Common Components Research Articles

Diverse mechanisms control amino acid-dependent environmental alkalization by Candida albicans.

Candida albicans has the capacity to neutralize acidic growth environments by releasing ammonia derived from the catabolism of amino acids. The molecular components underlying alkalization and its physiological significance remain poorly understood. Here, we present an integrative model with the cytosolic NAD+-dependent glutamate dehydrogenase (Gdh2) as the principal ammonia-generating component. We show that alkalization is dependent on the SPS-sensor-regulated transcription factor STP2 and the proline-responsive activator Put3. These factors function in parallel to derepress GDH2 and the two proline catabolic enzymes PUT1 and PUT2. Consistently, a double mutant lacking STP2 and PUT3 exhibits a severe alkalization defect that nearly phenocopies that of a gdh2-/- strain. Alkalization is dependent on mitochondrial activity and in wild-type cells occurs as long as the conditions permit respiratory growth. Strikingly, Gdh2 levels decrease and cells transiently extrude glutamate as the environment becomes more alkaline. Together, these processes constitute a rudimentary regulatory system that counters and limits the negative effects associated with ammonia generation. These findings align with Gdh2 being dispensable for virulence, and based on a whole human blood virulence assay, the same is true for C. glabrata and C. auris. Using a transwell co-culture system, we observed that the growth and proliferation of Lactobacillus crispatus, a common component of the acidic vaginal microenvironment and a potent antagonist of C. albicans, is unaffected by fungal-induced alkalization. Consequently, although Candida spp. can alkalinize their growth environments, other fungal-associated processes are more critical in promoting dysbiosis and virulent fungal growth.

Fall risk prediction ability in rehabilitation professionals: structural equation modeling using time pressure test data for Kiken-Yochi Training.

Falls occur frequently during rehabilitation for people with disabilities. Fall risk prediction ability (FRPA) is necessary to prevent falls and provide safe, high-quality programs. In Japan, Kiken Yochi Training (KYT) has been introduced to provide training to improve this ability. Time Pressure-KYT (TP-KYT) is an FRPA measurement specific to fall risks faced by rehabilitation professionals. However, it is unclear which FRPA factors are measured by the TP-KYT; as this score reflects clinical experience, a model can be hypothesized where differences between rehabilitation professionals (licensed) and students (not licensed) can be measured by this tool. To identify the FRPA factors included in the TP-KYT and verify the FRPA factor model based the participants' license status. A total of 402 participants, with 184 rehabilitation professionals (physical and occupational therapists) working in 12 medical facilities and three nursing homes, and 218 rehabilitation students (physical and occupational therapy students) from two schools participated in this study. Participant characteristics (age, gender, job role, and years of experience and education) and TP-KYT scores were collected. The 24 TP-KYT items were qualitatively analyzed using an inductive approach based on content, and FRPA factors were extracted. Next, the correction score (acquisition score/full score: 0-1) was calculated for each extracted factor, and an observation variable for the job role (rehabilitation professional = 1, rehabilitation student = 0) was set. To verify the FRPA factors associated with having or not having a rehabilitation professional license, FRPA as a latent variable and the correction score of factors as an observed variable were set, and structural equation modeling was performed by drawing a path from the job role to FRPA. The results of the qualitative analysis aggregated patient ability (PA), physical environment (PE), and human environment (HE) as factors. The standardized coefficients of the model for participants with or without a rehabilitation professional license and FRPA were 0.85 (p<0.001) for FRPA from job role, 0.58 for PA, 0.64 for PE, and 0.46 for HE from FRPA to each factor (p<0.001). The model showed a good fit, with root mean square error of approximation < 0.001, goodness of fit index (GFI) = 0.998, and adjusted GFI = 0.990. Of the three factors, PA and PE were common components of clinical practice guidelines for fall risk assessment, while HE was a distinctive component. The model's goodness of fit, which comprised three FRPA factors based on whether participants did or did not have rehabilitation professional licenses, was good. The system suggested that rehabilitation professionals had a higher FRPA than students, comprising three factors. To provide safe and high-quality rehabilitation for patients, professional training to increase FRPA should incorporate the three factors into program content.

Amine-Based MOF for Precious Metal Remediation.

Due to the continuous growth rate of the electronic industry, hi-tech companies depend on mining and extracting precious metals to meet the public demand. The high turnover of modern devices generates an alarming amount of electronic waste (e-waste), which contains more precious metals than mined ores and therefore needs efficient recovery procedures. A highly stable homopiperazine-derived Cd-MOF, poly-[Cd(H2L)]·9H2O, with a protonated amine ligand core, exists as a twofold interpenetrated 3D framework with 1D channels into which the N+-H bond is directed. The geometry of these channels appears to be suitable to host square planar metalate complexes. Under acidic conditions, [MCl4]x- anions containing Au, Cu, Ni, and Pt, representing common components of e-waste under extraction conditions, were tested for capture and recovery. Cd-MOF exhibits remarkable selectivity and uptake performance toward Au with an adsorbent capacity of 25 mg g-1ads and shows a marked selectivity for Au over Cu in competitive experiments. The adsorption mechanism of Au appears to be predominantly physical adsorption at the surface of the material.

Evaluating the effectiveness of artifact correction and rejection in event-related potential research.

Eyeblinks and other large artifacts can create two major problems in event-related potential (ERP) research, namely confounds and increased noise. Here, we developed a method for assessing the effectiveness of artifact correction and rejection methods in minimizing these two problems. We then used this method to assess a common artifact minimization approach, in which independent component analysis (ICA) is used to correct ocular artifacts, and artifact rejection is used to reject trials with extreme values resulting from other sources (e.g., movement artifacts). This approach was applied to data from five common ERP components (P3b, N400, N170, mismatch negativity, and error-related negativity). Four common scoring methods (mean amplitude, peak amplitude, peak latency, and 50% area latency) were examined for each component. We found that eyeblinks differed systematically across experimental conditions for several of the components. We also found that artifact correction was reasonably effective at minimizing these confounds, although it did not usually eliminate them completely. In addition, we found that the rejection of trials with extreme voltage values was effective at reducing noise, with the benefits of eliminating these trials outweighing the reduced number of trials available for averaging. For researchers who are analyzing similar ERP components and participant populations, this combination of artifact correction and rejection approaches should minimize artifact-related confounds and lead to improved data quality. Researchers who are analyzing other components or participant populations can use the method developed in this study to determine which artifact minimization approaches are effective in their data.

Comparative component analysis of registered Thai Ayuravej antidiarrheal regimen, yaleungpidsamuttara to classical Indian Ayurveda regimen

ABSTRACT Objective: Classical Indian Ayurveda is a very important traditional medicine system that is the rooted concept for several traditional medicine systems including Thai traditional medicine, Ayuravej. At present, there are many registered modern Ayuravej regimen products in the national drug list of Thailand including Yaleungpidsamuttara, which is an antidiarrheal regimen. Materials and Methods: The work is a clinical informatics analysis making use of data searching and systematic comparison. In this article, the authors analyze the registered components of the Yaleungpidsamuttara and compare them to the data on the classical Indian Ayurveda regimen. Results: Comparing to the classical Indian Ayurveda, there is no exact Indian Ayurveda with the same components. However, there are some antidiarrheal Indian Ayurveda regimens that have some common components. Conclusion: The studied Thai Ayuravej product has its rooted concept from classical Indian Ayurveda and the antidiarrheal activity is also confirmed by modern clinical evidence.

Assessment of Family Medicine Obstetrics Fellowship Websites in the United States: Content and Usability.

The United States is experiencing maternity care shortages. Family physicians can play a role in addressing these shortages. Family medicine obstetrics fellowships train family physicians in obstetrics care. Fellowship websites are important for promoting programs and attracting applicants. However, whether websites provide sufficient program information is unknown. This study aimed to assess completeness and utility of family medicine obstetrics fellowship websites across the United States. The study analyzed 46 family medicine obstetrics fellowship websites. The component analysis evaluated the presence of 17 components related to orientation, curriculum, program, personnel, and additional content. The qualitative analysis included ratings for navigation and application, information quality, and esthetics. Analysis included percentages for websites and components and average qualitative ratings. Common components included overviews, training requirements, and contact information. Description of the patient population was the least common component. Usability ratings varied across programs, with higher ratings observed for navigation and application, and information quality. Esthetics and visual appeal received lower ratings. Regional analysis indicated that websites from fellowships in the West and Southwest tended to include more components compared to those in the Southeast. Family medicine obstetrics fellowship websites serve as valuable sources of program information for prospective applicants. However, not all websites include essential program details. Some information is rarely provided. Given the shortage of maternity care providers, it is crucial to develop informative and functional websites to attract applicants. Improving website content and design could prove to be a cost-effective strategy to increase the number of applicants.

Choice of Cost Reduction Mode in a Contract Manufacturing Supply Chain with Substitutable Products

Cost reduction investment is relevant for manufacturers to achieve competitive advantage. This article investigates the choice of cost reduction mode in a supply chain with one original brand manufacturer (OBM) whose product incurs common and dedicated costs and one contract manufacturer (CM) offering substitutable products. The CM sharing OBM's investment spillover may be worse off with strong spillover. A costly common component may not lead the OBM to reduce common cost, especially when its investment substantially spills over to the CM. This spillover causes intense competition so that the OBM reduces dedicated cost; this choice also applies to a costly dedicated component. The OBM is incentivized to reduce common cost if the common component is costly and the spillover is weak. This article further analyzes the case that the CM invests in cost reduction and finds its mode choice opposite to the OBM's because of the direct benefits of cost reduction. Even with a costly dedicated component and strong spillover, the CM does not necessarily reduce dedicated cost but it reduces common cost. The OBM's and CM's investments may create a win–win mode.

Electron transfer reaction of TEMPO-based organic radical batteries in different solvent environments: comparing quantum and classical approaches.

In this study, we delve into the complex electron transfer reactions associated with the redox-active (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), a common component in organic radical batteries (ORBs). Our approach estimates quantum electron-transfer (ET) energies using Density Functional Theory (DFT) calculations by sampling from structures simulated classically. This work presents a comparative study of reorganization energies in ET reactions across different solvents. Furthermore, we investigate how changes in the electrolyte environment can modify the reorganization energy and, consequently, impact ET dynamics. We also explore the relationship between classical and quantum vertical energies using linear regression models. Importantly, this comparison between quantum and classical vertical energies underscores the role of quantum effects, like charge delocalization, in offering added stabilization post-redox reactions. These effects are not adequately represented by the classical vertical energy distribution. Our study shows that, although we find a significant correlation between the vertical energies computed by DFT and the classical force field, the regression parameters depend on the solvent, highlighting that classical methods should be benchmarked by DFT before applying them to novel electrolyte materials.

Chemometrics-driven monitoring of cheese ripening: a multimodal spectroscopic and scanning electron microscopy investigation.

The integration of spectroscopic techniques with chemometrics offers a means to monitor quality changes in dairy products throughout processing and storage. This study employed Attenuated Total Reflectance-Mid-Infrared Spectroscopy (ATR-MIR) coupled with Independent Components Analysis (ICA), and 3D Front-Face Fluorescence Spectroscopy (FFFS) paired with Common Components and Specific Weight Analysis (CCSWA). The research focused on Cheddar cheeses aged for 1, 2, 3, and 5 years, alongside Comté cheeses aged for 6, 9, and 12 months. The adopted approach offered valuable insights into the intricate cheese aging process within the food matrix. The ICA proportions and CCSWA scores highlighted the significant impact of biochemical transformations during maturation on the aging process. The extracted independent components (ICs) revealed variations in the vibration modes of amides, lipids, amino acids, and organic acids, facilitating the distinction between different cheese age categories. Additionally, CCSWA outcomes identified age-related differences through shifts in tryptophan fluorescence characteristics as the cheeses aged. These results were consistent with the observed alterations in the microstructure of cheese samples over time, corroborated by Scanning Electron Microscopy (SEM) imagery. The introduced multimodal methodology serves as a significant asset for determining the ripening stage of various types of cheese, offering a detailed perspective of cheese maturation beneficial to the dairy industry and researchers.

Enhancing lithium-ion battery safety: Investigating the flame-retardant efficacy of bis(2,2,2-trifluoroethyl) carbonate during ethyl methyl carbonate combustion

Bis(2,2,2-trifluoroethyl) carbonate (BtFEC) is a candidate fire suppressant for lithium-ion batteries (LIBs). The high flammability of the electrolyte is the reason behind the frequent fire incidents reported with LIBs. These incidents are due to various factors, such as a default in the conception of the battery or operational abuse. The flame-retardant effectiveness of BtFEC was investigated by measuring its effect on the oxidation of ethyl methyl carbonate (EMC), a common LIB electrolyte component. Laminar flame speed (LFS) measurements for EMC-BtFEC in air mixtures were carried out at 403 K, 1 atm, for equivalence ratios (ϕ) between 0.8 and 1.4, and with 0.5 % vol. BtFEC. Additional measurements were made at ϕ = 1.1 with BtFEC addition ranging from 0.1 up to 1.4 % vol. To further understand the combustion chemistry of the EMC-BtFEC system, ignition delay times (time at the maximum peak production of the excited radical OH*) and CO time histories were measured in a shock tube with temperatures ranging from 1217 to 1732 K, at near-atmospheric pressure (1.24–1.42 atm), and for three equivalence ratios (ϕ = 0.5, 1.0, and 2.0). These new results constitute an experimental database that was used to evaluate the performance of a model assembled for both BtFEC and EMC using previous work from our group. The updated, detailed chemical kinetics mechanism presented in this study consists of 237 species and 1630 reactions. Sensitivity, rate-of-production, and reaction pathway analyses permitted the oxidation of the BtFEC-EMC system to be described. A flame sensitivity analysis exhibited the significant effect from the reactions H + CF2O ⇆ HF + CFO and CF3 + H ⇆ CF2 + HF, which consume H radicals that are involved in the branching reaction H + O2⇆ OH + O, ultimately reducing the LFS. This study shows that improvements in the base fluorine chemistry are still necessary to obtain better agreement with the experiments, especially at the speciation level.

The cellular protrusions for inter-cellular material transfer: similarities between filopodia, cytonemes, tunneling nanotubes, viruses, and extracellular vesicles.

Extracellular vesicles (EVs) are crucial for transferring bioactive materials between cells and play vital roles in both health and diseases. Cellular protrusions, including filopodia and microvilli, are generated by the bending of the plasma membrane and are considered to be rigid structures facilitating various cellular functions, such as cell migration, adhesion, and environment sensing. Compelling evidence suggests that these protrusions are dynamic and flexible structures that can serve as sources of a new class of EVs, highlighting the unique role they play in intercellular material transfer. Cytonemes are specialized filopodia protrusions that make direct contact with neighboring cells, mediating the transfer of bioactive materials between cells through their tips. In some cases, these tips fuse with the plasma membrane of neighboring cells, creating tunneling nanotubes that directly connect the cytosols of the adjacent cells. Additionally, virus particles can be released from infected cells through small bud-like of plasma membrane protrusions. These different types of protrusions, which can transfer bioactive materials, share common protein components, including I-BAR domain-containing proteins, actin cytoskeleton, and their regulatory proteins. The dynamic and flexible nature of these protrusions highlights their importance in cellular communication and material transfer within the body, including development, cancer progression, and other diseases.

Capsaicin: a spicy way in liver disease.

The incidence of liver disease continues to rise, encompassing a spectrum from simple steatosis or non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH), cirrhosis and liver cancer. Dietary habits in individuals with liver disease may significantly impact the treatment and prevention of these conditions. This article examines the role of chili peppers, a common dietary component, in this context, focusing on capsaicin, the active ingredient in chili peppers. Capsaicin is an agonist of the transient receptor potential vanilloid subfamily 1 (TRPV1) and has been shown to exert protective effects on liver diseases, including liver injury, NAFLD, liver fibrosis and liver cancer. These protective effects are attributed to capsaicin's anti-oxidant, anti-inflammatory, anti-steatosis and anti-fibrosis effects. This article reviewed the different molecular mechanisms of the protective effect of capsaicin on liver diseases.

Evaluation of Nanomedicine Tissue Distribution and Stability by Alexa Fluor 488 and PEG Immunohistochemistry.

A primary issue with nanomedicine biological evaluation is determination of nanoparticle carrier tissue distribution and stability. Here we present a method to evaluate nanomedicine distribution in tissues that is applicable to most nanomedicine constructs. This method utilizes immunohistochemical (IHC) analysis of an Alexa Fluor 488-tag and/or polyethylene glycol (PEG), a very common nanomedicine component, for tissue localization. Using specific Alexa Fluor 488- and/or PEG antibody-based IHC staining procedures allows evaluation of high-resolution nanoparticle tissue distribution, nanoparticle tissue stability, and also allows correlation of distribution with morphological changes. This protocol outlines the methods to follow to ensure proper tissue collection and optimized immunohistochemical staining of Alexa Fluor 488-tag and PEG in tissues.

WonderFlow: Narration-Centric Design of Animated Data Videos.

Creating an animated data video with audio narration is a time-consuming and complex task that requires expertise. It involves designing complex animations, turning written scripts into audio narrations, and synchronizing visual changes with the narrations. This paper presents WonderFlow, an interactive authoring tool, that facilitates narration-centric design of animated data videos. WonderFlow allows authors to easily specify semantic links between text and the corresponding chart elements. Then it automatically generates audio narration by leveraging text-to-speech techniques and aligns the narration with an animation. WonderFlow provides a structure-aware animation library designed to ease chart animation creation, enabling authors to apply pre-designed animation effects to common visualization components. Additionally, authors can preview and refine their data videos within the same system, without having to switch between different creation tools. A series of evaluation results confirmed that WonderFlow is easy to use and simplifies the creation of data videos with narration-animation interplay.

CALCULATING THE NATURAL FREQUENCY OF PRE-TWISTED BEAM

Beams in two configurations; uniform and non-uniform, are common structural components utilized for several engineering applications. Thus, the studies dealing with their behavior under dynamic and vibrations have been increased. In this research, the transverse vibration phenomena of pre-twisted beams were experimentally and theoretically studied by investigating the effect of twisting angles on the first three transverse natural frequencies. In the present experimental part, the pre-twisted beams are manufactured using a 3D printer, and the fundamental frequencies of manufactured pre-twisted beams are measured by a suitable rig. In the theoretical work, the finite element method is used to simulate the transverse vibration behavior of the pre-twisted beams. The accuracy of the simulation process is checked by comparison of the first natural frequencies calculated by the finite element method (using ANSYS Workbench Software) with those measured experimentally. The results show that there is an excellent agreement between the experimental results and finite element outputs. For the clamped-free pre-twisted beam, there is no critical twisting angle. The critical twisting angle is equal to the mode number for simply – simply and clamped simple pre-twisted beam. While there is more than one value of critical twisting angle for the clamped-clamped pre-twisted beam.

Development of psycho-oncology telehealth guidelines: a modified Delphi consensus study

Abstract Objective: In response to COVID-19, psycho-oncology clinicians moved to a model of telephone and videoconference treatment in Australia. The Psycho-oncology Co-operative Research Group (PoCoG) identified a paucity of evidence available to guide adaptation of therapy for remote delivery. This research aimed to develop consensus for evidence-based guidelines on ways to adapt psychological therapies in psycho-oncology for remote delivery. Methods: A national expert advisory group (N = 11) was convened consisting of psycho-oncology clinicians and clinical researchers. An iterative codesign methodology was used to draft psycho-oncology telehealth guidelines. Australian psycho-oncology clinicians participated in a Delphi consensus process to guide the content included in the guidelines. Content was presented under six domains: (i) screening and outcome measures, (ii) formulation, (iii) safety considerations, (iv) resource adaptation, (v) adaptations to therapy, and (vi) example case studies. Participants rated items based on importance, therapeutic appropriateness, and/or usefulness. Consensus was defined as &gt;80% agreement. Results: Thirty-two psycho-oncology clinicians with telehealth experience participated in three Delphi rounds. Agreement was reached on (i) the importance of including screening and outcome measures (90%) and items (n = 5) related to how best to facilitate this; (ii) the importance of addressing provision of a formulation (100%), although only 2/6 strategies presented to facilitate formulation reached consensus; (iii) the appropriateness of proposed risk assessment and management strategies (84%); (iv) therapeutic appropriateness of simplifying resources (100%), including 3/5 visual optimization strategies; and (v) common behavioral components of therapy (n=5). Conclusions: Providing guidance to psycho-oncology clinicians for integrating telehealth into routine clinical practice must go beyond logistical considerations. These consensus-based guidelines provide support to clinicians for adaptation of psycho-oncology therapy to telehealth and will ensure evidence-based practice.

Using finite element modeling to predict stress concentration factors in tubular T, Y and K joints

Tubular offshore structures are commonly assembled using welded joints, creating areas of stress concentration and potential fatigue failure. This study focuses on tubular T, Y and K joints, a common offshore structural component. Finite element modeling is used to predict stress concentration factors (Kt) for various loading conditions on the T, Y and K joints. The goal is to calculate Kt values and compare them to existing theoretical solutions from literature. Additionally, the influence of different loading modes (tension, bending) on the Kt values is investigated. By using advanced modeling techniques, this work aims to provide new insight into the behavior of tubular T, Y and K joints connections under realistic offshore loading conditions. The results can help improve design standards and fatigue life predictions for these critical structural joints.

REVIEW AND OPPONENT`S REVIEW IN THE SYSTEM OF SCIENTIFIC AND LITERARY-CRITICAL GENRES (part 2)

The article analyzes the views of contemporary researchers on the essence of the concepts “criticism”, “literary criticism” and “art criticism”. It is noted that these concepts should be considered synonymous, since they all indicate the ability to analyze and evaluate artistic works. The authors of this research offer their own interpretation of the term “literary and artistic criticism”, which is understood as a scientific or professional interpretation of an artistic (literary) work in the context of ideological and aesthetic guidelines of the time, socio-political factors and professional skills of the interpreter. It was determined that in the contemporary literary and critical discourse, a review is understood as one of the most widespread genres in this field, the purpose of which is the analysis and evaluation of an artistic, artistic, journalistic, scientific work in the context of historical, social and political realities, as well as consideration of the corpus violated in the work problems. It was determined that the similarity of literary and critical review and opponent’s review is caused by common structural components, a common goal, the influence of the ideological and aesthetic paradigm of a certain period (the tendency to dominate modification forms in our time) and the desire to respond to the requests of the contemporary audience.

The technical innovation of integrating the gold mesh sampling method into FTIR spectroscopy, along with its application in the domain of transportation-related pollution studies, signifies a noteworthy advancement in analytical capabilities

Recently, Fourier transform infrared micro-spectroscopy (FTIR) has played a crucial role in the study of heterogeneous reactions in atmospheric chemistry. This includes research on aerosol hygroscopicity, nucleation kinetics, chemical composition analysis of aerosols, and heterogeneous chemical reactions on aerosol particle surfaces. This paper presents a novel approach that introduces a gold mesh during the sampling process, enabling the true spectrum of liquid water to be measured in transmission mode, thereby addressing spectral distortion issues at 3400 cm-1. Additionally, common inorganic components of atmospheric pollution were measured, providing a feasible method for using FTIR spectroscopy to address atmospheric pollution issues. Finally, the introduction of the gold mesh sampling method was employed to measure the heterogeneous chemical kinetics of road dust surface during traffic pollution processes, offering a viable solution for using FTIR spectroscopy to address atmospheric pollution concerns.

Suicide Attempt by Hanging - A Study on Patients Admitted in Tertiary Care Hospital in Eastern India.

Suicide is defined as a fatal self-injurious act with some evidence of intent to die. Despite the evolution of sophisticated methods to commit suicide, hanging remains one of the commonest methods to commit suicide across the world. To evaluate the individuals using hanging as a method of suicide and identify the contributing factors for this behaviour. The study was carried out in a tertiary care hospital, over a period of 1 year on the suicide attempters using the method of hanging. Semi-structured in-depth interviews were conducted with all the 46 attempters. The questions focused on the precipitating events present before the attempt. After the in interview the risk factors of the conversations were identified, tabulated and categorized using descriptive analysis. Findings from descriptive analysis reveals that significant age group using this method was below 19 years followed by 20-29 age group, female attempters were more compared to male. Psychiatric diagnosis was present in 8 attempters and 4 attempters had alcohol/substance dependence. The most common personality component in attempters was impulsivity. The most common immediate stressor found were financial stress, conflict with family, spouse, humiliation, substance abuse, exam stress and domestic violence. This study demonstrates that the reasons for suicide attempt by hanging is multifactorial. which includes, psychiatric diagnosis, personality factors, immediate stressors, ease of use, and accessibility, Overall, our study adds to understanding the intricates of this method and will help in developing effective suicide prevention strategies.