Comparative Clinical Evaluation Research Articles

Comparative Clinical Evaluation of Trapezoidal, Envelope, and Tunnel Type Coronally Advanced Flap in the Treatment of Gingival Recession: A Network Meta-Analysis of Randomized Clinical Trials.

This study evaluated the efficacy of trapezoidal coronally advanced flap (tCAF), envelope coronally advanced flap (eCAF), and coronally advanced tunnel flap (TUN) in treating gingival recession (GR) through a network meta-analysis. Eligible articles from the PubMed, Embase, and Cochrane Library databases published up to September 2020 were selected to identify randomized controlled trials (RCTs) on tCAF, eCAF, and TUN treatments. Sample size, treatment time, and outcome measures including complete root coverage (CRC), root coverage esthetic score (RES), and other data were extracted from the article, and integrated analysis was conducted. In total, 10 RCTs met the inclusion criteria, involving 310 patients. Direct meta-analysis showed no significant differences in CRC among the three surgical methods; A significant difference was seen for RES, with TUN worse than tCAF (weighted mean difference: -0.73; 95% CI: -1.44, -0.02; P = .045). The network meta-analysis showed no statistical significance in the cross-comparison of tCAF, eCAF, and TUN. However, eCAF had the most significant effect on improving CRC (SUCRA = 69.2) and RES (SUCRA = 85.0). eCAF has the best prognosis in the treatment of GR, followed by tCAF and TUN. This may influence the surgeon's treatment choice, as eCAF may be more effective in root coverage procedures.

Comparative Clinical and Serum Biochemical Evaluation of Two Intramuscular Anaesthetic Combinations (Diazepam/Ketamine and Diazepam/Fentanyl/Ketamine) in Rabbits

The research has been conducted to find the clinical efficacy and safety of preanaesthetics and induction agents based on clinical and serum biochemical indicators in rabbits. Eight healthy rabbits (3.0-3.5kg) of either sex were arbitrarily allocated into two groups: Group DK (diazepam-ketamine) and Group DFK (diazepam-fentanyl-ketamine). Rabbits were received intramuscular diazepam (5mg/kg), fentanyl (0.02 mg/kg) and ketamine (35 mg/kg). Data on clinical parameters (rectal temperature, heart rate, and respiratory rate) and reflexes (righting reflex, palpebral reflex, and pedal reflex) were evaluated before and at 10, 20, 30, 40, 50, 60, 70, 80, 90, and 100 minutes after injection of anaesthetics. Blood samples were aspirated before anaesthesia and 30 minutes following induction. Serum Albumin, Globulin, Cholesterol, Triglyceride, Total Protein, High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Creatinine, Calcium, Phosphorus, Sodium, Potassium, and Chlorine were evaluated through a semiautomatic biochemistry analyzer. In this study, no significant changes in rectal temperature were observed in the animals of group DK during anaesthesia. During anaesthetic cascade, heart rates and respiration rates in both the groups were reduced significantly (P< 0.05). In DFK-injected rabbits, the return of righting and palpebral reflexes were delayed. The DFK groups had considerably (P< 0.05) longer surgical anaesthesia than the DK groups. In terms of serum biochemistry, DK-treated rabbits had significantly lower total protein, globulin, creatinine, HDL, sodium, and potassium concentrations (P< 0.05). Total protein, cholesterol, HDL, and potassium levels decreased significantly (P<0.05) after DFK treatment. The DFK combination offered appropriate anaesthesia for rabbits, as evidenced by a prolonged anaesthetic time, acceptable cardiopulmonary and other clinical indices, and moderate changes in serum biochemical profiles.

A Comparative Clinical Evaluation of Effectiveness of Platelet-Rich Plasma, Synthetic Allograft, and Bioresorbable Xenograft During Immediate Implant Placement.

The use of an appropriate graft material helps in an adequate amount of osseointegration. The objective of this study was to compare the efficacy of platelet-rich plasma (PRP), a synthetic allograft (PerioGlas), and Bio-Oss, a bioresorbable xenograft in immediate implant procedures. In this randomized, prospective study, 90 patients were categorized into three groups with 30 samples in each asGroup A:patients who received PRP with an immediate implant; Group B: immediate implants with synthetic allograft (PerioGlas); and Group C: patients with immediate implants placed using bioresorbable xenograft (Bio-Oss). Postoperative follow-up was done based on plaque and gingival index, measurement of probing depths, and resorption of bone. Obtained data were statistically analyzed using the "one-way analysis of variance (ANOVA)" test. Inter-group statistical comparisons between gingival and plaque indices at three, six, and 12 months of follow-up in the study groups demonstrated no statistical significance (p > 0.05). The mean probing depths and resorption of bone at three, six, and 12 months of follow-up were statistically nonsignificant (p > 0.05) on the inter-group comparison. It could be concluded from the present study that there is no statistical superiority observed among PRP, PerioGlas, or Bio-Oss in terms of their usage as a graft material along with immediate implant placement procedure.

Comparative Clinical Evaluation of Matra Basti with Pippalyadi Taila and Ashtakatvara Taila in Katishoola

Ayurveda deals with good, bad, happy and unhappy life, its promoters and non-promoters, measurement and nature. Katishoola is the condition which is characterized by Shoola and Stabdata, due to vitiated Vata which gets lodged in the Kati pradesha. It is explained as one of the Lakshanas of Vata Vyadhi. But Bhavaprakasha and Gada Nigraha explained it as a separate Vyadhi. Charaka explained it in Vataja Nanatmaja Vikaras.
 The symptoms of Katishoola can be correlated to low back pain. It is one of the most common problems in the orthopedic field today. Pain effects about 3-12% of the populations and in turn have its impact on the socio-economic activity of an individual.
 Panchakarma play a vital role in Ayurvedic therapeutics and as such they occupy an important place in Ayurvedic medicine. Among these Basti Karma is the prime treatment modality in Vata Vyadhis. It is considered as the Ardha Chikitsa. Matra Basti is a type of Sneha Basti. It acts as Brumhana, Snehana and does Vata shamana.
 There are so many effective treatments presently available for Katishoola. In that, Basti is the primary and effective treatment not only for Katishoola but also for each and every Vata vyadhis. Pippalyadi Taila and Ashtakatvara Taila are having good effect on Vata Vyadhis.

Comparative clinical evaluation of Manjishta churna lepa and Jatiphala churna lepa in Vyanga (Melasma)

Vyanga (Melasma) is condition of localized hypermelanosis which affect face, and continues to be challenging problem as it causes immense mental stress and depression. In ayurvedic texts there is lot of ahara, aushadha, and vihara which were mentioned to enhance external beauty such as varnya varg told by Acharya Charak, and romsanjanan etc told by Acharya Shushrut. Melasma can be correlated with Vyanga in Ayurveda. The present study was aimed to evaluate and compare the efficacy of Manjishtha churna lepa and Jatiphala churna lepa in the management of Vyanga with special reference to Melasma. After ethical clearance, 90 patients of Vyanga (Melasma) in OPD of Kayachikitsa department of SST’s Ayurved Medical College, Sangamner, was selected and assigned randomly in Group A having 45 patients and Group B having 45 patients.Three criteria was assessed for this study-Dimension of affected skin area in sq.cm, Fairness meter score, MASI Score. Student paired t test and Student unpaired t test statistical test was used. On Statistical analysis it was found that- 1) Manjishtha churna lepa is effective in the management of Vyanga (Group A). 2 ) Jatiphala churna lepa is effective in the management of Vyanga (Group B). 3) But, while comparing the Group A vs Group B, the Jatiphala churna lepa is more effective than the Manjishtha churna lepa.

Personalized tobramycin dosing in children with cystic fibrosis: a comparative clinical evaluation of log-linear and Bayesian methods.

Children with cystic fibrosis (CF) pulmonary exacerbations receive IV tobramycin therapy, with dosing guided by either log-linear regression (LLR) or Bayesian forecasting (BF). To compare clinical and performance outcomes for LLR and BF. A quasi-experimental intervention study was conducted at a tertiary children's hospital. Electronic medical records were extracted (from January 2015 to September 2021) to establish a database consisting of pre-intervention (LLR) and post-intervention (BF) patient admissions and relevant outcomes. All consecutive patients treated with IV tobramycin for CF pulmonary exacerbations guided by either LLR or BF were eligible. A total of 376 hospital admissions (LLR = 248, BF = 128) for CF pulmonary exacerbations were included. Patient demographics were similar between cohorts. There were no significant differences found in overall hospital length of stay, rates of re-admission within 1 month of discharge or change in forced expiratory volume in the first second (Δ FEV1) at the end of tobramycin treatment. Patients treated with LLR on average had twice the number of therapeutic drug monitoring (TDM) blood samples collected during a single hospital admission. The timeframe for blood sampling was more flexible with BF, with TDM samples collected up to 16 h post-tobramycin dose compared with 10 h for LLR. The tobramycin AUC0-24 target of ≥100 mg/L·h was more frequently attained using BF (72%; 92/128) compared with LLR (50%; 124/248) (P < 0.001). Incidence of acute kidney injury was rare in both groups. LLR and BF result in comparable clinical outcomes. However, BF can significantly reduce the number of blood collections required during each admission, improve dosing accuracy, and provide more reliable target concentration attainment in CF children.

A Comparative Clinical Evaluation of Surgical Blade Abrasion and Partial Thickness Flap as Treatment Modalities for Gingival Pigmentation.

Gingival hyperpigmentation is a major esthetic concern for many people, although it is not a medical problem, many people complain of dark gums as unesthetic. Gingival depigmentation is a periodontal plastic surgical procedure that removes or reduces hyperpigmented gingiva. Various methods like scalpel, free gingival autografts, electrosurgery, cryosurgery, and abrasion with diamond bur gingival hyperpigmentation is a major esthetic concern for many people, although it is not a medical problem, many people complain of dark gums as unesthetic. Gingival depigmentation is a periodontal plastic surgical procedure that removes or reduces hyperpigmented gingiva. Various methods like scalpels, free gingival autografts, electrosurgery, cryosurgery, abrasion with diamond bur, and various types of lasers have been used for cosmetic therapy of gingival melanin pigmentation. This article compare the efficacy of gingival melanin depigmentation done by excision with a surgical blade using scarping and partial thickness flap technique. and various types of lasers have been used for cosmetic therapy of gingival melanin pigmentation. This article compares the efficacy of gingival melanin depigmentation done by excision with a surgical blade using scarping and partial thickness flap technique.

A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mulatta) model.

BackgroundScrub typhus is a vector-borne febrile illness caused by Orientia tsutsugamushi transmitted by the bite of Trombiculid mites. O. tsutsugamushi has a high genetic diversity and is increasingly recognized to have a wider global distribution than previously assumed.Methodology/principle findingsWe evaluated the clinical outcomes and host immune responses of the two most relevant human pathogenic strains of O. tsutsugamushi; Karp (n = 4) and Gilliam (n = 4) in a time-course study over 80 days post infection (dpi) in a standardized scrub typhus non-human primate rhesus macaque model. We observed distinct features in clinical progression and immune response between the two strains; Gilliam-infected macaques developed more pronounced systemic infection characterized by an earlier onset of bacteremia, lymph node enlargement, eschar lesions and higher inflammatory markers during the acute phase of infection, when compared to the Karp strain. C-reactive protein (CRP) plasma levels, interferon gamma (IFN-γ, interleukin-1 receptor antagonist (IL-1ra), IL-15 serum concentrations, CRP/IL10- and IFN-γ/IL-10 ratios correlated positively with bacterial load in blood, implying activation of the innate immune response and preferential development of a T helper-type 1 immune response. The O. tsutsugamushi-specific immune memory responses in cells isolated from skin and lymph nodes at 80 dpi were more markedly elevated in the Gilliam-infected macaques than in the Karp-infected group. The comparative cytokine response dynamics of both strains revealed significant up-regulation of IFN-γ, tumor necrosis factor (TNF), IL-15, IL-6, IL-18, regulatory IL-1ra, IL-10, IL-8 and granulocyte-colony-stimulating factor (G-CSF). These data suggest that the clinical outcomes and host immune responses to scrub typhus could be associated with counter balancing effects of pro- and anti-inflammatory cytokine-mediated responses.Currently, no data on characterized time-course comparisons of O. tsutsugamushi strains regarding measures of disease severity and immune response is available. Our study provides evidence for the strain-specificity of host responses in scrub typhus, which supports our understanding of processes at the initial inoculation site (eschar), systemic disease progression, protective and/or pathogenic host immune mechanisms and cellular immune memory function.Conclusions/significanceThis study characterised an improved intradermal rhesus macaque challenge model for scrub typhus, whereby the Gilliam strain infection associated with higher disease severity in the rhesus macaque model than the previous Karp strain infection. Difficulties associated with inoculum quantitation for obligate-intracellular bacteria were overcome by using functional inoculum titrations in outbred mice. The Gilliam-based rhesus macaque model provides improved endpoint measurements and contributes towards the identification of correlates of protection for future vaccine development.

Phenotypic polymorphism in Wilson’s disease – between genetics and epigenetics

Background: Wilson’s disease is a rare, autosomal recessive genetic disorder that affects the biliary excretion of copper and its toxic accumulation in various tissues, especially the liver and brain. It is widespread throughout the world, with a high prevalence in socio-culturally isolated communities. The course of the disease and the age of onset depend on the site of mutation in the gene and the degree of functional impairment of the ATP7B protein. The presence of the compound heterozygous patient complicates the comparative genetic and clinical evaluation. Therefore, it is necessary to analyze Wilson’s variants in both the homozygous and the compound-heterozygous conditions to better understand the genotype-phenotype correlations and the incomplete penetrance observed in this disorder. Outlining clear phenotype-genotype associations is difficult due to a large number of mutations and different clinical presentations, but the involvement of epigenetic factors, modifying genes, environmental and lifestyle factors could explain the differences in evolution and onset in members of the same family and not only. Conclusions: Wilson’s disease is a genetically and clinically complex disorder. Although the results of genotype-phenotype correlation studies are not well defined, and in some cases are completely contradictory, some peculiarities related to the age of onset, sex, clinical phenotype, and the evolution of the disease have been highlighted. The interaction between genetic mutations and epigenetic factors may explain the phenotypic variability, but needs further study.

Analysis of wound discharge microbiota in patients with drug-associated osteonecrosis of the jaw

Introduction. Chronic forms of inflammatory periodontal diseases, leading to deterioration of bone tissue quality and volume, are the most important and urgent problems for modern dentistry. Despite the measures taken at different levels of prevention the tendency to the increase of patients with periodontitis has been revealed. The aim of the investigation was to make a comparative clinical and radiological evaluation of the effectiveness of directed tissue regeneration (DTR) using different methods of membrane placement in the area of defects with complex configuration in patients with moderate-to-severe chronic periodontitis. Material and methods. Patients were divided into two groups of 30 patients each. Study design: open randomized. Patients of the first group were operated on using DTR technique and additional membrane fixation by means of periodontal micropins; patients of the second group were operated on using DTR without additional membrane fixation. The results were assessed by clinical and radiological examination after 1, 3, 6 and 12 months. Results. More active regenerative processes were registered in the first group; the periodontal pocket depth after one month was 2,77 ± 0,08 mm, in patients of the second group – 2,85 ± 0,03 mm (p &lt; 0,05); the tendency for decrease of this index remained during all investigation. The Hounsfield index after 12 months was 1658 ± 45.38 units in the first group and 1589 ± 12.02 units in the second group (p &lt; 0.05). Discussion. When comparing the obtained data with those of their foreign colleagues, the authors concluded that additional fixation of the membrane leads to a less pronounced deformation and preservation of the bone volume in the long-term postoperative period. Conclusion. The use of micropins for membrane fixation allows to work with defects of complex configuration and in the long term leads to formation of denser bone tissue with preservation of its volume.

Comparative clinical evaluation of conventional syringe irrigation, endoactivator and endovac in reducing the microbial count from infected root canal

Root canal decontamination is a crucial step in achieving endodontic success. For this, absolute eradication of microbes from root canal is of paramount importance. This in vivo study aimed at comparing the Conventional, EndoActivator and EndoVac irrigation system in reducing intracanal bacterial load. 70 necrotic, single rooted teeth having chronic periapical lesions were selected for endodontic therapy and randomly assigned into three groups. Group 1 – 20 teeth treated using Conventional needle irrigation. Group 2 – 20 teeth treated using EndoActivator system. Group 3– 20 teeth treated using EndoVac system. After the surface disinfection, access opening was done. Groupwise irrigation with NaOCl (VISHAL DENTOCARE PVT.LTD.) and EDTA (AMMDENT CANALARGE) was done with each canal in between instrumentation. Data were obtained by culturing bacterial samples of root canal before and after chemomechanical preparation under both aerobic and anaerobic conditions and CFU was counted. Statistical analysis - Paired‘t’ test was used for intragroup comparisons while ANOVA test followed by the “post hoc Games Howell test” for intergroup comparisons. Significant post-operative reduction in bacterial colony counts was seen with all the groups. EndoVac group had significantly higher mean log reduction in CFU counts than Conventional group.

One-year comparative clinical evaluation of ACTIVA Bioactive restorative material with Nano hybrid composite resin in class V cavity preparation

One-year comparative clinical evaluation of ACTIVA Bioactive restorative material with Nano hybrid composite resin in class V cavity preparation

A comparative Clinical Evaluation of Amritadya Guggulu with and without Yavamalaki choorna in the management of Dyslipidemia

As a result of confronting challenges of modernization, man has adapted himself to the fast paced life by modifying his dietary and lifestyle preferences to suit the modern era. This has resulted in a state of discrepancy between the external environment and his internal mechanism causing multitudes of diseases which referred as “lifestyle diseases”. Dyslipidemia is a condition in which the level of lipoproteins (cholesterol, triglycerides or both) is raised in the plasma. For this “Amritadya Guggulu” mentioned in Chakradatta and “Yava Amalaki Choorna” mentioned in Charaka sutra sthana is selected. The ingredients of Amritadya Guggulu like Guduchi, Truti, Vella, Vatsaka, Triphala are Medohara and Tiktarasa pradhana which is Kapha vata hara, Laghu, Kapha shoshaka effective in case of Dyslipidemia on the other hand Yava Amalaki choorna is also having Medohara property. In the present study, 40 patients of Dyslipidemia were registered and were randomly placed and observed in two groups, treated with Amritadya Guggulu and Amritadya Guggulu with Yavamalaki Choorna for 30 days. Each disease feature was scored according to the assessment criteria and each patient was assessed and scored with respect to his/her presenting complaints. Respective scores were subjected for statistical analysis using paired student ‘t’ test for the individuals groups and unpaired student ‘t’ test to compare both the groups.

Comparative clinical evaluation of removable partial denture frameworks fabricated traditionally or with selective laser melting: A randomized controlled trial

Statement of problemThe clinical efficacy of selective laser melting (SLM) for fabricating removable partial dentures (RPDs) is not well established. PurposeThe purpose of this clinical study was to compare the performance of SLM-fabricated frameworks with that of those fabricated via traditional lost wax casting. Material and methodsA double-blind, randomized, crossover design was used to compare cobalt chromium partial denture frameworks (n=29) fabricated by using SLM or traditional methods. The time taken for adjustments and the clinical fit and stability of the adjusted frameworks were appraised. The accuracy of the frameworks was assessed by measuring the space between the occlusal rest seat and the corresponding rest seat. Statistical comparisons between the 2 frameworks were carried out by using a linear mixed-effect model for repeated measurements (α=.05). ResultsFrameworks fabricated by using both SLM and traditional techniques had an acceptable fit based on subjective clinical evaluation. The overall mean ±standard deviation space between the occlusal rest and rest seat for SLM frameworks (273.7 ±44.5 μm) was comparable with that of traditional frameworks (242.2 ±44.5 μm). The clinical fit adjustment time, 7.76 ±6.43 minutes for SLM and 5.49 ±6.39 minutes for traditionally fabricated frameworks, was statistically similar (P=.067). ConclusionsDentures fabricated via SLM and traditional techniques had comparable accuracy of fit and clinical fitting time.

Comparative clinical evaluation of a self-adhering flowable composite with conventional flowable composite in Class I cavity: An in vivo study.

Context:The purpose of this study was to evaluate the efficiency of self-adhering flowable composite with that of a time-tested conventional flowable composite. Since the self-adhering composite reduces chair time and is convenient to use, its clinical behavior was monitored for a year.Aim:This study aimed to evaluate the clinical behavior of self-adhering flowable composite – Fusio Liquid Dentin – in small-sized Class I cavities and also to compare it with conventional flowable composite – Tetric N-Flow – bonded to the tooth structure with fifth-generation two-step-etch-and-rinse adhesive.Subjects and Methods:A total of 60 cavities were restored using flowable composite materials (30 cavities in each group) and evaluated at baseline, 1 month, 3 months, 6 months, and 1 year with modified United States Public Health Service criteria. The statistical analysis for the study was done using Fisher's exact test for intergroup comparison and Chi-square test for intragroup comparison. P < 0.05 was considered statistically significant.Results:Statistically no significant differences were observed in Fusio Liquid Dentin restorations during the recall visits. Statistically significant differences were found in color match evaluated for Tetric restorations during the recall visits.Conclusion:Based on the data acquired, the novel self-adhering composite material demonstrated good clinical behavior. As a result, at this point in the prospective clinical study, the use of Fusio Liquid Dentin to repair Class I cavities is acceptable.

A comparative clinical evaluation of “Varuna Kwatha” and “Kanchnara Triphala Kwatha” in the management of Dhatvagnimandhya with special reference to hypothyroidism

A comparative clinical evaluation of “Varuna Kwatha” and “Kanchnara Triphala Kwatha” in the management of Dhatvagnimandhya with special reference to hypothyroidism

Comparative Clinical Evaluation of Two Techniques of Arthroscopic Treatment of Partial Articular Rotator Cuff Tears.

Objectives To evaluate the clinical results of patients submitted to arthroscopic treatment of partial lesion of the articular part of the rotator cuff by transtendon suture techniques and after completing the lesion and to compare the postoperative recovery time of the two techniques. Method Retrospective study based on the identification of all cases with partial lesion of the articular part of the rotator cuff submitted to arthroscopic treatment from October 1999 to December 2016 at the Shoulder and Elbow Group of our institution. Thirty-nine patients were included and divided into two groups: those who underwent the transtendon technique and those in whom the lesion was completed. The two groups were statistically similar. The respective medical records were analyzed as well as the identification of the applied technique, the postoperative results, and the related complications. The functional evaluation was performed using the score of the University of California at Los Angeles (UCLA). Results There was no statistically relevant difference between the groups, with a mean UCLA score of 32, and no difference in the time required for rehabilitation. Conclusion There was no difference between the clinical outcome of the patients, regardless of the technique used to repair the partial lesions of the articular part of the rotator cuff, with satisfactory results in 93% of the cases.

EAO‐495 / OC‐SU‐005 | Comparative clinical evaluation of combination approach in augmenting periimplant keratinized mucosa

EAO‐495 / OC‐SU‐005 | Comparative clinical evaluation of combination approach in augmenting periimplant keratinized mucosa

Bipolar Disorder and Cardiovascular Risk in Rural versus Urban Populations in Colombia: A Comparative Clinical and Epidemiological Evaluation.

Background:Various multifactorial elements may contribute toward the urban and rural disparities in cardiovascular disease (CVD) risk, particularly among patients with psychiatric diseases.Objective:To investigate whether rural patients diagnosed and treated for Bipolar Disorder (BD) have different risk profiles and outcomes of CVD compared to urban (BD) patients.Methods:We conducted a case-control study that included 125 BD patients (cases) from rural Filadelfia, Colombia and 250 BD patients (controls) treated in Bogotá, Colombia. Cases and controls were 2:1, matched by age and sex. We applied the Framingham Heart Study (FHS) risk calculator to assess risk. Differences by rural/urban status (i.e., case-control status) were assessed by chi-square, paired t-tests, and logistic regression.Findings:Rural BD patients were found to have lower education (p = 1.0 × 10–4), alcohol consumption (p = 3.0 × 10–4), smoking (p = 0.015), psychiatric (p = 1.0 × 10–4) and CV family history (p = 0.0042) compared to urban BD patients. Rural BD patients were 81% more likely to have a more favorable CVD risk profile (OR: 0.19, 95% CI [0.06–0.62]) than urban BD patients, despite rural BD patients having increased CVD morbidity (p = 1.0 × 10–2).Conclusion:Based on increase in morbidity but lower predictive risk in the rural population, our study suggests that the FHS-CVD calculator may not be optimal to assess CVD risk in this population.

A Comparative Clinical Evaluation on the Efficacy of Kuberaksha &amp; Yava with Lifestyle Modification, in The Management of Prameha with Special Reference to Prediabetes

We are living in the age of complexity, contradiction, and challenge relating to various health issues such as lifestyle disorder, ageing, mental health euthanasia, drug resistance and so on. Diabetes Mellitus is a Giant disease and major health issue that has reached alarming level in spite of terrific advance in modern medical science. Prediabetes is the precursor stage before Diabetes Mellitus, in which not all of the symptoms required to diagnose diabetes are present, but blood sugar is abnormally high. Prediabetic persons are considered to be at increased risk for the subsequent development Diabetes Mellitus. Sushruta Samhita mentioned, all varieties of Prameha if not treated at appropriate time, become changed to Madhumeha which is incurable. So, early detection, treatment and prevention of this disease in Prediabetic stage is needed. The modification of lifestyle should be the first aim and objectives to restrict or combat such problems, beside this prime objective, some medication which is safe and efficacious to be introduced. So, a clinical study with 60 patients has been conducted on Prediabetes through the management with ‘Kuberaksha’ and ‘Yava’ in such 2 groups of treatment. The two drugs are carrying such properties which acts in Samprapti vighatana (prevent pathogenesis) of the disease. In both cases statistically significant results are found (P&lt;0.001 &amp; &lt;0.01). On comparison between two groups Kuberaksha powder showed better result than Yava powder.