AbstractBackgroundPosterior cortical atrophy (PCA) is a cognitive behavioral syndrome characterized by visual and cognitive alterations that is associated with neurodegeneration of the posterior cerebral cortex (occipital, parietal and posterior temporal). 95% of these cases also present neuropsychiatric symptoms (NPS), as anxiety, depression and irritability being the most reported. Due to the early presence of visual disturbances and the dysfunction that they generate, we considered that they could influence the presentation of NPS. The objective of the study was: Describe visual disturbances, neuropsychiatric symptoms and their association in patients with PCA.MethodObservational, descriptive and cross‐sectional study. Information was obtained from the clinical, neuro‐ophthalmological and neuropsychological evaluation of clinical records of patients with PCA, treated at the Cognitive Aging and Dementia Clinic of the National Institute of Neurology and Neurosurgery (Mexico), from January 2015 to September 2019. Sociodemographic and clinical variables of interest (visual and non‐visual alterations, NPS and baseline clinimetric measures) were analyzed. The association between visual disturbances and NPS was estimated by a bivariate analysis.ResultThe most frequent visual disturbances were difficulty reading (100%) and the visual agnosia (84.6%). The non‐visual acalculia (92.3%) and agraphia (76.9) and the NPS: apathy (76.9%) and irritability (69.2%) All patients had at least one NPS. In the bivariate analysis, a finding with clinical interest was that all patients with prosopagnosia presented anxiety, but only showed a tendency (p=0.06). It was also found that patients with visual agnosia and achromatopsia had less insomnia (p=0.03 and 0.04, respectively)ConclusionIt was found that the presence of visual agnosia and achromatopsia were associated with the lower presence of insomnia, however, we found no pathophysiological explanation for this relationship. In accordance with our results, an association between prosopagnosia and chronic anxiety has been described, however, in our analysis, this association was marginal, perhaps due to the small number of the sample.