Combined Effects Of Exercise Research Articles

Combined effects of exercise and nutritional interventions on sarcopenia and its associated quality of life in transfusion-dependent thalassemia patients: a single-arm, open-label study

Combined effects of exercise and nutritional interventions on sarcopenia and its associated quality of life in transfusion-dependent thalassemia patients: a single-arm, open-label study

Effect of Combined Exercise and Nutrition Interventions During Inpatient Chemotherapy in Acute Leukemia and Malignant Lymphoma Patients: A Randomized Controlled Trial

The aim of the present study was to determine the effectiveness of combined exercise and nutrition interventions on physical function and quality of life (QOL) in patients with acute leukemia or malignant lymphoma (ML) during inpatient chemotherapy. The study was a randomized controlled trial where patients with acute leukemia or ML who were receiving inpatient chemotherapy and exercise therapy were divided into an intervention group (IG) and a control group (CG). Both groups underwent resistance training and aerobic exercise. The patients in the IG were instructed to take nutritional supplements twice a day. Assessment items were muscle strength (handgrip strength and knee extension strength), 6-min walking test, skeletal muscle mass, QOL, nutritional status, and fatigue. Two-way analysis of variance showed a significant interaction for bilateral handgrip strength and knee extension strength. No significant interactions were found for the other items. The results of the present study showed improved muscle strength in the IG compared to the CG, indicating the effectiveness of combined exercise and nutrition interventions during inpatient chemotherapy in patients with acute leukemia or ML.

Impact of a Mediterranean-Inspired Diet on Cardiovascular Disease Risk Factors: A Randomized Clinical Trial.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. This study focused on evaluating the impact of a Mediterranean-type diet combined with physical exercise on CVD risk factors of high-risk individuals. A randomized clinical trial (RCT) recruited individuals (≥50 years old) with no history of acute myocardial infarction, but with high CVD risk criteria according to the SCORE2/SCORE2 OP. Anthropometric and biochemical parameters were assessed at baseline and after 12 weeks of diet and exercise intervention. Participants were randomly assigned into 3 groups: no intervention group (Group 1a), physical exercise group (Group 1b), and physical exercise (±2 h/week) plus diet group (Group 2). Briefly, the dietary intervention was based on the principles of an isocaloric Mediterranean diet (MD), with seven main meals/week centered on plant-based foods (legumes and pulses). The combined effect of exercise and the diet showed significant decrease in WC (p = 0.002), BST (p < 0.001), visceral fat (p < 0.001), and TG (p = 0.029), compared with control groups. The intervention significantly increased legume intake (p < 0.001), as well as adherence to the MD, which associates with WC decrease (p = 0.024) and visceral fat (p = 0.017). A combined intervention of exercise and diet should be endorsed as an efficient modifier of cardiometabolic parameters.

Exercise-Mediated Protection against Air Pollution-Induced Immune Damage: Mechanisms, Challenges, and Future Directions.

Air pollution, a serious risk factor for human health, can lead to immune damage and various diseases. Long-term exposure to air pollutants can trigger oxidative stress and inflammatory responses (the main sources of immune impairment) in the body. Exercise has been shown to modulate anti-inflammatory and antioxidant statuses, enhance immune cell activity, as well as protect against immune damage caused by air pollution. However, the underlying mechanisms involved in the protective effects of exercise on pollutant-induced damage and the safe threshold for exercise in polluted environments remain elusive. In contrast to the extensive research on the pathogenesis of air pollution and the preventive role of exercise in enhancing fitness, investigations into exercise resistance to injury caused by air pollution are still in their infancy. In this review, we analyze evidence from humans, animals, and cell experiments on the combined effects of exercise and air pollution on immune health outcomes, with an emphasis on oxidative stress, inflammatory responses, and immune cells. We also propose possible mechanisms and directions for future research on exercise resistance to pollutant-induced damage in the body. Furthermore, we suggest strengthening epidemiological studies at different population levels and investigations on immune cells to guide how to determine the safety thresholds for exercise in polluted environments.

Comparing the Effect of Eight Weeks of Aerobic and Combined Exercise on Some Hemorheological Indicators in Middle-Aged Male Patients Undergoing Coronary Artery Bypass Graft Surgery

Background: Hemorhological disorders are one of the primary causes of cardiovascular diseases. Accordingly, aerobic and combined exercises can improve hemorhological indicators and reduce cardiovascular complications in high-risk people. Objectives: This study aimed to compare the effects of eight weeks of aerobic and combined exercise on some hemorheological indicators in middle-aged male patients undergoing Coronary Artery Bypass Graft Surgery. Methods: This experimental study was conducted in 2023 on 30 middle-aged men (Age, 57.63 ± 6.38, BMI, 26.61 ± 3.60) undergoing Coronary Artery Bypass Graft Surgery in Kermanshah, Iran, who were divided into aerobic (10 people), combined (10 people), and control (10 people) groups. The intervention groups received selected exercises for eight weeks (24 sessions). Serum hemoglobin, hematocrit, fibrinogen, and erythrocyte sedimentation rate (ESR) were measured before and after the intervention. The parametric paired sample t-test and one-way ANOVA test were used to examine differences at a significance level of P ≤ 0.05. Results: The effect of combined exercises on hemoglobin and hematocrit was significant (P ≤ 0.05), but the amount of reduction in the aerobic group was not significant (P &gt; 0.05). Findings in the fibrinogen and ESR variables showed a significant decrease in both aerobic and combined groups (P ≤ 0.05). There was no significant difference between the effect of eight weeks of aerobic and combined training on the variables of hemoglobin, hematocrit, fibrinogen, and ESR (P &gt; 0.05). Conclusions: Based on the results, aerobic and combined exercises effectively improved the hemorheological indicators and overall conditions of patients who underwent Coronary Artery Bypass Graft Surgery. Therefore, these exercises should be included in the cardiac rehabilitation program as an effective treatment method.

Effects of combined exercises on shoulder mobility and strength of the upper extremities in breast cancer rehabilitation: a 3-week randomized controlled trial

PurposeThe aim of this study was to analyze the effects of mobility training with FIVE® devices in combination with device-supported strength exercises for shoulder mobility and strength of the upper extremities in women with breast cancer.MethodsWe conducted a pretest-posttest intervention study with female breast cancer patients (n = 41) who were randomly assigned to two groups by lot during their stationary follow-up treatment at a rehabilitation clinic in the south of Germany between February and March 2020. As part of exercise therapy, the intervention group (n = 24) performed a mobility training with FIVE® devices combined with device-supported strength training, whereas the control group (n = 17) completed device-supported strength training. Before and after the 3-week intervention (3 training sessions/week), shoulder mobility and isokinetic maximal strength were tested.ResultsBoth groups achieved significant improvements in shoulder mobility in the frontal and sagittal plane (between 3.8 and 15.35%; p < 0.05) and in strength performance (31.36% [IG] vs. 51.24% [CG]; p < 0.001). However, no robust evidence could be determined about potential interaction effects.ConclusionA combined device-supported strength and mobility training (FIVE®) showed no advantages. Therefore, a variety of exercise methods is possible in exercise therapy of breast cancer patients.Clinical trial registration numberSince the University of Education Weingarten does not assign clinical trial registration numbers or ethical approval numbers, none could be assigned for this study.

Combined effects of exercise and different levels of acute hypoxic severity: A randomized crossover study on glucose regulation in adults with overweight.

Purpose: The aim of this study was to investigate the influence of manipulating hypoxic severity with low-intensity exercise on glucose regulation in healthy overweight adults. Methods: In a randomized crossover design, 14 males with overweight (age: 27 ± 5years; body mass index (BMI) 27.1 ± 1.8kg⋅m2) completed three exercise trials involving 60min aerobic exercise cycling at 90% lactate threshold in normoxia (NM, FiO2 = 20.9%), moderate hypoxia (MH, FiO2 = 16.5%) and high hypoxia (HH, FiO2 = 14.8%). A post-exercise oral glucose tolerance test (OGTT) was performed. Venous blood samples were analyzed for incremental area under the curve (iAUC), plasma glucose and insulin, as well as exerkine concentrations (plasma apelin and fibroblast growth factor 21 [FGF-21]) pre- and post-exercise. A 24-h continuous glucose monitoring (CGM) was used to determine interstitial glucose concentrations. Heart rate, oxygen saturation (SpO2) and perceptual measures were recorded during exercise. Results: Post-exercise OGTT iAUC for plasma glucose and insulin concentrations were lower in MH vs. control (p = 0.02). Post-exercise interstitial glucose iAUC, plasma apelin and FGF-21 were not different between conditions. Heart rate was higher in HH vs. NM and MH, and MH vs. NM (p < 0.001), while SpO2 was lower in HH vs. NM and MH, and MH vs. NM (p < 0.001). Overall perceived discomfort and leg discomfort were higher in HH vs. NM and MH (p < 0.05), while perceived breathing difficulty was higher in HH vs. NM only (p = 0.003). Conclusion: Compared to higher hypoxic conditions, performing acute aerobic-based exercise under moderate hypoxia provided a more effective stimulus for improving post-exercise glucose regulation while concomitantly preventing excessive physiological and perceptual stress in healthy overweight adults.

Community-based exercise and nutritional interventions to improve frailty syndrome among older adults: A quasi-experimental study

This study aimed to explore the efficacy of single and combined effects of exercise and branched-chain amino acid (BCAA) supplements on improving frailty and quality of life in older adults. In total, 120 study participants were allocated into a combined exercise-and-BCAA supplementation group, an exercise-only group, a BCAA supplementation-only group, and a control group. Results showed that Fried's frailty score significantly decreased in the combined exercise-and-BCAA supplementation group (β= -1.73, p<0.001), exercise-only group (β= -1.68, p<0.001), and BCAA supplementation-only group (β= -0.73, p=0.005) compared to the control group. Moreover, the combination of exercise and BCAA supplements and the exercise-only program produced significant improvements in frailty compared to the BCAA supplement-only group and control group (p<0.05). Exercise should be a critical approach for older adults to improve frailty. Healthcare professionals in geriatric care should incorporate exercise programs as frailty management and prevention for older adults.

Effect of combined exercises with digital communication technology in developing forms of correction and deception for junior specialists in handball

Handball players aged 13–15 years in the Middle Euphrates belonging to the Central Handball Federation were distributed according to the specialised centers in the governorates (Karbala, Babylon, and Qadisiyah), which numbered 90 players. The specialised centers affiliated to Qadisiyah Governorate numbered thirty players, and the number of players of the studied age was twenty-two players. The renewal in the methods of communication and presentation of skills in advance and the possibility of reviewing them during performance and freely left to the learner contributed positively to the development of the combinatorial capabilities and the studied skills; and that the process of blending in the exercises prepared by the researcher between the combinatorial abilities and the studied skills contributed greatly to the development of the combinatorial capabilities and the studied skills; and that accreditation In developing skills for young ages in combination with combinatorial abilities, it is the one that will have a great impact in the future as it depends on a very high level.

Meta-Analysis of Antidepressant Pharmacotherapy in Patients Eligible for Cardiac Rehabilitation: ANTIDEPRESSANT AMBIVALENCE.

Many patients exhibit clinically significant depression upon enrollment in cardiac rehabilitation (CR). Antidepressants are a first-line treatment option for depression, but the effectiveness of antidepressants in patients with heart disease is mixed. The purpose of this meta-analysis was to evaluate the efficacy of antidepressants for depression in patients eligible for CR. A meta-analysis was conducted including randomized controlled trials of antidepressants from January 1990 to September 2021 that compared antidepressants with placebo. Random-effects models were used between group effect sizes (Hedges' g ). A total of 13 trials with predominately White (68% ± 12; n =7) male (70% ± 11) samples averaging 61 ± 5 yr compared antidepressants (1128 participants) with placebo (1079 participants). Antidepressants reduced depressive symptoms ( g = 0.17: 95% CI, 0.08-0.27), but the effect was small. Heterogeneity among study effects was low ( I2 = 6.42) and nonsignificant ( Q = 10.75, P = .46), although patients with heart failure ( gHF = 0.05: 95% CI, -0.09 to 0.18) demonstrated smaller effects compared with patients with other cardiovascular disease conditions (g non-HF = 0.22: 95% CI, 0.11-0.32) ( QB [1] = 3.97; P &lt; .05). No study reported safety concerns associated with antidepressants. The effect size of antidepressant pharmacotherapy in this population is small. No trials reported on the combined effects of exercise and pharmacotherapy. If the patient is not suicidal, CR staff may consider patient preference and refer patients for additional treatment as necessary.

Effect of combined exercises on mental, physical, and dribbling skills in young wheelchair basketball players

Wheelchair basketball is one of the sport that plays a significant role in the rehabilitation of individuals with special needs. Players must have a high degree of speed and focus their attention on different perceptual situations in the field. A total of 10 players were selected as sample from the Paralympics Subcommittee in the Babylon Province. They were randomly divided into experimental and control groups. After conducting the pre-tests, the combined exercises prepared by researchers were applied to the experimental group. These exercises were given to the experimental group in sessions of 30 minutes, three days per week. The control group followed the traditional curriculum. After conducting the post-test, the data were processed using the SPSS. The results indicated that the combined exercises positively contributed to the development of mental, physical, and dribbling skills of the wheelchair basketball players. Therefore, the authors recommend to include these combined physical exercises in the training curricula.

Regular Exercise Training Enhances Spatial Memory and Regulates Glucocorticoid System in Experimental Autoimmune Encephalomyelitis

Background &amp; objective: Exercise has been shown to improve cognitive function in patients with multiple sclerosis (MS). Experimentally, glucocorticoids (GCs) treatment has been observed to improve cognitive deterioration in an autoimmune model for MS, experimental autoimmune encephalomyelitis (EAE). We aimed to determine the combined effect of exercise and 4 mg/kg of dexamethasone (Dex) for 4 weeks on spatial memory in EAE.&#x0D; Materials &amp; Methods: Rats with EAE were subjected to the Morris water maze (MWM) for four days and a prop test for one day. The prop test was repeated on day 40 post-induction (dpi). Rats were randomly assigned to one of four groups (10 rats per group): control EAE without treatment; EAE + dexamethasone, (EAE + Dex); EAE + exercise (EAE + Ex); and EAE+Dex+Ex. Rats receiving dexamethasone were administered 4 mg/kg injections daily for two weeks after EAE induction. Exercise training was initiated on a motorized treadmill 2 weeks before EAE induction and continued until 14 dpi. On day 41, animals were dissected and CORT level was assessed by enzyme-linked immunosorbent assay corticosterone kit.&#x0D; Results: One-way analysis of variance (ANOVA) with repeated measures followed by a protected LSD post hoc test indicated that, EAE+Ex group increased body weight (P &lt; 0.001) and it displayed a significantly lower CORT concentration (P &lt;0.001) with delayed clinical score until day 13 dpi. Further EAE+Ex improved memory by time spent (p &gt; 0.001) and swimming speed (p&gt;0.002).&#x0D; Conclusion: The protocol selected in this study was an effective treatment for the EAE model to improve spatial memory and regulate corticosterone concentrations.

Effects of combined exercise on salivary oxidative stress in hypertensive and normotensive postmenopausal women

Aim: This study evaluated the effects of 10 weeks of combined exercise training on the salivary oxidative profile of hypertensive and normotensive postmenopausal women. Methods: Twenty-six non-obese postmenopausal women were divided into two groups: the hypertensive group (HT; n = 13; 58.9 ± 3.9 years; and BMI of 27.7 ± 4.6 kg/m2) or the normotensive group (NT; n = 13; 52.7 ± 5.2 years; and BMI of 26.9 ± 2.9 kg/m2). They performed 30 sessions of combined exercises over 10 weeks: 45 min per session, three times a week. Resting saliva samples were collected after an overnight fast to evaluate salivary nitrite levels and oxidative stress markers before and after training. Results: Two-way ANOVA showed that there was no difference in the responses over time between the hypertensive and normotensive groups in catalase, superoxide dismutase salivary activity, total antioxidant capacity, or lipid peroxidation. However, superoxide dismutase activity (δHT -0.87 ± 14.53 SOD/mg protein; δNT: 7.13 ± 9.39 SOD/mg protein; p < 0.01) and nitrite levels (δHT 10.32 ± 60.83 mM; δNT 101.92 ± 149.57 mM; p = 0.03) were higher overall in the hypertensive group compared to the normotensive group. Moreover, salivary nitrite levels increased over time (p = 0.04) in both groups. Conclusion: 10 weeks of combined exercise training did not change salivary oxidative stress markers in either normotensive or hypertensive postmenopausal women, although, after exercise training, nitrite levels increased in both groups, even with higher baseline salivary nitrite levels in hypertensive women. Thus, recurrent exercise seems to be a safe strategy after menopause from the standpoint of oxidative stress, regardless of the presence of hypertension.

12주간 복합운동이 성인 비만남성의 혈중지질, 세로토민 및 도파민에 미치는 영향

The purpose of this study was to find out the effect of combined exercise on blood lipids, serotonin and dopamine in adult obese men. For obese men in their 30s, exercise intensity (60-80% HRR) of 1 to 6 weeks (50-70% HRR) for 12 weeks for a total of 20 subjects (n=10) and control group (n=10) 7-12 weeks. After calculating the mean value (M) and standard deviation (M±SD) for the measured variables, the difference between the before and after mean values within the group was verified based on the paired t-test and the main effect test. Differences between groups and the interaction effects between groups(2-WAY ANOVA repeated measure).BR As a result of analyzing blood lipids, serotonin and dopamine after complex exercise, the following conclusions were obtained. Blood lipids significantly decreased TC, TG, LDL-C and increased HDL-C in the exercise group. Serotonin and dopamine were significantly increased in the exercise group, and serotonin was significantly decreased in the control group. As a result, participation in complex exercise for 12 weeks had a positive effect on blood lipids, serotonin and dopamine, and compound exercise is considered to have a positive effect on improvement and prevention of obesity in obese men.

Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty

BackgroundThe prevalence of precocious puberty is increasing. Obesity has been demonstrated to be associated with changes in the adipokine profile and incidence of early puberty in girls. This study assessed the pubertal signs, the levels of adiponectin, resistin, and tumor necrosis factor-alpha (TNF-α) after 12 weeks of combined exercise and 4 weeks of detraining in overweight and obese girls with precocious puberty.MethodsThirty overweight and obese girls (aged 7–9) with precocious puberty, who had received Triptorelin, were randomly divided into two groups (15 exercise and 15 control). Initially, serum levels of adiponectin, resistin, TNF-α, luteinising hormone (LH), and follicle-stimulating hormone (FSH) and the signs of puberty progression (bone age, uterine length, and ovarian volume) were measured. The exercise group performed 60 min of combined (aerobic and resistance) exercise three times/week for 12 weeks. The control group did not receive any exercise. 48 h after the last training session and after 4 weeks of detraining, all research variables were measured (also in the control group). The statistical method used for data analysis was repeated measures ANOVA.ResultsIn the exercise group, adiponectin significantly increased and resistin significantly decreased after 12 weeks. After 4 weeks of detraining, adiponectin significantly decreased, but resistin significantly increased. TNF-α levels did not change significantly during the study. There was no significant difference in all of the factors in the control group. Throughout the 16-week study period, the rate of puberty and LH significantly decreased in both exercise and control groups, but FSH, LH/FSH and ovarian volume significantly decreased in the exercise group alone (P<0.05).ConclusionsCombined exercise increased adiponectin and decreased resistin and the rate of puberty. However, after 4 weeks of detraining, these effects diminished but did not disappear.Trial registrationIRCT, IRCT56471. Registered 25 may 2021 - Retrospectively registered, https://fa.irct.ir/user/profile

Effectiveness of combined exercise in people with type 2 diabetes and concurrent overweight/obesity: a systematic review and meta-analysis

ObjectiveTo synthesise the available scientific evidence on the effects of combined exercise on glycaemic control, weight loss, insulin sensitivity, blood pressure and serum lipids among patients with type 2 diabetes...

12주간 복합운동이 성인 비만남성의 신체조성, 혈압, 인슐린저항성 및 CRP에 미치는 영향

The purpose of this study is to find out the effects of combined exercise on body composition, blood pressure, insulin resistance and CRP in adult obese men. For obese men in their 30s, a total of 20, experiments (n=10) and controls (n=10) For 12 weeks, 1-6 weeks (50-70% HRR) was set to a kinetic strength of (60-80% HRR) of 7-12 weeks. After calculating the mean value (M) and the standard deviation (M±SD) for the measurement variable, Verification of differences in the mean values of the pre and post in the group is based on the paired t-test, Test of main effects for differences between groups and intergroup and time-to-period interaction effects (repeated-measured ANOVA).<BR> Analysis of body composition, blood pressure, insulin resistance, and CRP after complex exercise resulted in the following conclusions. Body composition significantly reduced %BF in the exercise group and increased LBM. SBP and DBP significantly decreased in the exercise group, significantly decreased in the insulin, glucose, HOMA-IR, and CRP exercise group, and significantly increased HOMA-IR in the control group. As a result of this, participation in 12-week combined exercise has a positive effect on body composition, blood pressure, insulin resistance, and CRP, and it is believed that combined exercise has had a positive effect on obesity improvement and prevention of obese men in their 30s.

Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide.

Almost 40% of adults worldwide are classified as overweight or obese. Exercise is a beneficial intervention in obesity, partly due to increases in mitochondrial activity and subsequent increases in nicotinamide adenine dinucleotide (NAD+), an important metabolic cofactor. Recent studies have shown that increasing NAD+ levels through pharmacological supplementation with precursors such as nicotinamide mononucleotide (NMN) improved metabolic health in high-fat-diet (HFD)-fed mice. However, the effects of combined exercise and NMN supplementation are unknown. Thus, here we examined the combined effects of NMN and treadmill exercise in female mice with established obesity after 10 wk of diet. Five-week-old female C57BL/6J mice were exposed to a control diet (n = 16) or HFD. Mice fed a HFD were either untreated (HFD; n = 16), received NMN in drinking water (400 mg/kg; HNMN; n = 16), were exposed to treadmill exercise 6 days/wk (HEx; n = 16), or were exposed to exercise combined with NMN (HNEx; n = 16). Although some metabolic benefits of NMN have been described, at this dose, NMN administration impaired several aspects of exercise-induced benefits in obese mice, including glucose tolerance, glucose-stimulated insulin secretion from islets, and hepatic triglyceride accumulation. HNEx mice also exhibited increased antioxidant and reduced prooxidant gene expression in both islets and muscle, suggesting that altered redox status is associated with the loss of exercise-induced health benefits with NMN cotreatment. Our data show that NMN treatment impedes the beneficial metabolic effects of exercise in a mouse model of diet-induced obesity in association with disturbances in redox metabolism.NEW & NOTEWORTHY NMN dampened exercise-induced benefits on glucose handling in diet-induced obesity. NMN administration alongside treadmill exercise enhanced the ratio of antioxidants to prooxidants. We suggest that NMN administration may not be beneficial when NAD+ levels are replete.

Effects of combined exercise on psychological and physiological variables in cancer patients: A pilot study

Effects of combined exercise on psychological and physiological variables in cancer patients: A pilot study

Effect of combined exercises (aerobic-pilates) on the serum level of interleukin 10 and blood platelets in women with breast cancer

مقدمه: تمرین­های ورزشی می­تواند از راه تنظیم و تعدیل سایتوکینی، نقش حمایتی در بهبود سرطان پستان ایفا کند. اینترلوکین-10، سایتوکینی ضدالتهابی و ضدتوموری است که نقش مهمی در روند بازداری رشد تومور دارد. مطالعه حاضر با هدف بررسی تأثیر 12 هفته تمرین ترکیبی (هوازی-پیلاتس) بر سطح سرمی اینترلوکین-10 و پلاکت­ خون زنان مبتلا به سرطان پستان انجام شد. روش‌کار: این مطالعه تجربی در سال 1398 بر روی ۳۰ زن مبتلا به سرطان پستان که حداقل 6 ماه از عمل جراحی آنها گذشته بود، دوره شیمی‌درمانی را پشت سر گذارده و تحت درمان دارویی بودند، در دانشگاه شهید مدنی آذربایجان انجام شد. افراد به دو گروه تجربی و کنترل تقسیم شدند. گروه تجربی به‌مدت ۱۲ هفته و هر هفته 3 جلسه به فعالیت ورزشی (هوازی-پیلاتس) پرداختند. در این مدت، گروه کنترل در هیچ برنامه­ فعالیت ورزشی یا بدنی شرکت نکردند. نمونه‌های خونی آزمودنی‌ها در قبل و 48 ساعت بعد از اعمال مداخله تمرین جهت استخراج متغیر­ها اخذ شد. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 20) و آزمون‌های تی همبسته و مستقل انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد. یافته­ها: بر اساس نتایج آزمون تی همبسته، سطح سرمی اینترلوکین 10 (001/0=p) و تعداد پلاکت­ها خونی (041/0=p) آزمودنی­های گروه تجربی نسبت به پیش­آزمون پس از 12 هفته تمرین ترکیبی (هوازی-پیلاتس) افزایش معنی­داری داشت، در‌حالی‌که در گروه کنترل تغییر ات آنها معنی داری نبود (05/0p>). نتیجه­گیری: اجرای تمرینات ترکیبی (هوازی و پیلاتس) با بهبود وضعیت اینترلوکین 10 به‌عنوان یک سایتوکین ضد‌التهابی و ضد‌توموری می­تواند در بهبود وضعیت سلامتی زنان مبتلا به سرطان پستان مفید باشد. از این رو طراحی و اجرای چنین تمریناتی در این جمعیت، می­تواند بسیاری از مشکلات این عزیزان را رفع نماید.