Model-Based Systems Engineering (MBSE) supports the system-level design of complex products effectively. Currently, system design and optimization for complex products are two distinct processes that must be executed using different software or platforms, involving intricate data conversion processes. Applying multidisciplinary optimization to validate system optimization often necessitates remodeling the optimization objects, which is time-consuming, labor-intensive, and highly error-prone. A critical activity in systems engineering is identifying the optimal design solution for the entire system. Multidisciplinary Design Optimization (MDO) and reliability analysis are essential methods for achieving this. This paper proposes a SysML-based multidisciplinary reliability design optimization modeling method. First, by analyzing the definitions and mathematical models of multidisciplinary reliability design optimization, the SysML extension mechanism is employed to represent the optimization model based on SysML. Next, model transformation techniques are used to convert the SysML optimization model generated in the first stage into an XML description model readable by optimization solvers. Finally, the proposed method’s effectiveness is validated through an engineering case study of an in-vehicle environmental control integration system. The results demonstrate that this method fully utilizes SysML to express MDO problems, enhancing the efficiency of design optimization for complex systems. Engineers and system designers working on complex, multidisciplinary projects can particularly benefit from these advancements, as they simplify the integration of design and optimization processes, facilitating more reliable and efficient product development.