Introduction. According to Federal State Statistics Service (Rosstat) , in 2021, the Vladimir Region took 69th place among all subjects of the Russian Federation in terms of natural population growth (loss). In terms of the frequency of general morbidity over 2010, the region was the most disadvantaged in the Central Federal District; in 2017, it was at the second place. The purpose of the study is to analyze the medical and demographic situation in the Vladimir region during the pre‒pandemic period. Materials and methods. The official statistical data of the Federal State Statistics Service and collections of the medical information and analytical center of the Vladimir region for 2001–2019 were used. The analysis of the main demographic indicators, as well as data on the general morbidity in children, adolescents, and adults in sixteen classes of diseases of the WHO classification (ICD-10) was carried out. Results. The population of the Vladimir Region has decreased by 192,247 people since 2001. A significant differentiation of morbidity values is shown both by different age groups and by administrative districts. Limitations of the study are usually related to the lack of access to detailed statistical information within administrative territories. The peculiarities of collecting and presenting statistical information on morbidity do not allow implementing a more detailed analysis within each age group, limited to three contingents. Conclusion. For the first time, a study of the medical and demographic situation in the Vladimir region, which developed over a nineteen-year pre-pandemic period, made it possible to establish risk territories with characteristic features of their health status.