As one of the most dynamic and sustainable economic regions in China, Yangtze River Delta has been forming an innovation cluster of high-quality development. To explore the driving force during the integration of Yangtze River Delta, this article constructs a driving force model and makes an empirical study by the structural equation modeling method. The model proves that heterogeneity knowledge will positively affect innovation, that innovation performance has a strong positive impact on regional collaborative network innovation, that regional collaborative network innovation exerts a positive effect on knowledge spillover, and that organizational learning can affect innovation performance positively. Based on the above research results, some recommendations are proposed. Those recommendations consist of: (a) to forge a dynamic sustainable and innovative regional collaborative network system lay a foundation of high-quality development; (b) while the two driving forces of heterogeneity knowledge and organizational learning activated, the indices of enterprise innovation performance should be optimized.