intraoperative endoscopy (PAIOE) for avoidance of early anastomotic complications during gastrectomy in gastric cancer. This retrospective case-control study enrolled patients from a tertiary care, academic medical center. Routine PAIOE was performed on 319 patients undergoing gastrectomy for gastric cancer between 2015 and 2016. As controls, without PAIOE 270 patients from 2013 to 2014 were used for comparison. Early anastomotic complications and outcomes after PAIOE were determined. Although there were no differences between the PAIOE and non-PAIOE group in terms of overall complication rates (20.1% vs 26.7%; P > 0.05), there were fewer complications related to anastomosis (3.4% vs 8.9%; P < 0.01) in the PAIOE group. The PAIOE group had rates of 2.5% for anastomotic leakage, 0.9% for intra-luminal bleeding, and 0% for anastomotic stenosis, while the non-PAIOE group exhibited rates of 5.6%, 2.6%, and 0.7%, respectively. Thirty-one abnormalities were detected in 26 PAIOE patients (9.71%) (20 venous bleeding, 7 mucosal tearing, 2 air leaks, 1 arterial bleeding, and 1 anastomotic stricture). All abnormalities were corrected by proper interventions (13 reinforced additional suture, 13 endoscopic hemostasis, and 2 re-anastomosis). There were no morbidities associated with PAIOE. PAIOE appears to be a safe and reliable procedure to evaluate the stability of gastrointestinal anastomosis for gastric cancer patients. Further data collection and a well-designed prospective study are needed to confirm the validity of PAIOE.

How I do it: en-bloc subaxial cervical laminectomy using a high-speed drill with a footplate attachment.

Cervical laminectomy is a common strategy to decompress the spinal canal. The anatomy of the cervical spine and surrounding critical structures as viewed from the posterior approach is described. The use of a high-speed drill with a footplate attachment to make laminar troughs with an en-bloc subaxial cervical laminectomy is described with a discussion on surgical technique and complication avoidance. This technique allows for a safe, comfortable, and rapid decompression of the cervical spine with minimal risk. For routine cases, this may potentially be more safe and cost-effective than using a cutting bur or bone scalpel attachment.

Hospital nursing personnel staffing and patient outcome

The purpose of this review is to comment on the association between hospital nursing personnel staffing and patient outcomes, including the avoidance of errors and complications. A literature search was carried out in the Medline database on publications from the last 10years on nursing personnel staffing. Only overviews and observational studies on the topic were available and no controlled or prospective surveys. Most investigators assumed that there was an inverse relationship between low nursing staff levels of hospital wards and intensive care and adverse outcomes, including higher mortality rates; however, there is no clear significance for this assumption and evidence-based definitive lower limits for nursing staff cannot be given due to alack of randomized trials. The causes for unfavorable results in the case of inadequate nursing personnel staffing include hygiene deficiencies, orders not followed and unfulfilled nursing and monitoring measures. Furthermore, staff overload leads to staff dissatisfaction and burnout, which also has anegative impact on the results. Most studies required amaximum patient to nurse ratio of 2:1 for the intensive care unit and an average ratio of not more than 8:1 for surgical wards. With respect to these requirements, changing personnel needs must be considered depending on the current state of the patients being cared for, which enabled all investigators to require aflexible roster design; approval for fixed statutory lower limits for nursing staff was low. The level of education of the nursing staff also played an essential role as qualified nursing staff cannot be replaced at will by less qualified assistant staff. The level of training and the number of the nursing personnel influence hospital mortality and adverse outcomes; however, there are no evidence-based lower levels for nursing staff for inpatient care and perhaps this cannot be the case due to the changing complexity of the patients admitted, the comorbidities and possible treatment complications. There is aconsiderable need for research.

Pharmacologic Randomized Clinical Trials in Prevention of Type 2 Diabetes.

There have been many randomized clinical trials testing lifestyle and drug interventions to prevent the development of type 2 diabetes in nondiabetic adults at high risk of the disease. We review the major trials using pharmacologic interventions with the primary outcome of preventing diabetes. The trials are grouped according to the main mechanism by which the drugs were thought to have the potential for preventing diabetes. Drugs in several different classes have been effective in reducing the incidence of diabetes, but evidence for other long-term benefits, such as avoidance of complications and reducing mortality rates, is very limited. Both drugs and lifestyle interventions are effective in preventing and delaying the onset of type 2 diabetes in high-risk adults. The choices of what drugs to use and when during the development of type 2 diabetes to introduce them are not clear.

Amplified intracellular Ca2+ for synergistic anti-tumor therapy of microwave ablation and chemotherapy

BackgroundDeveloping new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of complications. We find that mild MW irradiation can significantly increase intracellular Ca2+ concentration in the presence of doxorubicin hydrochloride (DOX) and thus induce massive tumor cell apoptosis. Herein, we designed a synergistic nanoplatform that not only amplifies the intracellular Ca2+ concentration and induce cell death under mild MW irradiation but also avoids the side effect of thermal ablation and chemotherapy.ResultsThe as-made NaCl–DOX@PLGA nanoplatform selectively elevates the temperature of tumor tissue distributed with nanoparticles under low-output MW, which further prompts the release of DOX from the PLGA nanoparticles and tumor cellular uptake of DOX. More importantly, its synergistic effect not only combines thermal ablation and chemotherapy, but also obviously increases the intracellular Ca2+ concentration. Changes of Ca2+ broke the homeostasis of tumor cells, decreased the mitochondrial inner membrane potential and finally induced the cascade of apoptosis under nonlethal temperature. As such, the NaCl–DOX@PLGA efficiently suppressed the tumor cell progression in vivo and in vitro under mild MW irradiation for the triple synergic effect.ConclusionsThis work provides a biocompatible and biodegradable nanoplatform with triple functions to realize the effective tumor killing in unlethal temperature. Those findings provide reliable solution to solve the bottleneck problem bothering clinics about the balance of thermal efficiency and normal tissue protection.