Compatibility Issues Research Articles

Unlocking the Potential of Oxidative Asymmetric Catalysis with Continuous Flow Electrochemistry.

In the field of catalytic asymmetric synthesis, the less-treated path lies in oxidative catalytic asymmetric transformations. The hurdles of pinpointing the appropriate chemical oxidants and addressing their compatibility issues with catalysts and functionalities present significant challenges. Organic electrochemistry, employing traceless electrons for redox reactions, is underscored as a promising solution. However, the commonly used electrolysis in batch cells introduces its own set of challenges, hindering the advancement of electrochemical asymmetric catalysis. Here we introduce a microfluidic electrochemistry platform with single-pass continuous flow reactors that exhibits a wide-ranging applicability to various oxidative asymmetric catalytic transformations. This is exemplified through the sulfenylation of 1,3-dicarbonyls, dehydrogenative C-C coupling, and dehydrogenative alkene annulation processes. The unique properties of microfluidic electrochemical reactors not only eliminate the need for chemical oxidants but also enhance reaction efficiency and reduce the use of additives and electrolytes. These salient features of microfluidic electrochemistry expedite the discovery and development of oxidative asymmetric transformations. In addition, the continuous production facilitated by parallel single-pass reactors ensures straightforward reaction upscaling, removing the necessity for reoptimization across various scales, as evidenced by direct translation from milligram screening to hectogram asymmetric synthesis.

Dual-transgenic BiFC vector systems for protein-protein interaction analysis in plants.

Protein-protein interaction (PPI) play a pivotal role in cellular signal transduction. The bimolecular fluorescence complementation (BiFC) assay offers a rapid and intuitive means to ascertain the localization and interactions of target proteins within living cells. BiFC is based on fluorescence complementation by reconstitution of a functional fluorescent protein by co-expression of N- and C-terminal fragments of this protein. When fusion proteins interact, the N- and C-terminal fragments come into close proximity, leading to the reconstitution of the fluorescent protein. In the conventional approach, the N-terminal and C-terminal fragments of the fluorescent protein are typically expressed using two separate vectors, which largely relies on the efficiency of the transformation of the two vectors in the same cells. Furthermore, issues of vector incompatibility can often result in loss of one plasmid. To address these challenges, we have developed novel dual-transgenic BiFC vectors, designed as pDTQs, derived from the previously published pDT1 vector. This set of BiFC vectors offers the following advantages: 1) Both fluorescent fusion proteins are expressed sequentially within a single vector, enhancing expression efficiency; 2) Independent promoters and terminators regulate the expression of the two proteins potentially mitigating vector compatibility issues; 3) A long linker is inserted between the fluorescent protein fragment and the gene of interest, facilitating the recombination of the fused fluorescent protein into an active form; 4) Four distinct types of fluorescent proteins, namely, EYFP, mVenus, mRFP1Q66T and mCherry are available for BiFC analysis. We assessed the efficiency of the pDTQs system by investigating the oligomerization of Arabidopsis CRY2 and CRY2-BIC2 interactions in N. benthamiana. Notably, the pDTQs were found to be applicable in rice, underscoring their potential utility across various plant species.

Bio-based flame retardant for manufacturing fire safety, strong yet tough versatile epoxy resin

Bio-based flame retardants have attracted growing attention for sustainability and comparable efficiency to petroleum-based counterparts but suffer from compatibility issues with epoxy resins and the trade-off between strength and toughness. Here, a Schiff base-derived phosphorus-based flame retardant (TV-DOPO) was developed from biobased vanillin and tyramine. In the presence of the binary curing agents, nanoscale in-situ constructive phase separation induced by hierarchical thermal curing process and strong hydrogen bonding provide the composite resin with enhanced both stiffness and toughness. The flexural and impact strengths reached 159 MPa and 55.4 kJ m−2, which were increased by 36.5% and 129.6%, respectively, compared with the pristine epoxy, meanwhile excellent flame retardance was well maintained (UL-94 V-0 rating). Remarkably, these conjugated phosphaphenanthrene-containing composite resins demonstrate excellent UV-shielding capacity and optical transmittance. In this work, in-situ construction of a crosslinked network with tunable size of phase separation domains can be simply achieved by modulating the ratio of binary curing agents, to fabricate epoxy resins with all-around enhanced performance.

Electrolyte‐Gated Transistor Array (20 × 20) with Low‐Programming Interference Based on Coplanar Gate Structure for Unsupervised Learning

Compute‐in‐memory (CIM) is a pioneering approach using parallel data processing to eliminate traditional data transmission bottlenecks for faster, energy‐efficient data handling. Crossbar arrays with two‐terminal devices such as memristors and phase‐change memory are commonly employed in CIM, but they encounter challenges such as leakage current and increased power usage. Three‐terminal transistor arrays have potential solutions, yet large‐scale electrolyte‐gated transistors (EGTs) demonstrations are uncommon due to compatibility issues with existing photolithography processes. Herein, a 20 × 20 EGTs array is designed using indium‐gallium‐zinc‐oxide as the semiconductor channel and polyacrylonitrile (PAN) doped with C2F6LiNO4S2 as the electrolyte. Each transistor unit in the array can serve as a synapse, exhibiting a large conductance range, low energy consumption (6.984 fJ) for read–write operations, excellent repeatability, and quasilinear update characteristics. It has been confirmed that the EGTs array not only enables precise device programming but also virtually eliminates signal interference between neighboring devices during the programming process. Using 54 transistors in the EGTs array, unsupervised learning with a winner‐takes‐all neural network is successfully demonstrated. After 50 training iterations, the neural network achieves perfect 100% accuracy in classifying test‐set letters. The work demonstrates the potential of EGTs for constructing large‐scale integration synaptic array toward efficient computing architectures.

Unlocking superior safety, rate capability, and low-temperature performances in LiFePO4 power batteries

The safety concerns associated with lithium-ion batteries (LIBs) have sparked renewed interest in lithium iron phosphate (LiFePO4) batteries. It is noteworthy that commercially used ester-based electrolytes, although widely adopted, are flammable and fail to fully exploit the high safety potential of LiFePO4. Additionally, the slow Li+ ion diffusion and low electronic conductivity of LiFePO4 batteries limit their utility in high-power applications. Despite the crucial role played by liquid electrolytes in LIBs, achieving simultaneous improvements in safety, rate capability, and low-temperature performance remains a formidable challenge. In this study, we addressed these challenges by innovatively applying a single solvent ethyl vinyl sulfone (EVS) electrolyte to graphite/LiFePO4 batteries. While renowned for its broad electrochemical window, low freezing point and superior safety performance, the EVS electrolyte exhibited compatibility issues with the graphite anode. To overcome this hurdle effectively, we utilized vinylene carbonate as an additive with lower reductive reactivity than EVS to modify the interphase formed by EVS successfully. Simultaneously, the EVS-based electrolyte was found to create a sulfone-rich interphase on the LiFePO4 cathode surface, significantly enhancing Li+ ion diffusion both across the interphase and within the material. These modifications culminated in a conspicuous improvement in the performance of graphite/LiFePO4 batteries. Our study illuminates the potential of EVS-based electrolytes in boosting the rate capability, low-temperature performance, and safety of LiFePO4 power lithium-ion batteries. It yields valuable insights for the design of safer, high-output, and durable LiFePO4 power batteries, marking an important stride in battery technology research.

Analysis of the compatibility issue and its impact on the performance of houses of the Qajar period in Tabriz city

Analysis of the compatibility issue and its impact on the performance of houses of the Qajar period in Tabriz city

Modular segmentation, spatial analysis and visualization of volume electron microscopy datasets.

Volume electron microscopy is the method of choice for the in situ interrogation of cellular ultrastructure at the nanometer scale, and with the increase in large raw image datasets generated, improving computational strategies for image segmentation and spatial analysis is necessary. Here we describe a practical and annotation-efficient pipeline for organelle-specific segmentation, spatial analysis and visualization of large volume electron microscopy datasets using freely available, user-friendly software tools that can be run on a single standard workstation. The procedures are aimed at researchers in the life sciences with modest computational expertise, who use volume electron microscopy and need to generate three-dimensional (3D) segmentation labels for different types of cell organelles while minimizing manual annotation efforts, to analyze the spatial interactions between organelle instances and to visualize the 3D segmentation results. We provide detailed guidelines for choosing well-suited segmentation tools for specific cell organelles, and to bridge compatibility issues between freely available open-source tools, we distribute the critical steps as easily installable Album solutions for deep learning segmentation, spatial analysis and 3D rendering. Our detailed description can serve as a reference for similar projects requiring particular strategies for single- or multiple-organelle analysis, which can be achieved with computational resources commonly available to single-user setups.

Cryptography and DRM: A study of digital copyright protection in the gaming industry

This paper explores the role of cryptography and encryption technology in developing digital rights management (DRM) in the gaming industry. DRM aims to protect the rights of creators by preventing unauthorized copying and distribution of digital media. Cryptography plays a crucial role in DRM, ensuring the privacy, authenticity, and integrity of data. The early stages of game DRM involved physical disc methods, such as unique disc characteristics and online activation. However, these methods faced challenges such as compatibility issues and unauthorized copying. Modern DRM technologies combine advanced encryption techniques with account-binding mechanisms, requiring users to activate and access game content on specific accounts. Cryptography plays a key role in DRM by encrypting game data into unreadable formats, ensuring that only users with valid decryption keys can access the content, and ensuring secure distribution and consumption of digital content. The paper also discusses third-party DRM technologies, such as Denuvo, which employ strong encryption and obfuscation methods. However, third-party DRM may impact performance, inconvenience users, and lead to compatibility issues. The paper emphasizes the necessity of continually refining DRM technologies to balance copyright protection and consumer rights in the evolving gaming industry.

A High‐Stretchability, Wide Detection Range, and Wide Temperature Range Ti3C2Tx MXene/Graphene Strain Sensor Based on a Buckling Structure

AbstractFlexible wearable sensors have the characteristics of flexibility, comfort, and wearability, and have shown great potential in future electronic products. Despite significant efforts in developing stretchable electronic materials and structures, the development of flexible strain sensors with a wide temperature range, high sensitivity, broad detection range, and good interface stability remains challenging. Here, strain sensors with buckled structures are fabricated using high and low‐temperature resistant material Ti3C2Tx MXene/graphene, PDMS 184. The conductive material Ti3C2Tx MXene/graphene exhibits excellent interface interaction with PDMS 184, addressing not only the poor compatibility issue between the conductive material and the flexible substrate, but also demonstrating good stability and cycling performance. Buckled structure improves the stretchability and linearity of strain sensors. The fabricated strain sensor is suitable for a wide temperature range (−40 to 120 °C) and exhibits high stretchability (120% strain). The strain sensor demonstrates rapid response times at different temperatures: −40 (72.6 ms), 0 (62.7 ms), and 120 °C (52.7 ms). The strain sensor exhibits high sensitivity at different temperatures: −40 (GF = 0.38), 0 (GF = 0.24), 40 (GF = 0.66), and 120 °C (GF = 1.47). The strain sensor has a wide detection range (0.1% to 120%) and excellent cycling stability. In addition, Ti3C2Tx MXene/graphene strain sensors can accurately capture various human activities, such as blinking, speaking, finger bending, and wrist bending.

DFT study on the polyol sacrificial agents for improved clay tolerance of polycarboxylate superplasticizers

With the gradual scarcity of high-quality sand and gravel resources, the increasing mud content in concrete aggregates could strongly adsorb on polycarboxylate superplasticizers (PCE), greatly reducing their working performance. Modifying the molecular structure of PCE or compounding sacrificial agents can effectively improve the tolerance to clay minerals. In this article, using different small molecule polyols and polypropylene glycol (PPG) as examples, density functional theory (DFT) was employed to simulate the adsorption between clay minerals and hydration products. This exploration aims to further understand the anti-clay performance of various sacrificial agents from the perspective of adsorption energy. Ca-montmorillonite (CaMMT) exhibits the lowest adsorption energy among different clay minerals, making it the preferred site for sacrificial agent adsorption. With an increase in hydroxyl number, the adsorption energy between polyol sacrificial agents and montmorillonite decreases. Among polymeric polyols, the adsorption energy between PPG 600 and montmorillonite is the lowest (-10.86 eV), indicating superior anti-clay performance by preferentially occupying active sites on montmorillonite. As the interlayer spacing of montmorillonite increases, the adsorption energy between PPG 600 and montmorillonite initially decreases and then increases, reaching the lowest value at c=15.5 Å. There are more electron transfers (0.858) compared to the electron gain and loss, confirming more interaction between the sacrificial agents and montmorillonite at 15.5Å. This article also provides a crucial theoretical basis for the structural design of anti-clay sacrificial agents, offering insights into addressing compatibility issues between PCEs and clay minerals.

Self-Enhancement of Perfluorinated Sulfonic Acid Proton Exchange Membrane with Its Own Nanofibers.

High-performance proton exchange membrane (PEM) is crucial for the proton exchange membrane fuel cell (PEMFC). Herein, a novel "self-enhanced" PEM is fabricated for the first time, which is composed of perfluorinated sulfonic acid (PFSA) resin and its own nanofibers as reinforcement. With this strategy, the interfacial compatibility issue of conventional fiber-reinforced membranes is fully addressed and up to 80 wt% loading of PFSA nanofibers can be incorporated. Furthermore, on account of chain orientation within the PFSA nanofiber, single fiber exhibits super-high conductivity of 1.45 S cm-1, leading to state-of-the-art proton conductivity (1.1 S cm-1) of the as-prepared "self-enhanced" PEM so far, which is an order of magnitude increase compared with the bulk PFSA membrane (0.29 S cm-1). It surpasses any commercial PEM including the popular GORE-SELECT and Nafion HP membranes and is the only PEM with conductivity at 100 S cm-1 level. In addition, the mechanical strength and swelling ratio of membranes are both substantially improved simultaneously. Based on the high-performance "self-enhanced" PEM, high peak power densities of up to 3.6W cm-2 and 1.7W cm-2 are achieved in H2-O2 and H2-Air fuel cells, respectively. This strategy can be applied in any polymeric electrolyte membrane.

In-line buffer exchange in the coupling of Protein A chromatography with weak cation exchange chromatography for the determination of charge variants of immunoglobulin G derived from chinese hamster ovary cell cultures

Immunoglobulin G (IgG) is the most common monoclonal antibody (mAb) grown for therapeutic applications. While IgG is often selectively isolated from cell lines using protein A (ProA) chromatography, this is only a stepping stone for complete characterization. Further classification can be obtained from weak cation exchange chromatography (WCX) to determine IgG charge variant distributions. The charge variants of monoclonal antibodies can influence the stability and efficacy in vivo, and deviations in charge heterogeneity are often cell-specific and sensitive to upstream process variability. Current methods to characterize IgG charge variants are often performed off-line, meaning that the IgG eluate from the ProA separation is collected, diluted to adjust the pH, and then transferred to the WCX separation, adding time, complexity, and potential contamination to the sample analysis process. More recently, reports have appeared to streamline this separation using in-line two-dimensional liquid chromatography (2D-LC). Presented here is a novel, 2D-LC coupling of ProA in the first dimension (1D) and WCX in the second dimension (2D) chromatography. As anticipated, the initial direct column coupling proved to be challenging due to the pH incompatibility between the mobile phases for the two stages. To solve the solvent compatibility issue, a size exclusion column was placed in the switching valve loop of the 2D-LC instrument to act as a means for the on-line solvent exchange. The efficacy of the methodology presented was confirmed through a charge variant determination using the NIST monoclonal antibody standard (NIST mAb), yielding correct acidic, main, and basic variant compositions. The methodology was employed to determine the charge variant profile of IgG from an in-house cultured Chinese hamster ovary (CHO) cell supernatant. It is believed that this methodology can be easily implemented to provide higher-throughput assessment of IgG charge variants for process monitoring and cell line development.

가치분석 수업의 이론적 기초와 교수전략

Purpose: The purpose of this study was to theoretically explore issues raised in the transition from
 traditional values education to values education based on Western liberal philosophy in the context
 of values analysis by focusing on theory and teaching strategies.
 Methods: Firstly, the researcher analyzed the research outcomes of values education as a direct target
 of curriculum education through investigating values issues. Three fundamental issues arising from
 the changing trends in values education were identified. Subsequently, to gain a detailed understanding
 of these issues the discussion focused on the theoretical foundation of values analysis and teaching
 strategies. The theoretical basis of this theory based on the good reasons approach in analytic ethics
 was then examined. Finally in relation to these three issues, teaching strategies of values analysis
 were explored.
 Results: The two safety devices applied in values analysis teaching strategies, practical judgment,
 and value judgment serve as educational prescriptions to minimize limitations that may arise in granting
 young students the freedom to choose values. Regarding the relativistic issue of value criteria inherent
 in values education based on liberal philosophy, the values analysis theory not only takes a critical
 perspective but also applies it as a target for overcoming and implementing teaching strategies. Lastly,
 concerning the compatibility issue between granting individuals the freedom to choose values and
 establishing the universality of value judgment the values analysis theory applies to teaching strategies
 the possibility that both aspects can be pursued and implemented simultaneously, rather than being
 mutually exclusive.
 Conclusion: It cannot be denied that in the classroom, the act of judging and deciding values is
 given to students. The crucial point is to consider how the results of individual judgments can be
 universally accepted and to understand values education in the discourse of practice beyond the
 discourse of explanation.

Emerging Software and Tools in Higher Education Institutions

Due to digital revolution, new software and tools has been developed by many companies, organizations and higher education institutions which have created a kind of ease to automate our systems. For institution different software offers wide range of feature like automation, online data management, collaboration, planning, videoconferencing, plagiarism detection, language learning and many more. It has been found that the number of software and tools are being developed every day, therefore it is important to choose and install particular software from different resources. The quality of software is dependent on the process to be followed; therefore, it is necessary to investigate their different features. The risks associated with software include data security, unreliable backup systems, compatibility issues, system glitches, poor user interface, lack of control etc. In this paper, an attempt has been made to provide information about different software and tools that has been used recently in educational institution.

Soft X-ray Microscopy in Cell Biology: Current Status, Contributions and Prospects.

The recent advances achieved in microscopy technology have led to a significant breakthrough in biological research. Super-resolution fluorescent microscopy now allows us to visualize subcellular structures down to the pin-pointing of the single molecules in them, while modern electron microscopy has opened new possibilities in the study of protein complexes in their native, intracellular environment at near-atomic resolution. Nonetheless, both fluorescent and electron microscopy have remained beset by their principal shortcomings: the reliance on labeling procedures and severe sample volume limitations, respectively. Soft X-ray microscopy is a candidate method that can compensate for the shortcomings of both technologies by making possible observation of the entirety of the cellular interior without chemical fixation and labeling with an isotropic resolution of 40-70 nm. This will thus bridge the resolution gap between light and electron microscopy (although this gap is being narrowed, it still exists) and resolve the issue of compatibility with the former, and possibly in the near future, the latter methods. This review aims to assess the current state of soft X-ray microscopy and its impact on our understanding of the subcellular organization. It also attempts to look into the future of X-ray microscopy, particularly as relates to its seamless integration into the cell biology toolkit.

Comparative Analysis and Application of OpenGL and DirectX Libraries in the Context of 3D Visualization

Article represents a study and analysis of two main libraries: OpenGL and DirectX and their application in the field of three-dimensional visualization. The article conducts a comparative analysis of the capabilities and characteristics of each library, examining their technical specifications, capabilities in creating three-dimensional scenes, as well as their efficiency and usability in various contexts. It covers topics related to the process of library initialization, shader compilation, creation of three-dimensional objects, environment setup, and examples of library application in real scenarios. Additionally, it addresses compatibility issues of the libraries with different operating systems and hardware architectures. The goal of the article is to provide the reader with a comprehensive overview of the capabilities and characteristics of OpenGL and DirectX libraries, aiding in the selection of the most suitable technology for specific tasks in the field of three-dimensional visualization. It encompasses a comparison of the capabilities and characteristics of the libraries, analyzing their strengths, efficiency, and usability in various scenarios. The main focus is on technical aspects in working with graphics, including library initialization, shader compilation, creation of three-dimensional objects, and management of visual effects. Its aim is to provide readers with a deep understanding of both technologies, assisting in the selection of the appropriate library for specific tasks in three-dimensional visualization and shedding light on practical scenarios of using these technologies.

Analysis of Village Financial Management

This study examines the financial management of Wedi Village in Gedangan District, Sidoarjo Regency, focusing on the alignment between the Annual Village Budget (APBDes) and the Village Medium-Term Development Plan (RPJMDes), the capacity of village officials in report preparation and financial accounting, and the proficiency of SISKEUDES application operators. Applying a qualitative approach, the research employs observations, interviews, and documentation for data collection. While the village demonstrates adherence to regulatory guidelines, hindrances include incomplete accommodation of community aspirations in the APBDes, conflicting central government regulations, and diminished village autonomy in financial management. The study highlights the need for streamlined regulations to enhance village financial autonomy and recommends targeted training programs for officials to address operational challenges in financial management. Highlight : Comprehensive Analysis: This study provides a thorough examination of the financial management practices in Wedi Village, shedding light on the compatibility issues between the APBDes and RPJMDes, as well as challenges in utilizing the SISKEUDES application. Capacity Building: The research underscores the crucial need for targeted training programs for village officials, emphasizing the lack of skills in preparing accountability reports and financial accounting, thereby addressing a key obstacle in effective financial management. Autonomy Challenges: The study highlights the impact of overlapping central government regulations, reduced village autonomy, and the inability to accommodate all community aspirations in the APBDes, advocating for regulatory reforms to empower villages in managing their finances. Keywords: Village Financial Management, APBDes, RPJMDes, SISKEUDES Application, Regulatory Compliance

Influence of the IC power supply and decoupling capacitor arrangement on the electromagnetic emission

With the advancing development of integrated circuits (ICs), more and more complex functions and higher performance levels can nowadays directly be integrated into a single IC package. In this context, the issue of electromagnetic compatibility (EMC) is becoming more critical, as the higher the integration density, the higher the electromagnetic emissions tend to be. In this paper, an EMC test IC is used to investigate the influence of different power supply pinouts (arrangement of VDD and GND pins in center and corner configuration) on the electromagnetic emission of the IC. This is done on the basis of the surface-scanning technique described in the IEC 61967‑3 standard for characterizing the magnetic near field at the surface of the IC package, and on the basis of the 150 Ohm measurement method described in IEC 61967‑4 for determining the conducted interference emissions at the power supply pinout of the IC. Both measurement methods show a significant difference in electromagnetic emissions due to the dependence on the arrangement of the power supply pinouts. These results highlight the importance of careful power supply design in the development of electromagnetically compatible ICs.

New application of ionic liquid as a green-efficient lubricant

In the present work, it has been attempted to use ionic liquid as a green and compatible additive to base cutting fluid for the grinding process. Grinding forces in tangential and normal directions and the surface quality of the Inconel 718 superalloy were determined as a criterion for comparing the results, and the cutting parameters, such as the wheel rotation speed, workpiece speed, and cutting depth, were also selected as variable parameters in three levels. The experimental results showed that, in addition to the compatibility issue of the ionic liquids, the normal force in the case of ionic-liquid and mineral-based lubricants was declined by approximately 49.3 % than that of non-used cutting fluid technique. By increasing cutting depth from 20 to 60 μm, workpiece speed from 1000 to 3000 mm/min, and wheel speed from 10 to 30 m/s led to an increase of 168 % and 139 %, 46 % and 38 %, and 167 % and 78 % in normal and tangential forces, respectively. The results showed that the grinding forces reduced and the surface integrity of the workpiece improved when using ionic liquid as an additive compared to the mineral-based one. The reason of this superiority can be attributed to the more tendency of liquid molecules to adhere to the surface of the superalloy and form a strong lubricant layer with a lower static contact angle, compared to the mineral-based fluid, which leads to the creation of stable lubrication conditions in the high-stress grinding affected zone. The static contact angle of the DI water was approximately 62 °, while by changing the droplet type to mineral-based fluid and ionic liquid, the CA value was diminished to 51 ° and 38 °, respectively, with reducing rate of 18 %, and 39 %. In addition to experimental study, mathematical models were also developed to predict the grinding forces and surface roughness by means of response surface methodology (RSM). The result of analysis of variance (ANOVA) showed that the fitted models have high accuracy compared to the experimental results.

An Anonymous and Supervisory Cross-chain Privacy Protection Protocol for Zero-trust IoT Application

Internet of things (IoT) development tends to reduce the reliance on centralized servers. The zero-trust distributed system combined with blockchain technology has become a hot topic in IoT research. However, distribution data storage services and different blockchain protocols make network interoperability and cross-platform more complex. Relay chain is a promising cross-chain technology that solves the complexity and compatibility issues associated with blockchain cross-chain transactions by utilizing relay blockchains as cross-chain connectors. Yet relay chain cross-chain transactions need to collect asset information and implement asset transactions via two-way peg. Due to the release of user transaction information, there is the issue of privacy leakage. In this article, we propose a cross-chain privacy protection protocol based on the Groth16 zero-knowledge proof algorithm and coin-mixing technology, which changes the authentication mechanism and uses a combination of generating functions to map virtual external addresses in transactions. It allows fast cross-chain anonymous transactions while hiding the genuine user’s address. The experiment shows that, in a zero-trust IoT context, our scheme can effectively protect user privacy information, accomplish controlled transaction traceability operations, and guarantee cross-chain transaction security.