Background:Indoor air pollution is an important environmental health problem. Nanotechnology is one of the most important methods to reduce the indoor air pollution. Titanium dioxide (TiO2) is generally accepted as one of the most effective photoinduced catalysts. It is frequently used to oxidize organic and inorganic compounds in the air due to its strong oxidative ability and long-term photostability. The aim of this study was to determine the effectiveness of nanotechnology in the purification of ambient air by using Saudi myrtle plants treated with TiO2.Methods:Experiments were conducted in two academic departments of the laboratories at the Public Sector University. Concentration of formaldehyde, nitrogen dioxide (NO2), sulphur dioxide (SO2) and other toxic gases was measured in the environment of the laboratories. Myrtus plant was growing in the growth media which contained TiO2. After 8 hours of exposure of the plant, concentration of NO2, SO2 and other toxic pollutant gases in the air was measured. The total duration of the experiment was 4 days.Results:It was found that the levels of formaldehyde, volatile organic compounds (VOCs) and other pollutants were significantly reduced the concentration from 10% to 98% in the air. After intervention, air containing the concentration of formaldehyde, TVOCs, NO2 SO2 and carbon monoxide (CO) on the fourth day reduced from 0.251, 401, 0.032, 0.009 and 0.99 to 0.014, 54,0.0003, 0.003 and 0.01 after exposure of Myrtus plant to ambient air.Conclusions:Significant reduction of air pollutants in the air after application of TiO2 in the green plant (Myrtus communis). It is a novel approach and economically feasible for purification of indoor air.