Perforated steel members (PSMs) are now frequently used in building construction due to their beneficial features, including their proven blast-resistance abilities. To safeguard against structural failures from explosions and terrorist threats, perforated steel beams (PSBs) and perforated steel columns (PSCs) offer a viable alternative to traditional steel members. This is attributed to their impressive energy absorption potential, a result of their combined high strength and ductile behavior. In this study, numerical examinations of damage assessment under the combined effects of gravity and blast loads are carried out to mimic real-world scenarios of external explosions close to steel structures. The damage assessment for PSBs and PSCs considers not just the initial deformation from the blast, but also takes into account the residual capacities to formulate dependable damage metrics post-explosion. Comprehensive explicit finite element (FE) analyses are performed with the LSDYNA software. The FE model, when compared against test results, aligns well across all resistance phases, from bending and softening to tension membrane regions. This validated numerical model offers a viable alternative to laboratory experiments for predicting the dynamic resistance of PSBs and PSCs. Moreover, it is advisable to use fully integrated solid elements, featuring eight integration points on the element surface, in the FE models for accurate predictions of PSBs’ and PSCs’ behavior under blast loading. A parametric study is presented to investigate the effect of web-opening shapes, retrofitting, and different blast scenarios. The results obtained from the analytical FE approaches are used to obtain the ductile responses of PSMs, and are considered an important key in comparisons among the studied cases.