Four-dimensional compactifications of string theory provide a controlled set of possible gauge representations accounting for BSM particles and dark sector components. In this review, constraints from perturbative Type II string compactifications in the geometric regime are discussed in detail and then compared to results from heterotic string compactifications and nonperturbative/nongeometric corners. As a prominent example, an open string realization of the QCD axion is presented. The status of deriving the associated low-energy effective action in four dimensions is discussed and open avenues of major phenomenological importance are highlighted. As examples, a mechanism of closed string moduli stabilization by D-brane backreaction as well as one-loop threshold corrections to the gauge couplings and balancing a low string scale [Formula: see text] with unisotropic compact dimensions are discussed together with implications on potential future new physics observations. For illustrative purposes, an explicit example of a globally consistent D6-brane model with MSSM-like spectrum on [Formula: see text] is presented.