Scientific Community Research Articles

Patterns and predictors of COVID-19 vaccination among young adults at 44 US sites: Secondary analysis of a randomized, controlled, open-label trial, March – December 2021

Background: The introduction of vaccines during the COVID-19 pandemic provided an opportunity to slow transmission of SARS-CoV-2, but initial uptake of COVID-19 vaccination was slow. We analyzed data from a randomized clinical trial of the mRNA-1273 vaccine (NCT04811664) to describe the patterns of uptake of COVID-19 vaccines among young adults.Methods: The CoVPN 3006 trial randomized adults ages 18–29 from 44 sites in the United States to receive 1) immediate mRNA-1273 vaccination from the study site, or 2) standard of care, including the option to seek vaccination at any time in the future. Randomization occurred between March and November 2021, and an observational arm of adults who declined vaccination was enrolled beginning June 2021. Among participants in the standard of care (SoC) or Vaccine Declined arms, we estimated demographic, behavioral, and health history correlates of vaccination, and the four-month cumulative incidence of COVID-19 vaccination using inverse probability weighted Kaplan-Meier estimators.Results: Among 728 SoC and 470 Vaccine Declined participants, 79% and 16% received COVID-19 vaccination, respectively. SoC and Vaccine Declined participants were more likely to seek and receive vaccination if they reported COVID-19 preventive behaviors, including wearing masks, physically distancing, and avoiding large gatherings. We identified strong predictors of vaccination in the Vaccine Declined arm, including attending class in person (adjusted risk ratio [aRR]: 0.47, 95% confidence interval [CI] 0.21, 1.03), having a COVID-19 relevant medical condition (aRR: 1.95, 95% CI: 0.89, 4.26), and avoiding large gatherings (aRR: 2.24, 95% CI: 1.18, 4.25), though low vaccination rates in this arm led to imprecise estimates.Conclusions: Individuals who initially decline vaccination can be convinced to vaccinate, particularly if they are already practicing other forms of COVID-19 prevention. Continued outreach and education from the scientific community can combat low vaccine confidence.

Between continuous presents and disruptive futures: Identifying the ideological backbones of global environmental scenarios

Despite the great relevance of global environmental scenarios for the study of environmental change and sustainability transitions, they have rarely been the object of analysis for scholars of the social sciences. In this article, we analyze the ideological assumptions of 993 global environmental scenarios contained in 243 academic works. By developing a new categorization of environmental scenarios, we investigate the economic and governance organization reflected in the scenarios, as well as the portrayed human-nature relationships. We find that global environmental scenarios developed and used by the scientific community largely reproduce rather than break with dominant power structures in the economic, governance and cultural domain. The majority of scenarios reflects an anthropocentric worldview and assumes that the logic of global capitalism and of the Westphalian state-based governance system will not change radically during the 21st century. The implicit solution of sustainability problems dominating these scenarios is a combination of continuous economic growth, rapid technological progress and an international (environmental) agreement. ‘Alternative scenarios’ are scarce, often only problematize one dimension of the social structure of world society and frequently lack explicit drivers of change or pathways to desirable futures. To increase the diversity of scenarios, future research should focus on refining and quantifying existing post-capitalist, post-state-centric and/or ecocentric scenarios, and on developing a range of scenarios whose storyline systematically problematize or even break with current power structures.

How anatomical impairments found on CT affect perfusion percentage assessed by SPECT/CT scan?

CT images can identify structural and opacity alterations of the lungs while nuclear medicine's lung perfusion studies show the homogeneity (or lack of) of blood perfusion on the organ. Therefore, the use of SPECT/CT in lung perfusion scintigraphies can help physicians to assess anatomical and functional alterations of the lungs and to differentiate between acute and chronic disease. To develop a computer-aided methodology to quantify the total global perfusion of the lungs via SPECT/CT images and to compare these results with parenchymal alterations obtained in CT images. 39 perfusion SPECT/CT images collected retrospectively from the Nuclear Medicine Facility of Botucatu Medical School's Clinics Hospital in São Paulo, Brazil, were analyzed. Anatomical lung impairments (emphysema, collapsed and infiltrated tissue) and the functional percentage of the lungs (blood perfusion) were quantified from CT and SPECT images, with the aid of the free, open-source software 3D Slicer. The results obtained with 3D Slicer (3D-TGP) were also compared to the total global perfusion of each patient's found on their medical report, obtained from visual inspection of planar images (2D-TGP). This research developed a novel and practical methodology for obtaining lungs' total global perfusion from SPECT/CT images in a semiautomatic manner. 3D-TGP versus 2D-TGP showed a bias of 7% with a variation up to 67% between the two methods. Perfusion percentage showed a weak positive correlation with infiltration (p = 0.0070 and ρ = 0.43) and collapsed parenchyma (p = 0.040 and ρ = 0.33). This research brings meaningful contributions to the scientific community because it used a free open-source software to quantify the lungs blood perfusion via SPECT/CT images and pointed that the relationship between parenchyma alterations and the organ's perfusion capability might not be so direct, given compensatory mechanisms.

Effect of bedroom environment on sleep and physiological parameters for individuals with good sleep quality: A pilot study

Bedroom conditions affect sleep, overall health, and well-being. Field studies reporting measurements of bedroom environment and sleep parameters are almost lacking in the scientific community since the majority of research has been conducted in laboratories. To fill this knowledge gap, we have investigated the associations among bedroom environmental factors (temperature, humidity, CO2, pressure), measured sleep and physiological parameters (heart rate, heart rate variability, and breathing rate) in participants with good sleep quality. Six subjects were enrolled in the study, possessing a minimum of two years of experience in using the wrist actigraph chosen for the experimentation, and exhibiting good sleep quality. The air quality measurements were conducted using the air quality monitor, whereas advanced actigraphs were employed for the assessment of various sleep stage durations. The statistical analysis, carried out applying Linear Mixed Models, revealed that an increase of 100 ppm of CO2 concentration levels is associated with an approximate 0.29 % decline in sleep quality whereas, concerning the effect of the relative humidity, we observed a 0.1 % reduction in sleep quality associated with a 1 % rise in RH. On the other hand, a 1 °C rise in air temperature is associated with an approximate 0.16 % reduction in sleep efficiency, and, at a CO2 concentration of about 900 ppm, the autonomic nervous system (ANS) indicator remains positive for temperature values < 20 °C. These results contribute to mounting evidence underscoring the crucial role of the bedroom atmosphere in facilitating high-quality sleep.

Development of an emulator of the sustainable energy harvesting pad system on a bike lane for charging lithium batteries

In response to the urgent imperative of combating global warming and advancing sustainable energy solutions, an innovative approach has emerged, capitalizing on bicycles and road bike lane infrastructure. This solution integrates a Smart Lithium Battery Charging System with a Sustainable Energy Harvesting Pad (SEHP) designed for cyclists. The SEHP harnesses piezoelectric energy from mechanical vibrations and kinetic energy from lightweight vehicles. It produces clean, renewable electricity as an alternative to traditional power sources. Comprehensive assessments of the SEHP's energy generation performance at various proficiency levels have revealed impressive capabilities. An electronic emulator system is developed to support academic and research communities, simulating scenarios on bike lanes to efficiently charge 36.36 Wh lithium batteries at various cycling proficiency levels. The study involved specific circuit design, seamless integration with the custom Smart Lithium Battery Charging System, and optimization using Microcontroller hardware and software solutions. Practical prototypes verified the emulator's functionality and real-world applicability, making it an authentic replica of the SEHP's outcomes. This innovative technology enhances our understanding of SEHP and enables comparative analysis against other energy sources, contributing to a more sustainable future.

Exploring multiple phases and first-order phase transitions in Kármán Vortex Street

AbstractKármán Vortex Street, a fascinating phenomenon of fluid dynamics, has intrigued the scientific community for a long time. Many researchers have dedicated their efforts to unraveling the essence of this intriguing flow pattern. Here, we apply the lattice Boltzmann method with curved boundary conditions to simulate flows around a circular cylinder and study the emergence of Kármán Vortex Street using the eigen microstate approach, which can identify phase transition and its order-parameter. At low Reynolds number, there is only one dominant eigen microstate W1 of laminar flow. At Re c 1 = 53.6, there is a phase transition with the emergence of an eigen microstate pair W2,3 of pressure and velocity fields. Further at Re c 2 . = 56, there is another phase transition with the emergence of two eigen microstate pairs W4,5 and W6,7. Using the renormalization group theory of eigen microstate, both phase transitions are determined to be first-order. The two-dimensional energy spectrum of eigen microstate for W1, W2,3 after Rec1, W4–7 after Re c 2 exhibit −5/3 power-law behavior of Kolnogorov’s K41 theory. These results reveal the complexity and provide an analysis of the Kármán Vortex Street from the perspective of phase transitions.

Mobility and Temperature Sensitive Energy Efficient Routing (MTS-EER) protocol in a wireless body area network

Sensor technology advancements have provided the platform to implement wireless body area networks, thanks to the nanosized sensor units capable of sensing, aggregating, and forwarding physiological information. The collected information is routed to the desired destination unit for data analysis and decision-making in remote healthcare. However, improving energy utilization remains a brain-teasing problem for the research community, especially considering imbalanced energy consumption and postural movements. Mobility contributes to disconnectivity issues, high energy drainage, and retransmission delays. In addition, the sensor node’s thermal level also poses a challenge in maintaining safer and reliable data transmission. To overcome these issues, a novel Mobility and Temperature Sensitive Energy-Efficient Routing ¬(MTS-EER) algorithm has been proposed that includes a two-step process. In step 1, an Intelligent Path Estimation Function (IPEF) is designed considering the sensor’s mobility, temperature, and energy level. IPEF depends on crucial parameters i.e.: - residual energy, signal-to-noise ratio (SNR), distance, total energy, and most importantly temperature of the sensor unit. The sensor node with the least IPEF is selected as the Cluster Head (CH). In step 2, an optimized and sustainable energy conservation model (OSECM) is implemented based on the Adaptive Transmission Power (ATP) and the Power Management Module (PMM). The ATP conserves the energy via intelligently varying the transmission power and PMM manages the sleep pattern of sensor nodes to yield a high network lifetime and efficient energy utilization. The algorithm includes a clustering approach with dual sink nodes to conserve energy and improve reliability. Finally, the results are compared with the recent state-of-the-art research work. The proposed algorithm provides better results considering residual energy, throughput, network lifetime, and end-to-end delay.

Therapeutic Potential of a Biodynamic Supplement on Skin Pressure Ulcers: A Randomized Clinical Study.

Pressure ulcers (PUs) are a debilitating and often painful condition. They are localized lesions on the skin and/or underlying tissues and are common in the elderly, people with mobility difficulties, diabetics, and vascular disease or malnutrition, as well as in those requiring intensive or palliative care. The prevention and treatment of PUs involve strategies to optimize hydration, circulation, and nutrition. Nutrition plays a key role in pressure ulcer care because wounds require macronutrients and micronutrients to heal. Reports relating to the effectiveness of "Complementary Enzyme Therapy" also in the vulnological field led us to this study, the aim of which was to test the activity of a biodynamic food supplement (Citozym®) rich in carbohydrates, vitamins, and amylase and lactase and characterized by marked antioxidant activity. Citozym® administered topically and/or systemically, and in particular in both administrations, in patients suffering from Pus, has shown a marked reduction in bedsores and, in many cases, complete healing. Furthermore, it was possible to observe a lower incidence of side effects compared to conventional therapies. The results obtained, confirmed by various tests and recognized by the scientific community, allow us to conclude that treatment with Citozym® could represent a new and effective strategy for the treatment of PUs.

Flexible ZIF-67@PVDF tree-like nanofiber membrane with high piezoelectric output for energy harvesting

Modern demands for efficient, environmentally friendly, and self-powered devices have led to growing interest in piezoelectric polymers in the scientific community. In this paper, a ZIF-67 functionalized polyvinylidene fluoride/ tetrabutylammonium hexafluorophosphate tree-like nanofiber membrane (ZIF-67@PVDF/TBAHP-TLNMs) was developed as piezoelectric nanogenerator for energy harvesting. The ZIF-67@PVDF/TBAHP-TLNMs was prepared by in-situ growth of ZIF-67 on the surface of PVDF TLNMs, which demonstrated remarkable energy harvesting capabilities. The results indicated that the β-phase content of the in-situ growth of ZIF-67 reached 86.94 %, augmented the fiber's rotation radius, and elevated the electromechanical conversion efficiency. Notably, the short circuit current reached 3.87 μA and the output voltage exceeded 9.78 V, which was 10.7 times and 5.9 times higher than the electrical signal output of pure PVDF nanofiber membrane, respectively. Furthermore, the ZIF-67@PVDF/TBAHP-TLNMs exhibited exceptional mechanical properties, with an elastic modulus as high as 1.13 GPa, outperforming other nanofiber membranes and catering to the diverse requirements of wearable devices. During a 500 s test cycle, its layered structure remained intact, without any discernible damage or interlayer separation of the nanofibers. At the same time, the device exhibited high electromechanical conversion efficiency and a sensitive sensing function, which made it have broad application prospects in human motion monitoring and intelligent wearable devices.

Obtaining and characterization of natural extracts from mango (Mangifera Indica) peel and its effect on the rheological behavior in new mango kernel starch hydrogels.

Hydrogels based on natural polymers have aroused interest from the scientific community. The aim of this investigation was to obtain natural extracts from mango peels and to evaluate their addition (1, 3, and 5%) on the rheological behavior of mango starch hydrogels. The total phenolic content, antioxidant activities, and phenolic acid profile of the natural extracts were evaluated. The viscoelastic and thixotropic behavior of hydrogels with the addition of natural extracts was evaluated. The total phenol content and antioxidant activity of the extracts increased significantly (p<0.05) with the variation of the ethanol-water ratio; the phenolic acid profile showed the contain of p-coumaric, ellagic, ferulic, chlorogenic acids, epicatechein, catechin, querecetin, and mangiferin. The viscoelastic behavior of the hydrogels showed that the storage modulus G' is larger than the loss modulus G'' indicating a viscoelastic solid behavior. The addition of extract improved the thermal stability of the hydrogels. 1% of the extracts increase viscoelastic and thixotropic properties, while concentrations of 3 to 5% decreased. The recovery percentage (%Re) decreases at concentrations from 0% to 1% of natural extracts, however, at concentrations from 3% to 5% increased.

They returned to the Chinese mainland, and what? A collaborative autoethnographic study on the career transitions of Chinese international doctorates from the West to the east

ABSTRACT The purpose of this study is to analyse the approaches of three Chinese international doctoral degree holders who received their doctoral education in the West in tackling the challenges of relocation and career transition to the East after completing their doctoral degrees. Through a collaborative autoethnographic research from June 2020 to December 2022, from the theoretical perspectives of institutional theory, the study reveals four tactics of institutional arbitrage, driven by resources, purpose, practice, and legitimacy, allowed the Chinese international doctoral degree holders to extend their international academic networks to the local context, adapt research purposes to fit national needs, introduce effective practices from the international academic community to local institutions, and advocate for the legitimacy of cutting-edge research in the local academic community. Through these tactics, the multiple logics of profession, corporation, market, and state were found to be strengthened in the institutional environment, thus supporting their career development. The study further proposes to view Chinese international doctoral degree holders’ relocation to China as an important component of the international mobility of knowledge workers, contributing to the formation of global scholarship, rather than a simple return journey to their homeland.

The Application of Hydrogen Sulfide Fluorescent Probe in Food Preservation, Detection and Evaluation.

This work primarily reviewed the response mechanism of fluorescent probes for H2S detection in foodstuffs in recent years, as well as the methodologies employed for detecting foodstuffs. Firstly, the significance of studying H2S gas as an important signaling molecule is introduced. Subsequently, a review of the response mechanism of the scientific community on how to detect H2S in foodstuffs samples by fluorescent probe technology is carried out. Secondly, the methods commonly used for detecting foodstuffs samples are discussed, including the test strip method and the spiking recovery methods. Nevertheless, despite the significant advancements in this field, there remain some research gaps. Finally, the article identifies the remaining issues that require further attention in current research and proposes avenues for future investigation. More importantly, this work identifies the current limitations of research in this field and proposes future applications of fluorescent probes for H2S in assessing food freshness and determining food spoilage. Therefore, this review will provide robust technical support for the protection of consumer health and the advancement of the sustainable development of the food industry and also put forward some new ideas and suggestions for future research.

Occurrence, dissipation kinetics and environmental risk assessment of antibiotics and their metabolites in agricultural soils

Antibiotics are among the emerging contaminants of greatest concern to the scientific community. However, the occurrence and behaviour of their metabolites in soils have been scarcely studied. To address this research gap, this study investigates the occurrence, sorption, dissipation kinetics, and environmental risk of highly important antibiotics (sulfamethazine, sulfadiazine, sulfamethoxazole, trimethoprim) and their main metabolites in Mediterranean agricultural soils. Batch experiments were conducted under natural conditions for 120 days. Five different dissipation kinetics models were applied to elucidate antibiotics degradation. The sorption isotherms were evaluated by three different models. Most of the antibiotics and metabolites tested showed a good fit with the Linear Isotherm model (R2 >0.96) and biphasic dissipation kinetic models (R2 >0.90). The dissipation and the endpoints values (DT50 and DT90) depended on the soil type properties. A Lixisol soil demonstrated reduced degradation of the investigated compounds. Trimethoprim showed the highest persistence, followed by sulfamethazine, sulfamethoxazole, and sulfadiazine. Parent compounds exhibited lower degradation rates than their metabolites. Remaining antibiotic concentrations were found to be below the predicted no-effect concentration in soil, suggesting that they may not pose a risk to terrestrial biota. This study provides valuable insights into the behaviour of these antibiotics and their metabolites in soil.

Using machine learning to dissect host kinases required for Leishmania internalization and development

The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and macrophages) to establish infection. When these phagocytes die or break down, amastigotes must be re-internalized to survive within the acidic phagolysosome and establish disease. To define host kinase regulators of Leishmania promastigote and amastigote uptake and survival within macrophages, we performed an image-based kinase regression screen using a panel of 38 kinase inhibitors with unique yet overlapping kinase targets. We also targeted inert beads to complement receptor 3 (CR3) or Fcγ receptors (FcR) as controls by coating them with complement/C3bi or IgG respectively. Through this approach, we identified several putative host kinases that regulate receptor-mediated phagocytosis and/or the uptake of L. amazonensis. Findings included kinases previously implicated in Leishmania uptake (such as Src family kinases (SFK), Abl family kinases (ABL1/c-Abl, ABL2/Arg), and spleen tyrosine kinase (SYK)), but we also uncovered many novel kinases. Our methods also predicted host kinases necessary for promastigotes to convert to amastigotes or for amastigotes to survive within macrophages. Overall, our results suggest that the concerted action of multiple interconnected networks of host kinases are needed over the course of Leishmania infection, and that the kinases required for the parasite’s life cycle may differ substantially depending on which receptors are bound and the life cycle stage that is internalized. In addition, using our screen, we identified kinases that appear to preferentially regulate the uptake of parasites over beads, indicating that the methods required for Leishmania to be internalized by macrophages may differ significantly from generalized phagocytic mechanisms. Our findings are intended to be used as a hypothesis generation resource for the broader scientific community studying the roles of kinases in host-pathogen interactions.

Pan-genome and phylogenomic analyses highlight Hevea species delineation and rubber trait evolution.

The para rubber tree (Hevea brasiliensis) is the world's sole commercial source of natural rubber, a vital industrial raw material. However, the narrow genetic diversity of this crop poses challenges for rubber breeding. Here, we generate high-quality de novo genome assemblies for three H. brasiliensis cultivars, two H. brasiliensis wild accessions, and three other Hevea species (H. nitida, H. pauciflora, and H. benthamiana). Through analyzing genomes of 94 Hevea accessions, we identify five distinct lineages that do not align with their previous species delineations. We discover multiple accessions with hybrid origins between these lineages, indicating incomplete reproductive isolation between them. Only two out of four wild lineages have been introduced to commercial rubber cultivars. Furthermore, we reveal that the rubber production traits emerged following the development of a large REF/SRPP gene cluster and its functional specialization in rubber-producing laticifers within this genus. These findings would enhance rubber breeding and benefit research communities.

X-chromosome inactivation pattern and telomere length in recurrent pregnancy loss

Recurrent pregnancy loss is a reproductive disorder affecting about 1 to 5 % of pregnant women worldwide that requires our attention, especially considering that about 50 % of cases are idiopathic. The present study is focused on testing a possible association between extreme skewed X-chromosome inactivation patterns and/or shortened telomeres with idiopathic cases since both are considered non-consensual potential causes underlying recurrent pregnancy loss in the scientific community. For this purpose, two groups of women were analyzed and compared: a group of women with idiopathic recurrent pregnancy loss and a second group of age-matched women with proven fertility, and both X-chromosome inactivation patterns and telomere length were measured and compared from maternal DNA extracted from peripheral blood. Our data showed no statistically significant differences between groups, suggesting no association between extreme skewed X-chromosome inactivation or shortened telomeres with recurrent pregnancy losses. Additionally, the effect of maternal age on both X-chromosome inactivation pattern and telomere length was tested, but no significant correlation was observed between advanced maternal age and extreme skewed X-chromosome inactivation or telomere shortening. This study represents one more valid contribution to the investigation of causes underlying recurrent pregnancy loss suggesting that, new variables may be considered since the pattern of X-chromosome inactivation and telomere length do not seem to be related to this reproductive disorder. Briefly, considering its clinical relevance, it is mandatory a continuous effort in the scientific community to cover new potential recurrent pregnancy loss-related causes.

Computational Research of the Efficiency of Using a Three-Layer Panel Made of Highly Porous Polystyrene Concrete.

This paper presents linking computational research of the multilayer structure of the cladding of a three-layer panel made of highly porous polystyrene concrete developed using a new technology in comparison with traditional ones. The calculation of the thermal efficiency of the exterior fence was carried out in three stages, where the thermal regime was calculated from the values of temperature fields in the ELCUT 6.6 system, and the humidity and air modes were determined by the analytical method in the Maple system. The territory of central Kazakhstan (Karaganda) was selected as the research region, where the research showed that equating the thickness by the values of the actual and required heat transfer resistances of traditional multilayer structures to the developed one, the thickness of traditional structures increases from 3.09% to 27.83%. Moisture accumulation relative to the developed one occurs in all the studied structures. Thus, if in some cases of traditional structures moisture is collected by 2.61% and 9.48% less, in others moisture is collected by 27.94% and 119% more. However, the value of evaporated moisture during the drying period showed that all the moisture will evaporate during the specified period. Thus, all the structures meet the conditions for the inadmissibility of moisture for the annual period and the period of moisture accumulation. Moreover, the values of the actual and required permeabilities to air satisfy the condition, which affected the values of the temperature fields taking into account air filtration; the developed structure showed a positive effect for this value, and in traditional structures, the value of τint decreased to 1.35 °C depending on the option. The analytical results of the thermal inertia values of the developed and traditional multilayer structures showed that the developed structure exceeds traditional ones by up to 30.04% depending on the option, which is positive in the cold period. It was also found that the market prices of all traditional structures exceed the developed one by 1.2-2.5 times, depending on the design, which also emphasizes the positive aspects of the new design. Thus, the findings of this research will positively complement the catalog of products of external multilayer cladding structures made of effective materials and can be used by research communities and design organizations in the design of residential buildings.

Influence of HIV status on outcomes of children admitted with sepsis at a paediatric hospital in Zambia: protocol for a prospective longitudinal study

IntroductionSepsis, a condition of global public health concern, is a major cause of morbidity and mortality, especially in patients with underlying HIV infection. This study aims to determine outcomes, aetiology...

Consejos para escribir un manuscrito y publicarlo en una revista biomédica

Science barely exists until it is published. It is only then that the information surpasses the limits of the author and can be shared by the scientific community. Although scientific articles must follow a rigidly defined structure, there is still room to tell a fascinating story, one that clearly conveys the science and is, at the same time, enjoyable for the reader. To do this, we must use the attributes that characterize good scientific style, with simple, clear, precise, direct, rigorous, and consistent language. Authorship implies authenticity and authority, and considering a researcher as an author entails rights and responsibilities. Scientific writing is not easy, it requires patience and practice; learning to write well is a lifelong task. With the philosophy that most of the qualities required to proficiently write a scientific article depend on attitude, and can be learned and improved upon, in this manuscript we will share with the reader a series of recommendations (based on our own experiences, both positive and negative), which we consider important for writing and successfully publishing. We will focus on the so-called "original" articles (as opposed to review articles, although many of the recommendations presented are applicable to both). Our main purpose is to encourage researchers to take the necessary step and face the challenge of becoming authors of their own scientific articles and successfully publishing their research.

How do software practitioners perceive human-centric defects?

Context:Human-centric software design and development prioritises the way users prefer to complete their jobs, rather than expecting users to adapt to the software. Software users can have different genders, ages, cultures, languages, disabilities, socioeconomic statuses, and educational backgrounds, among many other differences. Due to the inherently varied nature of these differences and their impact on software usage, preferences and issues of users can vary, resulting in user-specific defects that we term as ‘human-centric defects’ (HCDs). Objective:This research aims to understand the perception and current management practices of such HCDs by software practitioners, identify key challenges in reporting, understanding and fixing them, and provide recommendations to improve HCDs management in software engineering. Methods:We conducted a survey and interviews with software engineering practitioners to gauge their knowledge and experience on HCDs and the defect tracking process. Results:We analysed fifty (50) survey- and ten (10) interview-responses from SE practitioners and identified that there are multiple gaps in the current management of HCDs in software engineering practice. There is a lack of awareness regarding human-centric aspects, causing them to be lost or under-appreciated during software development. Our results revealed that handling HCDs could be improved by following a better feedback process with end-users, a more descriptive taxonomy, and suitable automation. Conclusion:HCDs, given their diverse end-user base, present a major challenge to software practitioners. In the software engineering domain, research on HCDs has been limited and requires effort from research and practice communities to create awareness and support for human-centric aspects.