Collimator Angle Research Articles

Defining the Role of Intensity Modulation in Electron Conformal Therapy for the Treatment of Head and Neck Cancer

The use of bolus electron conformal therapy (BECT) in the treatment of cancers of the head and neck is often limited by an inability to reduce dosimetric hot spots resulting from surface or tissue heterogeneity. In this study, we examined the potential benefits of using a recently patented, low-cost form of Intensity Modulation for electron therapy (IM-BECT) to reduce treatment hotspots in patients undergoing electron beam therapy for cancer of the Head and Neck (HN). The treatment plans from twelve patients with HN cancer previously treated with BECT were identified (treatment energies ranged from 6-18 MeV and field sizes of 36-625 cm2). Each case included the treatment targets and at least one primary OAR that were defined by the original treating radiation oncologist. Additionally, a target + 2 cm rind structure was created for analysis of the dose deposition in areas immediately surrounding the target volume as a measure of conformality. Each patient plan was transferred into a novel IM-BECT planning software and each case was recomputed as per the original prescription, gantry, couch, collimator angles, and original clinically used bolus. Next, each case was replanned with the inclusion of intensity modulation, as well as a new custom conformal bolus that was designed for optimized range compensation. The patient plans were then normalized such that 100% equals the prescription dose value and then transferred to a plan analysis software for comparison of the target coverage/dose and OAR dose. Comparison of the BECT and IM-BECT treatment plans demonstrated that IM-BECT was able to significantly reduce dosimetric hotspots for this cohort of patients undergoing radiation therapy for HN cancer, bringing the average maximum dose down from 130.6% to only 120.6% (p = 0.044, paired t-test). Moreover, the impact of IM-BECT appeared to be most substantial in the patients with the highest baseline maximum dose. For patients who had a hotspot of 125% or greater, the hotspot was on average reduced by 19%. Further dosimetric analysis demonstrated a small resultant increase in the low dose deposition to the surrounding normal tissues. For BECT, the average primary OAR mean dose and Target+2cm rind mean dose were 27.5% and 60.0%, respectively. For IM-BECT, the average primary OAR mean dose and Target+2cm rind mean dose increased slightly to 30.9% and 64.6%, respectively [Primary OAR mean (P = 0.0008), and Target+2cm rind mean (P = 0.0001), paired t-test]. IM-BECT is an effective method of reducing dosimetric hotspots in patients undergoing radiation therapy for cancer of the HN. This improvement came at the expense of a small increase in dose to the underlying tissues. This retrospective planning study represents the first example of IM-BECT being applied to real patient cases and suggests further development of IM-BECT is warranted.

Dosimetric Comparison of Automated Non-Coplanar Volumetric-Modulated Arc Therapy and Intensity-Modulated Proton Therapy in Angiosarcoma of the Scalp

Angiosarcoma of the scalp (AS) is a rare tumor and has often been treated by total scalp irradiation (TSI). TSI is a challenging technique because of the target close to the organs at risks (OARs), located in the skin surface, and helmet-shape of the target. We performed the dosimetric comparison of automated non-coplanar volumetric-modulated arc therapy (HA) and intensity-modulated proton therapy (IMPT) in TSI for AS. A planning study was performed on 20 patients with AS. The clinical target volume (CTV) 1 and CTV2 were defined as gross tumor volume with margin and entire scalp, respectively. For HA, planning target volume (PTV) 1 and PTV2 were defined as CTV1 and CTV2 with 5-mm margins, respectively. For IMPT, robust optimization was utilized which accounted for a 5-mm setup and a 3.5% range uncertainty and dose was prescribed to CTV1 robust and CTV2 robust. The prescription doses were 70 Gy and 56 Gy in 35 fractions to PTV1 (CTV1 robust) and PTV2 (CTV2 robust), respectively, using the simultaneous integrated boost technique. The HA plan was performed using a 6-MV photon beam machine and a 1-cm thick virtual bolus. The HA plan included three half non-coplanar and one full coplanar arc fields. The HA plan used collimator angles of 15°, 60°, 15°, and 120° in the beam with couch rotations of 0°, 45°, 90°, and 315°, respectively. The IMPT plan was performed using a compact proton beam machine dedicated to pencil beam scanning. The IMPT plan used gantry angles of 70°, 150°, 70°, 150°, and 30° in the beam with couch rotations of 0°, 0°, 180°, 180°, and 270°, respectively. The IMPT plan was optimized assuming a relative biological effectiveness of 1.1. The dose distribution and dosimetric parameters for each plan were evaluated. All plans met the goals within the acceptable range in target volume coverage, conformity, and homogeneity. Table shows the dosimetric parameters of OARs in HA and IMPT plans. The doses receiving 0.1 cc of the volume for hippocampus, optic passway, eye, and lens in the IMPT plan were significantly lower than those in the HA plan. The IMPT plan showed a significant reduction in the percentage of brain volume receiving at least 5 Gy (V5 Gy) compared to the HA plan, while the HA plan showed a significant reduction of V10 Gy - V60 Gy and mean brain dose compared to the IMPT plan. The HA plan provided a shorter beam-on time (184 ± 9 s) than did the IMPT plan (446 ± 49 s). The HA and IMPT plans demonstrated different strengths with respect to OARs sparing.

Automatic Treatment Planning for Multi-focal Dynamic Conformal Arc GRID Therapy for Late-Stage Lung Cancer: A Feasibility Study

Palliative management of large, symptomatic pulmonary lesions, either as primary lung cancers or metastases, can be challenging due to need to balance effective radiation doses for cytoreduction with safety. Spatially Fractionated Radiation Therapy (SFRT), or GRID Therapy, is an emerging technique, which delivers ablative doses of radiotherapy to small, selected areas of tumor, while sparing organs-at-risk (OARs), and has been shown to debulk large lesions in preliminary studies. Conventionally, an alloy GRID block is manufactured to deliver GRID therapy. However, this delivery technique poses a challenge due to need for block, and dosimetrically when the tumor is deep-seated as excess dose may be delivered to OARs, such as skin and chest wall. This study aims to develop a fast, automatic planning solution using multi-focal dynamic conformal arcs (DCA) on modern Linear Accelerator. One late-stage lung cancer patient with simulated sphere target grid was included in this study. The sphere targets are 1.5cm in diameter and 4.3cm spacing. Four co-planar full arcs were used for optimization. The problem is formalized as finding optimal multi-leaf collimator (MLC) sequencing to cover N targets with K control points (CPs) for each arc. The state of each target's MLC opening at each CP is binary. In order to solve this NP-hard problem, the optimal solution was approximated by eliminating projection collision at each CP. MLC motion continuity and maximum speed were included in the cost function to ensure deliverability. The optimization started with randomized initial CP apertures, followed by solving state-transition equations for following CPs. Two grid arrays (9 and 10 targets respectively) were tested for plan quality. For each grid of target, the arc collimator angle was planned with 0 and 30 degrees for comparison. Prescription was 20 Gy per fraction. Monte Carlo simulation dose engine from matRad toolkit was used for dose calculation. Key dosimetric endpoints including target mean dose, D5%(Gy) and D95%(Gy), were reported. Average calculation time on the AMD Ryzen 5 5600 × 6-Core 3.7GHz CPU and 32GB RAM platform varied from 31 to 44 minutes. One zero-degree collimator and one thirty-degree collimator were generated for each target array. For nine-target array, mean target dose from both plans ranged from 23.41 to 26.55 Gy, while D5%(Gy) and D95%(Gy) ranged from 25.45 to 30.16 Gy, and 20.00 to 22.21 Gy, respectively. For ten-target array, the range of target mean, D5%(Gy) and D95%(Gy) were 23.82 to 28.74 Gy, 26.50 to 33.11 Gy, and 20.00 to 22.49 Gy. A fast, automatic planning solution for multi-focal DCA GRID therapy was developed. It provides clinically feasible plans with high efficiency for small target arrays for the late-stage cancer patient. The implementation provides excellent coverage for deep-seated tumors where alloy grid solution could fail to meet coverage objectives. Additional patients are needed in the future to further refine the technique.

Deep learning-based fluorescence image correction for high spatial resolution precise dosimetry

Objective. While radiation-excited fluorescence imaging has great potential to measure absolute 2D dose distributions with high spatial resolution, the fluorescence images are contaminated by noise or artifacts due to Cherenkov light, scattered light or background noise. This study developed a novel deep learning-based model to correct the fluorescence images for accurate dosimetric application. Approach. 181 single-aperture static photon beams were delivered to an acrylic tank containing quinine hemisulfate water solution. The emitted radiation-exited optical signals were detected by a complementary metal-oxide semiconductor camera to acquire fluorescence images with 0.3 × 0.3 mm2 pixel size. 2D labels of projected dose distributions were obtained by applying forward projection calculation of the 3D dose distributions calculated by a clinical treatment planning system. To calibrate the projected dose distributions for Cherenkov angular dependency, a novel empirical Cherenkov emission calibration method was performed. Total 400-epoch supervised learning was applied to a convolutional neural network (CNN) model to predict the projected dose distributions from fluorescence images, gantry, and collimator angles. Accuracy of the calculated projected dose distributions was evaluated with that of uncorrected or conventional methods by using a few quantitative evaluation metrics. Main results. The projected dose distributions corrected by the empirical Cherenkov emission calibration represented more accurate noise-free images than the uncalibrated distributions. The proposed CNN model provided accurate projected dose distributions. The mean absolute error of the projected dose distributions was improved from 2.02 to 0.766 mm·Gy by the CNN model correction. Moreover, the CNN correction provided higher gamma index passing rates for three different threshold criteria than the conventional methods. Significance. The deep learning-based method improves the accuracy of dose distribution measurements. This technique will also be applied to optical signal denoising or Cherenkov light discrimination in other imaging modalities. This method will provide an accurate dose verification tool with high spatial resolution.

Viability of the virtual cone technique using a fixed small multi-leaf collimator field for stereotactic radiosurgery of trigeminal neuralgia.

Dosimetric uncertainties in very small (≤1.5×1.5 cm2 ) photon fields are remarkably higher, which undermines the validity of the virtual cone (VC) technique with a diminutive and variable MLC fields. We evaluate the accuracy and reproducibility of the VC method with a very small, fixed MLC field setting, called a fixed virtual cone (fVC), for small target radiosurgery such as trigeminal neuralgia (TGN). The fVC is characterized by 0.5 cm x 0.5cm high-definition (HD) MLC field of 10MV FFF beam defined at 100cm SAD, while backup jaws are positioned at 1.5 cm x 1.5cm. A spherical dose distribution equivalent to 5mm (diameter) physical cone was generated using 10-14 non-coplanar, partial arcs. Dosimetric accuracy was validated using SRS diode (PTW 60018), SRS MapCHECK (SNC) measurements. As a quality assurance measure, 10 treatment plans (SRS) for TGN, consisting of various arc ranges at different collimator angles were analyzed using 6 MV FFF and 10 MV FFF beams, including a field-by-field study (n=130 fields). Dose outputs were compared between the Eclipse TPS and measurements (SRS MapCHECK). Moreover, dosimetric changes in the field defining fVC, prompted by a minute (±0.5-1.0mm) leaf shift, was examined among TPS, diode measurements, and Monte Carlo (MC) simulations. The beam model for fVC was validated (≤3% difference) using SRS MapCHECK based absolute dose measurements. The equivalent diameters of the 50% isodose distribution were found comparable to that of a 5mm cone. Additionally, the comparison of field output factors, dose per MU between the TPS and SRS diode measurements using the fVC field, including±1mm leaf shift, yielded average discrepancies within 5.5% and 3.5% for 6 MV FFF and 10 MV FFF beams, respectively. Overall, the fVC method is a credible alternative to the physical cone (5mm) that can be applied in routine radiosurgical treatment of TGN.

P18.08.B COMPARISON OF DOSE CALCULATION PLANNING SYSTEMS FOR RECCURENT MENENGIOMA TREATED WITH FRACTIONATED RE-IRRIDATION

Abstract PURPOSE Meningioma is among the most common tumors of the central nervous system, accounting for approximately one-third of all brain tumors. Surgery is mainstay treatment and Radiotherapy (RT) provides long-term control in many patients, however recurrences following RT may occur and the safety and efficacy of a second course of RT is not well defined, technical and planning features are yet to be clarified. In this study, we compared various treatment planning systems (TPS) used in RT in a patient who had progressed meningioma after three applications of Gammaknife radiosurgery (GK-SRS). Case Presentation: 55-year-old male patient was diagnosed with grade-1 meningioma of the sphenoid wing in 2014 and subtotal excision was performed, with no further treatment. Progression was detected in 2016, and 11 Gy single fraction GK-SRS was applied in two sessions (inferior and superior parts of the tumor was irradiated in separate GK-SRS applications with 2 months apart) to the recurrent lesion in the right spheno-orbital region in a GK center. Patient was well until June 2022 when progression was detected in the right infratemporal region. Another GK-SRS application of 11 Gy was performed to the patient at the same institute.In April 2023 progression of the tumor was detected, tumor was irresectable and patient referred to our department for fractionated radiotherapy. Recurrent tumor was originating from right sfenoid wing and extending to right infratemporal fossa. We obtained the radiation dose distributions from the previous GK-SRS plans. Due to dose limits on the right optic nerve due to previous radiation dose disturbution , the conventional fractionated radiotherapy was planned . The PTV dose was planned to be 45 Gy/25 fx. Eclipse and Brainlab systems were compared for treatment planning. Right optic nerve dose of EQD2 was already above the limits, thus conventional fractionation (45 Gyin 25 fractions) was prescribed. Two separate plans were generated using Varian-Eclipse and Brainlab-Elements TPS, and the dose distribution of those plans were compared. Plan optimization was performed in both planning systems to provide PTV D%95. While the PTV Dmax was 57.24 Gy in BrainLAB, it was 48.7 Gy in Eclipse. Dmax doses for Brainlab and Eclipse were: right optic nerve 10.11 Gy vs. 26.9 Gy, chiasm 6.68 Gy vs. 20.5 Gy respectively. In Eclipse plan optimization, the collimator and table angles were optimized manually, while in Brainlab planning system, they were automatically handled, therefore normal tissues can be better preserved with increase of hot spots inside the PTV. This situation is observed clearly in this case. CONCLUSION Using different table and collimator angles in plan optimization can yield better results in providing normal tissue dose tolerance, especially in the irradiation of central nervous system.

Technical note: Feasibility of gating for dynamic trajectory radiotherapy - Mechanical accuracy and dosimetric performance.

Dynamic trajectory radiotherapy (DTRT) extends state-of-the-art volumetric modulated arc therapy (VMAT) by dynamic table and collimator rotations during beam-on. The effects of intrafraction motion during DTRT delivery are unknown, especially regarding the possible interplay between patient and machine motion with additional dynamic axes. To experimentally assess the technical feasibility and quantify the mechanical and dosimetric accuracy of respiratory gating during DTRT delivery. A DTRT and VMAT plan are created for a clinically motivated lung cancer case and delivered to a dosimetric motion phantom (MP) placed on the table of a TrueBeam system using Developer Mode. The MP reproduces four different 3D motion traces. Gating is triggered using an external marker block, placed on the MP. Mechanical accuracy and delivery time of the VMAT and DTRT deliveries with and without gating are extracted from the logfiles. Dosimetric performance is assessed by means of gamma evaluation (3% global/2 mm, 10% threshold). The DTRT and VMAT plans are successfully delivered with and without gating for all motion traces. Mechanical accuracy is similar for all experiments with deviations<0.14° (gantry angle),<0.15° (table angle),<0.09° (collimator angle) and<0.08 mm (MLC leaf positions). For DTRT (VMAT), delivery times are 1.6-2.3 (1.6- 2.5) times longer with than without gating for all motion traces except one, where DTRT (VMAT) delivery is 5.0 (3.6) times longer due to a substantial uncorrected baseline drift affecting only DTRT delivery. Gamma passing rates with (without) gating for DTRT/VMAT were ≥96.7%/98.5% (≤88.3%/84.8%). For one VMAT arc without gating it was 99.6%. Gating is successfully applied during DTRT delivery on a TrueBeam system for the first time. Mechanical accuracy is similar for VMAT and DTRT deliveries with and without gating. Gating substantially improved dosimetric performance for DTRT and VMAT.

Ninety-degree angled collimator: a dosimetric study related to dynamic intensity-modulated radiotherapy in patients with endometrial carcinoma

BackgroundOur purpose was to ensure that the dose constraints of the organs at risk (OARs) were not exceeded while increasing the prescription dose to the planning target volume (PTV) from 45 to 50.4 Gray (Gy) with the dynamic intensity-modulated radiotherapy (IMRT) technique. While trying for this purpose, a new dynamic IMRT technique named 90° angled collimated dynamic IMRT (A-IMRT) planning was developed by us.MethodsThis study was based on the computed tomography data sets of 20 patients with postoperatively diagnosed International Federation of Gynecology and Obstetrics stage 2 endometrial carcinoma. For each patient, conventional dynamic IMRT (C-IMRT, collimator angle of 0° at all gantry angles), A-IMRT (collimator angle of 90° at gantry angles of 110°, 180°, 215°, and 285°), and volumetric modulated arc therapy (VMAT) were planned. Planning techniques were compared with parameters used to evaluate PTV and OARs via dose-volume-histogram analysis using the paired two-tailed Wilcoxon’s signed-rank test; p < 0.05 was considered indicative of statistical significance.ResultsAll plans achieved adequate dose coverage for PTV. Although the technique with the lowest mean conformality index was A-IMRT (0.76 ± 0.05) compared to both C-IMRT (0.79 ± 0.04, p = 0.000) and VMAT (0.83 ± 0.03, p = 0.000), it protected the OARs especially the bladder (V45 = 32.84 ± 2.03 vs. 44.21 ± 6.67, p = 0.000), rectum (V30 = 56.18 ± 2.05 vs. 73.80 ± 4.75, p = 0.000) and both femoral heads (V30 for right = 12.19 ± 1.34 vs. 21.42 ± 4.03, p = 0.000 and V30 for left = 12.58 ± 1.48 vs. 21.35 ± 4.16, p = 0.000) better than C-IMRT. While the dose constraints of the bladder, rectum and bilateral femoral heads were not exceeded in any patient with A-IMRT or VMAT, they were exceeded in 19 (95%), 20 (100%) and 20 (100%) patients with C-IMRT, respectively.ConclusionsOARs are better protected when external beam radiotherapy is applied to the pelvis at a dose of 50.4 Gy by turning the collimator angle to 90° at some gantry angles with the dynamic IMRT technique in the absence of VMAT.

Effect of the local energy distribution of x-ray beams generated through inverse Compton scattering in dual-energy imaging applications.

X-ray sources based on the inverse Compton interaction between a laser and a relativistic electron beam are emerging as a promising compact alternative to synchrotron for the production of intense monochromatic and tunable radiation. The emission characteristics enable several innovative imaging techniques, including dual-energy K-edge subtraction (KES) imaging. The performance of these techniques is optimal in the case of perfectly monochromatic x-ray beams, and the implementation of KES was proven to be very effective with synchrotron radiation. Nonetheless, the features of inverse Compton scattering (ICS) sources make them good candidates for a more compact implementation of KES techniques. The energy and intensity distribution of the emitted radiation is related to the emission direction, which means different beam qualities in different spatial positions. In fact, as the polar angle increases, the average energy decreases, while the local energy bandwidth increases and the emission intensity decreases. The scope of this work is to describe the impact of the local energy distribution variations on KES imaging performance. By means of analytical simulations, the reconstructed signal, signal-to-noise ratio, and background contamination were evaluated as a function of the position of each detector pixel. The results show that KES imaging is possible with ICS x-ray beams, even if the image quality slightly degrades at the detector borders for a fixed collimation angle and, in general, as the beam divergence increases. Finally, an approach for the optimization of specific imaging tasks is proposed by considering the characteristics of a given source.

The Effect of Varying Collimator Angles on VMAT planning of Prostate Cancer

Background: The variation in collimator angles in the Volumetric Modulated Arc Therapy (VMAT) has been a factor of consideration in modern radiotherapy techniques for the treatment of cancer. Aim: To investigate dose-volume evaluation in planning target volume (PTV) and organs-at-risk (OARs) in prostate carcinoma patients planned with 1.5 arcs for different collimator angles. Methods: The collimator angle plays a vital role in VMAT planning due to leakage of radiation from the leaves of multi-leaf collimator (MLCs). Using the same optimization parameters on designated treatment planning system (TPS), the arcs of VMAT plans were optimized with 0°, 10°, 20°, 30°, 45°, and 90°, and 0°, 350°, 340°, 330°, 315° and 270° collimator angles. Different parameters like homogeneity index (HI), conformity index (CI), gradient index (GI), monitoring units (MUs), low dose coverage (V40Gy), maximum dose (Dmax), mean dose (Dmean), dose-volume histogram (DVH), D98%, D95%, etc. were calculated with Anisotropic Analytical Algorithm (AAA) Version 15.6.04 and results were analyzed. Results: It was found that at 20°, 30° and 45° collimator angles, the dose conformity, homogeneity, and MUs have optimal values. The target coverage and dose to organ at risks at all angles is not significantly affected by different collimator angles. Conclusion: According to this study it is advised to clinical medical physicists to make a solid decision about the collimator angles for treatment. The dosimetric analysis shows that the optimal collimator angle is necessary for different plan analyzing parameters like better conformity and homogeneity. Keywords: Volumetric Modulated Arc Therapy. Prostate cancer, Planning Target Volume, organs-at-risk

A Dosimetric Study on the Impact of Collimator Angles in Nasopharynx Carcinoma using VMAT Planning

Objective: This study aims to rule out the best collimator angle using Monte- Carlo algorithm in Nasopharynx Carcinoma (NPC) with adequate tumour coverage and less OAR. Methods: Twenty-nine NPC patients were selected retrospectively. VMAT with dual arc were made with same constraints but with different collimator angles for each patient. Total often plans were created for each patient with a collimator angles of 0;5;10;15;20;25;30;35;40;45 in Monaco Treatment Planning System(TPS) using Monte-Carlo algorithm. Plans were evaluated based on Dosimetric parameters such as target coverage, organ at risk (OAR), conformity index(CI) and homogeneity index(HI). Mean dose (Dmean), and Maximum dose (Dmax) of OARs were also analysed. Data were further evaluated by using SPSS software. Findings: The VMAT plans with collimator angles 15◦-30◦ demonstrated better target coverage with a range of (92-94) %0.7195 for the high-dose PTV and significant reduction in monitor units (MU) by an average of 75 with a CI (0.95-0.96)0.0068. Moreover, significant reduction in Dmax of Brainstem and Right optic nerve were obtained with increasing angles. Also,5◦-10◦ showed least PTV coverage and 45◦ got highest MUs compared to 0◦. Novelty : This study shows that collimator angles 15◦-30◦ is superior compared with other angles in Ca Nasopharynx VMAT planning by Elekta-HD Versa Linac using Monte-Carlo algorithm. Keywords: Ca Nasopharynx; Collimator angle; Montecarlo algorithm; Elekta HD Versa Linac; VMAT

Impact of electronic portal image quality on Elekta AQUA® collimator isocenter.

The collimator radiation isocenter position determined in AQUA® v3.0 [Elekta AB, Stockholm, Sweden] software test "MLC Leaf and Jaw Position" was independently validated using an in-house MATLAB [Natick, MA: The MathWorks Inc.] script. The AQUA test determines radiation isocenter using the mean field center of nine 4 cm × 4 cm electronic portal imager (EPID) exposures at equidistant collimator angles. Impact of EPID image quality on AQUA reported isocenter for thirteen Elekta linear accelerators with Agility MLC heads were evaluated. Of the thirteen, three had visually and quantitatively identifiable artifacts. For the ten good EPID's there was a systematic 0.25 mm offset of the MATLAB calculated mean field center relative to AQUA in the X-axis and Y-axis. This corresponds to one image pixel and was found to be due to differences in software co-ordinate convention. After subtracting this offset there was no significant difference in AQUA and MATLAB calculated isocenter. For the three machines with poor image quality there was a demonstrated variation in AQUA calculated field center and therefore radiation isocenter relative to MATLAB. Restricting the region of interest (ROI) in AQUA software to only the irradiated section of the EPID brought AQUA and MATLAB result for these three machines into agreement.

Modified Dynamic Conformal Arcs With Forward Planning for Radiosurgery of Small Brain Metastasis: Each Double Arc and Different To-and-Fro Leaf Margins to Optimize Dose Gradient Inside and Outside the Gross Tumor Boundary.

Dynamic conformal arcs (DCA) are a widely used technique for stereotactic radiosurgery (SRS) of brain metastases (BM) using a micro-multileaf collimator (mMLC), while the planning design and method considerably vary among institutions. In the usual forward planning of DCA, the steepness of the dose gradient outside and inside the gross tumor volume (GTV) boundary is simply defined by the leaf margin (LM) setting to the target volume edge. The dose fall-off outside the small GTV tends to be excessively precipitous, especially with an MLC of 2.5-mm leaf width, which is predisposed to the insufficient coverage of microscopic brain invasion and other inherent inaccuracies. Meanwhile, insufficient dose increase inside the GTV boundary, i.e., less inhomogeneous GTV dose, likely leads to inferior and less sustainable tumor response. The more inhomogeneous GTV dose is prone to the steeper dose gradient outside the GTV and vice versa. Herein, we describe an alternative simply modified DCA (mDCA) planning that was uniquely devised to optimize the dose gradient outside and inside the GTV boundary for further enhancing and consolidating local control of small BM. For a succinct exemplification, a 10-mm spherical target was assumed as a GTV for DCA planning using a 2.5-mm mMLC. The benchmark plan was generated by adding a 0-mm LM to the GTV edge byassigning a single fraction of 30 Gy to the isocenter, in which the GTV coverage by 24 Gy with 80% isodose surface (IDS) was 96%, i.e., D96%, while the coverage of GTV + isotropic 2 mm volume by 18 Gy with 60% IDS was 70%, with the D98% being 12 Gy with 40% IDS, viz., too steep dose fall-off outside the GTV boundary. Alternatively, the increase of LM with or without decreasing the isocenter dose enablesthe increase of the GTV + 2 mm coverage by 18 Gy while resulting in an inadequate GTV dose with either a less inhomogeneous dose or an excessive marginal dose. Meanwhile, in the newly devised mDCA planning, everysingle arc was converted to a double to-and-fro arcwith different LM settings under the same spatial arrangement, which enabled GTV + 2 mm volume coverage with 18 Gy while preserving the GTV marginal dose and inhomogeneity similar to those for the benchmark plan. Additionally, the different collimator angle (CA) setting for the to-and-fro arcs led to further trimming of the dose conformity. The limitations of general forward planning with only adjusting the LM for everysingle arc were demonstrated, which can be a contributing factor for local tumor progressionof small BM. Alternatively, the mDCA with each double to-and-fro arc and different LM and CA settings enables optimization of the dose gradient both outside and inside the GTV boundary according to the planners' intent, e.g., moderate dose spillage margin outside the GTV and steep dose increase inside the GTV boundary.

Overcoming Problems Caused by Offset Distance of Multiple Targets in Single-isocenter Volumetric Modulated Arc Therapy Planning for Stereotactic Radiosurgery.

The purpose of the study is to investigate the impact of large target offset distances on the dose distribution and gamma passing rate (GPR) in single-isocenter multiple-target stereotactic radiosurgery (SIMT SRS) using volumetric modulated arc therapy (VMAT) with a flattening filter-free (FFF) beam from a linear accelerator. Two targets with a diameter of 1 cm were offset by "±2, ±4, and ±6 cm from the isocenter in a verification phantom for head SRS (20 Gy/fr). The VMAT plans were created using collimator angles that ensured the two targets did not share a leaf pair from the multi-leaf collimator. To evaluate the low-dose spread intermediate dose spill (R50%), GPRs were measured with a criterion of 3%/2 mm using an electronic portal imaging device and evaluated using monitor unit (MU), modulation complexity score for VMAT (MCSv), and leaf travel (LT) parameters. For offsets of 2, 4, and 6 cm, the respective parameters were: R50%, 4.75 ± 0.36, 5.13 ± 0.36, and 5.11 ± 0.33; GPR, 95.01%, 93.82%, and 90.67%; MU, 5893 ± 186, 5825 ± 286, and 5810 ± 396; MCSv, 0.24, 0.16, and 0.13; and LT, 189.21 ± 36.04, 327.69 ± 67.01, and 430.39 ± 114.34 mm. There was a spread in the low-dose region from offsets of ≥4 cm and the GPR negatively correlated with LT (r = -0.762). There was minimal correlation between GPR and MU or MCSv. In SIMT SRS VMAT plans with an FFF beam from a linear accelerator, target offsets of <4 cm from the isocenter can minimize the volume of the low-dose region receiving 10 Gy or more. During treatment planning, it is important to choose gantry, couch, and collimator angles that minimize LT and thereby improve the GPR.

Dosimetric Effects of Dynamic Jaw Tracking and Collimator Angle Optimization in Non-Coplanar Cranial Arc Radiotherapy.

The stereotactic treatment of single cranial targets using noncoplanar volumetric modulated arc therapy (VMAT) allows for effective dose delivery to the target, while sparing normal brain tissue. In this study, the dosimetric effect of adding dynamic jaw tracking and automatic collimator angle selection in the optimization of single target cranial VMAT plans was investigated. Twenty-two cranial targets, previously treated with VMAT without dynamic jaw tracking and automatic collimator angle optimization (CAO) were chosen for replanning. Target volumes ranged from 0.441cc to 25.863cc with doses between 18Gy and 30Gy delivered in 1 to 5 fractions. Original plans were reoptimized with automatic CAO, keeping all other objectives the same (CAO plans). Next, original plans were reoptimized with both dynamic jaw tracking and CAO (DJT plans). Original, CAO, and DJT target doses were compared using the Paddick gradient index (GI) and the Paddick inverse conformity index (ICI), while normal tissue dose was compared using the volume of the normal brain receiving 5Gy, 10Gy, and 12Gy. The normal tissue volume was normalized to target size to allow cross comparison between plans. A one-sided t-test was performed to determine whether the changes in the plan metrics were statistically significant. CAO plans had improved GIs compared to the originals (p = 0.03) with insignificant changes in other plan metrics (p > 0.20). The addition of dynamic jaw tracking in DJT plans greatly improved ICIs and normal brain metrics (p < 0.01) compared to the CAO plans with minor improvement in ICIs (p = 0.07). The combined effect of adding dynamic jaw tracking and collimator optimization led to improvements in all metrics of the DJT plans when compared to the original (p < 0.02). The addition of dynamic jaw tracking and CAO led to improvements in both target and normal tissue dose metrics for single-target noncoplanar cranial VMAT plans.

A Study on the Change in Surface Dose Caused by Electromagnetic Radiation According to the Angle of the Collimator

During radiation therapy, the mobility of the multi-leaf collimator varies according to the shape of the tumor and the angle of the collimator. Therefore, the purpose of this study is to understand the change in surface dose according to the collimator angle and the shape of the tumor. Using 10MV electromagnetic radiation, a treatment plan was implemented according to the length and short axis ratio of the tumor and the collimator angle, and the surface dose was compared with the actual measured value. As a result of the evaluation, the surface dose increased as the length of the tumor decreased and the angle of the collimator increased. If it is necessary to reduce the surface dose through this, the collimator angle should be applied in consideration of the short/long ratio.

Evaluation of treatment plans for different target volume (PTV) sizes according to changes in collimator angle during the radiation treatment of rectal cancer using Halcyon equipment

Evaluation of treatment plans for different target volume (PTV) sizes according to changes in collimator angle during the radiation treatment of rectal cancer using Halcyon equipment

Error detection using EPID-based 3D in vivo dose verification for lung stereotactic body radiotherapy

PurposeTo investigate the error detectability limitations of an EPID-based 3D in vivo dosimetry verification system for lung stereotactic body radiation therapy (SBRT). MethodsThirty errors were intentionally introduced, consisting of dynamic and constant machine errors, to simulate the possible errors that may occur during delivery. The dynamic errors included errors in the output, gantry angle and MLC positions related to gantry inertial and gravitational effects, while the constant errors included errors in the collimator angle, jaw positions, central leaf positions, setup shift and thickness to simulate patient weight loss. These error plans were delivered to a CIRS phantom using the SBRT technique for lung cancer. Following irradiation of these error plans, the dose distribution was reconstructed using iViewDose™ and compared with the no error plan. ResultsAll errors caused by the central leaf positions, dynamic MLC errors, Jaw inwards movements, setup shifts and patient anatomical changes were successfully detected. However, dynamic gantry angle and collimator angle errors were not detected in the lung case due to the rotation-symmetric target shape. The results showed that the γmean and γpassrate indicators can detect 13 (81.3%) and 14 (87.5%) of the 16 errors respectively without including the gantry angle error, collimator angle error and output error. ConclusionsIn summary, iViewDose™ is an appropriate approach for detecting most types of clinical errors for lung SBRT. However, the phantom results also showed some detectability limitations of the system in terms of dynamic gantry angle and constant collimator angle errors.

A simplified and effective off-axis Winston-Lutz for single-isocenter multi-target SRS.

To safely perform single-iso multi-target (SIMT) stereotactic radiosurgery (SRS), clinics must demonstrate SRS delivery accuracy for off-axis targets. The traditional Winston-Lutz (W-L) was widely adopted because it provides a simple and accurate solution for testing radiation-isocenter coincidence that uses a static target, enables testing arbitrary treatment angles, and does not require expensive commercial phantoms. The current noncommercial tests are cumbersome and insufficiently accurate. For an off-axis Winston-Lutz (OAWL) test, one must design MLC fields centered on off-axis targets. Unfortunately, because MLC leaf-interfaces are often misaligned with the target center, accomplishing this presents a nontrivial geometry problem that has not been previously solved in the literature. We present a solution for evaluating SIMT SRS accuracy that provides a straightforward method for creating OAWL test fields and offers all the benefits of the standard W-L test. We have developed a method to use any gantry, table, and initial collimator angles to create OAWL fields. This method calculates a series of nested coordinate transformations that produce a small collimator angle adjustment to align the MLC and create a symmetric field around an off-axis target. For an 8cm off-axis target, the described method yields OAWL results within 0.07mm of standard isocentric W-L results. Our six most recent isocentric W-L tests show max and mean errors of 0.59 and 0.37mm, respectively. For six runs of our proposed OAWL test, the average max and mean errors are 0.66 and 0.40mm, respectively. This method accurately evaluates SRS delivery accuracy for off-axis distances that span the majority of a typical human brain for a centered SIMT arc. We have made this method publicly available, so that physicists can employ it within their clinics, foregoing the need for expensive phantoms and improving access to the state-of-the-art SIMT SRS technique.

Validation of pencil beam scanning proton therapy with multi-leaf collimator calculated by a commercial Monte Carlo dose engine.

This study aimed to evaluate the clinical beam commissioning results and lateral penumbra characteristics of our new pencil beam scanning (PBS) proton therapy using a multi-leaf collimator (MLC) calculated by use of a commercial Monte Carlo dose engine. Eighteen collimated uniform dose plans for cubic targets were optimized by the RayStation 9A treatment planning system (TPS), varying scan area, modulation widths, measurement depths, and collimator angles. To test the patient-specific measurements, we also created and verified five clinically realistic PBS plans with the MLC, such as the liver, prostate, base-of-skull, C-shape, and head-and-neck. The verification measurements consist of the depth dose (DD), lateral profile (LP), and absolute dose (AD). We compared the LPs and ADs between the calculation and measurements. For the cubic plans, the gamma index pass rates (γ-passing) were on average 96.5%±4.0% at 3%/3mm for the DD and 95.2%±7.6% at 2%/2mm for the LP. In several LP measurements less than 75mm depths, the γ-passing deteriorated (increased the measured doses) by less than 90% with the scattering such as the MLC edge and range shifter. The deteriorated γ-passing was satisfied by more than 90% at 2%/2mm using uncollimated beams instead of collimated beams except for three planes. The AD differences and the lateral penumbra width (80%-20% distance) were within±1.9% and±1.1mm, respectively. For the clinical plan measurements, the γ-passing of LP at 2%/2mm and the AD differences were 97.7%±4.2% on average and within±1.8%, respectively. The measurements were in good agreement with the calculations of both the cubic and clinical plans inserted in the MLC except for LPs less than 75mm regions of some cubic and clinical plans. The calculation errors in collimated beams can be mitigated by substituting uncollimated beams.