The article is devoted to a comprehensive analysis of the foreign policy of the Republic of Croatia in close connection with its domestic policy. The author examines the balance of political forces in the country on the eve, during and after the presidential elections in 2019/2020, as well as the elections to Sabor (parliament) in July 2020. He describes in detail the situation in the party that won the elections to Sabor, - the Croatian Democratic Union, - and the internal party struggle between representatives of the centrist and right-wing nationalist groups. Largely thanks to the current leader and prime minister of Croatia A. Plenković, it ended in 2020 with the victory of the centrists. At the same time, the presidential elections in December 2019 - January 2020 were won by the candidate of the left-center - Social Democrat Z. Milanović, who defeated the CDU representative K. Grabar-Kitarović, who held this post. The author believes that in Croatia, as a result of the presidential and parliamentary elections in 2019/2020, a situation has developed in which the president and the prime minister, representatives of the left and the right centers respectively, can, through joint efforts, pursuing their own political goals, update Croatia’s domestic and foreign policy, including in the Balkan / South-Eastern Europe region. The previous policy of Croatia, according to the author, was unsuccessful. The previous leadership of Croatia, using as a basis the ideology of nationalism and fearing that Croatia would be historically associated with Yugoslavia and the Balkans, pursued a policy of self-isolation in the very region in which Croatia could play an important role. The balance of power formed in Croatia in 2020 makes it possible to intensify Croatia’s policy in the region, on the basis of a possible normalization of relations with the Serbian community of the country as well as through the process of improving relations with Serbia and Bosnia and Herzegovina. Without this transformation, the final stabilization in the Balkans / South-Eastern Europe region is impossible.