Coat Color Patterns Research Articles

PELIZAEUS-MERZBACHER DISEASE. A STUDY IN NOSOLOGY.

Three brains from patients with Pelizaeus-Merzbacher disease were almost completely lacking in stainable myelin, in contrast to a normal myelin stainability in the peripheral nerves. There is no need to consider these cases as different from Pelizaeus-Merzbacher disease or to designate them “sudanophil leucodystrophy”. In discussing the pathogenesis, we point out the pathomorphologic diagnosis of the disease has been overestimated while insufficient consideration has been given to clinical and genetic data. Although unable to present a completely adequate pathogenic theory, we suggest that presently discussed theories fail to explain the total phenomena of the disease. Basically the pathogenetic mechanism is not demyelination, but a disturbance in myelination and possibly neurobiotaxis. The tigroid pattern of myelin stainability, an intriguing finding, can be set in analogy to similar coat-color patterns of heterozygous females by applying the Lyon hypothesis of heteropyknotic inactivation of X-chromosomes. Since myelin stainability has been shown to be linked to the presence of proteolipids and other myelin proteins, it may be more promising to investigate these substances rather than glycerophastides, because the former occur almost exclusively in the central nervous system, while the latter are ubiquitous in the body.

TWO-WAY SELECTION FOR BODY SIZE IN RATS, WITH OBSERVATIONS ON SIMULTANEOUS CHANGES IN COAT COLOR PATTERN AND HOOD SIZE

TWO-WAY SELECTION FOR BODY SIZE IN RATS, WITH OBSERVATIONS ON SIMULTANEOUS CHANGES IN COAT COLOR PATTERN AND HOOD SIZE

The Induction of Germinal Mutations by Chemical Means

Previous articleNext article No AccessThe Induction of Germinal Mutations by Chemical MeansLeonell C. StrongLeonell C. Strong Search for more articles by this author PDFPDF PLUS Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinkedInRedditEmail SectionsMoreDetailsFiguresReferencesCited by The American Naturalist Volume 81, Number 796Jan. - Feb., 1947 Published for The American Society of Naturalists Article DOIhttps://doi.org/10.1086/281499 Views: 2Total views on this site Citations: 16Citations are reported from Crossref PDF download Crossref reports the following articles citing this article:G. Röhrborn The Activity of Alkylating Agents I. Sensitive Mutable Stages in Spermatogenesis and Oogenesis, (Jan 1970): 294–316.https://doi.org/10.1007/978-3-642-85874-1_19L. FISHBEIN, W.G. FLAMM, H.L. FALK Tabular Summaries of Chemical Mutagens, (Jan 1970): 98–141.https://doi.org/10.1016/B978-0-12-257150-3.50011-8L. FISHBEIN, W.G. FLAMM, H.L. FALK Drugs, Food Additives, Pesticides, and Miscellaneous Mutagens, (Jan 1970): 235–306.https://doi.org/10.1016/B978-0-12-257150-3.50014-3B.M. Cattanach Chemically induced mutations in mice, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 3, no.44 (Aug 1966): 346–353.https://doi.org/10.1016/0027-5107(66)90041-8Karl-Heinrich Bauer Krebs durch chemische Stoffe, (Jan 1963): 330–428.https://doi.org/10.1007/978-3-642-86062-1_9LOUIS PELNER HOST-TUMOR ANTAGONISM. XVII. TRAUMA AND CANCER*, Journal of the American Geriatrics Society 9, no.11 (Apr 2015): 58–76.https://doi.org/10.1111/j.1532-5415.1961.tb05265.xRoy Robinson Mosaicism in mammals, Genetica 29, no.11 (Dec 1959): 120–145.https://doi.org/10.1007/BF01535705Leonell C. Strong GENETIC CONCEPT FOR THE ORIGIN OF CANCER: HISTORICAL REVIEW, Annals of the New York Academy of Sciences 71, no.6 Genetic Conce6 Genetic Conce (Sep 1958): 810–838.https://doi.org/10.1111/j.1749-6632.1958.tb46811.xPaula Hertwig Lehren und Probleme aus der vergleichenden und experimentellen Säugetiergenetik, (Jan 1953): 528–543.https://doi.org/10.1007/978-3-642-53823-0_122Hermann Druckrey Die Pharmakologie krebserregende Substanzen, Zeitschrift f�r Krebsforschung 57, no.11 (Jan 1950): 70–85.https://doi.org/10.1007/BF00524089CHARLOTTE AUERBACH CHEMICAL MUTAGENESIS, Biological Reviews 24, no.33 (Jul 1949): 355–391.https://doi.org/10.1111/j.1469-185X.1949.tb00580.xKarl Heinrich Bauer Die Mutationstheorie der Krebsentstehung, (Jan 1949): 369–433.https://doi.org/10.1007/978-3-642-49659-2_10BENTLEY GLASS The Genes and Gene Action, (Jan 1949): 15–57.https://doi.org/10.1016/B978-1-4832-0000-2.50005-6S. BHATTACHARYA A Test for Mutagenicity of Methylcholanthrene, Nature 162, no.41194119 (Oct 1948): 573–573.https://doi.org/10.1038/162573a0Hans Nothdurft Zur Theorie der prim�ren Geschwulstursachen, Zeitschrift f�r Krebsforschung 56, no.22 (Jan 1948): 176–204.https://doi.org/10.1007/BF00524704P. B. MEDAWAR CELLULAR INHERITANCE AND TRANSFORMATION, Biological Reviews 22, no.44 (Oct 1947): 360–389.https://doi.org/10.1111/j.1469-185X.1947.tb00340.x