In recent years micro-cogeneration systems (μ-CHPs), based on fuel cells technology, have received increasing attention because, by providing both useful electricity and heat with high efficiency, even at partial loads, they can have a strategic role in reduction of greenhouse gas emissions. For residential applications, the proton exchange membrane fuel cell (PEMFC), is considered the most promising, since it offers many advantages such as high power density, low operating temperature, and fast start-up and shutdown. In this paper the electrical and thermal behaviors of a PEMFC stack, suitable for μ-CHP applications, have been investigated through experimental and numerical activity. The experimental activity has been carried out in a test station in which several measurement instruments and controlling devices are installed to define the behavior of a water-cooled PEMFC stack. The test station is equipped by a National Instruments Compact DAQ real-time data acquisition and control system running Labview™ software. The numerical activity has been conducted by using a model, properly developed by the authors, based on both electrochemical and thermal analysis. The experimental data have been used to validate the numerical model, which can support and address the experimental activity and can allow to forecast the behavior and the performance of the stack when it is a component in a more complex energy conversion system.