This paper studies a wireless communication control module with AT89S52 microcontroller as the control core. The basic principle, main circuit, hardware framework and software framework of the system are described in detail. The whole system adopts modular design, which mainly includes wireless communication control circuit between single-chip microcomputer and lower-level computer, and communication interface circuit between wireless communication module and 51 single-chip microcomputer. The communication control system communicates with the nRF2401 through the SPI of the 51 single chip microcomputer, thereby forming a connection with the lower computer through the wireless communication control module, controlling the lower machine motion controller, and saving the data received by the communication into the extended memory. The communication method of this module is simple, in addition to remote real-time control, it can also be widely used in industrial monitoring and data acquisition systems.