Combination Of Surfactants Research Articles

Screening of Chemicals to Enhance Oil Recovery in a Mature Sandstone Oilfield in Kazakhstan: Overcoming Challenges of High Residual Oil

Chemical flooding, such as alkaline-surfactant (AS) or nanoparticles-surfactant (NS) flooding, is an enhanced oil recovery (EOR) technique that has been increasingly utilized to enhance the oil production rate and recovery factor while reducing chemical adsorption. The AS/NS flooding process involves the injection of a mixture of surfactant and alkali/nanoparticles solutions into an oil reservoir to reduce the interfacial tension between the oil and water phases by surfactant and lower surfactant adsorption by alkali or nanoparticles (NPs) to improve the residual oil recovery. In this study, the AS/NS flooding is evaluated for a Kazakhstani oilfield by systematically screening the chemical constituents involved. Field A in Kazakhstan, one of the oldest fields in the country, has been waterflooded for decades and has not produced even 50% of the original oil in place (OOIP). Currently, the water cut of the field is more than 90%, with a high residual oil saturation. Therefore, besides polymer flooding to control mobility, chemical EOR is proposed as a tertiary recovery method to mobilize residual oil. This study aimed to screen chemicals, including surfactant, alkali, and NPs, to design an effective AS/NS flooding program for the target field. The study focused on conducting laboratory experiments to identify the most effective surfactant and further optimize its performance by screening suitable alkaline and NPs based on their compatibility, stability, and adsorption behavior under reservoir conditions. The performance of the screened chemicals in the porous media was analyzed by a set of coreflood experiments. The findings of the study indicated that alkali agents, particularly sodium carbonate, positively affected surfactant performance by reducing its adsorption by 9–21%. The most effective surfactant combination was found, which gave Winsor type III microemulsion and the lowest interfacial tension (IFT) of 0.2 mN/m. The coreflood tests were conducted with the screened surfactant, alkali, and NPs. Both AS and NS tests demonstrated high residual oil recovery and microemulsion production. However, NS flooding performed better as the incremental oil recovery by NS flooding was 5% higher than standalone surfactant flooding and 9% higher than AS flooding. The results of this screening study helped in designing an efficient chemical formulation to improve the remaining oil recovery from Field A. The findings of this study can be used to design EOR projects for oil fields similar to Field A.

FORMULATION AND EVALUATION OF NIOSOMAL GEL OF AZELAIC ACID FOR ANTIACNE ACTIVITY

Objective: This study aimed to develop niosomes loaded with azelaic acid (AA) to administer in gel form. The primary objective was to achieve controlled and sustained release of the drug while minimizing potential side effects. Methods: Niosomes were fabricated using a combination of various non-ionic surfactants and cholesterol through the application of thin film hydration technique. Furthermore, the processing parameters were optimized and drug excipient compatibility study was conducted using FTIR spectroscopy. The formulations were extensively characterized in terms of entrapment efficiency, particle size, shape, and in vitro release. Subsequently, the improved niosomal dispersions were employed to formulate gels, which underwent analysis to evaluate their visual properties, pH, and rheological behavior. Stability study was also conducted. Results: Total 15 formulations were prepared, out of which 3 formulations F3, F9 and F15 were found to exhibit maximum entrapment efficiency. These formulation were having particle size 260.1 nm, 272.3 nm and 226.3 nm respectively. In vitro drug release was found to be maximum in F9 formulation. The release was found to be dose-dependent across all formulations, with regression values between 0.97 and 0.99, confirming first-order release kinetics. FTIR spectra indicated the absence of any drug-cholesterol-nonionic surfactant interaction in the formulation. The niosomal gel formulations exhibited optimal performance when stored within the temperature range of 4 to 8 °C. Conclusion: This investigation demonstrates the utility of the thin film hydration technique in effectively incorporating poorly water-soluble medications such as azelaic Acid (AA) into niosomes, resulting in high entrapment efficiency. These findings suggest that niosomes containing AA, when topically applied as a gel, have the potential to be an efficacious treatment for acne.

Efficiency of exogenous surfactant combined with intravenous N-acetylcysteine in two-hit rodent model of ARDS

Accumulation of reactive oxygen species during hyperoxia together with secondary bacteria-induced inflammation leads to lung damage in ventilated critically ill patients. Antioxidant N-acetylcysteine (NAC) in combination with surfactant may improve lung function. We compared the efficacy of NAC combined with surfactant in the double-hit model of lung injury. Bacterial lipopolysaccharide (LPS) instilled intratracheally and hyperoxia were used to induce lung injury in Wistar rats. Animals were mechanically ventilated and treated intravenously with NAC alone or in combination with intratracheal surfactant (poractant alfa; PSUR+NAC). Control received saline. Lung functions, inflammatory markers, oxidative damage, total white blood cell (WBC) count and lung oedema were evaluated during 4 hrs. Administration of NAC increased total antioxidant capacity (TAC) and decreased IL-6. This effect was potentiated by the combined administration of surfactant and NAC. In addition, PSUR+NAC reduced the levels of TNFα, IL-1ß, and TAC compared to NAC only and improved lung injury score. The combination of exogenous surfactant with NAC suppresses lung inflammation and oxidative stress in the experimental double-hit model of lung injury.

Role and impact of surfactants in carbon nanotube dispersions and sorting

AbstractCarbon nanotubes (CNTs) are proving to be versatile nanomaterials that exhibit superior and attractive electrical, optical, chemical, physical, and mechanical properties. Different kinds of CNTs exist, and their associated properties have been actively explored and widely exploited from fundamental studies to practical applications. Obtaining high‐quality CNTs in large volumes is desirable, especially for scalable electronic, photonic, chemical, and mechanical systems. At present, abundant but random CNTs are synthesized by various growth methods including arc discharge, chemical vapor deposition, and molecular beam epitaxy. An economical way to secure pristine CNTs is to disperse the raw soot of CNTs in solutions, from which purified CNTs are collected via sorting methods. Individual CNTs are generally hydrophobic, not readily soluble, requiring an agent, known as a surfactant to facilitate effective dispersions. Furthermore, the combination of surfactants, polymers, DNA, and other additives can enhance the purity of specific types of CNTs in confidence dispersions. With highly‐pure CNTs, designated functional devices are built to demonstrate improved performance. This review surveys and highlights the essential roles and significant impacts of surfactants in dispersing and sorting CNTs.

Experimental investigation on the stability of foam using combination of anionic and zwitterionic surfactants: A screening scenario to obtain optimum compound

The use of foam injection as an enhanced oil recovery (EOR) technique has been suggested since the 1960s to address issues with gas injection. Foam is composed of gas, water, and surfactant, which is utilized to stabilize the foam. This study investigates the synergy effect of anionic surfactant and two zwitterionic surfactants on enhancing solution stability. The anionic surfactant used is sodium dodecyl sulfate, while the chosen zwitterionic surfactants are cocamidopropy hydroxy sultine and Cocamido Propyl Betaine. Analyzing the images of the generated foam showed that initially, the small and uniform bubbles are formed in all concentrations. The foam size is then increased and in concentrations higher than a critical value, the bubbles grow faster which is likely due to the formation of micelles and deposition of surfactants. This leads to early collapse of the foam structure. The quantitative half-life results approved that the most optimal compound was obtained with equal proportions of sodium dodecyl sulfate and Cocamido Propyl Betaine with concentration of 3 wt% (1:1 ratio, 0.15 wt%-0.15 wt%). To quantitatively study on foam characteristics, conductivity and interfacial tension tests were performed. The results of the conductivity tests showed that micelles were formed in concentrations of more than 0.3 wt%. Interfacial tension measurements revealed that addition of a small amount of surfactants to the base solution, led to reduction of the interfacial tension value from 29.2 (mN/m) in base solution to less than 1 mN/m for solutions treated with surfactant.

Enhancing ASP Flooding by Using Special Combinations of Surfactants and Starch Nanoparticles.

This study aimed to address the challenges faced by mature oilfields in extracting substantial oil quantities. It focused on improving the efficiency of alkaline-surfactant-polymer (ASP) flooding technique, which is a proven tertiary recovery technology, to overcome scaling issues and other hindrances in its large-scale implementation. Appropriate materials and their suitable concentrations were selected to enhance the ASP flooding technique. Special surfactants from Indonesia were introduced to improve the interfacial tension reduction and wettability alteration. Reservoir rock model that resembling Langgak oilfield in Sumatra was utilized, and low-salinity water was employed to mimic the oilfield conditions. Starches derived from cassava nanoparticles (CSNPs) and purple yam nanoparticles (PYNPs) were combined separately with conventional hydrolyzed polyacrylamide (HPAM) polymer to enhance its performance. Sodium hydroxide and sodium carbonate were used as alkaline in final ASP formula. It was demonstrated from this research that only two combinations of ASP formulations have led to improved oil recovery. One combination utilizing PYNPs resulted in 39.17% progressive recovery, while the other combination incorporating CSNPs achieved 35% incremental oil recovery. The ASP combination that resulted in recovery rate of 39.17% was composed of sodium hydroxide (NaOH) at a concentration of 1.28 wt.%, PSC EOR 2.2 (0.98 wt.%), and a combined polymer consisting of HPAM (0.2 wt.%) and PYNPs nano-starch (0.6 wt.%). The second combination led to 35% recovery rate and involved NaOH also at concentration 1.28 wt.%, PSC HOMF (0.63 wt.%), and a combined polymer comprising from HPAM (0.2 wt.%) and CSNPs nano-starch (0.8 wt.%). These findings of this study highlighted the potential of this modified ASP flooding to enhance oil recovery in mature oilfields, thereby offering valuable insights for oil industry.

Deciphering the role of sugars on aggregation and interfacial behavior of Gemini surfactant

The current study describes the mechanism of micellization and physical as well as chemical characteristics of ethylene-1, 2-bis (N, N-dimethyl-N-tetradecylammonium bromide) (14−2−14) in an aqueous solution of saccharides/sugars/carbohydrates (D-mannose, sucrose and raffinose) with concentrations 0.05, 0.1 and 0.2 mol/kg at different temperatures between 298.15 and 328.15 K. Conductometric and tensiometric measurements were applied to examine micellar modulation of 14–2–14 in terms of critical micelle concentration (CMC). The values of CMC from conductivity measurements are validated by the outcomes of surface tension measurements. Moreover, dependency of CMC over temperature has been used for computing thermodynamic parameters of micellization so as to acquire an enhanced insight into 14–2–14 behavior and occurrence of intermolecular interactions in the system. Since Gemini surfactants have lower CMC as well as greater surface activity in comparison to conventional surfactants, they result in the better formulation of saccharides-emulsifier (surfactant) combination in various food as well as cosmetic products.

Biohydrogen production through energy efficient surfactant induced microwave pretreatment of macroalgae Ulva reticulata

Macroalgal biomass being rich in carbohydrates, proteins and lipids in their cell wall has been considered as the most efficient organic rich sources for biofuel (biohydrogen) production. In this study, Pluronic P-123-induced microwave pretreatment was applied to disintegrate the marine macroalgae biomass, Ulva reticulata. Microwave disintegration was done by varying the treatment time and microwave power from 0 to 40 min and 0.09 KW to 0.63 KW. A maximum chemical oxygen demand (COD) solubilization of 22.33% was achieved at a microwave power and time duration of 0.36 kW and 15 min. Chemical (Pluronic P-123, a mild surfactant) was combined with optimum microwave disintegration conditions to increase the solubilization efficiency and this combined pretreatment achieved a maximum COD solubilization of 31.02% at 10 min pretreatment time and 0.06 g per g TS of Pluronic P-123 dosage. The present study indicated that combination of surfactant with microwave pretreatment substantially improves the COD solubilization with reduced pretreatment -time than mono microwave pretreatment. An optimal hydrogen yield of 98.37 mL was achieved through this combined pretreatment. The biohydrogen data was modelled with Gompertz model and the kinetic parameters derived through this model implies that the calculated adjusted R squared values for all the samples lies between 0.95 and 0.99. This shows that the model fitted biohydrogen experimental values accurately. In addition, Pluronic P-123-induced microwave pretreatment was regarded as energy efficient and cost effective than microwave pretreatment alone with net energy production and a greater energy ratio of 504.38 kWh/Ton macroalgae and 1.2 when compared to microwave pretreatment alone (−2975.6 kWh/Ton macroalgae and 0.5).

Experimental investigation of wettability alteration, IFT reduction, and injection schemes during surfactant/smart water flooding for EOR application

In recent years, the application of smart water and surfactant in order to improve oil recovery has attracted special attention in carbonate reservoirs. In this research, the effects of various salts in smart water and two surfactants of Cetyl Trimethyl Ammonium Bromide (CTAB) and Sodium Dodecyl Sulfate (SDS) on the wettability alteration of carbonate rock and IFT were studied. Besides, along with micromodel flooding, core flooding tests were conducted to assess the amount of oil recovery at reservoir conditions as an injection scheme was used. In this regard, the results illustrated that the presence of CTAB or SDS in seawater (SW) can act better in contact angle reduction compared to smart water. Also, a four times increase in the concentration of SO42− and removing Na+ from SW reduced the contact angle to 68° and 71°, respectively, being the best possible options to alter the carbonate surface wettability to more water-wet states. Moreover, in the second-order process in which the rock section was first placed in SW, and then was put in the smart solution (with or without surfactant), CTAB had a great effect on the wettability alteration. In the case of IFT reduction, although SW4Mg2+, compared to other ions, better decreased the IFT to 17.83 mN/m, SW + SDS and SW + CTAB further declined the IFT to 0.67 and 0.33 mN/m, respectively. Concerning different ions, divalent cations (Mg2+ and Ca2+) show better results in improving oil recovery factor. However, the combination of SW and surfactants has a more positive effect on boosting oil recovery, as compared to smart water flooding. It should be mentioned that the first-order injection is better than the second-order one since SW is flooded at first, and then, after the breakthrough, smart water is injected into the micromodel. In addition, the core flooding tests showed that SW + CTAB and SW + SDS in tertiary injection increased the oil recovery to about 59 and 57%, respectively, indicating that the presence of CTAB could be more effective than that of SDS.

Influence of droplet size on the antibacterial efficacy of citral and citronella oil nanoemulsions in polysaccharide coated fresh-cut apples

Fresh-cut fruits are highly perishable and susceptible to bacterial contamination. Polysaccharides edible coating loaded with essential oils nanoemulsions have the potential to extend shelf life and improve quality of fruits. The effectiveness of this approach is dependent on the properties of the nanoemulsions, such as droplet size (DS) and stability. This study aimed to optimize the production of citral (CT) and citronella oil (CTO) nanoemulsions (CT-CTO-NEs) incorporated in edible coating film to be used as natural antimicrobial agent in fresh-cut apples. After testing different combinations of surfactant (tween 80) and cosurfactant (propylene glycol) to obtain stable oil-in-water (o/w) nanoemulsions, the results demonstrated that optimized CT-CTO-NEs with DS less than 500 nm have been successfully achieved with high stability for 3 weeks at 4 °C. In addition, CT-CTO-NEs were obtained by In situ formation under magnetic stirring without applying complex high shear homogenization processes. Desired stability of CT-CTO-NEs also has been achieved within semi-solid matrix (sodium alginate cross-linked film). The relationship between DS and antibacterial activity was observed, with the smallest DS (< 100 nm) showing the highest antibacterial efficacy against Listeria monocytogenes and Escherichia coli. These results emphasize the importance of DS in the effectiveness of CT-CTO-NEs as an antibacterial coating for fresh-cut fruits.

Effects of cationic and anionic surfactants on the stability, rheology and proppant suspension of nanoparticle-stabilized fracturing foams at elevated temperature

Much attention has been paid to applying liquid foams in hydraulic fracturing in the past few years due to their significant benefits, including minimal formation damage. In the current literature, the combination of anionic surfactants and nanoparticles (NP) has been thoroughly studied to improve foam-based fracturing fluids' thermal stability and viscosity. However, very little research has focused on the synergy between cationic surfactants and NP, which results in a limited understanding of the effects of this mixture on enhancing the properties of fracturing foams, especially at reservoir temperature. This paper investigates and compares the synergy between cationic/anionic surfactant and silica nanoparticles (SNP) in improving the fracturing foams' stability, rheology and proppant-carrying capacity under ambient and elevated temperature conditions. The experiments involved foamability, bulk static stability, viscosity measurement and proppant settling tests at fixed NP concentration and varied surfactant concentrations. The results showed that the foams' properties were gradually enhanced with increasing surfactant concentration until reaching a peak at around 0.05–0.1 wt%. At ambient and elevated temperatures, the foams stabilized by SNP and cationic hexadecyltrimethylammonium bromide (CTAB) surfactant had higher half-life, apparent viscosity, and better proppant-carrying ability than those stabilized by SNP and anionic sodium dodecyl benzene sulfonate (SDBS) surfactant. The properties of CTAB/SNP foams were found most outstanding at medium CTAB concentration; however, they declined dramatically at very low or very high surfactant concentration. This study enhances our understanding of the influences of surfactant type and concentration on the stability, rheology and proppant suspension behaviour of nanoparticle-stabilized foams, which directly contributes to developing an effective foam system for high-temperature fracturing application.

Combination of surfactants and enzyme cocktails for enhancing woody biomass saccharification and bioethanol production from lab-scale to pilot-scale

Converting woody biomass to bioethanol might be more affordable, environmentally friendly, and efficient for making biofuel commercially feasible, but it would still need a significant optimization process and expand pilot-scale research. A combination of commercial low enzymes loading at 10 FPU/g glucan and compound additives utilizing Tween 80, PEG8000 and sophorolipid applied from lab-scale to pilot-scale have been studied in this work at economically viable dosages for enhancing bioethanol production. In lab-scale saccharification and fermentation, pretreated poplar at a high solid loading of 20% yielded the highest ethanol titers of 30.96 g/L and theoretical ethanol yield of 92.79%. Additionally, pilot-scale operation was used to investigate the bioethanol amplification, a final volume of 33 m3 which yielded the greatest ethanol amount of 599.6 kg from poplar wood while gaining on-site value-added production of hemicellulosic and cellobiose liquor 1122 kg and lignin residues 2292 kg.

Folic acid functionalised mesoporous core-shell silica nanoparticles loaded with carboplatin for lung cancer therapy

The development of versatile mesoporous silica nanomaterials (MSNSs) with suitable textural properties is essential for the targeted and precise delivery of therapeutic drugs for the treatment of various diseases. Especially, loading of highly toxic platinum-based drugs is essential to reduce their toxic side effects. However, loading platinum-based drugs such as carboplatin in high quantity in porous materials is extremely challenging owing to the high hydrophobicity and lack of functional groups for interacting with surfaces of MSNS. In this study, we report a facile synthesis of core-shell MSNS by employing a unique combination of triple surfactants - pluronic P123, cetyltrimethylammonium bromide (CTAB) and fluorocarbon-4 (FC-4) for targeted delivery of the carboplatin for the treatment of lung cancer. The highly hydrophobic FC-4 plays a vital role in tuning the self-assembly and thereby controls the size, morphology, textural properties and uniform pore size distribution of the MSNS. The optimised MSNS with the size range of 300–320 nm, uniform size distribution, high surface area and ordered structure was successfully synthesised. A high drug loading of 26.7% was achieved on both bare and amine functionalised MSNS with a steady release of up to 60% and 37%, respectively, in PBS. The targeting efficiency of the folic acid functionalised particles was established by confocal microscopy, which showed higher cellular uptake of these particles in A549 cells. The high carboplatin loading and targeting ability resulted in high cytotoxicity from the folic acid functionalised and drug-loaded MSNS samples in PC9 cells compared to non-targeted and bare MSNS samples. Overall, this study proposes a new single-step synthesis of core-shell MSNS with high drug loading capacity that can be used to deliver drugs in treating different types of cancers.

Thermodynamics and Viscoelastic Property of Interface Unravel Combined Functions of Cationic Surfactant and Aromatic Alcohol against Gram-Negative Bacteria.

Lipopolysaccharides (LPSs), the major constituents of the outer membranes of Gram-negative bacteria, play a key role in protecting bacteria against antibiotics and antibacterial agents. In this study, we investigated how a mixture of cationic surfactants and aromatic alcohols, the base materials of widely used sanitizers, synergistically act on LPSs purified from Escherichia coli using isothermal titration calorimetry (ITC), surface tension measurements, and quartz crystal microbalance with dissipation (QCM-D). ITC data measured in the absence of Ca2+ ions showed the coexistence of exothermic and endothermic processes. The exotherm can be interpreted as the electrostatic binding of the cationic surfactant to the negatively charged LPS membrane surface, whereas the endotherm indicates the hydrophobic interaction between the hydrocarbon chains of the surfactants and LPSs. In the presence of Ca2+ ions, only an exothermic reaction was observed by ITC, and no entropically driven endotherm could be detected. Surface tension experiments further revealed that the co-adsorption of surfactants and LPS was synergistic, while that of surfactants and alcohol was negatively synergistic. Moreover, the QCM-D data indicated that the LPS membrane remained intact when the alcohol alone was added to the system. Intriguingly, the LPS membrane became highly susceptible to the combination of cationic surfactants and aromatic alcohols in the absence of Ca2+ ions. The obtained data provide thermodynamic and mechanical insights into the synergistic function of surfactants and alcohols in sanitation, which will enable the identification of the optimal combination of small molecules for a high hygiene level for the post-pandemic society.

Glycosylated heterocyles emulsified with antifungal fraction of Moringa oleifera for potentiation of mycolytic activity

To enhance the clinical effect of antifungal medications for treating deadly fungal infections there is an increasing demand for novel treatments. Exploration of multiple-drug targeting in antifungal therapeutics is the need of the present era. In this pursuit, we identified potent antifungal compounds that were directed towards the multiple virulent targets in Rhizopus arrhizus. Quinoxaline di-N-oxide and piperazine derivatives were identified to exhibit antifungal activities. 03 bioactive compounds were identified from the docking results and antifungal activity. Furthermore, these compounds which were combined with the alkaline extract of M. olifera to make the aqueous phase, an oil phase containing cinnamon oil or clove oil and a combination of surfactants was made to prepare a bioactive composite emulsion. A significant antimycotic activity was seen for the bioactive composite emulsion when compared with the clinically used antifungal drugs. Our results indicate the synergy and potentiation of antimycotic drugs based on integrative medicine.

Kill two birds with one stone: Solubilizing PAHs and activating PMS by photoresponsive surfactants for the cycle remediation of contaminated groundwater

Polycyclic aromatic hydrocarbons (PAHs) represent a dangerous threat to the groundwater environment. PAHs are difficult to be effectively removed from groundwater because of their hydrophobicity. In this study, a combination of a Gemini photosensitive surfactant (N1, N2-bis[4-[4-[(4-butylphenyl) azo] phenoxy] butyl]-N1, N2-tetramethylethane-1,2-diammonium bromide, AzoPBT) with peroxymonosulfate (PMS) is developed to treat PAHs-contaminated groundwater. To investigate the reaction mechanism of the PMS/AzoPBT process, we chose naphthalene (Nap) and phenanthrene (Phe) as target pollutants. The quenching experiments, electron paramagnetic resonance (EPR) spectroscopy and the identified degradation products indicated that singlet oxygen could contribute to the degradation of PAHs. A tentative solution for Phe degradation was proposed based on the degradation products. The role of surfactant micelles in the PMS/AzoPBT process is further explored. The positively charged micelles in the PMS/AzoPBT process escalate the removal of PAHs by electrostatically polymerizing Br- and HSO5- in the solution. Although increasing the number of micelles can enhance the solubilization of PAHs by surfactant solutions, the encapsulation of PAHs by micelles can “protect” PAHs, which hinders the removal of PAHs. The PMS/AzoPBT process can be applied in a broad range of pH values. In the process of recycling AzoPBT to activate PMS to remediate groundwater, PAHs can be completely removed in the first cycle, and 51.4 % of them can be removed after four times of surfactant use. The combination of photoresponsive surfactants and PMS achieves efficient oxidation of PAHs without additional activators while increasing the solubility of PAHs in groundwater. This novel technology of PAHs-contaminated groundwater treatment may provide insights into the degradation mechanism of the PMS/AzoPBT process.

Design and in vitro assessment of chitosan nanocapsules for the pulmonary delivery of rifabutin

Tuberculosis (TB) is a life-threatening disease and a main cause of death worldwide. It mainly affects the lungs, and it is attributed to the infection with Mycobacterium tuberculosis (MTB). Current treatments consist of the oral administration of combinations of antibiotics including rifabutin, in high doses and for long periods of time. These therapeutic regimens are associated with many side effects and high rates of drug resistance. To overcome these problems, this study aims at developing a nanosystem for the improved delivery of antibiotics, with potential application in pulmonary delivery.Chitosan-based nanomaterials are widely used in biomedical applications, due to their biodegradability and biocompatibility, as well as their potential antimicrobial effects and lack of toxicity. In addition, this polymer is particularly attractive for mucosal delivery due to its bioadhesive properties. Therefore, the structure of the proposed nanocarrier consists of a chitosan shell and a lipid core with a combination of different oils and surfactants to allow optimal association of the hydrophobic drug rifabutin. These nanocapsules were characterized in terms of size, polydispersity index, surface charge, morphology, encapsulation efficiency and biological stability. The release kinetics of the drug-loaded nanostructures was evaluated in simulated lung media. Moreover, in vitro studies in different cell models (A549 and Raw 264.7 cells) demonstrated the safety of the nanocapsules as well as their efficient internalization. An antimicrobial susceptibility test was performed to evaluate the efficacy of the rifabutin-loaded nanocapsules against Mycobacterium phlei. This study indicated complete inhibition for antibiotic concentrations within the expected susceptibility range of Mycobacterium (≤ 0.25–16 mg/L).

Enhancing Functionalization of Health Care Textiles with Gold Nanoparticle-Loaded Hydroxyapatite Composites.

Hospitals and nursing home wards are areas prone to the propagation of infections and are of particular concern regarding the spreading of dangerous viruses and multidrug-resistant bacteria (MDRB). MDRB infections comprise approximately 20% of cases in hospitals and nursing homes. Healthcare textiles, such as blankets, are ubiquitous in hospitals and nursing home wards and may be easily shared between patients/users without an adequate pre-cleaning process. Therefore, functionalizing these textiles with antimicrobial properties may considerably reduce the microbial load and prevent the propagation of infections, including MDRB. Blankets are mainly comprised of knitted cotton (CO), polyester (PES), and cotton-polyester (CO-PES). These fabrics were functionalized with novel gold-hydroxyapatite nanoparticles (AuNPs-HAp) that possess antimicrobial properties, due to the presence of the AuNPs' amine and carboxyl groups, and low propensity to display toxicity. For optimal functionalization of the knitted fabrics, two pre-treatments, four different surfactants, and two incorporation processes were evaluated. Furthermore, exhaustion parameters (time and temperature) were subjected to a design of experiments (DoE) optimization. The concentration of AuNPs-HAp in the fabrics and their washing fastness were critical factors assessed through color difference (ΔE). The best performing knitted fabric was half bleached CO, functionalized using a surfactant combination of Imerol® Jet-B (surfactant A) and Luprintol® Emulsifier PE New (surfactant D) through exhaustion at 70 °C for 10 min. This knitted CO displayed antibacterial properties even after 20 washing cycles, showing its potential to be used in comfort textiles within healthcare environments.

Application of Novel Magnetic Surfactant-Based Drilling Fluids for Clay Swelling Inhibition

Water-based drilling fluids are widely employed in the oilfield industry for the efficient and smooth drilling of wellbore reservoirs. In this study, a novel drilling formulation was prepared by mixing a magnetic surfactant in the base mud formulation. Several drilling fluid tests were conducted, which include steady shear and dynamic rheology, filtration, clay sedimentation, clay swelling, and particle size distribution analysis. Different analytical techniques─XRD, FTIR, and TGA analyses─were performed to study the interactions of magnetic surfactant with the clay platelets. The experimental results of the surfactant-modified formulations were compared to the base mud formulation. Thermal gravimetric analysis of the surfactant-modified mud showed improved thermal stability compared to the base mud. FTIR analysis results of the base mud and surfactant-modified mud were compared. In the steady shear rheology experiments, the flow curves of the base mud and surfactant-modified mud showed that the addition of surfactant in the base mud affects the shear stress of formulation. The shear stress data of rheology was fitted to the Herschel–Bulkley model, and model parameters trends were assessed with and without the addition of surfactant in the base mud. Shale inhibition tests showed that the incorporation of magnetic surfactant minimized the clay hydration of swelling, thus proving a superior shale inhibitor. The particle size analysis showed that the average particle size of clay particles increased with the increasing concentration of the magnetic surfactant. The linear swelling analysis of clay showed that the rate of swelling was 90% in the surfactant-modified mud as compared to the swelling rate in deionized water. According to the zeta potential, the combination of surfactants significantly affects the electrokinetic behavior of dispersion. Further, the XRD proved that the interlayer spacing of clay increasing while interacting with magnetic surfactant molecules indicates the ability of magnetic surfactant as a shale swelling and hydration inhibitor for water-based drilling formulations.

A Concise review on application of solid lipids and various techniques in the formulation development

Lipids have wide range of applications in food and pharmaceuticals. The pharmaceuticals application of lipid is to improve solubility of drug also helps to improve the bioavailability. The dissolution/dissolving phase, which is probably the rate-limiting component for oral absorption of poorly water-soluble drugs, is eliminated by pre-dissolving pharmaceuticals in lipids, surfactants, or combinations of lipid excipients and surfactants. The most widely used co-solvents, together with lipid excipients, are propylene glycol, glycerol, and polyethylene glycols-400, poloxamer etc. various technologies are used such as melt extrusion, melt granulation for preparation of lipid based oral modified released dosage forms. This review summaries the overview of the lipid excipients in terms of their classification, methods of absorption, and lipid-based product development. The manufacture of solid and semi-solid lipid formulations using various methodologies, applications, phase behaviour, and the regulatory outlook of lipid excipients are covered.&#x0D; Keywords: Solid lipids, lipid classification, solidification techniques, modified released.