In the present work, a numerical model was developed to analyze a commercial diesel engine. The adequacy of this model was validated using experimental results. This model was employed to study several pre-injection strategies. Particularly, the pre-injection rate, duration and starting instant were analyzed in the ranges 5% to 25%, 1° to 5° and −22° to −18°, respectively. The effect on consumption and emissions of NOx, CO, and HC wereas evaluated. Since some of these configurations have opposite effects on consumption and/or emissions, it is necessary to develop a formal tool to characterize the most appropriate injection pattern. To this end, a multiple-criteria decision making approach was employed. It was found that the injection duration must remain as low as possible due to significant reductions in NOx. The most appropriate injection pattern resulted 1° pre-injection duration, 20% pre-injection rate, and −19° pre-injection starting instant. This configuration leads to increments of 6.7% in consumption, 3.47% in CO, and 3.83% in HC but reduces NOx by 34.67% in comparison with the case without pre-injection.