This study focuses on the three-dimensional flow and combustion characteristics of a cavitied scramjet engine with multi-position injection. A single-equation large eddy simulation (LES) turbulence model is employed, with a detailed reaction mechanism for hydrogen combustion, as described by Jachimowski. The combustion characteristics of hydrogen in the scramjet combustion chamber are analyzed. Based on the combustion chamber model, the influence of different equivalence ratios, injection timing, injection positions, and injection pressures on the flame formation and propagation process are compared. The results indicate that within a certain range, an increase in the equivalence ratio enhances the combustion intensity and chamber pressure. In the case of multi-position injection, the order of injection from different nozzles has little effect on the final flame stabilization mode and pressure distribution. The opposite-side distribution of nozzles can effectively improve the fuel efficiency and the internal pressure. Furthermore, when the nozzles are closely placed in the opposite-side distribution, the combustion efficiency increases, although this leads to a higher total pressure loss. In scenarios where the fuel injection duration is short, an increase in the injection pressure at the upstream nozzles of the cavity results in a higher local equivalence ratio, as well as reduced fuel mixing and ignition time.