Our lab has reported discrete results into Epic EMR since the initial Epic Go Live allowing for access to electronic data for clinical and research use. YNHH initiated the LIS update from SoftLab to Epic Beaker in 2016. This update dramatically changed our workflow. Initially, the Epic Beaker team set up our lab with a workaround to report results back into Epic without completing the standard Beaker sample workflow. Generic sample labels and incomplete specimen collection information often led to confusion and samples were redrawn or orders were automatically canceled in Epic before results were posted to the EMR. In 2017, a project was initiated to incorporate the HLA lab into the Epic Beaker workflow. This project faced three primary challenges. First, Beaker lacked support for Epic order panels with multiple tests and sample types, which were initially set up to improve efficiency when ordering multiple concurrent tests. As a solution, these panels were split into orders based on the various tube types necessary to perform the test and order sets were created in Beaker. The second challenge was the Beaker required update of the HL7 orders and results interfaces to support the data transfer between Epic and HistoTrac. The final hurdle was that every result message needed to be updated with the Beaker sample ID. This prompted the HLA Lab to consolidate our Epic orders removing organ specificity and reducing orders from 28 to 10 unique order codes. Furthermore, Beaker enforced a one to one relationship between orders and results. To accommodate this rule, SystemLink added status logic to the results message. All results are sent as preliminary until the last outstanding test result is signed off in HistoTrac and sent as final. Prior to the HLA lab Go Live the Epic team trained the sample collection staff to process our orders with the standard Beaker workflow, updated the clinicians with an Epic splash screen message, and trained the HLA staff to receive samples in Beaker before processing in HistoTrac. All Epic outstanding orders, standing orders and preference lists were updated by the Epic consolidation team. Post-Go Live optimization has included filing results for all pre-Go Live outstanding tests in HistoTrac, and identifying sample collection sites needing updated order transmittal rules which add the Beaker sample ID at collection. As a result of the Epic Beaker implementation order specific labels are printed for all samples, sample status is updated in real time, and samples are processed with the standard Beaker workflow.