AbstractThe Mediterranean region is an important agricultural center and is expected to be most affected by climate change due to its location. In this study, the role of climate change on agriculture is examined for eight South European countries on the Mediterranean coast for the period of 1996–2016. Carbon dioxide emissions, temperature and precipitation values are used as the indicators of climate change while cereal production is taken as a proxy for agricultural production. Results of the panel vector autoregression approach reveal that an increase in the carbon dioxide emissions and temperature have a negative impact on the cereal production. However, this effect is statistically significant only in the initial periods. On the other hand, an increase in rainfall has a statistically significant positive effect on crop production only in one period. However, eventually this effect turns to negative as expected, since excessive rainfall has a negative effect on agriculture as much as drought. In conclusion, the importance of bringing the policies and strategies to the forefront in ensuring the sustainability of agriculture and minimizing the negative effects of climate change in the region are discussed.