Based on principles of the regional hydrogeodeformatics, we reveal the earth’s global arrhythmic deformation pulsation, which manifests itself in short-term (several months) cycles of expansion and compaction of lithosphere plates. These processes are most evident within the global Endodrainage system (GEDS), which connects the deep segments of the Earth with its surface. We show that the global principal direction of the deformation signal movement is eastward (arriving from areas where this deformation pulse is initiated). Using some examples, we demonstrate the interconnection between deformation cycles and a series of catastrophic earthquakes, as well as some natural and natural-technogenic catastrophes. The need to monitor the global “geodynamic weather” is substantiated and the principles of a monitoring system for the Earth’s deformation are discussed.