Two field experiments were conducted at the ExperimentalResearch Station in El-Serw, Agricultural Research Center during theseasons 2012/2013 and 2013/2014 to study the effect of mineral nitrogenand organic nitrogen of compost combination treatments on grain andstraw yield and N, P, K- uptake in grain and straw of some wheatvarieties. The experiments were carried out in a split plot design withthree replicates. Main plots were assigned to three wheat cultivars i.e.,Sakha 93, Gemmiza 9 and Gemmiza 10. The sub main plots weredevoted to mineral nitrogen and compost combination treatments asfollows: 100% inorganic nitrogen (90 kg fed-1), 75% inorganic nitrogen(67.5 kg fed-1 ) + 25 % organic nitrogen (22.5 kg fed-1), 50% inorganicnitrogen (45.0 kg fed-1 ) + 50 % organic nitrogen (45.0 kg fed-1 ), 25 %inorganic nitrogen (22.5 kg fed-1 ) + 75% organic nitrogen (67.5 kg fed-1) and 100 % organic nitrogen (90 kg fed-1). Obtained results showedthat the greatest values of wheat grain , straw yields , N, P and K uptakein both grain and straw were those of Gemmeza 10, Gemmeza 9 andSakha 93, respectively and 100% inorganic nitrogen, 75% inorganicnitrogen + 25% organic nitrogen, 50 % inorganic nitrogen + 50%organic nitrogen, 25% inorganic nitrogen + 75% organic nitrogen and100% organic nitrogen, respectively. 100% inorganic nitrogen forGemmiza 10 gave the highest wheat grain and straw yields and N, P, andK uptake in grain and straw. While, applying 75% inorganic nitrogenwith 25% organic nitrogen produced economic wheat grain and strawyields for Sakha 93 only. So, 25% inorganic nitrogen, could be saved,and environmental pollution with mineral- N fertilizers could also bereduced. As well as improved soil properties i.e increased hydraulicconductivity,on the contrary,bulk density,Ece and pH values weredecreased.