This integrative study explores the pivotal role of big data in enhancing epidemic preparedness and response strategies in Southeast Asia. The region, characterized by its diverse socio-economic landscape and frequent exposure to infectious disease threats, necessitates innovative approaches to mitigate the impact of epidemics. Big data, with its vast and varied sources, offers unprecedented opportunities to revolutionize epidemic surveillance, prediction, and management. Drawing on a comprehensive review of literature and case studies, this paper delves into the multifaceted applications of big data in epidemic preparedness. It examines the utilization of diverse data sources, including social media, mobile phones, and IoT devices, for real-time monitoring of disease outbreaks and trends. Moreover, it elucidates the role of advanced analytics techniques, such as machine learning and data visualization, in informing timely and targeted response strategies. Furthermore, this study underscores the importance of collaborative efforts and partnerships in leveraging big data for epidemic preparedness. It explores successful initiatives that have demonstrated the effectiveness of data sharing and interdisciplinary collaboration in enhancing epidemic response capabilities across borders. However, the integration of big data into epidemic preparedness initiatives presents various challenges, including data quality issues, privacy concerns, and the need for robust infrastructure and expertise. Addressing these challenges requires concerted efforts from governments, healthcare organizations, and the private sector. In conclusion, this study advocates for continued research, investment, and policy support to harness the full potential of big data in epidemic preparedness. By embracing innovative technologies and fostering collaboration, Southeast Asia can build resilient health systems capable of effectively combating emerging infectious disease threats.