Interaction of lateral loading, combined with axial force needs to be determined with care in reinforced concrete (RC) one-dimensional structural members (1D SMs) such as beam-columns (BCs) and columns. RC 1D SMs under heavy axial loading are known to fail by brittle mode and small lateral displacements. In this paper, a macro element-based algorithm is proposed to analyze the RC 1D SMs under monotonic or cyclic combined loading. The 1D SMs are discretized into macro-elements (MEs) located between the critical sections and the inflection points. The critical sections are discretized into fixed rectangular finite elements (FRFE). The nonlinear behavior of confined and unconfined concretes and steel elements are considered in the proposed algorithm. The proposed algorithm has been validated by the results of experimental tests carried out on full-scale RC structural members. The evolution of ultimate strain at extreme compression fiber of a rectangular RC section for different orientations of lateral loading shows that the ultimate strain decreases with increasing the axial force. In the examined cases, this ultimate strain ranges from 0.0024 to 0.0038. Therefore, the 0.003 value given by ACI-318 code for ultimate strain, is not conservative and valid for the combined load cases with significant values of axial force (i.e. for the axial forces heavier than 70% of the ultimate axial force).