Complicated Operations Research Articles

Miniaturization of CRISPR/Cas12-Based DNA Sensor Array by Non-Contact Printing.

DNA microarrays have been applied for comprehensive genotyping, but remain a drawback in complicated operations. As a solution, we previously reported the solid-phase collateral cleavage (SPCC) system based on the clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 12 (CRISPR/Cas12). Surface-immobilized Cas12-CRISPR RNA (crRNA) can directly hybridize target double-stranded DNA (dsDNA) and subsequently produce a signal via the cleavage of single-stranded DNA (ssDNA) reporter immobilized on the same spot. Therefore, SPCC-based multiplex dsDNA detection can be performed easily. This study reports the miniaturization of SPCC-based spots patterned by a non-contact printer and its performance in comprehensive genotyping on a massively accumulated array. Initially, printing, immobilization, and washing processes of Cas12-crRNA were established to fabricate the non-contact-patterned SPCC-based sensor array. A target dsDNA concentration response was obtained based on the developed sensor array, even with a spot diameter of 0.64 ± 0.05 mm. Also, the limit of detection was 572 pM, 531 pM, and 3.04 nM with 40, 20, and 10 nL-printing of Cas12-crRNA, respectively. Furthermore, the sensor array specifically detected three dsDNA sequences in one-pot multiplexing; therefore, the feasibility of comprehensive genotyping was confirmed. These results demonstrate that our technology can be miniaturized as a CRISPR/Cas12-based microarray by using non-contact printing. In the future, the non-contact-patterned SPCC-based sensor array can be applied as an alternative tool to DNA microarrays.

Parameter collaborative analysis and multi-objective optimization of a nanofluid filtered solar membrane distillation system using heat pump

The distributed solar powered membrane distillation (SPMD) system for water/electricity co-production is a valuable solution for relieving energy pressure in remote areas but it suffers from a complicated operation mechanism. This paper performs a comprehensive parameter analysis and user-oriented optimization on a nanofluid filtered solar membrane distillation system using heat pump to enhance its competitiveness. Response surface methodology is employed to examine the interactions of the influencing factors on the system performance, and the plots reveal significant interactions, particularly on equivalent specific thermal energy consumption (eSTEC). An artificial neural network is integrated with genetic algorithm to perform single and multi-objective system performance optimization. The results show that maximum system exergy efficiency, permeate flux and minimum eSTEC are 19.39 %, 35.8 kg·m−2·h−1 and 463.5 kWh·m−3, respectively. Furthermore, the technique for order preference by similarity to an ideal solution is utilized, based on performance indicator weight derived from the analytical hierarchy process, to offer a user-oriented optimal solution. It demonstrates that after optimization, the system exergy efficiency and permeate flux are improved by 9.9 % and 30.2 %, respectively, along with a reduction of eSTEC by 5.7 %. This research contributes to advancing solar-to-water/electricity efficiency and offering valuable insights for the development of SPMD systems.

Research on the Technical Model of Resource Utilization of Rural Domestic Sewage

At present, China’s rural sewage treatment technology is mostly used in municipal sewage treatment methods, with high energy consumption and complicated operation and maintenance. Through analyzing the problem of rural sewage management, we discussed the necessity and feasibility of rural sewage resource utilization, presented the principles that should be followed in the resource utilization according to local conditions, promoting the treatment, economic rationality, and ecological safety, and Summarized the technical models of irrigation utilization, ecological dissipation and decentralized on-site utilization for the resource utilization of rural domestic wastewater. The expansion of the resource utilization model will be more conducive to reducing the cost of rural sewage management and enhancing the quality of the rural environment and human settlements.

Commercially available ionic liquids enable high-performance aqueous zinc–iodine batteries: sequestered nitrogen-sites for efficient electrocatalytic iodine conversion

Commercial 1,2-dimethyl-3-propylimidazolium iodide towards high-performance zinc–iodine batteries without any complicated operations.

Recent advances in nucleic acid signal amplification-based aptasensors for sensing mycotoxins.

Mycotoxin contamination in food products may cause serious health hazards and economic losses. The effective control and accurate detection of mycotoxins have become a global concern. Even though a variety of methods have been developed for mycotoxin detection, most conventional methods suffer from complicated operation procedures, low sensitivity, high cost, and long assay time. Therefore, the development of simple and sensitive methods for mycotoxin assay is highly needed. The introduction of nucleic acid signal amplification technology (NASAT) into aptasensors significantly improves the sensitivity and facilitates the detection of mycotoxins. Herein, we give a comprehensive review of the recent advances in NASAT-based aptasensors for assaying mycotoxins and summarize the principles, features, and applications of NASAT-based aptasensors. Moreover, we highlight the challenges and prospects in the field, including the simultaneous detection of multiple mycotoxins and the development of portable devices for field detection.

A lightweight attribute-based signcryption scheme based on cloud-fog assisted in smart healthcare.

In the environment of big data of the Internet of Things, smart healthcare is developed in combination with cloud computing. However, with the generation of massive data in smart healthcare systems and the need for real-time data processing, traditional cloud computing is no longer suitable for resources-constrained devices in the Internet of Things. In order to address this issue, we combine the advantages of fog computing and propose a cloud-fog assisted attribute-based signcryption for smart healthcare. In the constructed "cloud-fog-terminal" three-layer model, before the patient (data owner)signcryption, it first offloads some heavy computation burden to fog nodes and the doctor (data user) also outsources some complicated operations to fog nodes before unsigncryption by providing a blinded private key, which greatly reduces the calculation overhead of resource-constrained devices of patient and doctor, improves the calculation efficiency. Thus it implements a lightweight signcryption algorithm. Security analysis confirms that the proposed scheme achieves indistinguishability under chosen ciphertext attack and existential unforgeability under chosen message attack if the computational bilinear Diffie-Hellman problem and the decisional bilinear Diffie-Hellman problem holds. Furthermore, performance analysis demonstrates that our new scheme has less computational overhead for both doctors and patients, so it offers higher computational efficiency and is well-suited for application scenarios of smart healthcare.

Myricetin-based fluorescence probes with AIE and ESIPT properties for detection of hydrazine in the environment and fingerprinting

BackgroundHydrazine (N2H4) is a highly toxic and versatile chemical raw material, which poses a serious threat to the environment and human health when used in large quantities. However, the traditional methods for the detection of N2H4 have the disadvantages of time-consuming, complicated operation and expensive instruments. In contrast, fluorescence probes have many advantages, such as simple operation, high sensitivity, good selectivity, and fast response time. Therefore, there is an urgent need for a fluorescence probe that can rapidly and accurately detect the presence of N2H4 and monitor the changes in its concentration. ResultsFor this purpose, we designed and synthesized a series of myricetin fluorescence probes 3-(substituent group)-5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxy.phenyl)-4H-chromen-4-one (Myr-R) for N2H4 detection. In the presence of N2H4, the probe 5,7-dimethoxy-3-(2,3,4,5,6-pentafluorobenzoate)-2-(3,4,5-trimethoxyphen-yl).-4H-chr-omen-4-one (Myr-3) shows significant fluorescence changes, double emission properties and a large Stokes shift (183 nm), and exhibits high selectivity and sensitivity to N2H4 (The detection limit is 93 nM). Importantly, the qualitative and quantitative analysis of N2H4 in water, soil, and air can be accomplished using fluorescence, smartphone, and UV lamps coupled with Myr-3. In addition, Myr-3 can be used for monitoring and imaging intracellular N2H4. Meanwhile, the fluorophore 3-hydroxy-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-benzopyran-4-one (Myr-Me) was applied to fingerprinting of different substrate materials due to the fact that it exhibits strong yellow fluorescence emission in the solid state and shows excellent contrast and high resolution. SignificanceThe probe Myr-3 is not only able to rapidly detect N2H4 in complex environments, but also can be used for imaging intracellular N2H4. In addition, the fluorophore Myr-Me can be used as an effective imaging agent for visual fingerprinting. These properties enable the probe Myr-3 and the fluorophore Myr-Me for a wide range of potential applications in related fields.

A rare case of a large tumour located under the facial nerve trunk

Aim: to introduce a technique of total parotidectomy sparing the facial nerve branches based on a clinical case. The article presents a clinical case of a large parotid tumour located under the facial nerve trunk, the stages of its surgical removal, and the postoperative course. Parotidectomy is one of the most complicated operations in maxillofacial surgery. When performing this surgical intervention, a surgeon must observe the principles of ablastics, consider individual peculiarities of the facial nerve anatomy structure and relations of nerve and tumour, and be ready to expand the scope of the operation from subtotal to total parotidectomy. Conclusions. To improve the treatment outcomes of patients with benign parotid tumours and to reduce the number of such postoperative complications as paresis and paralysis of the mimetic muscles caused by facial nerve injury, one should know and follow the technique of parotidectomy, especially in the case of a neoplasm located under the trunk or branches of facial nerve. The research was adhered to the principles of the Declaration of Helsinki. The patient informed consent was obtained for the study. No conflict of interests was declared by the authors.

A Low-Cost and Fault-Tolerant Stochastic Architecture for the Bernsen Algorithm Using Bitstream Correlation

Many algorithms for image processing do not require particularly high precision, but they rely on complicated arithmetic operations for every pixel in an image. The Bernsen algorithm is a typical local thresholding algorithm for solving the problem of uneven lighting. However, this algorithm requires a significant computing overhead and is extremely sensitive to noise. In this work, two stochastic computing architectures are proposed for implementing the Bernsen algorithm by using, respectively, uncorrelated and correlated input bitstreams. Experimental results show that both designs, especially the one using correlated bitstreams, present high fault tolerance of soft errors and low hardware cost in comparison with its conventional binary implementation. However, SC logic with uncorrelated inputs is not always superior to its corresponding binary circuit in energy consumption, especially the circuit that needs long input bitstreams. That means that a reasonable use of correlation can further optimize the SC circuit design.

Biomineralization–powered integrated immunoprobe and its application in Immunochromatographic assay

Immunochromatographic assay (ICA) has attracted widespread attention owing to its advantages of economy, simplicity, and rapidity. However, the synthesis of immunoprobes is still limited by complicated design ideas and multistep operations from preparing nanoparticles to conjugating monoclonal antibodies (mAb) onto nanoparticles. Inspired by the biomineralization of zeolitic imidazolate framework-8 (ZIF-8), we proposed a strategy for the rapid synthesis of an integrated immunoprobe (ZIF-8@QDs-mAb), achieving a one-step integration with strong fluorescent signal output capability and specific recognition ability. In addition, different fluorescent colors of ZIF-8@QDs-mAb were generated by doping red and green quantum dots (QDs) in various ratios. With a smart detection platform, the developed ZIF-8@QDs-mAb-based multiplex ICA (ZIF-8@QDs-mAb-mICA) achieved the on-site quantitative detection of enrofloxacin, sulfamethazine, and kanamycin in milk within 15 min, with the limit of detection (LOD) of 0.052, 0.186 and 0.216 ng mL−1, which were 5.69, 2.20 and 4.40 times higher than that of gold nanoparticles-based mICA, respectively. The quantitative detection of alpha-fetoprotein and human chorionic gonadotropin was also achieved with LOD of 0.516 ng mL−1 and 0.225 mIU mL−1, respectively, which verified the universality of the strategy. This work provides a novel idea for the design of an efficient integrated immunoprobe and has broad application prospects in ICA.

Automated multi-functional system for the characterization of plate valves in reciprocating compressors

At present, there are two independent technologies and equipment for the test of the reciprocating compressor plate valve: the sealing test and blowing test. This method has single function and complicated test operation and may rely on theoretical calculations, which reduces the reliability of the test conclusion because the motion law of valve disk during opening and closing is extremely complicated. The existing test methods cannot meet the needs of more in-depth and accurate research, development and improvement of the plate valve. This study proposes a test device and method that can not only quantitatively test the performance of the plate valve but also qualitatively test the dynamic process of the suction valve plate, which can greatly reduce the testing time provide more intuitive and accurate valve plate motion tracks and valve paths. This paper takes the primary plate suction valve as the test object and adopts the automated multi-functional system to accurately obtain the valve’s sealing property, effective flow area, thrust coefficient, flow coefficient, drag drop, valve gap Mach number, initial opening pressure difference, maximum opening, and residence time of the valve plate on the valve lift guard to provide necessary data for valve design and performance evaluation. The test results of valve opening time are verified by industrial reciprocating compressor, which proves the accuracy and practicability of the system.

Chemical recycling of Polylactic acid to methyl lactate catalyzed by choline chloride/ZnCl2 deep eutectic solvents

Methyl lactate (ML) is a green and biodegradable chemical product, which can be used as a solvent for cellulose, paints and dyes. Although several kinds of catalysts have been reported for the methanolysis of Polylactic acid (PLA) into ML, low catalytic activity and high cost and complicated operation are still problems. Renewable, environmentally friendly, and non-toxic choline chloride-based Deep eutectic solvents (DESs) are the newest alternatives to conventional catalysts for the methanolysis of PLA to obtain the valuable product ML. In this study, the methanolysis of PLA into ML using DESs composed of choline chloride (ChCl) and Zinc chloride (ZnCl2) was investigated by experiments and calculations. Experimental results reveal that ChCl-2ZnCl2 can catalyze the methanolysis of PLA to produce ML, more importantly, ML is easily obtained by vacuum distillation, and the catalyst can be reused for 5 times without significant loss of activity. Moreover, the possible reaction mechanism was derived from experimental data and density functional theory (DFT) calculations. And the kinetics of the methanolysis of PLA catalyzed by ChCl-2ZnCl2 was studied and the activation energy was obtained. This work reveals that ChCl/ZnCl2 DESs are conducive to the methanolysis of PLA to ML under moderate conditions, which can also provide strategies for other polymer degradation.

Code observation-specific biases estimation for the modernized multi-GNSS and multi-frequency signals: An approach considering signal distortion biases

With the continuous development of global navigation satellite systems (GNSS) modernization, the code bias presented in the form of observation-specific biases (OSB) is more flexible and effective when processing modern multi-frequency and multi-GNSS signals, and therefore widely accepted by the GNSS community. However, the newly reported signal distortion biases (SDB) are ignored in the existing OSB estimation methods, which may affect the reliability of the final OSB estimation. In addition, the existing studies about SDB estimation are independent of OSB estimation, and thus a set of SDB products is generated independent of OSB products, which undoubtedly brings more complicated correction operations to GNSS users. In view of it, this study proposes an approach to code OSB estimation for multi-frequency and multi-GNSS arbitrary signals by reparameterization, which considers the SDB parameter. The aim of this study is to generate a set of code OSB products that take into account SDB parameters for the GNSS users to use. Due to considering the influence of SDB on raw code observations, the OSB estimation obtained by the proposed method is related to specific satellite-receiver pairs, which makes it different from the traditional OSB estimation methods. To achieve this, an extended model for multi-frequency and multi-GNSS arbitrary signal is first established based on the undifferenced and uncombined model, in which the SDB parameter is taken into account by re-parameterization. Based on the proposed model, three types of code bias that contain the OSB information can be obtained for the subsequent OSB estimation. Then, the three types of code bias in the first step are used as virtual observations for multi-frequency and multi-GNSS arbitrary signal OSB estimation through a two-step method. The proposed method is validated with a whole month of real measured data from 418 stations in MGEX and GA CORS to generate OSBs for GPS, GLONASS, and Galileo. The comparison between the estimated OSBs and the OSB products from CAS indicates the reliability of the proposed method. Besides, all types of OSB for four receiver groups are generated based on the proposed method to analyze the relationship between OSB and receiver groups. Results indicate that the estimated OSBs are related to receiver groups, and specific differences exist between different satellites and GNSS signals. It also proves that the OSB estimation is biased by the inconsistencies of the deviation in different receiver groups, which is more obvious for GLONASS.

Label-free fluorescence detection of human 8-oxoguanine DNA glycosylase activity amplified by target-induced rolling circle amplification

BackgroundHuman 8-oxoG DNA glycosylase 1 (hOGG1) is one of the important members of DNA glycosylase for Base excision repair (BER), the abnormal activity of which can lead to the failure of BER and the appearance of various diseases, such as breast cancer, bladder cancer, Parkinson's disease and lung cancer. Therefore, it is important to detect the activity of hOGG1. However, traditional detection methods suffer from time consuming, complicated operation, high false positive results and low sensitivity. Thus, it remains a challenge to develop simple and sensitive hOGG1 analysis strategies to facilitate early diagnosis and treatment of the relative disease. ResultsA target-induced rolling circle amplification (TIRCA) strategy for label-free fluorescence detection of hOGG1 activity was proposed with high sensitivity and specificity. The TIRCA strategy was constructed by a hairpin probe (HP) containing 8-oxoG site and a primer probe (PP). In the presence of hOGG1, the HP transformed into dumbbell DNA probe (DDP) after the 8-oxoG site of which was removed. Then the DDP formed closed circular dumbbell probe (CCDP) by ligase. CCDP could be used as amplification template of RCA to trigger RCA. The RCA products containing repeated G4 sequences could combine with ThT to produce enhanced fluorescence, achieving label-free fluorescence sensing of hOGG1. Given the high amplification efficiency of RCA and the high fluorescence quantum yield of the G4/ThT, the proposed TIRCA achieved highly sensitive measurement of hOGG1 activity with a detection limit of 0.00143 U/mL. The TIRCA strategy also exhibited excellent specificity for hOGG1 analysis over other interference enzymes. SignificanceThis novel TIRCA strategy demonstrates high sensitivity and high specificity for the detection of hOGG1, which has also been successfully used for the screening of inhibitors and the analysis of hOGG1 in real samples. We believe that this TIRCA strategy provides new insight into the use of the isothermal nucleic acid amplification as a useful tool for hOGG1 detection and will play an important role in disease early diagnosis and treatment.

A study of teeth generation for arbitrary-shaped sprockets

ABSTRACT In the noncircular sprocket designing process, drawing the teeth cannot be automatically performed using any function in the drawing software, and it needs complicated manual operations and adjustments. The accuracy and time waste are big problems here. This paper proposes a procedure to automatically generate a complete 3D sprocket design from a set of sprocket pitch coordinates. Japanese standard tooth profile (JIS B 1801) is used as an example model in the procedure development. First, the tooth profile equation is derived using the theory of gearing in a particular coordinate system. Subsequently, the coordinate transformation matrix is built to attach the tooth profile on every sprocket pitch coordinate in the correct direction, remove some coordinates surpassing the outer diameter limit, and build the complete 3D sprocket profile. The proposed procedure can be implemented into programming languages with the sprocket pitch coordinate file as the input and the set of sprocket teeth coordinate as the output. With the proposed procedure, a 3D design of any shape sprocket can be generated quickly and accurately.

Research on Shackles of Agricultural Modernization in Northeast China -Taking the Promotion of the Western-style Agricultural Machinery in Northeast China as an Example

In the late Qing Dynasty and the early Republic of China, with the gradual development of social economy, agriculture in Northeast China also gradually began to modernize. In this context, businessmen from western developed countries saw the opportunity to actively promote their advanced agricultural machinery through various marketing strategies. Although they achieved satisfactory results in the initial years, their sales gradually weakened over time. Due to the lagging sales of Western-style agricultural machinery, agricultural production in most areas continues adopted the old method until Japan occupied the northeastern China in 1931. This phenomenon was result of the combination of multiple factors, such as special farming conditions, weak farmers 'economy, low self-organization ability of farmers, low labor cost, and complicated operation of western agricultural machinery. These adverse factors are also the shackles of the modernization of agriculture in Northeast China.

Restaurant Liquid Waste Treatment into Clean Water Using Graded Filter-Ultrafiltration Membrane Polyethersulfone (PES) Method

Restaurant liquid waste contains elevated pollutant levels and is commonly discharged directly into the environment, leading to adverse impacts on ecosystems and aquatic life. The traditional methods for processing such wastewater often involve extensive land usage and complicated operations, posing challenges for effective treatment. Therefore, there is a need for a more practical technology to manage restaurant liquid waste, and one promising approach is the utilization of membrane technology for wastewater treatment. In this study, the researchers employed a combination process of multilevel filters with downflow flow and PES membrane ultrafiltration to treat the restaurant liquid waste. The multilevel filter comprised several layers of filter media, including silica sand, activated carbon, zeolite, and gravel, with specific thicknesses on a PVC pipe. For the PES membrane, two different concentrations were tested: 15% and 20% PES. To evaluate the efficiency of the treatment process, pollutant parameters such as pH, TSS (Total Suspended Solids), COD (Chemical Oxygen Demand), and turbidity were measured. The results indicated significant pollutant reduction: pH levels could reach 6.9, TSS degradation achieved up to 98.37%, COD degradation up to 88.14%, and turbidity degradation up to 97.03%. Based on the outcomes, the most effective treatment for converting restaurant wastewater into clean water involved the combined use of multilevel filters and a 20% PES membrane ultrafiltration system.

Incidence and Predictive Risk Factors for Post-Cataract Surgery Endophthalmitis in Ministry of Health Hospitals from 2012 to 2020

ABSTRACT Purpose Postoperative endophthalmitis is a devastating complication, leading to poor visual prognosis. The purpose of this study is to determine the incidence, risk factors, and visual outcome of post-cataract surgery endophthalmitis in Malaysia over a 9-year period (2012–2020). Methods Data from National Eye Database (NED), involving all patients who have undergone cataract surgery from January 2012 until December 2020 were analyzed. Results Total number of patients who had undergone cataract surgery between the year 2012 till 2020 were 231,281 patients (267,781 eyes). Incidence of POE in this population was 0.08%. Patient aged 70 and above (p-value 0.047), Malay ethnicity (p-value: 0.009), presence of ischemic heart disease, renal failure, diabetic retinopathy, and poorer preoperative vision were shown to have a higher risk of POE. Cataract surgeries done in KK-KKM, duration more than 45 minutes, use of general anaesthesia, and no IOL or ACIOL implantation were significantly more in POE patients. Multivariate analysis revealed Malay ethnicity, presence of ocular comorbidity, poor preoperative vision, ACIOL, and presence of intra-operative complication were predictive factors for POE. Conclusions Incidence of POE is low in the Malaysian population. Surgeons have to be aware that Malay ethnicity, presence of ocular comorbidity, poor preoperative visual acuity, placement of IOL and complicated cataract operation have higher risk of POE.

Enhanced magnetic relaxation switching immunoassay for chlorpyrifos based on tyramine signal amplification

AbstractChlorpyrifos, an organophosphorus pesticide, is widely used in agriculture to protect crops from insects. However, the presence of its residues in food has caused widespread concern due to the serious risks to human health. Traditional detection methods suffer from limitations, such as low sensitivity, long detection time, and complicated operations. Herein, based on the tyramine signal amplification (TSA) strategy, we developed a sensitive and rapid magnetic relaxation switching (MRS) immunosensor for the detection of chlorpyrifos. Wherein, magnetic Fe3O4 nanoparticles modified with tyramine (MNP150‐tyramine) acted as magnetic probes for magnetic relaxation signal output. In the presence of hydrogen peroxide (H2O2) and horseradish peroxidase (HRP), tyramine can be converted to the highly reactive intermediate that covalently binds with the nearby proteins, such as HRP and antibody, thus assembling MNPs to magnetic clusters and showing changes in transverse relaxation time (T2) signals. Based on the “antibody–antigen” immunoreaction, chlorpyrifos could make a connection of HRP/antibody‐modified MNPs and MNP150‐tyramine with a result of MNPs aggregation and strong T2 signals. In this study, the TSA‐MRS method showed sensitive detection of chlorpyrifos with a limit of detection of 0.54 ng/mL, a 4.5‐fold enhancement in the sensitivity compared with the ELISA method, providing an alternative method for the detection of harmful substances in food samples.

Octopi Tentacles‐Inspired Architecture Enables Self‐Healing Conductive Rapid‐Photo‐Responsive Materials for Soft Multifunctional Actuators

AbstractTo mimic biological systems' healing mechanism and sensory motion, the combination of self‐healing, perception, and actuation in a singular soft artificial material is required, which would be enormously valuable for soft robotics that commit to obtaining multifunction and local sensing capacities approaching living organisms. However, most existing soft somatosensory actuators lack self‐healing capability to injuries, and suffer from insufficient actuating performance and sensitivity, and complicated manufacturing operations. Herein, a bioinspired conductive photo‐responsive architecture is reported. Rapidly photo‐responsive anthracene, self‐healing matrix with dynamic interactions, and high‐conductivity slideable silver nanowires chemically integrated with matrix are respectively utilized to mimic the neuromuscular system and effectors, biological tissue systems, and nerve cords and receptors of octopus tentacles. Such a soft somatosensory actuator exhibits rapid actuation (light‐driven bending velocity, 10o s−1), distinctive intrinsic strain sensitivity (gauge factor, 90.88), and decent self‐healing efficiency (92.2%). As a proof of concept, octopi tentacles‐inspired smart grippers are fabricated for various photo‐responsive motions including bending, weightlifting and object grasping that can contemporaneously detect actions by real‐time resistance changes and provide information feedback. This work is anticipated to bring fresh horizons in the design of multifunctional sensory actuating materials and establish a pathway for the advancement of self‐diagnostic soft robots.