60Co Gamma Research Articles

Relative efficiency of radiophotoluminescent glass dosimeters in a scanning pencil proton beam

The increasing role of hadron therapy, and particularly of proton therapy, in cancer treatment requires dosimetric characterization of luminescent detectors in heavy charged particle beams. The ionization density, which is related to the linear energy transfer (LET), is changing when heavy charged particle is penetrating through a material. Therefore, it is crucial to evaluate how efficiency of the used dosimeters depends on the change in LET.The aim of this study was to evaluate relative efficiency of radiophotoluminescent (RPL) glass dosimeters (type GD-352M) in a clinical scanning pencil proton beam of 100 MeV and compare it to the results obtained with thermoluminescent (TL) dosimeters (type TLD-100). LETf and LETd at the selected dosimeter's position were evaluated and compared by two Monte Carlo codes (MCNP and PHITS). Linear dose response is precondition for the evaluation of dosimeter efficiency and first, dose response in proton beam was evaluated and compared with those in 60Co gamma ray field.Linear dose response up to 9 Gy was confirmed for RPLs in proton beam, and gamma ray field. For TLDs, supralinearity from about 5 Gy was observed. A constant relative efficiency is observed along the plateau (corresponding to LETf from 0.7 keV/μm to 1.7 keV/μm) of non-modulated proton beam with an average value 1.00 ± 0.02 for RPL and 0.97 ± 0.02 for TL dosimeters. Relative efficiency decrease of 10 % is observed for RPLs within the Bragg peak with LETf = 2.3 keV/μm. Future work will be focused on the evaluation of the efficiency for higher LET values using more energetic proton beams and precise positioning along the Bragg peak.

Radiation crosslinking and grafting of chitosan: Conversion of biowaste to an efficient adsorbent for removal of cationic dyes

By the mutual radiation grafting technique using Co60 gamma radiation, a novel anionic adsorbent “CRChitosan-g-SSS” was developed where in p-Sodium Styrene Sulphonate was covalently grafted onto crosslinked chitosan backbone. The synthesized radiation-grafted adsorbent was tested for the adsorptive removal of cationic dyes: methylene blue, malachite green and Congo red from aqueous solutions. The adsorbed amount of the respective dyes was 89.12, 73.13, and 29.14 (mg/g) respectively, which could be better described with Langmuir isotherm and pseudo-second-order reaction according to the correlation coefficient values, indicating favorable and feasible adsorption. Various factors influencing the adsorption capacity of“CRChitosan-g-SSS” like initial dye concentration, contact time, solution pH, and temperature were also studied. Different thermodynamic parameters such as standard free energy, standard enthalpy, and standard entropy were calculated which revealed the adsorption process to be exothermic and spontaneous. The radiation-grafted anionic adsorbent showed promising properties for the removal of toxic cationic dyes (i.e. Methylene blue, Malachite green, and Congo red).

Development of an event-by-event based Li–ZnS(Ag) neutron imaging detector with selective neutron detection capability

High sensitivity and high resolution is desired in such technologies as neutron radiography. However, the contamination of gamma photons in neutron images decreases the accuracy of neutron radiography. To solve this problem, we developed an event-by-event based neutron imaging system that can selectively detect neutrons. The developed neutron imaging system consists of an Li–ZnS(Ag) scintillator plate optically coupled to a flat panel photomultiplier tube (FP-PMT) with a light guide. Scintillation light emitted from the Li–ZnS(Ag) by the interaction with neutron-induced particles is used to calculate the position based on the center of mass calculations. The spatial resolution of the neutron imaging detector is ∼2.3 mm FWHM, and the sensitivity for 252Cf at 2 cm from the source with 2-cm-thick polystyrene is 20 cps/MBq. Background count fraction from 60Co gamma photons was 0.2 %. For various types of neutron absorption phantoms, high-contrast and high-resolution neutron images are obtained with the developed neutron imaging detector using a252Cf neutron source.

Radiation-Induced De Novo Defects in Metal-Organic Frameworks Boost CO2 Sorption.

Defects in metal-organic frameworks (MOFs) can significantly change their local microstructures, thus notably leading to an alteration-induced performance in sorption or catalysis. However, achieving de novo defect engineering in MOFs under ambient conditions without the scarification of their crystallinity remains a challenge. Herein, we successfully synthesize defective ZIF-7 through 60Co gamma ray radiation under ambient conditions. The obtained ZIF-7 is defect-rich but also has excellent crystallinity, enhanced BET surface area, and hierarchical pore structure. Moreover, the amount and structure of these defects within ZIF-7 were determined from the two-dimensional (2D) 13C-1H frequency-switched Lee-Goldburg heteronuclear correlation (FSLG-HETCOR) spectra, continuous rotation electron diffraction (cRED), and high-resolution transmission electron microscopy (HRTEM). Interestingly, the defects in ZIF-7 all strongly bind to CO2, leading to a remarkable enhancement of the CO2 sorption capability compared with that synthesized by the solvothermal method.

Enhancement of thermoluminescence properties of Sr2SiO4: Eu by addition of flux for dosimetric applications

Sr2SiO4: Eu is synthesized using NaF flux by the combustion method. The synthesized product is a promising candidate for dosimetric applications. The introduction of flux allows monitoring its properties and obtaining materials with improved thermoluminescence properties. In the present work, the phosphor was characterized by X-ray diffraction, FTIR, and thermoluminescence studies. Thermoluminescence of Sr2SiO4: Eu nanophosphor prepared with and without flux has been irradiated with 60Co gamma rays and its properties are measured at room temperature. The effect of heating rate on Sr2SiO4: Eu with flux was investigated. Thus, the results reveal that the phosphors may be suitable candidates for dosimetric applications.

Surface modification of PVDF membrane by radiation-induced admicellar polymerization of acrylamide in the presence of cationic surfactant

This article discusses the admicellar polymerization induced by radiation on the poly(vinylidene fluoride) (PVDF) membrane. There are four major stages of admicellar polymerization, which are admicelle formation, adsolubilization, polymerization, and purification. The polymerization stage was realized by using cobalt-60 (Co-60) gamma ray and PVDF as a membrane in water treatment processes, but the use of the latter is restricted due to its inherent hydrophobicity, high fouling tendency, and lack of functional groups. Therefore, this study aims to improve the water flux and permeation efficiency of the PVDF membrane by incorporating complex coordination functional groups, such as amino and carboxyl groups. Acrylamide (AAm) was radiation-grafted onto PVDF membrane in the presence of cationic surfactant, inducing admicellar polymerization. The PAAm-grafted PVDF membrane was obtained by varying the monomer concentration and irradiation dose, while the degree of grafting was found to be proportional to the concentration of monomer and irradiation dose. The changes in properties of PVDF-g-PAAm were investigated by Fourier-transform infrared (FTIR) spectroscopy, thermogravimetry, atomic force microscopy (AFM), scanning electron microscopy (SEM), and contact angle measurement. As the amount of polyacrylamide grafted increased, the hydrophilicity introduced by AAm grafting improved in water flux.

Effect of gamma rays irradiation in the structure, optical, and electrical properties of samarium doped bismuth titanate ceramics

AbstractCeramics have enormous potential in several emerging technologies, including nuclear reactors. Materials with chemical inertness, high-temperature operation, and physical properties stability under applied radiation with high energy are all desired in this field of technology. Given these broad specifications, bismuth titanate ceramics may prove to be a valuable material. Regarding this task, the effect of gamma rays on the structural, optical, and ferroelectric properties of samarium-modified bismuth titanate ceramics was investigated. The Bi3.15Sm0.85Ti3O12(BSmT) compound was irradiated for 0, 50, 100, and 200 kGy using a60Co gamma source at a dose rate of 10 kGy h−1. The phase structure confirmed the orthorhombic, single-phase nature even after gamma irradiation. The results show that the unit cell volume decreases from 966.39 to 962.38 Å3with an increase in gamma dose from 0 to 200 kGy. The X-ray photoelectron spectroscopy study shows an irradiation-induced defect in the host matrix. The results show that the bandgap energy, dielectric constant, Curie temperatures, and remnant polarization slightly decreased with an increase in gamma irradiation. According to the findings of this study, the BSmT exhibits adequate stability against gamma irradiation, which offers tremendous promise in their utilization in nuclear reactor technology.

Pre- and post-melatonin mitigates the effect of ionizing radiation-induced damage in wheat by modulating the antioxidant machinery

As an indolamine, melatonin (C13H16N2O2) performs essential roles in the regulation of plant growth and development and ameliorates the harmful effects of abiotic stresses. This study examined two types of melatonin application, pre-sowing (prMel) and application during growth (ptMel), in wheat (Triticum aestivum L.) seedlings exposed to four different doses (100, 200, 300, and 400 Gy) of radioactive cobalt (60Co) gamma rays as dry seeds to investigate their ameliorative effects on ionizing radiation (IR) stress. Peroxidase, catalase, superoxide dismutase, ascorbate peroxidase, glutathione reductase, mono- and dihydroxyperoxidase, and phenylalanine ammonia-lyase activities, and levels of lipid peroxidation, H2O2, and total glutathione (GSH), and phenolic acids (PHAs) in soluble free, ester, glycoside and ester-bound forms were examined in the seedlings. Both melatonin applications were found to increase lipid peroxidation, H2O2, and GSH contents previously reduced by gamma irradiation. The IR treatment-induced increases in enzyme activities were significantly reduced by melatonin applications. The study findings indicated that high doses of IR resulted in significant decreases in the activity and levels of the measured traits. The predominant PHAs in the tissues were vanillic, ferulic, and p-coumaric acids. In addition, ptMel application combined with IR stress lowered the total phenolic acid contents in the soluble forms while increasing those in the cell wall-bound form. In conclusion, the antioxidant system in the seedlings exposed to the different gamma ray doses was regulated by prMel and ptMel applications in such a manner as to alleviate IR stress-induced oxidatives damages in the wheat.

Dose mapping of the 60Co gamma irradiation facility and a real irradiated product – Measurements and Monte Carlo simulation

A model of the 60Co gamma irradiation facility in Croatia has been developed using the Monte Carlo code PHITS for particle transport. For the high dose rate area (i.e. inside the source rack), the calculated dose rate distribution was compared with the measurements performed with the chemical ethanol-chlorobenzene dosimeters and good agreement was observed with a relative difference of up to 6%. For the low dose rate area (i.e., outside the source rack), the calculated dose rate distribution was compared with previous simulation (using Geant4) and experimental (using ionisation chamber) study and good agreement was observed with a relative difference of less than 5%. The application of the PHITS model in everyday practice has been successfully tested on a real product, a medical implant, commonly irradiated inside the source rack for the purpose of sterilization. It was found that the simulation and experimental dose maps agree very well. Both methods can be used and will improve everyday work in both radiation processing and research.

PEGylated thrombopoietin mimetic, JNJ‑26366821 a novel prophylactic radiation countermeasure for acute radiation injury

Thrombopoietin (TPO) is the primary regulator of platelet generation and a stimulator of multilineage hematopoietic recovery following exposure to total body irradiation (TBI). JNJ‑26366821, a novel PEGylated TPO mimetic peptide, stimulates platelet production without developing neutralizing antibodies or causing any adverse effects. Administration of a single dose of JNJ‑26366821 demonstrated its efficacy as a prophylactic countermeasure in various mouse strains (males CD2F1, C3H/HeN, and male and female C57BL/6J) exposed to Co-60 gamma TBI. A dose dependent survival efficacy of JNJ‑26366821 (− 24 h) was identified in male CD2F1 mice exposed to a supralethal dose of radiation. A single dose of JNJ‑26366821 administered 24, 12, or 2 h pre-radiation resulted in 100% survival from a lethal dose of TBI with a dose reduction factor of 1.36. There was significantly accelerated recovery from radiation-induced peripheral blood neutropenia and thrombocytopenia in animals pre-treated with JNJ‑26366821. The drug also increased bone marrow cellularity and megakaryocytes, accelerated multi-lineage hematopoietic recovery, and alleviated radiation-induced soluble markers of bone marrow aplasia and endothelial damage. These results indicate that JNJ‑26366821 is a promising prophylactic radiation countermeasure for hematopoietic acute radiation syndrome with a broad window for medical management in a radiological or nuclear event.

Effect of PEG-400 on the ZnO morphology activated by gamma rays in the realization of gas sensors

This work focuses on the preparation of ZnO nanostructures using a PEG-4000 catalyst. Zinc acetate is precipitated to form zinc hydroxide, which is then subjected to various analysis techniques including FTIR transmission spectra, SEM, UVvisible spectrophotometry, and X-ray diffraction (XRD) to study the morphological and structural properties of ZnO. The samples are exposed to different doses of radiation from a 60Co gamma source, ranging from 50 to 600 kGy. Thermal analysis (TGA and DSC) confirms the thermal stability of the ZnO nanostructures. Electrical characteristics are evaluated through AC impedance measurements, which reveal that the amount of charge carriers in ZnO films increases linearly with gamma radiation. The study also investigates the potential use of irradiated nanorod and spherical ZnO samples for the detection of butane gas. At a radiation dosage of 150 kGy, the gamma-ray-irradiated sensors exhibit increased butane responses of 66.73% and 69% for nanorod and spherical samples, respectively. The findings suggest that gamma irradiation can effectively modify materials and enhance their gas sensing properties.

Impact of gamma rays on the structural, optical, and current-voltage characteristics of CuPbI3/p-Si heterojunctions

Copper lead iodide (CuPbI3) perovskite thin films were spin-coated on p-type silicon (p-Si) substrates to manufacture CuPbI3/p-Si heterojunctions. A Co-60 gamma source has been used to examine the influence of gamma exposure doses of 0–100 kGy on the nanostructural, electrical, morphological, and optical, properties of the CuPbI3/p-Si heterostructure. The X-ray diffraction (XRD) consequences showed an enhancement in crystalline naturre and confirmed the hexagonal structure of the prepared thin films. Field emission scanning electron microscopy (FESEM) images revealed that the average grain size decreased (92–56 nm) up to 50 kGy, and the small particles agglomerated with a further increase in the gamma dose. The photoluminescence (PL) results of the deposited sample revealed only one broad bandgap peak. However, the PL spectra of the gamma ray-exposed samples exhibited induced defect emission near the valence band edge. The I–V properties revealed the charge transportation mechanism in the heterojunction, and the impacts of different gamma exposure doses on the electrical characteristics of the fabricated CuPbI3/p-Si heterojunction were investigated. Electrical parameters, such as the barrier potential, saturation current, series resistance, and ideality factor (IF) of the CuPbI3/p-Si heterostructure changed with the gamma irradiation dose owing to interfacial inhomogeneities, induced defect concentration, charge accumulation at the interface, and barrier thickness.

Study of The Structural, Optical, and Morphological Properties of Sno2 Nanofilms under the Influence of Gamma Rays

This study reports the fabrication of tin oxide (SnO2) thin films using pulsed laser deposition (PLD). The effect of 60Co (300, 900, and 1200 Gy) gamma radiation on the structural, morphological, and optical features is systematically demonstrated using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM), and ultraviolet-visible light analysis (UV-Vis), respectively In XRD tests, the size of the crystallites decreased from 45.5 to 40.8 nm for the control samples and from 1200 Gy to 60Co for the irradiated samples. Using FESEM analysis, the particle diameter revealed a similar trend to that attained using XRD; in particular, the average diameters were 93.8 and 79.9 nm for the samples mentioned above. A similar profile was observed for the AFM analysis in which an increase in the radiation dose from 300 to 1200 Gy resulted in a decrease in the RMS values from 74.6 to 32.25 nm. Contrariwise, the calculated optical band gap demonstrated an increasing profile where optical band gaps of 3.08 and 3.18 eV were acquired for control and samples irradiated with 900 Gy. However, the attained optical band gap was further increased to 3.24 eV due to the 60Co gamma radiation increment to 1200 Gy.

Radioadapted Response Early Effects and Late Effects on Survival of White Blood Cells in Mice (Mus musculus L) Post C0-60 Gamma Radiation

Aims: Determine the radioadapted response to the early and late effects of white blood cells in mice after Co-60 gamma radiation. Furthermore, the effect of the radioadapted early and late effects of the radioresponse with the interval dose adaptation (DA) with the challenge dose (DC) to the white blood cells of mice, as well as the survival rate of mice white blood cells after gamma Co-60 radiation through the radio-adapted response of the early effect and the late effect.
 Place and Duration of Study: The Radioteraphy Installation in Prof. I.G.N.G. NGOERAH Hospital, between from August to October 2022.
 Methodology: This research used a low-dose method (adapted-DA dose) and at certain time intervals was continued with a larger dose (dose challenge-DC) in mice with six treatments and one as a control. From each treatment, mice's white blood cells were taken to determine the number of leukocytes and their components. Through the number of leukocytes, it is possible to analyze the radio-adaptated response to the early effect and the late effect, so that thesurvival rate of whiteblood cells inmice after gamma Co-60 radiation can be determined.
 Results: The results of research on the survival of leukocyte cells, neutrophils, and lymphocyte cell components show early-responding tissue and late-responding tissue. As for cell survival, other componentssuch asmonocytes, eosinophils, andbasophils did not respond in the same way after gamma Co-60 radiation. In general, giving a time delay to the challenge dose for all radiation dose treatments gives a fast response (early effect) to cell survival within a few days after radiation, then with time the full response that occurs is a slow (late effect). The longer the delay in giving the challenge dose, the slower the response will fully occur in the tissue after gamma Co-60 radiation. The cell survival curve also shows that the α/β ratio for the early effect is 3 and for the late effect is 10, which is an illustration of the early effect on radiation, with a linear shape of the cell death curve indicating that tissue is more sensitive to changes in radiation dose and has a greater α/β ratio. When compared to the tissue with a late effect on radiation, the tissue has a smaller α/β ratio indicating that the tissue is less sensitive to changes in the timing of the challenge dose.
 Conclusion: Radioadapted response to the survival of leukocytes, neutrophils cell components, and lymphocytes have shown early responding tissue and late responding tissue after gamma Co-60 radiation. By giving a time lag for the challenge dose, an early response to cell survival occurs for only a few days, then with time, fully the response that occurs is late responding.

Experimental and theoretical investigation for shielding efficiency of self-compacted concrete containing lead smelting waste for gamma ray

Lead smelter waste is considered as one of the most hazardous waste that pollute the environment by releasing hazardous effluents, a lot of particle matter, and other different solid wastes. In this research lead smelter waste is used as a concrete additive and fine aggregate constituent in self-compacted concrete casting to be used as a gamma ray shield. Three types of traditionally used coarse aggregate (basalt, crushed dolomite, and gravel) were used in casting normal and high strength self-compacted concrete. The fresh and hardened concrete properties were investigated. The cast samples were tested for 137Cs and 60Co gamma rays with energies 0.662 and 1.25 Mev. The mass attenuation coefficients (µ/ρ) and linear attenuation (µ) were measured and calculated using WinXCom program for gamma rays. The experimental measurements and the used theoretical calculation method were highly compatible. The usage of lead smelter waste in concrete casting improved the concrete gamma rays shielding.

In-situ critical current measurements of REBCO coated conductors during gamma irradiation

Rare-earth-barium-copper-oxide (REBCO) coated conductor tapes within next-generation tokamak pilot and power plant magnets will be exposed to broad-spectrum gamma-ray and neutron irradiation concurrently. It has been known since the 1980s that cumulative neutron fluence affects the superconducting properties of REBCO, but the effects of gamma rays are less certain, as are the effects of radiation (of any kind) during current flow. However, the use of superconductors as photon detectors suggests that energetic photons interact directly with the superconducting state, locally destroying superconductivity. Hence, as well as the effect of the overall radiation dose (fluence), the effect of radiation dose rate (flux) on the superconductor’s properties must be quantified to understand how REBCO magnets will perform during fusion magnet operation. In-situ measurements of the self-field critical current at 77 K, of several REBCO coated conductor tapes were performed during Co-60 gamma ray exposure at a dose rate of 86 Gy min−1. Samples were fully submerged in liquid nitrogen throughout the measurements. No change in the critical current of any sample during or after irradiation was observed within standard error. These are the first reported in-situ measurements of critical current during fusion-relevant gamma irradiation. Two samples were irradiated to a further dose of 208 kGy at room temperature and a second round of in-situ measurements was performed. No change in the critical current of these samples was observed within standard error. This corroborates recent studies, but is in conflict with older literature.

Bi-PMMA composite materials and their shielding capability for low energy gamma rays

The composite materials filled with different metal particles could provide the potential to meet the proper advantages for gamma radiation protection in both medicine and industry. In this paper, a new, fast, simple and low costing synthesis of bismuth powders using aluminum foil is presented as a gamma-shielding alternative to lead and cement base materials. The synthesized powders were characterized by XRD and FE-SEM. Flexible Bi-PMMA composites having 40, 50 and 60 wt% of bismuth were subsequently prepared and their gamma-shielding properties were investigated. The attenuation constants of the composites such as linear attenuation coefficient (LAC), mass attenuation coefficient (MAC), half-value layer (HVL), and mean free path (MFP) were then obtained using the relevant measured values at available energies of Am-241, Cs-137 and Co-60 gamma sources. Gamma-shielding properties of the composites (at each gamma energy) were improved with the weight percentage increase of the bismuth powder in the polymer matrix but on the other hand the shielding capability reduced with the increase of the gamma energy. The HVL value for the sample containing 60 wt % of bismuth powder at a gamma energy level of 59.5 keV was found to be 0.072 cm. This HVL value was very close to that of lead, 0.068 cm, at the same energy. Moreover, the developed composites had the following features: easy and rapid fabrication process, nontoxic nature, lightweight, flexible, environment-friendly, and cost-effective.

PRECISION AND RELIABILITY: CALIBRATION COEFFICIENTS AND LONG-TERM STABILITY ANALYSIS OF RADIOTHERAPY DOSIMETERS CALIBRATED BY SSDL, NUKLEAR MALAYSIA

One of the main objectives of the Secondary Standard Dosimetry Laboratory (SSDL) in radiotherapy dosimetry is verifying the radiation dose provided to patients is accurate and meets globally recognised standards. Properly calibrating the therapy dosimeters used in the radiotherapy centres is the first step the SSDL must take to ensure this goal is attained. This study analyses the calibration coefficients and long-term stability of therapy dosimeters calibrated by Nuklear Malaysia's SSDL. The dosimeters were calibrated in the absorbed dose to water using 60Co gamma rays, following the procedure described in IAEA TRS No. 398 and IAEA TRS No. 469. Two hundred therapy dosimeters from 33 radiotherapy centres were evaluated for the percentage deviation of the calibration coefficients provided by the SSDL and the manufacturer. Furthermore, the variation in calibration coefficient and the long-term stability of therapy dosimeters from 2011 to 2021 were examined. The percentage deviation of calibration coefficients between the SSDL and manufacturers found that most (82%) user dosimeters were within the IAEA's acceptance limit of ± 1.5%. Overall, the stability of calibration coefficient values ranged between 33.25% and -27.24%, with an average of 0.03%. As predicted, only 15% of the therapy dosimeters fulfill the criteria for long-term stability of 0.5%. In conclusion, proper maintenance and annual calibration of therapy dosimeters are very important to improve accuracy, minimise measurement uncertainty, and thus reduce the likelihood of errors in radiotherapy dosimetry.

The Preparation and Characterization of N,N-Dimethyl Acrylamide-Diallyl Maleate Gel/Hydrogel in a Non-Aqueous Solution.

A few drugs need non-aqueous gels for release in the specific region of the intestine. The present work focuses on preparing N,N-Dimethyl acrylamide-Diallyl Maleate (DMAA-DAM) gel in Dimethyl sulfoxide (DMSO) solvent by applying different doses of gamma radiation and then characterization. The blend solution of 10%: 10%-DMAA: DAM was prepared in DMSO and irradiated at 2, 5, 10, 20, and 30 kGy doses from the Co-60 gamma source. After extraction, it was observed that all of the radiation doses yielded more than 95% gel content. The best gel content was found for 10 kGy dose, which was 97%. The equilibrium swelling was optimized 1800% of the dried gel for 5 kGy dose. Gel formation was confirmed by analyzing characteristic functional groups and the environment of protons in the gel structure by using FTIR and NMR spectroscopy. The thermal stability was tested using DSC and TGA which showed the glass transition temperature at 86.55 °C and the degradation started at 320 °C. The XRD pattern analysis revealed the semi-crystalline nature of the gel. Therefore, DMAA-DAM gels can be a good candidate for use in different fields of study, especially in drug delivery.

Extreme γ-Ray Radiation Tolerance of Spectrometer-Grade CsPbBr3 Perovskite Detectors.

The perovskite compound CsPbBr3 has recently been discovered as a promising room-temperature semiconductor radiation detector, offering an inexpensive and easy-to-manufacture alternative to the current benchmark material Cd1-x Znx Te (CZT). The performance of CsPbBr3 sensors is evaluated under harsh conditions, such as high radiation doses often found in industrial settings and extreme radiation in space. Results show minimal degradation in detector performance after exposure to 1Mrad of Co-60 gamma radiation, with no significant change to energy resolution or hole mobility and lifetime. Additionally, many of the devices are still functional after being exposed to a 10Mrad dose over 3 days, and those that do not survive can still be refabricated into working detectors. These results suggest that the failure mode in these devices is likely related to the interface between the electrode and material and their reaction, or the electrode itself and not the material itself. Overall, the study suggests that CsPbBr3 has high potential as a reliable and efficient radiation detector in various applications, including those involving extreme fluxes and energies of gamma-ray radiation.