Depending on the design, the connections of precast concrete (PC) structures can be susceptible to severe damage under large deformation. Consequently, PC structures may behave differently from cast-in-situ reinforced concrete (RC) structures under column loss scenarios. This study focuses on a class of PC structures that utilize splice sleeves (SSs) to assemble the precast components with integrated beam-column connections (IBCCs). This PC design can alleviate rebar congestion issues and minimize the need for post-cast concrete in the connection regions during assembly. The IBCCs are typically designed to mimic the behavior of corresponding RC connections under service loading conditions. However, the extent of structural emulation under column loss scenarios is not immediately clear. In this paper, the collapse behavior of PC structures with IBCCs under an internal column removal scenario is thoroughly assessed using experimental investigations and numerical analyses. Three PC subassemblages and one RC subassemblage are tested experimentally to provide experimental data for the calibration and validation of finite element (FE) models. The collapse behavior of full-span PC and RC subassemblages are next compared numerically under the internal column loss scenario, with an accompanying investigation on the influence of horizontal SSs. It is found that the PC subassemblages exhibit emulative collapse behavior as the RC subassemblage under internal column loss scenarios, provided that the horizontal SSs are located beyond the beam plastic region under the internal column loss scenario. To achieve the latter, a minimum distance of 0.15 L (L is clear beam span before column removal) is recommended for the positioning of horizontal SSs under the internal column loss scenario. Finally, it is shown that the fracture load and corresponding displacement can be enhanced with the incorporation of high ductility rebars.