Common Denominator Research Articles

Exploring Vulnerability Indicators: Tourist Impact on Cultural Heritage Sites in High Arctic Svalbard

This article reports findings from two research projects that aimed to understand the vulnerabilities of cultural heritage sites in Svalbard and investigated factors that influence tourism-induced pressures and site degradation. It draws upon fieldwork conducted at ten selected historic locations, including interviews with tourists and guides, consultations with regional and central cultural heritage management authorities, on-site observations, and condition assessments. The primary goal was to explore indicators rendering cultural heritage sites susceptible to the impacts of tourism and human visitors. These indicators were common denominators and encompassed the sites’ physical state/degree of decay, legibility, accessibility, and quantity and quality of objects at the sites. This article seeks to enhance the understanding of these sites’ vulnerabilities and provide insights for effective heritage site management and sustainable tourism development. The principal findings highlight key factors contributing to cultural heritage sites’ vulnerability. These factors encompass intensity and frequency of visitor traffic, suboptimal visitor management strategies, tourists’ limited awareness of proper site behaviour and conservation practices, and restricted resources for site maintenance and protection. These findings can guide policymakers, site managers, and tourism stakeholders in formulating strategies to balance tourism promotion with site conservation, ensuring the long-term preservation of cultural heritage in this unique and vulnerable environment.

Metabolic features of treatment-refractory major depressive disorder with suicidal ideation

Peripheral blood metabolomics was used to gain chemical insight into the biology of treatment-refractory Major Depressive Disorder with suicidal ideation, and to identify individualized differences for personalized care. The study cohort consisted of 99 patients with treatment-refractory major depressive disorder and suicidal ideation (trMDD-SI n = 52 females and 47 males) and 94 age- and sex-matched healthy controls (n = 48 females and 46 males). The median age was 29 years (IQR 22–42). Targeted, broad-spectrum metabolomics measured 448 metabolites. Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) were measured as biomarkers of mitochondrial dysfunction. The diagnostic accuracy of plasma metabolomics was over 90% (95%CI: 0.80–1.0) by area under the receiver operator characteristic (AUROC) curve analysis. Over 55% of the metabolic impact in males and 75% in females came from abnormalities in lipids. Modified purines and pyrimidines from tRNA, rRNA, and mRNA turnover were increased in the trMDD-SI group. FGF21 was increased in both males and females. Increased lactate, glutamate, and saccharopine, and decreased cystine provided evidence of reductive stress. Seventy-five percent of the metabolomic abnormalities found were individualized. Personalized deficiencies in CoQ10, flavin adenine dinucleotide (FAD), citrulline, lutein, carnitine, or folate were found. Pathways regulated by mitochondrial function dominated the metabolic signature. Peripheral blood metabolomics identified mitochondrial dysfunction and reductive stress as common denominators in suicidal ideation associated with treatment-refractory major depressive disorder. Individualized metabolic differences were found that may help with personalized management.

“Common Denominator” in Solving Multi-Factory Problems by Intelligent Systems

The most important property, a distinctive feature of any intelligent system, is its decision-making ability. In this case, the more complex the problem to be solved, the more and more diverse the initial data, and the more critical it is that the decision to be made was comprehensively considered and evaluated. In many cases, simultaneously arriving various initial data, if considered separately, and decisions based on such consideration lead to completely different results, often contradicting each other. Therefore, in the process of development and implementation of artificial intelligence (AI), it is especially important to investigate the “mechanism” of decision-making in conditions of the inconsistency of incoming initial data and the need to establish some generalizing rule, according to which it is possible to find a harmonizing solution taking into account various influencing factors. It is evident that when establishing the rules of decision-making, it is necessary to strive for a “positive” result from the point of view of the problem being solved. This undoubtedly requires analyzing the consequences of the decision made in a set time scale, which can be provided by appropriate feedback that will allow us to make the necessary corrective actions. Artificial intelligence in modern forms of practical realization has, as a rule, a digital embodiment. It should be taken into account that the digital representation of data inevitably shows an inaccurate display of initial values when processes of a continuous nature are considered and analyzed. Since a digital model has certain limitations and characteristic properties when analyzing and processing initial data, it is logical to assume that for this reason, there can be some general approach, some general rule, according to which a decision is made in the conditions of diverse initial data and the need to take into account the relevant consequences after the decision is made. This paper attempts to find a decision-making mechanism, harmonizing it according to the incoming external and available internal input data.

The place-new relation in the context of experience and meaning: a bibliometric review (1992-2023)

ABSTRACT The research analyzes the literature by questioning the common denominator between “place and the new” through the concepts of experience and meaning to expand and deepen the existing knowledge on the meaning of place in the production of place. The paper discovers current approaches and notions in the place-new relationship and identifies leading keywords, authors, documents, sources, organizations, and references. It presents a systematic literature review based on bibliometric data in the context of place concept research. The analysis conducted on 27 May 202327 May 2023, with the concepts of place, new, experience, and meaning, covers the bibliometric data of 870 publications which included English articles and book chapters published since 1992 and chosen from specific research categories on the Web of Science. Documents published before 1992 without available content were excluded. Findings show an increasing tendency towards the concepts of sustainability, place-making, place attachment, urban regeneration, architectural design, and cultural heritage. While the number of investigations concentrating on landscape and COVID-19 has increased; concepts like everyday life, emotions, behavior, urban politics, phenomenology, design research, and displacement have been discovered as current research topics. This paper is potentially useful for future theoretical and practical work to create meaningful places and contributes to the further implementation of design and planning studies.

Polyphony in the Literary Works of Ewa Kuryluk

This article discusses the uses of polyphony in the literary works of Ewa Kuryluk. They manifeststhemselves on various levels in texts that may appear formally distinct from each other but havea crucial common denominator. Polyphony in Kuryluk’s works is examined in reference to the constructionof literary characters, as well as to categories such as hybridization, transmediality andinterdiscursivity.

Could Microbiome Be the Common Co-Denominator between Type 2 Diabetes and Pancreatic Cancer?

Similar microorganisms, via similar mechanisms, play a role in the development of both pancreatic cancer (PC) and type 2 diabetes (T2D). Since the new onset of T2D is potentially one of the earliest signs of PC, it is highly plausible that a common denominator might be responsible for both, as the growth of the cancer will take a longer time to manifest compared to the insulin resistance. Although a variety of host-dependent factors and susceptibility play a role, and the mechanisms connecting the two diseases remain poorly understood, future well-designed trials should hypothesize whether a microbial intervention (modification and/or transplantation) results in a lower incidence and the better treatment of both diseases since the T2D–PC–gut microbiome interconnection seems scientifically logical.

Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms.

Mental disorders that are comorbid with chronic infectious diseases may worsen clinical outcomes and patients' quality of life. We hypothesized that depression and/or anxiety syndromes or symptoms comorbid with human immunodeficiency virus (HIV) or hepatitis B virus (HBV) infection might stem from shared biological mechanisms. We conducted a systematic review applying the PRISMA statement by searching into the PubMed, APA PsycInfo, and Scopus databases. We examined the literature on HIV/HBV infection comorbid with depression and/or anxiety in adults ≥18 years. Thirty-one studies on HIV and three on HBV were analyzed. The Tat protein contributed to HIV-associated mood disorders due to the protein's ability to cause neurodegeneration and induce hypothalamic-pituitary-adrenal (HPA) axis dysregulation in response to natural stressors. The decreased brain-derived neurotrophic factor (BDNF) levels also emerged as a mechanism involved in HIV neuropathogenesis and the associated mood symptoms. Neuroinflammation was implicated in depression and/or anxiety onset in patients with HIV/HBV infections. Microglial activation and release of cytokines, in particular, appeared as potential pathogenetic mechanisms. Furthermore, an altered balance between quinolinic acid and kynurenic acid production emerged in HIV patients with comorbid depression, indicating a glutamatergic dysfunction. Inflammatory cytokine production and the downregulation of cellular immune responses contributed to persisting inflammation, delayed healing, and functional decline in patients with chronic hepatitis B (CHB) infection. A shift in type 1-type 2 cytokine balance might be implicated in HBV-related immune pathogenesis, and depression and anxiety might be considered immunomodulatory factors. Cytokines also caused HPA axis hyperactivity, frequently observed in HIV/HBV patients with comorbid depression/anxiety. The present systematic review showed, for the first time, that HIV/HBV and depression and/or anxiety might have several biological mechanisms as common denominators. The longitudinal course of the highlighted biological mechanisms should be explored to establish the causative interrelationship among the involved mechanisms. In addition, future research should investigate the possibility that a patient's clinical outcome might improve using pharmacological treatments acting on the biological mechanisms we described as common denominators of chronic inflammatory infective diseases and depression/anxiety.

Cognitive Performance in Relation to MIND and MEPA III Accordance among NHANES Participants

AbstractBackgroundThere is growing evidence from cohort studies and clinical trials that MIND and Mediterranean‐like diets are associated with better cognitive performance, but most rely on food frequency questionnaires that may not specify key food items consistent with these patterns.MethodIn this cross‐sectional sample from two NHANES cycles (2011‐2014), scores for the MIND dietary pattern (maximum score = 14) and those for the Mediterranean Eating Pattern for Americans III (maximum score = 22) were calculated based on reported foods consumed on two non‐consecutive 24‐hour dietary recalls. Only those adults with two completed recalls and cognitive tests were studied (n = 2598). Cognitive assessments included the word learning and recall components from the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), the Animal Fluency test (AFT), and the Digit Symbol Substitution test. The Complex Sample module in SPSS (version 26) was used to produce representative estimates of the older American population with the dietary weighting variable applied following the “least common denominator” rule.ResultThe average age of sample participants was 69.2 ± 0.3 years, with almost equal proportion of men and women. The average MIND score was (mean ± SD) 5.0 ± 0.0, whereas for MEPA III, this was 8.6 ± 2.1. There were positive associations between continuous MIND scores and education‐dependent standardized cognitive scores for each test as well as global cognition (β = 0.05‐0.10, all p‐values ≤ 0.002 when adjusted for covariates); these associations were not observed for MEPA III scores. Compared to those in the lowest MIND accordance tertile, those in the highest tertile were less likely to exhibit low cognitive performance on the AFT [odds ratio, 95% CI)] 0.45 (0.29–0.69)], CERAD Delayed Recall [0.52 (0.33–0.83)], and global cognition [0.50 (0.27–0.94)].ConclusionOlder Americans in this sample were generally non‐accordant to MIND and MEPA III patterns. However, those who reported greater MIND diet accordance exhibited better cognitive performance.

Dissociations between APP pathology and metabolic signalling in the neuron‐specific hBACE1 knock‐in PLB4 mouse

AbstractBackgroundPatients with Alzheimer’s Disease (AD) frequently suffer comorbidities such as type 2 diabetes mellitus (T2DM) alongside shared common pathologies e.g. increased inflammation, endoplasmic reticulum (ER) stress, and impaired energy homeostasis (Plucinska et al., 2016, https://doi.org/10.1007/s00125-016-3960-1). The complexity of neurodegenerative and metabolic diseases requires a systems‐based approach that examines the interplay between brain pathology and metabolic regulation. Emerging evidence points towards abnormal cellular energy regulation as a common denominator, investigated here in hBACE1 associated pathologies (Findlay et al., 2015, https://doi.org/10.3389/fncel.2015.00382).MethodGlucose tolerance tests were performed in male PLB4 and PLB‐WT controls (3 – 8 months) to determine diabetic status (Plucinska et al., 2014, https://doi.org/10.1523/JNEUROSCI.0433-14.2014). Protein analysis was employed to characterise beta‐amyloid/APP processing, ER stress, glucose regulatory signalling, and bioenergetic metabolites in brain, liver, muscle or plasma, and gene expression analysis examined hypothalamic alterations in energy regulation.ResultNeuronal hBACE1 expression caused early pathological cleavage of APP, in parallel with increased brain ER stress (p‐eIF2α) and the chaperone binding immunoglobulin protein (BIP). APP processing declined over time, alongside increased ER stress (IRE1α) in brain and liver. Systemic glucose intolerance was evident from 3 months, varied between tissues and ages, and was confined to the periphery. All key markers normalised to control levels at 8 months. Evidence for altered bioenergetics metabolites (LDH‐A and BCKDH) in brain and liver, also affected by ageing, were detected in PLB4 mice. Furthermore, hypothalamus‐specific changes in energy and appetite regulators (NPY and GLP‐1 receptor) were uncovered in the hBACE1 mice.ConclusionhBACE1 resulted in early APP misprocessing alongside ER stress but not post‐insulin receptor signalling changes. Peripheral metabolic and bioenergetic alterations were age‐ and tissue‐specific but did not correlate with APP processing. Further tissue analyses are ongoing to determine cellular consequences of hBACE1 expression on systemic bioenergetics.

Deprecatory Ethnonyms: The Case of Bozgor

Abstract In this study, we wish to debate upon some aspects regarding the lexical and semantic implications of ethnonyms. We aim to analyse the origin and semantics of one of two lexemes used by Romanians to refer to Hungarians: bozgor. Besides a meta-analysis of the term (its emergence, meaning), we also refer to archaic usages and meanings (buzguroi, bozga, bozga, bâzga, etc.). We discard previous theories regarding the meaning and origin of the lexeme. Bozgor is a word that is considered an instance of verbal abuse, mockery, or insult, which displays a significant amount of collectively formed, pejorative connotation. Our hypothesis is that it comes from the Hungarian bodza, in its archaic form and meaning (‘border forest’). Bozgor in its earlier versions came to designate, through semantic extension, ‘inhabitant of the border forest’, ‘Hungarian’. The associative meanings which led to the emergence of its present pejorative status (as an ethnic slur) appeared later. The roots we analyse in the article all share a common denominator of meaning and all have led to a large number of words related to the semantic field of forest both in Romanian and in Hungarian.

HPR43 Are There Any Common Denominators for Early Access Programs in Europe?

HPR43 Are There Any Common Denominators for Early Access Programs in Europe?

The Estonian Language and Its Influence on Music: A Cognitive Sciences Approach

Musicology may seem a specific small sector of humanitarian scholarship to the layman, but it hides variety within from highly theoretical subjects such as music theory to the fieldwork with indigenous repertoires and their performance, as found in ethnomusicology. There is a shift in contemporary musicology, its focus moving more towards studies of musical performances and the use of empirical study designs to complement the analysis of musical scores. These interdisciplinary empirical studies cross the border of humanitarian scholarship and apply the methods of the natural sciences, for example spectrogram analysis of singing and the measurement of the temporal structure of recorded music. The cognitive sciences of music (CSM) can be looked at as an umbrella term for branches of musicology that use empirical research methods and draw their research questions from music related individual and group processes. One of the major topics of CSM relates to research in linguistics. Music and language, as well as speech, are closely linked as the human voice is a natural part of vocal music and is considered a quintessential element in musical thinking, vocal and instrumental alike. The music–language–speech relationship intrigues Estonian musicologists as research questions focusing on related topics arise in different fields of musicology, including natural settings and functional songs (musical development, spontaneous singing, runosong, ecclesiastical singing) to the vocal art music performed by professional singers (some chronological examples: Ross & Lehiste 2001; Raju 2015; Lippus & Ross 2017; Jõks 2021; Vurma et al. 2022). The purpose of this referative overview article is to introduce a selection of previous research and discuss the results. The endeavour of the authors is to find an abstract common denominator of selected CSM research projects to establish the most estimable useful knowledge that Estonian CSM has to offer to the international scholarly community, as well as to follow-up research in Estonia. Although we can see the results of that support, and we can see the universal perception and cognitive processes of language and music in Estonian research, there are also several interesting prosodic-musical differences relating to the fact that Estonian belongs to the Uralic language family, more specifically Western Finnish language group. Indo-Germanic (mainly German, Russian, Latin, Italian, and English) language related prosody and singing culture does not necessarily support the natural language usage and therefore represses emotional and spontaneous involvement in singing. It seems that in the process in which Estonian scholars deal with their distinctive mother tongue, indigenous musical repertoires, and idiomatic singing, intuition – more precisely a scholarly intuition –, might play an important role.

КАЧЕСТВО ЖИЗНИ ПАЦИЕНТОВ ПОСЛЕ РЕАБИЛИТАЦИИ ИХ С ИСПОЛЬЗОВАНИЕМ КОСТНО-ПЛАСТИЧЕСКИХ ОПЕРАЦИЙ РЕДУЦИРОВАННЫХ АЛЬВЕОЛЯРНЫХ ОТРОСТКОВ И МЕТОДА ДЕНТАЛЬНОЙ ИМПЛАНТАЦИИ (РЕТРОСПЕКТИВНОЕ ИССЛЕДОВАНИЕ)

In recent years, more and more attention has been paid to the problems of using dental implants in complex anatomical conditions due to bone deficiency. The probability of a favorable outcome after the treatment is quite high, which in turn is supported by the long-term results obtained after using various approaches in the rehabilitation of patients with a reduced volume of jaw bone tissue. Of course, the rehabilitation of such patients is difficult not only in terms of surgical preparation, but also in terms of orthopedic benefits, which impose restrictions on the capabilities of the patient's chewing and speech apparatus. In turn, the patient is faced with the task of maintaining as long as possible the result that the doctor originally sought, namely, using various methods of bone grafting, to create the necessary amount of bone tissue for the installation of implants, which are later used for orthopedic constructions, largely replenishing the functional characteristics. previously lost dentition. There are many studies that are devoted to modern methods of rehabilitation of patients with reduced alveolar processes of the jaws, however, only a small part affects the observation of delayed results of treatment of patients using bone grafting methods in combination with dental implantation. One of the advantages of this study is the ability to follow in dynamics what happens to these patients over a time period of up to 10 years, how strong the adaptive capabilities of the body are after major surgical interventions, what patient management tactics turned out to be the most effective. The assessment of the quality of life of such patients makes it possible to fully determine the feasibility of the operations and techniques to restore the function of the masticatory-speech apparatus. The duration of the positive result obtained directly depends on the further interaction between the doctor and the patient. The key point is the dispensary observation of the patient, as a result of which the doctor gains clinical experience, and therefore the ability to predict further complications with one or another approach to the rehabilitation of patients in this category. On the other hand, for an objective assessment of the treatment performed, it is necessary to determine a common denominator that reflects the quality of life of our patients, therefore, the article presents the results of chewing assessment, as a fundamental criterion for the quality of life for most of these patients, using the SF-36 questionnaire, which is a kind of translator between subjective feelings of the patient and an objective assessment of the doctor.

Towards standardising the collection of game statistics in Europe: a case study

In order to monitor wildlife populations in a manner that supports policy makers and natural resource managers, data must be collected using frameworks and methodologies that allow for comparisons between projects and across time. Though hunting statistics may represent a reliable data source for monitoring population trends in game species, a standardised framework for collecting and analysing this data has never been established in Europe, even within countries. Here we describe a case study on the use of hunting statistics in Spain in order to (i) describe the variability in big game statistics collection frameworks across mainland regions of Spain and (ii) propose a minimum common denominator for a standardised approach at the country level. The main differences in methodologies identified are that each region collects different variables, uses different spatial and temporal resolution, and follows different methodologies. We described spatial patterns by grouping regions based on similarities in the hunting data collection system and identified socio-economic factors as a potential driver of differences in methodologies among regions. Hunting effort-related variables and improved temporal resolution (to the event level) must be incorporated in order to achieve country-level standardisation of methodologies. The use of application software to collect information from the field in a standardised way is recommended, which necessitates engaging stakeholders as part of the monitoring process. Applications software should be designed intentionally, and only after clear objectives for the monitoring program have been defined. Making hunting data open access will improve collaboration and information transfer to scientific and professional sectors. Our recommendations can be adapted to other European countries, which would make hunting data more useful for population monitoring and wildlife policy-making at large spatial scales. Initiatives such as the “European Wildlife Observatory” (www.wildlifeobservatory.org), a network of wildlife observation and monitoring points in Europe, may improve data exchange and standardise protocols, leading to better utilisation of hunting statistics for European wildlife population monitoring.

Defining Hereditary Pyropoikilocytosis (HPP) in the Molecular Diagnostic Era

Misconceptions continue in distinguishing hereditary elliptocytosis (HE) with hemolysis in early perinatal period and hereditary pyropoikilocytosis (HPP). In 1975, Zarkowsky and colleagues described a group of children with transfusion dependent congenital hemolytic anemia with the unique morphology of “microspherocytes, measuring 2-3 microns in diameter, and cells with blunted projections or triangular in shape”, a morphology resembling the heat induced damage to normal erythrocytes - hence the name hereditary pyropoikilocytosis (HPP). Subsequently, similar cases were described with or without demonstrable heat sensitivity (Ravindranath & Johnson, 1985). Regardless, the common denominators were 1) transfusion dependency early in infancy - resolved with splenectomy, 2) severe microcytosis, often <60 fL, and 3) a decrease in membrane bound spectrin (decreased spectrin/band3 ratio). Family studies showed normal RBC morphology in both parents (Ravindranath & Johnson, 1985) or in some cases, one parent with HE (Zarkowsky et al., 1975). Protein chemistry studies showed decreased tetramer formation and tryptic digests showed mutations within the n-terminal alpha 1 domain of alpha spectrin - the dimer/dimer interaction site. Thus, homozygosity or double heterozygosity of mutations in the dimer/dimer interaction site of alpha spectrin (alpha 1 domain of alpha spectrin) defined HPP while classical HE cases showed heterozygous mutations in the alpha 1 domain. A fact unexplained was how this results in spectrin deficiency, specifically, alpha spectrin deficiency (Ravindranath & Johnson, 1985). Using the molecular analytical tool AnemiaID (courtesy of Agios Pharmaceuticals, Inc.), we show that HPP is defined by the co-inheritance of two SPTA1 mutations and Alpha-LeLy polymorphism ( αLeLy rs28525570; SPTA1[c.5572C>G;c.6531-12C>T]) in one or both alleles, thus explaining the increased propensity for red cell fragmentation and the spectrin deficiency noted on acrylamide gels [Table: Clinical and molecular characteristics of our cases]. Of note, homozygosity for αLeLy polymorphism and one SPTA1 variant did not result in clinical HPP phenotype [HE-2 in Table]. At a clinical laboratory level, the extreme microcytosis in HPP is evident in the markedly diminished band3 content on eosin-5'-maleimide (EMA) binding test- mean channel fluorescence (MCF) of <275.0 (control: 473.0-549.0) while HE (including neonatal HE with hemolysis) show a double peak pattern in EMA (the minor peak representing the fragmented cells while the major peak had MCF higher than control MCF) and the characteristic trapezoid pattern on osmotic gradient ektacytometry (not shown).

Making Sense of (Post)Neoliberalism

The many contradictory interpretations of neoliberalism raise doubts about the value of this concept. This article discusses the literature on neoliberalism for identifying a “minimum common core” that warrants preserving this concept. I argue that neoliberalism entails an ideology and a political practice that aim to subordinate the state and all social domains to the market—to its logic and to the economic powers within it—thereby undermining democracy. This conceptualization emerges as a “common lowest denominator” among many otherwise incompatible scholarly definitions of neoliberalism, reflects central neoliberal ideas (despite their own inconsistencies), and illuminates crucial features of contemporary neoliberal society. I discuss the implications of this interpretation for established democracies and for those countries that experienced democratization processes during the neoliberal era, for the debates on postneoliberalism, and for the political identity of the Left.

Adjudicated Adolescents Located on a State Sex Offender Registry Website as Adults: Common Denominators

ABSTRACT This is a landmark study, the first to use a listing on a state sex offender registry website as a predictive variable for tracking adult recidivism of male adolescents adjudicated for sex offenses, and the longest to follow a cohort of these youth after discharge from a secure residential treatment program. Upon admission, the sample (N = 145) were assessed by JSORRAT-II and MEGA ♪ , two contemporary standardized, validated risk assessment tools for assessing youth who have engaged in sexually abusive behavior. They were then followed once discharged for 17.08 years into adulthood (mean follow-up = 14.0 years, SD = 1.71). Recidivism rate was 6.2% (defined as a listing for the subject on the California Megan’s Law Sex Offender Registry Website). The study offers a baseline for future studies that use a state sex offender registry website as a predictive variable for recidivism. Shared common denominators of recidivists and non-recidivists were risk level (i.e. most were High Risk or Very High Risk on MEGA ♪ ); and having a history of adverse childhood experiences other than sexual abuse (i.e. child neglect/emotional abuse and exposure to domestic violence). A history of sexual abuse, experienced by twice as many non-recidivists as recidivists, differentiated the sample. Recidivists also had fewer protective factors than non-recidivists, as assessed by the MEGA ♪ upon admission to the facility. The mean age of recidivists was younger than non-recidivists, suggesting they may have been removed from their home at an early age, and/or had an early onset of persistent coarse sexual improprieties and/or sexually abusive behaviors that persisted into adulthood. The results highlight the importance of integrating trauma-informed interventions in treatment programs for those individuals who are sexually abusive that have a history of multiple adverse childhood experiences.

The Impact of Social Media on Adolescent Depression and Anxiety

As technology progresses and social media platforms continue to proliferate, a complex bond between young peoples virtual presence and their psychological welfare has developed. This paper explores the intricate dynamics of this link, scrutinizing how apps like Instagram, TikTok, and Facebook have integrated themselves into the daily routines of tech-savvy young individuals. These online platforms provide avenues for communication, artistic expression, and learning; however, they also pose challenges such as exposure to unrealistic lifestyle presentations and beauty benchmarks. The authors highlighted the connection between regular social media engagement and augmented levels of depression and anxiety among adolescents, particularly concerning appearance-related insecurities. Each platform provides a distinct experience through its unique design and purpose but consistently promotes virtual human connection as a common denominator. Furthermore, the text stresses the importance of having comprehensive methods to assess the psychological influence of these digital platforms on the younger generation, paving the way for enhanced understanding and fostering more balanced internet experiences.

Wczesnośredniowieczne bursztynowe krzyżyki z terenu Pomorza na tle porównawczym. Materiały i problemy interpretacyjne

This paper presents early medieval amber cross pendants that display a great degree of diversity not only concerning form and morphology but also with regard to chronology and – as we assume – functionality, with the pendants examined herein sharing one common denominator: the raw material from which are made. This paper analyses amber artefacts discovered in Pomerania, shown in a broad comparative context. Thus, the research objectives undertaken are twofold: first, to present the sources of the relevant materials, which are formally, chronologically, and contextually diverse, and second, to point out the main interpretative problems relating to the possibility of deciphering their original meanings and functions.

APLICAÇÃO DO CONCEITO DE LOGÍSTICA REVERSA NO PROCESSO DE SCRAP DE COMPONENTES ELETRÔNICOS PARA REDUÇÃO DE KPI EM UMA EMPRESA DE MONTAGEM DE PLACA SMD DO POLO INDUSTRIAL DE MANAUS

At all times, large-scale companies in the world market are more concerned with promoting ways and spending more resources that favor their gains in reducing expenses and reducing indicators that contribute to their final profitability. Therefore, the theme of reverse logistics is increasingly relevant within the scenarios of global companies, given the growing statistics of the common denominator, the waste of raw materials. Among the most expressive are the electronics sector, as its productive material, in addition to being expensive, sets a precedent for the debate on another topic, which would be electronic waste, it mixes with the concept of reverse logistics in the sense of a set of actions which involve a system of reutilization, reuse or recycling of waste treatment produced by the disposal of postconsumer products. Therefore, this present research dealt with a case study scenario, within a company in this sector that proposed to conceptualize reverse logistics through a specific internal project to reduce its numbers with material loss. The case, in addition to being an overwhelming result, demonstrated that the expectations generated by the company can be a reference factor for other projects.