Complex Organization Research Articles

Concept of architectural formation of construction production complexes in the cities of Donbass

The scientific research is a continuation of the author’s publications and for the first time provides a complete conceptual set of principles and techniques, systematically covering all levels of the architectural and planning organization of construction production complexes. A concept for the architectural formation of construction industrial complexes in the cities of Donbass is proposed, which includes recommendations for the formation of these complexes. The urban planning approach to the selection of territories of non-operating coal mines is generalized. An analysis of existing buildings and structures of the coal mine and the features of construction production complexes was also carried out.

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Reducing greenhouse gas (GHG) emissions through renovation of the existing building stock is high on national and international agendas, but a broader understanding that includes building inventory and the circular economy is not often included. By 2028, the Norwegian University of Science and Technology (NTNU) plans to consolidate university campuses and rehabilitate up to 45 000 m2 of buildings. There are some signs of circular economy at the university in institutionally established practices such as waste sorting, and green procurement, but there exists a greater potential. In 2021, the authors organised a living lab at the university, aiming to investigate whether further measures could be implemented to reduce the consumption of university inventory, such as furniture and computer equipment. We found that reuse, in contrast to the centralised administrative provision of inventory, encouraged practices of care. The experiments in the living lab addressed the dominant homogeneity and standardised character of university fixtures and fittings, provoking enthusiasm for previously discarded and unwanted objects and offering opportunities for new caring relationships. The paper asks, in what ways caring practices are performed in efforts to reduce consumption and achieve sustainability goals in complex organisations such as universities. Data was collected during experiments organised as part of the living lab. The caring practices that we identified are context-aware, empowering, egalitarian, and avoid prioritising some kinds of practices and objects over others.

Nuclear pore complexes undergo Nup221 exchange during blood-stage asexual replication of Plasmodium parasites.

Malaria, caused by Plasmodium species, remains a critical global health challenge, with an estimated 249 million cases and over 600,000 deaths in 2022, primarily affecting children under five. Understanding the nuclear dynamics of Plasmodium parasites, particularly during their unique mitotic processes, is crucial for developing novel therapeutic strategies. Our study leverages advanced microscopy techniques, such as ultrastructure expansion microscopy, to reveal the organization and turnover of nuclear pore complexes (NPCs) during the parasite's asexual replication. By elucidating these previously unknown aspects of NPC distribution and homeostasis, we provide valuable insights into the molecular mechanisms governing parasite mitosis. These findings deepen our understanding of parasite biology and may inform future research aimed at identifying new targets for anti-malarial drug development.

Organizational Rigidity and Demands: A Qualitative Study on Nursing Work in Complex Organizations

Background/Objectives: The nursing work environment is a critical element in healthcare delivery and a strong predictor of both patient and nurse outcomes. Understanding the complexity and multifaceted nature of this environment is essential for improving nursing practices and optimizing healthcare systems. This study aimed to gain insights into the perceived characteristics of the nursing work environment, considering it as a complex and multifaceted system. Methods: A qualitative research approach was employed, involving 42 semi-structured interviews with 43 nurses and managers from academic, teaching, and general hospitals in The Netherlands. Data were collected between July 2020 and August 2021 through convenience sampling. Thematic coding was conducted to identify key patterns and themes. Results: The findings revealed that nurses demonstrated flexibility and a strong commitment to high-quality care, despite grappling with rigorous organizational tasks and processes. Four key themes emerged: (1) direct patient care as a standard feature of nursing work; (2) nurses’ flexibility for hospital productivity; (3) interdependencies, which decrease autonomous nursing practices; and (4) organizational structures that determine how nurses can shape their work. Nurses found it difficult to balance direct care with broader tasks due to organizational rigidity, revealing a gap between ideal nursing practices and daily reality. Conclusions: This study highlighted the challenges within the nursing work environment, particularly in balancing direct care with organizational demands. Addressing this gap between ideal nursing practice and reality requires a systems approach. This includes autonomous practices, supportive management, and flexible structures, allowing nurses to shape their work and enhance job satisfaction and care quality.

Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation.

The Notch receptor is activated by the Delta/Serrate/Lag-2 (DSL) family of ligands. The organization of the extracellular signaling complex is unknown, although structures of Notch/ligand complexes comprising the ligand-binding region (LBR), and negative regulatory region (NRR) region, have been solved. Here, we investigate the human Notch-1 epidermal growth factor-like (EGF) 20-27 region, located between the LBR and NRR, and incorporating the Abruptex (Ax) region, associated with distinctive Drosophila phenotypes. Our analyses, using crystallography, NMR and small angle X-ray scattering (SAXS), support a rigid, elongated organization for EGF20-27 with the EGF20-21 linkage showing Ca2+-dependent flexibility. In functional assays, Notch-1 variants containing Ax substitutions result in reduced ligand-dependent trans-activation. When cis-JAG1 was expressed, Notch activity differences between WT and Ca2+-binding Ax variants were less marked than seen in the trans-activation assays alone, consistent with disruption of cis-inhibition. These data indicate the importance of Ca2+-stabilized structure and suggest the balance of cis- and trans-interactions explains the effects of Drosophila Ax mutations.

Complex Brain Morphology Discovered in the Shark Parasite Nybelinia surmenicola (Cestoda: Trypanorhyncha).

The ultrastructure of the nervous system has been studied in sexually mature Nybelinia surmenicola (Cestoda: Trypanorhyncha) from the intestine of a shark Lamna ditropis. The central nervous system (CNS) reveals a complex organization within cestodes and corresponds to the trypanorhynch pattern of brain architecture. The brain of N. surmenicola is differentiated into nine clearly defined lobes and semicircular, median, and X-shaped cruciate commissures. A specific feature is the presence of a powerful extracellular capsule that surrounds the brain lobes with the cortical glial cells. Moreover, the architecture of the anterior lobes clearly distinguishes the species of Tentacularioidea. The neurons of the anterior lobes form compact groups looking like frontal horns. There are approximately 120 neurons in the anterior lobes and a preliminary estimate of more than 300 perikarya in the brain. Several ultrastructural types of neurons have been identified, differing in the size and shape of the soma, the density of the cytoplasm, and the ultrastructure of synaptic vesicles. Numerous synapses involving clear and electron-dense vesicles have been observed in neuropils. Two types of glial cells have been found in the brain that participate in neuronal metabolism and wrap around the giant axons, brain lobes, neuropil compartments, and the main nerve cords. Such a powerful extracellular fibrillar brain capsule has not been observed in the brain of other studied cestodes and has been demonstrated in this study for the first time. The differentiation of the brain lobes reveals the important role of the rhyncheal system in the evolution of cestodes and correlates with their behavior. The anterior nerves arising from the anterior lobes innervate the radial muscles stabilizing the position of the tentacle sheaths and movements of the attachment organs. The nervous system anatomy and the brain architecture may reflect the morphofunctional aspects of the tapeworm evolution.

Membrane fusion by dengue virus: The first step

Flaviviruses include important human pathogens such as Dengue, Zika, West Nile, Yellow fever, Japanese encephalitis, and Tick-borne encephalitis viruses as well as some emerging viruses that affect millions of people worldwide. They fuse their membrane with the late endosomal one in a pH-dependent way and therefore the merging of the membranes is one of the main goals for obtaining new antivirals. The envelope E protein, a membrane fusion protein, is accountable for fusion and encompasses different domains involved in the fusion mechanism, including the fusion peptide segment. In this work we have used molecular dynamics to study the interaction of the distal end of domain II of the DENV envelope E protein with a membrane like the late endosomal membrane in order to observe the initiation of membrane fusion carried out by a number of trimers of the DENV envelope E protein interacting with a complex biomembrane and demonstrate its feasibility. Our results demonstrate the likelihood of membrane disorganization and pore formation by trimer complex organization, the amino acids responsible for such condition and the secondary structure arrangements needed for such fundamental process. At the same time, we define new targets of the envelope E protein sequence which could permit designing potent antiviral bioactive molecules.

The Study of Intraparty Frictions: Conceptual Reflections on Preference Heterogeneity, Disagreement, and Conflict

Every complex organization is sometimes marked by preference heterogeneity, disagreement, and conflict. Within political parties, such frictions are traditionally viewed negatively, while recent research has started to perceive them more positively. How might such contradictory evaluations be explained? Through a three-step conceptual analysis we (1) identify two analytical perspectives on intraparty friction, one rooted in a primarily structural conception of parties, one in a primarily behavioral conception; and (2) specify a minimal definition of intraparty friction, which underpins a hierarchical concept structure to (3) suggest a way to resolve contradictions in the consequences attributed to intraparty frictions. Structuralist accounts often view frictions as negative due to a more demanding conceptual threshold, suggesting different types and levels of risk taking by conflict partners. Conversely, behavioralist perspectives see friction more often as beneficial because they focus on expressed disagreement without necessitating an organizational response. Our conceptual tools have important implications for research on membership organizations generally.

Effective decision-making in public health organizations: reference to the COVID-19 pandemic.

The role of public health organizations during the COVID-19 pandemic was crucial. These groups acted to slow the spread of infection through the implementation of initiatives, policies, research and more. However, the rapidly changing and uncertain climate of the pandemic resulted in suboptimal processes and decision-making within these organizations. These already complex organizations and networks of people became even more nuanced. Thus, organizational decision-making processes must be improved upon based on previous experiences and lessons learnt. With minimal peer-reviewed literature available, resources for effective organizational decision-making in these organizations are scarce. This served as the impetus for this review. To conduct this literature review, both peer-reviewed and grey literature were incorporated to better understand effective organizational decision-making practices for public health organizations. Recommendations found in the literature review were identified, coded and themed to provide a novel decision-making framework to be used by public health executives. Nine key themes of effective organizational decision-making were identified, including utilize decision-making tools, define the problem and acknowledge an imminent decision, establish decision rights, outline a clear escalation path, create a supportive organizational culture, set decision objectives and goals, and evaluate decision alternatives. These findings in conjunction with existing decision-making models were used to create a seven-step effective decision-making framework for public health organizations. The review and analysis of effective organizational decision-making practices is instructive. Public health executives and decision-makers should incorporate the themes identified and employ the proposed decision-making framework to encourage improved decision-making practices.

Architectural Organization of Ecological Tourist Complexes (The South Russia Case Studies)

This article analyzes the domestic and foreign experience in design of ecological tourist complexes, their architectural organization, three architectural models of ecological tourist complexes, and identifies the main design techniques. The relevance is determined by the growing interest of society in ecology; an increase in the tourist potential of the territories of southern Russia due to changing conditions; the emergence of a new type of tourist architecture, as well as an insufficient amount of design experience.Purpose: To identify the architecture of ecological tourist complexes and develop design proposals for such complexes in the south of Russia.Methodology/approach: The analysis of formative factors: urban planning, architectural planning, functional, environmental, affecting the architecture of ecological tourist complexes, their classification by organizational structure, functional content, accessibility, social efficiency and environmental factors. The concept of an ecological tourist complex in Krasnodar is proposed.Research findings: The organization of ecological tourism in the natural environment, environmental education of the population in the process of recreation are considered. Architectural models of ecological tourist complexes are proposed: adventure, scientific and recreational elements of environmental education, their comparative analysis, and selection of the effective model for Krasnodar.

Unravelling the architecture of major histocompatibility complex class II haplotypes in rhesus macaques.

The regions in the genome that encode components of the immune system are often featured by polymorphism, copy number variation, and segmental duplications. There is a need to thoroughly characterize these complex regions to gain insight into the impact of genomic diversity on health and disease. Here we resolve the organization of complete major histocompatibility complex (MHC) class II regions in rhesus macaques by using a long-read sequencing strategy (Oxford Nanopore Technologies) in concert with adaptive sampling. In particular, the expansion and contraction of the primate DRB-region appear to be a dynamic process that involves the rearrangement of different cassettes of paralogous genes. These chromosomal recombination events are propagated by a conserved pseudogene, DRB6, which features the integration of two retroviral elements. In contrast, the DRA locus appears to be protected from rearrangements, which may be owing to the presence of an adjacently located truncated gene segment, DRB9 With our sequencing strategy, the annotation, evolutionary conservation, and potential function of pseudogenes can be reassessed, an aspect that was neglected by most genome studies in primates. Furthermore, our approach facilitates the characterization and refinement of an animal model essential to study human biology and disease.

Integration as innovation in healthcare systems.

Healthcare systems in Canada are under pressure and require change-the status quo is no longer fit for purpose, if it ever was. Innovation is often held up as a cure for what ails us, but shiny new things or novel technologies alone have not been enough. This article will explore the concepts of differentiation and integration as being important drivers in the evolution of living organisms, ecosystems, and complex human organizations. The implications of this deep pattern of systems change are essential to understanding the roles of specialization in medicine, and optionality in primary care. Specifically, overspecialization without attention to the principles of healthcare integration can lead to fragmentation of care and worse patient outcomes. Finally, this article will describe some practical examples of system integration as innovation in the form of better public health and care delivery connections, health homes, and community care coordination centres.

Shh signaling directs dorsal ventral patterning in the regenerating X. tropicalis spinal cord.

Tissue development and regeneration rely on the deployment of embryonic signals to drive progenitor activity and thus generate complex cell diversity and organization. One such signal is Sonic Hedgehog (Shh), which establishes the dorsal-ventral (D/V) axis of the spinal cord during embryogenesis. However, the existence of this D/V axis and its dependence on Shh signaling during regeneration varies by species. Here we investigate the function of Shh signaling in patterning the D/V axis during spinal cord regeneration in Xenopus tropicalis tadpoles. We find that neural progenitor markers Msx1/2, Nkx6.1, and Nkx2.2 are confined to dorsal, intermediate and ventral spatial domains, respectively, in both the uninjured and regenerating spinal cord. These domains are altered by perturbation of Shh signaling. Additionally, we find that these D/V domains are more sensitive to Shh perturbation during regeneration than uninjured tissue. The renewed sensitivity of these neural progenitor cells to Shh signals represents a regeneration specific response and raises questions about how responsiveness to developmental patterning cues is regulated in mature and regenerating tissues.

Using Kantian Ethics in Dissolving Disputes over Management and Distribution of Natural Resources in Tanzania

The broad range of the managements of the natural resources in Tanzania has resulted into the creation of complex organizations and systems which has led to the exploitation of the workers depending on these resources for livelihood. These are various groups of actors such as insurgents’ groups, minority groups, and corrupt democratically elected leaders. Obviously, these leads to internal mistrust and commotion within a state rendered in calmness and contrary to peaceful coexistence. As a researcher the bottom line of these constrains needs holistic education and realization to combat the eminent crisis at hand. Each person has a role to play for the peaceful living in a society with great goals and opportunities. The dignity and integrity of each person is a very important and at stake. My research analysis indicates how Kantian ethics will tackle the above mentioned constrains for the peaceful coexistence in the society. For Kant, every human being has a right and obligation for every moral action. In any democratic society where laws and statutes are adhered to the issues of natural resources must be accounted for with the aim of common good. Using Immanuel Kant’s dictum on categorical imperative, these transformations in the management of the natural resources in Tanzania can be effectively be achieved.

The impact of geopolitical processes in Bosnia and Herzegovina on urban development and cultural identity

The historical-geographical development of Bosnia and Herzegovina (BH) in the area of the fusion of Western and Eastern Christian civilizations and the Orient resulted in ethnic and religious heterogeneity, occasional political crises and ethnic conflicts that shaped the cultural identity and character of the entire development. BH was separated from the Yugoslav community in the conditions of the civil war. After the war in 1995, a complex administrative-territorial organization of the new state was established, based on the ethnic and religious affiliation of the population. At the same time, the transition of the socialist social system took place, as well as other geopolitical processes and social changes in the Western Balkans initiated by globalization. The paper focuses on cultural disintegration and changes in urban identity and development of cities through the analysis of the six largest urban centers as indicators of social changes in BH. The results of the analysis suggest that there has been a cultural differentiation of society, which is reflected in changes in the ethnic and religious structure of the population and their spatial distribution. Economic stagnation and depopulation of urban centers, as a consequence of the civil war and social reforms, were confirmed by a comparative analysis of statistical indicators of economic and demographic development. Cultural changes were determined by relevant scientific methods and approaches: historical-geographical method, comparative analysis of statistics of demographic indicators and changes in spatial distribution, ethnic and religious structure of the population, and economic changes by analysis of employment in sectors of the economy. The scientific results of previously published papers devoted to some of the mentioned problems, primarily economic development and population dynamics in BH and its large cities, were also taken into account. In this paper, social changes are observed through the cause-and-effect relationships of geopolitical and cultural processes (political, economic and cultural disintegration), social and economic reforms (ownership transition and deindustrialization) and their manifestations on cultural identity and the development of urban centers.

Cell-cell junctions in focus - imaging junctional architectures and dynamics at high resolution.

Studies utilizing electron microscopy and live fluorescence microscopy have significantly enhanced our understanding of the molecular mechanisms that regulate junctional dynamics during homeostasis, development and disease. To fully grasp the enormous complexity of cell-cell adhesions, it is crucial to study the nanoscale architectures of tight junctions, adherens junctions and desmosomes. It is important to integrate these junctional architectures with the membrane morphology and cellular topography in which the junctions are embedded. In this Review, we explore new insights from studies using super-resolution and volume electron microscopy into the nanoscale organization of these junctional complexes as well as the roles of the junction-associated cytoskeleton, neighboring organelles and the plasma membrane. Furthermore, we provide an overview of junction- and cytoskeletal-related biosensors and optogenetic probes that have contributed to these advances and discuss how these microscopy tools enhance our understanding of junctional dynamics across cellular environments.

An early cladoxylopsid with complex vascular architecture: Paracladoxylon kespekianum gen. et sp. nov. from the Lower Devonian (Emsian) of Quebec, Canada.

Cladoxylopsids, one of the first lineages with complex organization to rise from the plexus of structurally simple plants that comprised the earliest euphyllophyte floras, are moniliformopsid euphyllophytes. They formed Earth's earliest forests by the Middle Devonian and are thought to have given rise to the equisetopsids and probably some fern lineages. The Lower Devonian (Emsian) Battery Point Formation (Quebec, Canada) contains previously unrecognized cladoxylopsids preserved anatomically. One of these provides new data on structural evolution among euphyllophytes and is described here. The anatomy and morphology of permineralized axes of the new plant were studied with light and electron microscopy on sections produced using the cellulose acetate peel technique. Morphological comparisons and phylogenetic analysis were used for taxonomic placement of the plant. The plant represents a new species, Paracladoxylon kespekianum Chu et Tomescu, gen. et sp. nov., that has tracheids with modern-looking bordered pits and the complex cauline vascular architecture characteristic of the genus Cladoxylon. Its dissected ultimate appendages have complex regular taxis and a pattern of vascularization that suggests bilateral symmetry. Paracladoxylon kespekianum is one of the largest Early Devonian euphyllophytes, among the oldest representatives of the cladoxylopsid group, and older than any species of the closely related Cladoxylon by at least 35 million years. It is also one of the oldest anatomically preserved representatives of the cladoxylopsid group. Its anatomical organization pushes the rise of complex vascular architecture among moniliformopsid euphyllophytes deeper in time than previously recognized.

Digital Game Based Learning (A Literature Review)

Game Base Learning (GBL) has gained a lot of attention in the field of Instructional Design and Technology (IDT). The increased adoption levels in institutions and complex organizations have led to the growth of studies around the area with the goal of assessing their effectiveness in the learning process. This descriptive paper conducts an analysis of GBL as a learning process and the issues involving the IDT. The information is gathered from secondary sources where a systematic review of previous literature is conducted, was used to provide general knowledge about GBL. Particularly, the main issues addressed by this descriptive paper include overview of GBL, brief history of the concept, benefits, drawbacks, and successes addressed by current studies. Overall, GBL has become a significant area of interest in IDT in the world today. Most educational institutions and corporations are adopting this concept in their learning process due to its numerous benefits. Some of the benefits include development of cognitive skills, motivation during learning process and helping learners to gracefully accept failures. The findings indicate that most users and implementers of GBL decide to focus on the benefits in spite of various criticisms. Also, experts continue to support the concept as an alternative learning approach to the traditional methods of teaching.

Structural proteomics defines a sequential priming mechanism for the progesterone receptor.

The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR interactions remain poorly understood. Using structural mass spectrometry, we investigate the sequential binding mechanism of purified full-length PR and intact CoRs, steroid receptor coactivator 3 (SRC3) and p300, as complexes on target DNA. Our findings reveal selective CoR NR-box binding by PR and unique interaction surfaces between PR and CoRs during complex assembly, providing a structural basis for CoR sequential binding on PR. Antagonist-bound PR showed persistent CoR interactions, challenging the classical model of nuclear receptor activation and repression. Collectively, we offer a peptide-level perspective on the organization of the PR transcriptional complex and infer the mechanisms behind the interactions of these proteins, both in active and inactive conformations.

Organizational Ethics and Employee Productivity of Microfinance Banks

The study empirically examined the organizational ethics and employee productivity in Microfinance banks in Cross River State, Nigeria. Descriptive and correlational research designs were employed in the study. Data for this study were gathered from primary source and through structured questionnaire from the respondents of the microfinance banks in Cross River State. The study employed Pearson Product Moment Correlation analysis to measure the relationship between the variables tested in the study. Based on the analysis of the results, the finding was summarized; thus, there was a significant relationship between organizational ethics and employee productivity. The study recommended that management should create a healthy work environment where employees can be motivated towards productivity. Also, efforts should be made to ensure and observe etiquette and ethical conduct within work centers for the expected goals of the complex organization to be attained.