Colorectal Dis Research Articles

Leukocyte-depletion of blood components does not significantly reduce the risk of infectious complications: Results of a double-blinded, randomized study: I.L. Titlestad, L.S. Ebbesen, A.P. Ainsworth, et al. Int J Colorectal Dis 16:147–153, 2001

Leukocyte-depletion of blood components does not significantly reduce the risk of infectious complications: Results of a double-blinded, randomized study: I.L. Titlestad, L.S. Ebbesen, A.P. Ainsworth, et al. Int J Colorectal Dis 16:147–153, 2001

Rapunzel syndrome

33 Jones B, Dale RG. Mathematical models of tumour and normal tissue response. Acta Oncol 1999; 38: 883–93. 34 Withers HR, Peters LJ, Taylor JMG. Dose-response relationship for radiation therapy of subclinical disease. Int J Radiat Oncol Biol Phys 1995; 31: 353–59. 35 Feinstein AR, Sosin DM, Wells CK. The Will Rogers’ phenomenon: stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med 1985; 312: 1604–08. 36 Gelman R, Gelber R, Henderson IC, et al. Improved methodology for analyzing local and distant recurrence. J Clin Oncol 1990; 8: 548–55. 37 Swedish Rectal Cancer Trial. Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma. Br J Surg 1993; 80: 1333–36 38 Frykholm GJ, Glimelius B, Pahlman L. Pre-operative or postoperative irradiation in adenocarcinoma of the rectum: final treatment results of a randomized trial and an evaluation of late secondary effects.Dis Colon Rectum 1993; 36: 564–72. 39 Holm T, Singnomklao T, Rutqvist LE, Cedermark B. Adjuvant preoperative radiotherapy in patients with rectal carcinoma. Adverse effects during long-term follow-up of two randomised trials. Cancer 1996; 78: 968–76. 40 Lindmark G, Elvin A, Pahlman L, et al. The value of endosonography in preoperative staging of rectal cancer. Int J Colorectal Dis 1992; 7: 162–66. 41 Quirke P, Durdey P, Dixon MF, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 1986; 2: 996–99. 42 Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1986; 1: 1479–82. 43 Kapiteijn E, Marijnen CAM, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001; 345: 638–46. 44 NIH Consensus Conference: adjuvant cancer therapy. JAMA 1990; 264: 1444–50. 45 Cancer Guidance Subgroup of the Clinical Outcomes Group. Improving outcomes in colon cancer: The Research Evidence. London: NHS Executive, Department of Health 1997. 46 Wolmark N, Wieand HS, Hyamns DM, et al. Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum. National Surgical Adjuvant Breast and Bowel Project Protocol R-02. J Natl Cancer Inst 2000; 92: 388–96. ARTICLES

A Genomewide Analysis Provides Evidence for Novel Linkages in Inflammatory Bowel Disease in a Large European Cohort

Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on the basis of clinical and histologic features: Crohn disease and ulcerative colitis (UC). Previous genomewide searches identified regions harboring susceptibility loci on chromosomes 1, 3, 4, 7, 12, and 16. To expand our understanding of the genetic risk profile, we performed a 9-cM genomewide search for susceptibility loci in 268 families containing 353 affected sibling pairs. Previous linkages on chromosomes 12 and 16 were replicated, and the chromosome 4 linkage was extended in this sample. New suggestive evidence for autosomal linkages was observed on chromosomes 1, 6, 10, and 22, with LOD scores of 2.08, 2.07, 2.30, and 1.52, respectively. A maximum LOD score of 1.76 was observed on the X chromosome, for UC, which is consistent with the clinical association of IBD with Ullrich-Turner syndrome. The linkage finding on chromosome 6p is of interest, given the possible contribution of human leukocyte antigen and tumor necrosis-factor genes in IBD. This genomewide linkage scan, done with a large family cohort, has confirmed three previous IBD linkages and has provided evidence for five additional regions that may harbor IBD predisposition genes.

Designing the optimal surgery for rectal carcinoma

CancerVolume 78, Issue 9 p. 1847-1850 EditorialFree Access Designing the optimal surgery for rectal carcinoma Warren E. Enker M.D., Corresponding Author Warren E. Enker M.D. Department of Surgery, and Division of Colorectal Surgery, Beth Israel Medical Center, New York, New York.350 East 17th Street, Baird Hall 1622, New York, NY 10003===Search for more papers by this author Warren E. Enker M.D., Corresponding Author Warren E. Enker M.D. Department of Surgery, and Division of Colorectal Surgery, Beth Israel Medical Center, New York, New York.350 East 17th Street, Baird Hall 1622, New York, NY 10003===Search for more papers by this author First published: 1 November 1996 https://doi.org/10.1002/(SICI)1097-0142(19961101)78:9<1847::AID-CNCR1>3.0.CO;2-CCitations: 23AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Enker WE, Laffer UT, Block GE. Enhanced survival of patients with colon and rectal cancer is based upon wide anatomic resection. Ann Surg 1979; 190: 350– 60. 2 Heald RJ. A new approach to rectal cancer. Br J Hosp Med 1979; 277. 3 Sugihara K, Moriya Y, Akasu T, Fujita S. Pelvic autonomic nerve preservation for patients with rectal carcinoma: oncologic and functional outcome. Cancer 1996; 78: 1871– 80. 4 Church JM, Raudkivi PJ, Hill GL. The surgical anatomy of the rectum: a review with particular relevance to the hazards of rectal mobilization. Int J Colorectal Dis 1987; 2: 158– 66. 5 Beart RW, Steele GD, Menck HR, Chmiel JS, Ocwieja KE, Winchester DP. Management and survival of patients with adenocarcinoma of the colon and rectum: a national survey of the Commission on Cancer. J Am Coll Surg 1995; 181: 225– 36. 6 Enker WE, Thaler HT, Cranor ML, Polyak T. Total mesorectal excision in the operative treatment of rectal cancer. J Am Coll Surg 1995; 181: 335– 46. 7 Heald RJ, Husband EM, Ryall RDH. The mesorectum in rectal cancer surgery: the clue to pelvic recurrence. Br J Surg 1982; 69: 613– 6. 8 Quirke P, Durdey P, Dixon MF, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumor spread and surgical excision. Lancet 1986; 1: 996– 9. 9 Adam IJ, McHamdee MO, Martin IG. et al. Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 1994; 344: 707– 11. 10 Paty PB, Enker WE, Cohen AM, Lauwers GY. Treatment of rectal cancer by low anterior resection with coloanal anastomosis. Ann Surg 1994; 219: 365– 73. 11 MacFarlane J, Ryall RDH, Heald RJ. Mesorectal excision for rectal cancer. Lancet 1993; 341: 457– 60. 12 Enker WE. Potency, cure, and local control in the operative treatment of rectal cancer. Arch Surg 1992; 127: 1396– 1402. 13 Havenga K, Enker WE, McDermott K, Cohen AM, Minsky BD, Guillem J. Male and female sexual and urinary function after total mesorectal excision with autonomic nerve preservation for carcinoma of the rectum. J Am Coll Surg 1996; 182: 495– 502. 14 Minsky BD. Preoperative combined modality treatment for rectal cancer. Oncology 1994; 8: 53– 8. 15 Swedish Rectal Cancer Trial. Local recurrence rates in a randomized multiculture trial of preoperative radiotherapy compared with operation alone in resectable rectal carcinoma. Eur J Surg 1996; 162: 397– 402. 16 Stockholm Colorectal Cancer Study Group. Randomized study on preoperative radiotherapy in rectal carcinoma. Ann Surg Oncology 1996; 3: 423– 30. 17 Dutch Colorectal Cancer Group. Total mesorectal excision (TME) with or without preoperative readiotherapy in the treatment of primary rectal cancer. A multicenter phase III study. January 1996. 18 Norstein J, Bergan A, Langmark F. Risk factors for local recurrence after radical surgery for rectal carcinoma: a prospective multicentre study. Br J Surg 1993; 80 (Suppl): 22. 19 Quirke P. The pathologist's role in the evaluation of local recurrence in rectal cancer. In: Surgical Workshop and Prosection Course, Royal College of Surgeons of London, London, United Kingdom, April 25–26, 1995. Citing Literature Volume78, Issue91 November 1996Pages 1847-1850 ReferencesRelatedInformation

How big is too big?

How big is too big?