Cities today are host to myriad public health problems related to transport — unnecessary traffic crashes and pedestrian deaths, polluted air and sedentary lifestyles, that can cut lives short, reduce economic productivity, and harm overall quality of life. This presentation describes an assessment of major health issues before and after the implementation of the 27-km Metrobus Line 5 BRT corridor in Mexico City. Opened in November, 2015, the project includes 50 stations and serves approximately 200,000 passengers per day, with a dedicated BRT lane, completely reconstructed carriageways, new sidewalks with green features, improved pedestrian crossings and access to a central green median, and a protected bicycle lane. The previous road only offered small microbuses and a road design that lacked facilities for active transport. The World Resources Institute and other organizations supported the city in planning and designing the corridor, including road safety audits, resident surveys and operations support. Ex-ante studies were used as health impacts assessments to offer insights into the project. In addition, ex-post studies were carried out with regard to road fatalities and serious injuries, physical activity rates of residents in catchment areas, and personal exposure to air pollutants on the corridor and inside buses. The findings show that after implementation of the BRT, physical activity has increased, air quality and exposure have improved and that traffic crashes have likely fallen, though more research is needed and additional attention is needed to certain user groups and their well-being. For example, with residents walking more, additional attention to the condition of sidewalks may be necessary, as well as looking further into the mobility needs between genders. Overall, the implementation of BRT, especially when a complete street can be viewed as an urban transport measure that may improve public health, though further attention drawn to the built environment around stations.