Automatic Treatment Planning for Multi-focal Dynamic Conformal Arc GRID Therapy for Late-Stage Lung Cancer: A Feasibility Study

Abstract

Palliative management of large, symptomatic pulmonary lesions, either as primary lung cancers or metastases, can be challenging due to need to balance effective radiation doses for cytoreduction with safety. Spatially Fractionated Radiation Therapy (SFRT), or GRID Therapy, is an emerging technique, which delivers ablative doses of radiotherapy to small, selected areas of tumor, while sparing organs-at-risk (OARs), and has been shown to debulk large lesions in preliminary studies. Conventionally, an alloy GRID block is manufactured to deliver GRID therapy. However, this delivery technique poses a challenge due to need for block, and dosimetrically when the tumor is deep-seated as excess dose may be delivered to OARs, such as skin and chest wall. This study aims to develop a fast, automatic planning solution using multi-focal dynamic conformal arcs (DCA) on modern Linear Accelerator. One late-stage lung cancer patient with simulated sphere target grid was included in this study. The sphere targets are 1.5cm in diameter and 4.3cm spacing. Four co-planar full arcs were used for optimization. The problem is formalized as finding optimal multi-leaf collimator (MLC) sequencing to cover N targets with K control points (CPs) for each arc. The state of each target's MLC opening at each CP is binary. In order to solve this NP-hard problem, the optimal solution was approximated by eliminating projection collision at each CP. MLC motion continuity and maximum speed were included in the cost function to ensure deliverability. The optimization started with randomized initial CP apertures, followed by solving state-transition equations for following CPs. Two grid arrays (9 and 10 targets respectively) were tested for plan quality. For each grid of target, the arc collimator angle was planned with 0 and 30 degrees for comparison. Prescription was 20 Gy per fraction. Monte Carlo simulation dose engine from matRad toolkit was used for dose calculation. Key dosimetric endpoints including target mean dose, D5%(Gy) and D95%(Gy), were reported. Average calculation time on the AMD Ryzen 5 5600 × 6-Core 3.7GHz CPU and 32GB RAM platform varied from 31 to 44 minutes. One zero-degree collimator and one thirty-degree collimator were generated for each target array. For nine-target array, mean target dose from both plans ranged from 23.41 to 26.55 Gy, while D5%(Gy) and D95%(Gy) ranged from 25.45 to 30.16 Gy, and 20.00 to 22.21 Gy, respectively. For ten-target array, the range of target mean, D5%(Gy) and D95%(Gy) were 23.82 to 28.74 Gy, 26.50 to 33.11 Gy, and 20.00 to 22.49 Gy. A fast, automatic planning solution for multi-focal DCA GRID therapy was developed. It provides clinically feasible plans with high efficiency for small target arrays for the late-stage cancer patient. The implementation provides excellent coverage for deep-seated tumors where alloy grid solution could fail to meet coverage objectives. Additional patients are needed in the future to further refine the technique.