Acceptance of cage fish farming within Volta Lake in Ghana, was assessed in the lake’s riparian sub-communities by estimating opinion case of community members generally and specifically on issues including Interference of fish culture with fishing; Cage culture interference with local boat transportation activities; Integration level of cage fish culture into other lake activities; Awareness of lake’s community of the lake as a multipurpose resource; Primary occupation of community members; Co-existence level of fish farm operators and communities and cumulative acceptance of fish culture compared to other lake uses and users currently and in the future when the lake is zoned. Methods used were Formal survey and Focus Group Discussions (FGD) in two conceptualized zones (Afram Plains and Asuogyaman) of the lake and data was analyzed by SPSS. A study was undertaken to enhance integration and acceptance of cage fish culture into activities on the Volta Lake and by extension on potential other water bodies where cage fish culture might be practiced. Results indicated that several mutually beneficial situations existed between cage fish farming operators and lake communities. However, there were also conflict flashpoints between cage fish farming practices and livelihood activities of communities at some places as well as fish culture-related outcomes, such as effluents of the culture on lake water quality for communities. The benefits of cage fish farming to communities observed in the results confirm some previous reports. Suggestions of communities to the resolution of conflict flashpoints of operations with operators of cage fish farming provide avenues for enhanced integration thus acceptance and sustainability of cage culture in riparian communities of the lake and other water bodies that could be found suitable for cage fish culture.