Objective – to study the clinical features of the comorbid course of arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) in combination with obesity.Material and methods. 45 people were examined and divided in 2 groups, first – 20 patients with AH (І-ІІ stages, 1-3 degrees), COPD (global initiative for COPD (GOLD 1-3)) in phase of unstable remission and obesity, second – 25 patients with AH (І-ІІ stages, 1-3 degrees) and obesity. All patients were passed general clinical and instrumental examination: spirometry, echocardiography, electrocardiogam, blood lipid spectrum.Results. Patients with arterial hypertension, COPD and obesity were characterized by the following: significant decrease in indicators of function of external respiration (forced expiratory volume in one second (FEV1) (р < 0,01), forced vital capasity (FVC) (р < 0,01)), increase in right ventricle (RV) size (p <0,05), left ventricle (LV) (p <0,01), and thickness of interventricular septum (IVS) (p <0,05) and hypertriglyceridemia (p <0,01), comparing with patients with AH and obesity. They had normal indicators of function of external respiration, less expressed changes in echocardiography, and increased level of total cholesterol and low-density lipoprotein (LDL) cholesterol. Patients of both groups were indentified increased size of left atrium (LA) with saved ejection fraction (EF).Conclusions. There are some features of clinical course of comorbid pathology of arterial hypertension, chronic obstructive pulmonary disease and obesity, which characterized by appropriate changes in spirometry, echocardiography and blood lipid spectrum which indicate more unfavorable course of this pathology, comparing with course of arterial hypertension and obesity.