Cobalt Ferrite Magnetic Nanoparticles Research Articles

A simple microwave-assisted synthesis of cobalt ferrite nanoparticles and its application for the determination of lead ions in rooibos (Aspalathus linearis) tea.

In this study, a magnetic sorbent assisted dispersive solid phase extraction (DSPE) method was used to preconcentrate lead ions from rooibos tea samples for determination by slotted quartz tube-flame atomic absorption spectrometry (SQT-FAAS). Cobalt ferrite magnetic nanoparticles (CoFe2O4 MNPs) were synthesized by microwave assisted digestion. Limits of detection and quantification were calculated as 5.3 and 17.6µg/L, respectively, in a linear dynamic range of 20-800µg/L. The enhancement factor of the developed method was found to be 80-folds when compared to the detection limit of the regular FAAS system. The percent recoveries obtained for rooibos tea samples spiked at different concentrations were in the range of 77 - 125%, with high repeatability as indicated by low standard deviations. The findings of the study demonstrated that the CoFe2O4 MNPs-based extraction method is a straightforward, fast, affordable, safe, and eco-friendly approach to qualifying/quantifying lead with high precision in the selected beverage sample.

Development of a new method for the preparation of mesoporous magnetic nanoparticles of cobalt ferrite (CoFe2O4) with applied parameters for magnetic hyperthermia

This study introduces a novel method for preparing mesoporous magnetic cobalt ferrite nanoparticles (CoFe2O4) for magnetic hyperthermia and other applications. The synthesis of nanoparticles was carried out using the solvo thermal method assisted by Cetyltrimethylammonium Bromide. TEM results revealed a spherical and mesoporous shape, and according to the histogram, the average particle size distribution is uniform, with a diameter of 132 ± 21 nm. This study provides a new platform for the application of magnetic mesoporous nanoparticles in magnetic hyperthermia therapy. The methodology is relevant because it allows the formation of mesoporous structures.

Fabrication and characterization of magnetic cobalt ferrite intercalated chitosan grafted polyaniline ternary nanocomposites for removing some heavy metals simultaneously

Chitosan grafted polyaniline (Ch-g-PANI) loaded with different concentrations of cobalt ferrite magnetic (CoFM) nanoparticles (2, 5 and 10 wt%) to form (Ch-g-PANI/CoFM) nanocomposites were fabricated. X-ray diffraction (XRD), High-Resolution Transmission Electron Microscope (HRTEM), Scanning Electron Microscope (SEM), Energy-Dispersive X-ray (EDX), Fourier transform inferred (FT-IR), and Vibrating Sample Magnetometer (VSM) were carried out to investigate the structure, morphology, chemical composition, and magnetic properties of Ch-g-PANI and Ch-g-PANI/CoFM) nanocomposites. Adsorption performance of these prepared samples towards heavy metals (Pb2+, Cu2+, Fe3+, Cd2+, Li1+, Co2+, Al3+, Mn2+, Zn2+, Ni2+, Cr2+, and V2+) was investigated. The effects of CoFM NPs concentraion doped in grafted polymer, initial metal concentration, temperature, pH, and contact time on heavy metal removal efficiency were optimized. SEM revealed abundant pores for optimum sample that enhance the heavy metal removal efficiency. Competitive adsorption tests proved that Ch-g-PANI/CoFM5 NPs showed higher efficiency for tested heavy metals. The removal efficacy of optimum sample (Ch-g-PANI/CoFM5) reached maximum values 98, 95.3, 96, 99.2, 97, 99.9, 88, 94.4, 99.8, 93.4, 98.96, 93, and 93.9 % for Pb2+, Cu2+, Fe3+, Cd2+, Li1+, Co2+, Al3+, Mn2+, Zn2+, Ni2+, Cr2+, and V2+, respectively at 90 min(equilibrium time), the element ions concentration of 10 mg/L and pH range of 4–6 depending on the kind of metal ions. Freundlich model is the best isotherm model for the equilibrium data, suggesting the multilayer adsorption on the heterogeneous surface. The kinetic data specified that the pseudo-first-order model fitted the adsorption of heavy metal ions on Ch-g-PANI/CoFM5. Thermodynamic studies elucidated the feasible, spontaneous, random, and endothermic adsorption. From an economic viewpoint, the regeneration study implied that the optimal sample Ch-g-PANI/CoFM5 was efficiently recovered up to four successive cycles.

Structural and magnetic properties of cobalt ferrite nano-particles

This paper delves into the comprehensive study of the structural and magnetic properties of cobalt ferrite nanoparticles, magnetic Cobalt Ferrite nanoparticles were successfully synthesised by the sol–gel method using the needed precursors in the desired amount. The resultant CFO nanoparticle prepared is black, and XRD results say that the prepared cobalt ferrite has an average particle size of 37 nm which has been confirmed the same by HR-TEM. XPS confirmed the occupancy of cation at octahedral and tetrahedral site. RAMAN displays all its five modes, confirming the presence of cobalt ferrite. A vibrating sample magnetometer (VSM) was applied to determine magnetic characteristics at room temperature.

An Efficient One-Pot Synthesis of Octahydroquinazolinone Derivatives Using Magnetic Cobalt Ferrite Catalyst

In this work, octahydroquinazolinone derivatives were synthesized using magnetic cobalt ferrite nanoparticles using oxalate precursor method. The XRD pattern and IR spectrum confirmed the formation of single segment cubic spinel cobalt ferrite. The average size of the crystallites was determined to be 26.599 nm, while the lattice constant was found to be 8.365 Å. A fine spherical CoFe2O4 particles with some quantity of aggregation may be observed within the SEM and TEM images. Nano spinel cobalt ferrite nanoparticles is a easily synthesized, non-toxic, less expensive, effortlessly magnetically recoverable and green catalyst for the synthesis of octahydroquinazolinone derivatives through the condensation of aromatic aldehydes with urea or thiourea and dimedone. The advantages of this technique are quick reaction time, ease of product isolation and high yields.

Inducing Magnetic Properties with Ferrite Nanoparticles in Resins for Additive Manufacturing.

Additive manufacturing and nanotechnology have been used as fundamental tools for the production of nanostructured parts with magnetic properties, expanding the range of applications in additive processes through tank photopolymerization. Magnetic cobalt ferrite (CoFe2O4) and barium ferrite (BaFe12O19) nanoparticles (NPs) with an average size distribution value (DTEM) of 12 ± 2.95 nm and 37 ± 12.78 nm, respectively, were generated by the hydroxide precipitation method. The dispersion of the NPs in commercial resins (Anycubic Green and IRIX White resin) was achieved through mechanochemical reactions carried out in an agate mortar for 20 min at room temperature, with limited exposure to light. The resulting product of each reaction was placed in amber vials and stored in a box to avoid light exposure. The photopolymerization process was carried out only at low concentrations (% w/w NPs/resin) since high concentrations did not result in the formation of pieces, due to the high refractive index of ferrites. The Raman spectroscopy of the final pieces showed the presence of magnetic NPs without any apparent chemical changes. The electron paramagnetic resonance (EPR) results of the pieces demonstrated that their magnetic properties were maintained and not altered during the photopolymerization. Although significant differences were observed in the dispersion process of the NPs in each piece, we determined that the photopolymerization did not affect the structure and superparamagnetic behavior of ferrite NPs during processing, successfully transferring the magnetic properties to the final 3D-printed piece.

Sulfonated Silica Coated CoFe2O4 Magnetic Nanoparticles for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-One and Octahydroquinazoline Derivatives

Sulfonated-silica-coated cobalt ferrite (CoFe2O4) magnetic nanoparticles (MNPs-SiCoFe-SO3H) are efficient heterogeneous catalysts for the synthesis of 3,4-dihydropyrimidin-2(1H)-one and octahydroquinazoline derivatives in the absence of solvent. The effects of solvent, temperature, and catalyst amount on the reaction are investigated. The easy separation, reusability of the catalyst, simplicity of the procedure, mild reaction conditions, and good yields (68–95%) within short reaction times (15–70 min) are the advantages of this method. The catalyst can be reused up to eight times with not much loss of activity. Scanning electron microscopy images, X-ray diffraction spectra, and elemental analysis of the recycled catalyst show that the catalyst is stable after the reaction.

Optimization of Magnetic Cobalt Ferrite Nanoparticles for Magnetic Heating Applications in Biomedical Technology.

Using magnetic nanoparticles for extracorporeal magnetic heating applications in bio-medical technology allows higher external field amplitudes and thereby the utilization of particles with higher coercivities (HC). In this study, we report the synthesis and characterization of high coercivity cobalt ferrite nanoparticles following a wet co-precipitation method. Particles are characterized with magnetometry, X-ray diffraction, Mössbauer spectroscopy, transmission electron microscopy (TEM) and calorimetric measurements for the determination of their specific absorption rate (SAR). In the first series, CoxFe3-xO4 particles were synthesized with x = 1 and a structured variation of synthesis conditions, including those of the used atmosphere (O2 or N2). In the second series, particles with x = 0 to 1 were synthesized to study the influence of the cobalt fraction on the resulting magnetic and structural properties. Crystallite sizes of the resulting particles ranged between 10 and 18 nm, while maximum coercivities at room temperatures of 60 kA/m for synthesis with O2 and 37 kA/m for N2 were reached. Magnetization values at room temperature and 2 T (MRT,2T) up to 60 Am2/kg under N2 for x = 1 can be achieved. Synthesis parameters that lead to the formation of an additional phase when they exceed specific thresholds have been identified. Based on XRD findings, the direct correlation between high-field magnetization, the fraction of this antiferromagnetic byphase and the estimated transition temperature of this byphase, extracted from the Mössbauer spectroscopy series, we were able to attribute this contribution to akageneite. When varying the cobalt fraction x, a non-monotonous correlation of HC and x was found, with a linear increase of HC up to x = 0.8 and a decrease for x > 0.8, while magnetometry and in-field Mössbauer experiments demonstrated a moderate degree of spin canting for all x, yielding high magnetization. SAR values up to 480 W/g (@290 kHz, 69 mT) were measured for immobilized particles with x = 0.3, whit the external field amplitude being the limiting factor due to the high coercivities of our particles.

Anticancer potentiality of green synthesized Mg-Co ferrites nanoparticles against human breast cancer MCF-7 cells

Inherent magnetic features of engineered nanomaterials are quite important parameters for biomedical applications and cancer treatments. In this study, cobalt ferrite (CF-NPs) and magnesium-cobalt ferrite (MCF-NPs) magnetic nanoparticles were synthesized by aqueous extract of turmeric, characterized by various instruments, and utilized for anticancer activity. These are characterized with TG-DTG, XRD, SEM, BET, FTIR, and UV–Vis sophisticated techniques. The results revealed that they have inverse cubic spinel structure, optically active and nanoscale spherical morphology. The particle size was calculated by the Scherrer formula and was found to be 24.78 nm for CF-NPs and 27.48 nm for MCF-NPs, respectively. Moreover, MTT method was used to find out anticancer activity of the fabricated CF-NPs and MCF-NPs using the human breast cancer cells (MCF-7) and data discloses that cytotoxicity effects of CF-NPs are higher than MCF-NPs, and dose dependent. At high dose (100 μg/ml), CF-NPs shows 45.76% and 61.57% in CF-NPs and MCF-NPs cell viability, respectively. Similarly, cellular ROS generation was found to be higher in CF-NPs (183 %) as compared to MCF-NPs (159% in at 100 μg/ml). By the obtained results it can be claimed that ferrites will be useful model for cancer treatments if they are explored at advance level.

Effect of annealing temperature on phase transitions and photo-Fenton catalytic activity of CoFe2O4 nanopowder

In this work, the hydrothermal technique was used to synthesize cobalt ferrite (CFO) magnetic nanoparticles. Then, the as-prepared CFO sample was annealed at four different temperatures (600, 700, 800, and 900 °C) to study the effect of the annealing temperature on the crystallite growth, magnetic properties, phase transitions, and photo-Fenton catalytic activity of CFO powder samples. The properties of CoFe2O4 were characterized by X-ray powder diffraction, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, field-emission scanning electron microscopy, Brunauer–Emmet–Teller analysis, vibrating sample magnetometry, and catalytic tests. The results showed that the annealing temperature significantly affected the phase structure, crystallite size, morphology, specific surface area, magnetic properties, and catalytic activity of CFO powder samples. The calcined CFO sample had higher catalytic activity than the as-prepared CFO. At the annealing temperature of 600 °C (CFO-600), the catalytic efficiency and rate constant of this material for the degradation of methylene blue under ultraviolet A irradiation for 60 min reached 95% and 3.16 h−1, respectively, in the presence of oxalic acid as a potential oxidizing agent. We also found that a higher number of Fe3+ ions occupying octahedral sites on the CFO surface resulted in a higher activity of the CFO photo-Fenton catalyst. In particular, the CFO-600 powder with excellent magnetic properties exhibited a good recycling catalytic performance. The present material holds promise as a potential practical candidate for treating pollution caused by organic dyes and limiting secondary contaminants released during the photocatalyst process.

Reaction time-induced improvement in hyperthermia properties of cobalt ferrite nanoparticles with different sizes

Chemical reaction conditions involved in the formation of nanoscale materials can enormously affect their properties. However, the correlation between the reaction time (RT) and hyperthermia properties of magnetic nanoparticles (MNPs) is yet to be understood. Here, we synthesize cobalt ferrite magnetic nanoparticles (MNPs) using a thermal decomposition technique with different RT values. The variation in RT (70–180 min) is designed in such a way that the nucleation and growth process can be affected and improved considerably, achieving monodisperse spherical-like MNPs with superparamagnetic nature as confirmed by first-order reversal curve analysis. Hyperthermia properties are studied for cobalt ferrite MNP ferrofluids with different concentrations (1–5 mg/ml) at various magnetic field strengths (100–400 Oe). We obtain a maximum specific loss power (SLP) value of 510 W/g for MNPs synthesized using RT = 150 min. By extracting magnetic characteristic, we find a correlation between SLP and coercive field values as a function of RT, which can shed light on subtle changes in hyperthermia properties of MNPs.

Poly-(lactic-co-glycolic acid) /poly-(vinyl alcohol) and cobalt ferrite magnetic nanoparticles as vanillin carriers

ABSTRACT Besides being known by food and perfume industries, vanillin has also important pharmacological properties such as anti-inflammatory and antibacterial activities. The use of magnetic nanoparticles as carriers for a vanillin delivery system is a way to explore its benefits in human beings. In this paper, poly(lactic-co-glycolic acid) (PLGA) nanoparticles stabilized by poly(vinyl alcohol) (PVA) and containing magnetic CoFe2O4 and vanillin have been prepared using a double emulsion-solvent evaporation method. The morphology, particle size, structure, and surface properties of the nanoparticles were investigated by transmission electron microscopy, zeta-potential measurements, X-ray diffractometry, Fourier transform infrared spectroscopy, magnetic hysteresis loops, and thermogravimetric analysis. The spherical nanoparticles presented negative charge, with zeta-potential values ranging from −9.15 to −5.64 mV, high thermal stability, superparamagnetic properties, and excellent encapsulation of the vanillin (around 80%). Accordingly, such PLGA/PVA nanoparticles encapsulating vanillin and CoFe2O4 exhibited the desired features to suggest their potential use as drug delivery systems.

Green synthesis of magnetic nanoparticles of Cobalt Ferrite with Kiwi (Actinidia delicious) and its activity against the proliferation of Trypanosoma cruzi

Green synthesis of magnetic nanoparticles of Cobalt Ferrite with Kiwi (Actinidia delicious) and its activity against the proliferation of Trypanosoma cruzi

Quantum-Chemical and Experimental Study on the Interactions between the Magnetic Core and the Molecular Shell of Cobalt Ferrite Nanoparticles in Aqueous Suspensions

This article is focused on the theoretical and experimental study of the interactions between the perchlorate anions and the cations of cobalt ferrite magnetic nanoparticles prepared by a co-precipitation method. The magnetic nanoparticles with surface modified using perchloric acid were stabilized in aqueous dispersion based upon the predominant electric repulsive forces between the coated nanoparticles, balancing the magnetic dipole-dipole attraction. Quantum chemical modeling has revealed the physical-chemical properties of perchlorate anion (electric charges, dipole moment, and energies of frontier orbitals) that suggests the ability to interact with both nanoparticle metal cations and surrounding water molecules. Microstructural investigations by scanning electron microscopy, X-ray diffractometry, and vibrating sample magnetometry revealed crystallinity and granulation of the suspended ferrophase, thus confirming the adequate surface coating with perchlorate anions. The nanotoxicity study, carried out on agricultural plantlets in early ontogenetic stages has revealed differences in the photosynthesis pigment concentrations induced by the magnetic nanoparticle supply.

Optimization of cobalt ferrite magnetic nanoparticle as a theranostic agent: MRI and hyperthermia.

Magnetic nanoparticles (MNPs) are considered a theranostic agent in MR imaging, playing an effective role in inducing magnetic hyperthermia. Since, high-performance magnetic theranostic agents are characterized by superparamagnetic behavior and high anisotropy, in this study, cobalt ferrite MNPs were optimized and investigated as a theranostic agent. CoFe2O4@Au@dextran particles were synthesized and characterized by DLS, HRTEM, SEM, XRD, FTIR, and VSM methods. After cytotoxicity evaluation, MR imaging parameters (r1, r2 and r2 / r1) were calculated for these nanostructures. Afterward, magnetic hyperthermia at the frequency of 425kHz was applied to calculate specific loss power (SLP). Formation of CoFe2O4@Au@dextran was confirmed by UV-Visible spectrophotometry. On the basis of the relaxometric and hyperthermia induction findings of nanostructures in all stages of synthesis, the CoFe2O4@Au@dextran could produce the highest parameters of r2 and r2/r1 and SLP with values ​​of 389.7, 51.2mM-1s-1, and 2449 W/g, respectively. The formation of multi-core MNPs by dextran coating is expected to improve the magnetic properties of the nanostructure, leading to optimization of theranostic parameters, so that CoFe2O4@Au@dextran NPs can create contrast-enhanced images more than three times the clinical use and require less contrast agent, reducing side effects. Accordingly, CoFe2O4@Au@dextrancan be introduced as a suitable theranostic nanostructurewith optimal efficiency.

Preparation of a 3D printable high-performance GelMA hydrogel loading with magnetic cobalt ferrite nanoparticles.

Osteosarcoma remains a worldwide concern due to the poor effectiveness of available therapies in the clinic. Therefore, it is necessary to find a safe and effective therapy to realize the complete resection of osteosarcoma and reconstruction of the bone defect. Magnetic hyperthermia based on magnetic nanoparticles can kill tumor cells by raising the temperature without causing the side effects of conventional cancer treatments. This research aims to design a high-performance magnetic hydrogel composed of gelatin methacrylate and highly magnetic cobalt ferrite (CFO) nanoparticles for osteosarcoma treatment. Specifically, CFO is surface functionalized with methacrylate groups (MeCFO). The surface modified CFO has good biocompatibility and stable solution dispersion ability. Afterward, MeCFO nanoparticles are incorporated into GelMA to fabricate a three-dimensional (3D) printable MeCFO/GelMA magnetic hydrogel and then photocross-linked by UV radiation. MeCFO/GelMA hydrogel has high porosity and swelling ability, indicating that the hydrogel possesses more space and good hydrophily for cell survival. The rheological results showed that the hydrogel has shear thinning property, which is suitable as a bioprinting ink to produce desired structures by a 3D printer. Furthermore, 50μg/mL MeCFO not only decreases the cell activity of osteosarcoma cells but also promotes the osteogenic differentiation of mBMSCs. The results of the CCK-8 assay and live/dead staining showed that MeCFO/GelMA hydrogel had good cytocompatibility. These results indicated that MeCFO/GelMA hydrogel with potential antitumor and bone reconstruction functions is a promising therapeutic strategy after osteosarcoma resection.

Synthesis of the cobalt ferrite magnetic nanoparticles by sol–gel auto-combustion method in the presence of egg white (albumin)

Synthesis of the cobalt ferrite magnetic nanoparticles by sol–gel auto-combustion method in the presence of egg white (albumin)

Preparation and characterization of chitosan/polyethylene glycol and cobalt ferrite magnetic-polymeric nanoparticles as resveratrol carriers: preparation, analytical methodology validation and in vitro applicability

ABSTRACT The objective of this research was to produce, characterize and evaluate biological activities of magnetic-polymeric nanoparticles loaded with resveratrol. Magnetic nanoparticles of cobalt ferrite (CoFe2O4), polymeric nanoparticles of chitosan (CS) and polyethylene glycol (PEG), and polymeric-magnetic nanoparticles containing resveratrol (RSV) were developed. An analytical method using UV-VIS spectroscopy was developed and validated for the determination of RSV in the nanoparticles. The samples were analyzed by dynamic light scattering (DLS) for size, polydispersity index (PDI) and zeta potential. The encapsulation efficiency was determined by an indirect method. Antioxidants (ABTS and DPPH) and antibacterial (MIC and CBM) activities were evaluated. The average size of the nanoparticles varied between 184.6 and 276.5 nm. The magnetic-polymeric nanoparticles showed high encapsulation efficiency (EE) (98.75%) with a slow and prolonged release rate of 33.49% in 120 h. Furthermore, three months of storage showed less than 10% of RSV degradation. Its antioxidant activity (AA) was 170.55 mmol TE g−1 (by the ABTS method) and 130.60 mmol TE g−1 (by the DPPH method). The resveratrol-loaded magnetic-polymeric nanoparticles inhibited the growth of four tested bacteria. Their MIC values were less than 52.36 µg mL−1, and the CBM values of the nanoparticles >52.36 µg mL−1.

Greener synthesis of lightweight, self‐standing PMMA/CoFe2O4 polymeric film for magnetic, electronic, and terahertz shielding applications

AbstractThis work aims to develop a multifunctional PMMA/CoFe2O4 polymeric film of low loss dielectric constant, high magnetic properties, and perceptible terahertz shielding effectiveness. Pure cobalt ferrite magnetic nanoparticles (CoFe2O4 MNPs) were prepared by a facile‐modified solution deposition method. Then, the nanoparticles were loaded to poly (methyl methacrylate) of different ratios (x = 0, 5, 10, 15, and 20 wt%) to synthesize films by evaporative casting technique. X‐ray diffraction (XRD) evidenced the formation of CoFe2O4 MNPs in the cubic spinal structure. The FTIR confirmed the interaction of CoFe2O4 MNPs with PMMA chains. Compared to the pure PMMA, the PMMA/CoFe2O4 nanocomposites were more thermally stable, as evidenced by thermogravimetric analysis, (TGA) and differential scanning calorimetry (DSC). The micrograph images by FESEM unraveled that CoFe2O4 MNPs have formed in different geometrical shapes (nanocubes, nanotubes, and nano oval). The values of the band gap energy were computed by the absorption spectra fitting (ASF) method. It varied from 4.94 to 4.68 eV, as the CoFe2O4 MNPs contents were changed from 0 to 20 wt%. Compared to host PMMA, the dielectric permittivity was enhanced, while the dielectric loss was slightly decreased. Therefore, the prepared film can be employed as a passive component in electronic circuits, namely capacitors and supercapacitors. The shielding effectiveness (SE) was found to be improved with frequency and CoFe2O4 content, reflecting the applicability of PMMA/CoFe2O4 MNPs films in terahertz shielding. The magnetic parameters were investigated by a vibrating sample magnetometer (VSM) and were found to increase with CoFe2O4 content, which could be used as a flexible film in magnetic applications.

Preparation, physicochemical characterization, and AC induction heating properties of colloidal aggregates of ferrimagnetic cobalt ferrite nanoparticles coated with a bio-compatible polymer

AC induction heating properties of colloidal nano-aggregates of ferrimagnetic cobalt ferrite magnetic nanoparticles (MNPs) are reported in this study. Bio-compatible chitosan polymer-coated CoFe2O4 MNPs are synthesized using a co-precipitation method. Powder X-ray diffraction indicates the formation of mixed spinel structures for the uncoated (CP) and chitosan-coated (CP–CHN) MNPs, which is also supported by the cation distributions obtained from the Mössbauer spectra. The presence of chitosan coating on the surface of the CP-CHN MNPs is confirmed using X-ray photoelectron and Fourier transform infrared spectroscopy studies. Transmission electron microscopy shows primary particle sizes of ∼13 nm, which is larger than the superparamagnetic size limit of the CoFe2O4 MNPs. Hence, the CP and CP-CHN MNPs exhibit ferrimagnetic behaviour at room temperature with estimated saturation magnetization values of ∼77.4 emu/g and ∼74.4 emu/g, respectively. The average hydrodynamic diameter is found to be ∼90 ± 8 nm for an aqueous dispersion of the CP-CHN MNPs, which indicate the formation of colloidal nano-aggregates due to the ferrimagnetic interaction of the primary MNPs. The CP-CHN sample exhibits a significantly high AC induction heating efficiency of ∼267.2 ± 4.0 W/gFe, where the higher heating efficiency is attributed to the combination of hysteresis and relaxation-mediated magneto-thermal energy conversion, as confirmed using Stoner-Wohlfarth model-based dynamic hysteresis loop calculations. Further, the heating efficiency decreases with increasing sample concentration due to an increase in dipolar interaction, which is confirmed using semi-empirical calculations, where a lowering of the initial susceptibility is observed at higher concentrations. The higher AC induction heating efficiency, coupled with the demonstrated significant bio-compatibility during in vitro cytotoxicity studies, make the cobalt ferrite nano-aggregates potential candidates for magnetic hyperthermia.