BackgroundAncient grains with ethnic food origins are gaining renewed interest in contemporary food design due to its balanced nutritional profiles and health benefits. The “North Dakota Common Emmer Wheat” (Triticum dicoccum), a tetraploid species, had ethnic origins with German immigrants from Russia migrating to North Dakota in late 19th century. Targeting such grains with ethnic origins that are rich in fibers, amino acids, minerals, and other bioactive compounds has significant merit for advancing health benefits against emerging diet-linked chronic diseases. Based on this rationale, phenolic-linked antioxidant and antihyperglycemic properties of North Dakota Common Emmer Wheat was compared with those of other commercial wheat cultivars in order to integrate it into a health-targeted food design based on past ethnic food insights. MethodsAqueous extracts of the North Dakota Common Emmer Wheat (with and without hull) and two other commercial wheat varieties, Barlow and Coteau, were analyzed before and after milling. The total soluble phenolic content, phenolic acid profile, protein content, antioxidant activity, type 2 diabetes relevant α-amylase, and α-glucosidase enzyme inhibitory activities were determined using in vitro assay models. ResultsNorth Dakota Common Emmer Wheat with hull had highest total soluble phenolic content and associated antioxidant and antihyperglycemic properties (before and after milling) when compared to the other commercial wheat cultivars. ConclusionResults indicated that North Dakota Common Emmer Wheat with hull can be integrated into a health-targeted contemporary food design as a part of dietary support against chronic hyperglycemia and oxidative stress associated with early stages type 2 diabetes.