The textile industry produces large amounts of wastewater from various finishing and dyeing processes. The eco-friendly coagulants which are readily available and low-cost, can be chosen as an alternative to other conventional coagulation methods. A study on the removal of commercially used dye from textile wastewater was conducted to investigate the effectiveness of coagulation with natural coagulants. Natural coagulants can treat low to high turbid water and have remarkable color removal efficiency that can be used for various purposes. Four types of Natural coagulants, viz Maize, Green beans, Nirmal seeds (Strychnos potatorum), and Moringa seeds, were studied. Moringa seeds were the promising coagulant for color removal from textile wastewater. Further, the process parameters like coagulant concentration, pH, and mixing time to decolorize textile wastewater were optimized using Response surface methodology (RSM). The optimum conditions from RSM for the maximum decolorization were obtained at coagulant concentration 55 mg/L, pH 6.5, and mixing time 62.5 min. At these optimum conditions, maximum decolorization obtained 98.7%, TDS-312 ppm & Turbidity-3 NTU. The decolorization of the textile wastewater using natural coagulants was best described by a second-order polynomial equation with a correlation coefficient R2 of 0.9868.